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Article: Signing of absentee medical certificates by physicians.

Dardick, I

2010 Volume 119, Issue 3, Page(s) 216–217

Language	English
Publishing date	2010-03-22
Publishing country	Canada
Document type	Journal Article
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
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Article ; Online: Robust Response to

Ravelonandro, Michel / Briard, Pascal / Scorza, Ralph / Callahan, Ann / Zagrai, Ioan / Kundu, Jiban K / Dardick, Chris

Genes

2021 Volume 12, Issue 6

Abstract: Our goal was to target silencing of ... ...

Abstract	Our goal was to target silencing of the
MeSH term(s)	Biotechnology/methods ; Capsid Proteins/genetics ; Capsid Proteins/metabolism ; Disease Resistance ; Gene Silencing ; Genetic Engineering/methods ; Plum Pox Virus/genetics ; Plum Pox Virus/pathogenicity ; Prunus/genetics ; Prunus/virology ; Transgenes
Chemical Substances	Capsid Proteins
Language	English
Publishing date	2021-05-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12060816
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Article: Re-Evaluating Stroke Systems of Care: Association of Transfer Status With Thrombectomy Outcomes at an Urban Comprehensive Stroke Center.

Javed, Kainaat / Boyke, Andre / Naidu, Ishan / Ryvlin, Jessica / Dardick, Joseph / Kadaba, Devikarani / Altschul, David J / Haranhalli, Neil

Cureus

2021 Volume 13, Issue 7, Page(s) e16732

Abstract: Introduction Given the efficacy of mechanical thrombectomies (MT) for large vessel occlusions (LVO), there is concern that the Hub and Spoke model of stroke care, which prioritizes initial assessment of the acute ischemic stroke (AIS) patient at a ... ...

Abstract	Introduction Given the efficacy of mechanical thrombectomies (MT) for large vessel occlusions (LVO), there is concern that the Hub and Spoke model of stroke care, which prioritizes initial assessment of the acute ischemic stroke (AIS) patient at a primary stroke center, would cause a delay in arterial reperfusion, thus leading to worse outcomes. In this study that occurred at our comprehensive stroke center in New York, we compared the clinical outcomes of patients that were either directly admitted for thrombectomy versus those who were transferred from another institution. Methods Retrospective review of the electronic medical record (EMR) was performed on all adult patients treated with endovascular therapy for ischemic stroke between January 2016 and February 2020. A bivariate analysis was performed to compare patients in the direct admit versus transfer group. A multivariable logistic regression model was developed to determine which factors affect 90-day modified Rankin score (mRS) and to evaluate if transfer status was an independent predictor in this model. Results Three hundred and twenty-five patients were included in this study; 127 patients belonged to the direct admit group while 198 were in the transfer group. Thirteen patients (20%) in the direct admit group had a 90-day mRS score of 0-2 and so did 29 patients (25.2%) in the transfer group; thus, no statistically significant difference found in clinical outcomes between both groups (p-value = 0.427). In a multivariable logistic regression model that accounts for age, gender, smoking status, baseline mRS, presenting National Institute of Health Stroke Scale (NIHSS), procedure duration, thrombolysis in cerebral infarction (TICI) score, post-NIHSS and decompressive hemicraniectomy, transfer status was not found to be predictive of clinical outcomes (OR 0.727 95% CI 0.349-1.516; p-value = 0.396). Conclusion Transfer status is not significantly associated with 90-day outcome. Since Hub and Spoke is not associated with worse outcomes compared to direct admit, it remains a viable model for providing effective care to stroke patients in an urban setting.
Language	English
Publishing date	2021-07-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.16732
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Article ; Online: A Predictive Model for Functional Outcome in Patients with Acute Ischemic Stroke Undergoing Endovascular Thrombectomy.

Haranhalli, Neil / Javed, Kainaat / Boyke, Andre / Dardick, Joseph / Naidu, Ishan / Ryvlin, Jessica / Kadaba, Devikarani / Fluss, Rose / Derby, Carol / Altschul, David

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2021 Volume 30, Issue 11, Page(s) 106054

Abstract: Introduction: Endovascular thrombectomy (EVT) is a well-established treatment of acute ischemic stroke. Variability in outcomes among thrombectomy patients results in a need for patient centered approaches to recovery. Identifying key factors that are ... ...

Abstract	Introduction: Endovascular thrombectomy (EVT) is a well-established treatment of acute ischemic stroke. Variability in outcomes among thrombectomy patients results in a need for patient centered approaches to recovery. Identifying key factors that are associated with outcomes can help prognosticate and direct resources for continued improvement post-treatment. Thus, we developed a comprehensive predictive model of short-term outcomes post-thrombectomy. Methods: This is a retrospective chart review of adult patients who underwent EVT at our institution over the last four years. Primary outcome was dichotomized 90-day mRS (mRS 0-2 v mRS 3-6). Bivariate analyses were conducted, followed by logistic regression modelling via a backward-elimination approach to identify the best fit predictive model. Results: 326 thrombectomies were performed; 230 cases were included in the model. In the final predictive model, adjusting for age, gender, race, diabetes, and presenting NIHSS, pre-admission mRS = 0-2 (OR 18.1; 95% 3.44-95.48; p < 0.001) was the strongest predictor of a good outcome at 90-days. Other independent predictors of good outcomes included being a non-smoker (OR 5.4; 95% CI 1.53-19.00; p = 0.01) and having a post-thrombectomy NIHSS<10 (OR 9.7; 95% CI 3.90-24.27; p < 0.001). A decompressive hemicraniectomy (DHC) was predictive of a poor outcome at 90-days (OR 0.07; 95% CI 0.01-0.72; p = 0.03). This model had a Sensitivity of 79%, a Specificity of 89% and an AUC=0.89. Conclusion: Our model identified low pre-admission mRS score, low post-thrombectomy NIHSS, non-smoker status and not requiring a DHC as predictors of good functional outcomes at 90-days. Future works include developing a prognostic scoring system.
MeSH term(s)	Adult ; Humans ; Ischemic Stroke/physiopathology ; Ischemic Stroke/surgery ; Models, Statistical ; Retrospective Studies ; Thrombectomy ; Treatment Outcome
Language	English
Publishing date	2021-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1131675-5
ISSN	1532-8511 ; 1052-3057
ISSN (online)	1532-8511
ISSN	1052-3057
DOI	10.1016/j.jstrokecerebrovasdis.2021.106054
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Zs.A 3519: Show issues

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Article ; Online: Impact of Antithrombotic Medications and Reversal Strategies on the Surgical Management and Outcomes of Traumatic Acute Subdural Hematoma.

Vattipally, Vikas N / Ran, Kathleen R / Giwa, Ganiat A / Myneni, Saket / Dardick, Joseph M / Rincon-Torroella, Jordina / Ye, Xiaobu / Byrne, James P / Suarez, Jose I / Lin, Shih-Chun / Jackson, Christopher M / Mukherjee, Debraj / Gallia, Gary L / Huang, Judy / Weingart, Jon D / Azad, Tej D / Bettegowda, Chetan

World neurosurgery

2023 Volume 182, Page(s) e431–e441

Abstract: Objective: Careful hematologic management is required in surgical patients with traumatic acute subdural hematoma (aSDH) taking antithrombotic medications. We sought to compare outcomes between patients with aSDH taking antithrombotic medications at ... ...

Abstract	Objective: Careful hematologic management is required in surgical patients with traumatic acute subdural hematoma (aSDH) taking antithrombotic medications. We sought to compare outcomes between patients with aSDH taking antithrombotic medications at admission who received antithrombotic reversal with patients with aSDH not taking antithrombotics. Methods: Retrospective review identified patients with traumatic aSDH requiring surgical evacuation. The cohort was divided based on antithrombotic use and whether pharmacologic reversal agents or platelet transfusions were administered. A 3-way comparison of outcomes was performed between patients taking anticoagulants who received pharmacologic reversal, patients taking antiplatelets who received platelet transfusion, and patients not taking antithrombotics. Multivariable regressions, adjusted for injury severity, further investigated associations with outcomes. Results: Of 138 patients who met inclusion criteria, 13.0% (n = 18) reported taking anticoagulants, 16.7% (n = 23) reported taking antiplatelets, and 3.6% (n = 5) reported taking both. Patients taking antiplatelets who received platelet transfusion had longer intraoperative times (P = 0.040) and higher rates of palliative care consultations (P = 0.046) compared with patients taking anticoagulants who received pharmacologic reversal and patients not taking antithrombotics. Across groups, no significant differences were found in frequency of in-hospital intracranial hemorrhage and venous thromboembolism, length of hospital stay, rate of inpatient mortality, or follow-up health status. In multivariable analysis, intraoperative time remained longest for the antiplatelets with platelet transfusion group. Other outcomes were not associated with patient group. Conclusions: Among surgical patients with traumatic aSDH, those taking antiplatelet medications who receive platelet transfusions experience longer intraoperative procedure times and higher rates of palliative care consultation. Comparable outcomes were observed between patients receiving antithrombotic reversal and patients not taking antithrombotics.
MeSH term(s)	Humans ; Fibrinolytic Agents/therapeutic use ; Hematoma, Subdural, Acute/surgery ; Hematoma, Subdural, Acute/drug therapy ; Hematoma, Subdural/surgery ; Hematoma, Subdural/drug therapy ; Anticoagulants/therapeutic use ; Retrospective Studies ; Hematoma, Subdural, Intracranial/drug therapy
Chemical Substances	Fibrinolytic Agents ; Anticoagulants
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.11.117
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Zs.A 1159: Show issues

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Article: Predictors of Radiographic and Symptomatic Hemorrhagic Conversion Following Endovascular Thrombectomy for Acute Ischemic Stroke Due to Large Vessel Occlusion.

Javed, Kainaat / Boyke, Andre / Naidu, Ishan / Ryvlin, Jessica / Fluss, Rose / Fortunel, Adisson N / Dardick, Joseph / Kadaba, Devikarani / Altschul, David J / Haranhalli, Neil

Cureus

2022 Volume 14, Issue 4, Page(s) e24449

Abstract: Background Endovascular therapy is known to achieve a high rate of recanalization in patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO) and is currently the standard of care. Hemorrhagic conversion is a severe complication that ...

Abstract	Background Endovascular therapy is known to achieve a high rate of recanalization in patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO) and is currently the standard of care. Hemorrhagic conversion is a severe complication that may occur following AIS in patients undergoing endovascular thrombectomy (EVT). There is a scarcity of data on the risk factors related to HV in post-EVT patients, especially those who develop symptomatic hemorrhagic conversion. The main objective of our study is to identify independent predictors of radiographic and symptomatic hemorrhagic conversion in our diverse patient population with multiple baseline comorbidities that presented with AIS and were treated with EVT as per the most updated guidelines and practices. Methodology This is a retrospective chart review in which we enrolled adult patients treated with EVT for AIS at a comprehensive stroke center in the Bronx, NY, over a four-year period. Bivariate analyses followed by multiple logistic regression modeling were performed to determine the independent predictors of all and symptomatic hemorrhagic conversion. Results A total of 326 patients who underwent EVT for AIS were enrolled. Of these, 74 (22.7%) had an HC, while 252 (77.3%) did not. In total, 25 out of the 74 (33.7%) patients were symptomatic. In the logistic regression model, a history of prior ischemic stroke (odds ratio (OR) = 2.197; 95% confidence interval (CI) = 1.062-4.545; p-value = 0.034), Alberta Stroke Program Early CT Score (ASPECTS) of <6 (OR = 2.207; 95% CI = 1.477-7.194; p-value = 0.019), and Thrombolysis in Cerebral Infarction (TICI) 2B-3 recanalization (OR = 2.551; 95% CI = 1.998-6.520; p-value=0.045) were found to be independent predictors of all types of hemorrhagic conversion. The only independent predictor of symptomatic hemorrhagic conversion on multiple logistic regression modeling was an elevated international normalized ratio (INR) (OR = 11.051; 95% CI = 1.866-65.440; p-value = 0.008). Conclusions History of prior ischemic stroke, low ASPECTS score, and TICI 2B-3 recanalization are independent predictors of hemorrhagic conversion while an elevated INR is the only independent predictor of symptomatic hemorrhagic conversion in post-thrombectomy patients.
Language	English
Publishing date	2022-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.24449
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Article: Mounting evidence against current histogenetic concepts for salivary gland tumorigenesis.

Dardick, I

European journal of morphology

1998 Volume 36 Suppl, Page(s) 257–261

Abstract: Various morphological observations of salivary gland tumors are frequently used to support histogenetic concepts, such as the semipluripotential bicellular reserve cell hypothesis, for these tumors. Singularly, evidence in support of this hypothesis ... ...

Abstract	Various morphological observations of salivary gland tumors are frequently used to support histogenetic concepts, such as the semipluripotential bicellular reserve cell hypothesis, for these tumors. Singularly, evidence in support of this hypothesis remains unavailable. Indeed, physiological evidence from studies of salivary glands have long existed proving the semipluripotential bicellular reserve cell hypothesis was incorrect. More recent studies reconfirm this and show that all cell types in these complex glands are quite capable of replication and, therefore, of being involved in tumorigenic processes. The demise of the bicellular reserve cell hypothesis is long overdue.
MeSH term(s)	Animals ; Cell Division/physiology ; Humans ; Parotid Gland/chemistry ; Parotid Gland/pathology ; Proliferating Cell Nuclear Antigen/analysis ; Salivary Ducts/chemistry ; Salivary Ducts/pathology ; Salivary Gland Neoplasms/pathology
Chemical Substances	Proliferating Cell Nuclear Antigen
Language	English
Publishing date	1998-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1054139-1
ISSN	0924-3860
ISSN	0924-3860
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Zs.A 343: Show issues

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Article ; Online: Clear cell carcinoma: review of its histomorphogenesis and classification as a squamous cell lesion.

Dardick, Irving / Leong, Iona

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics

2009 Volume 108, Issue 3, Page(s) 399–405

Abstract: In current classification schemes, clear cell carcinoma-including both the hyalinized and nonhyalinized variety--is now an accepted subtype of malignant salivary gland tumors. Despite this, the underlying cellular differentiation process leading to the ... ...

Abstract	In current classification schemes, clear cell carcinoma-including both the hyalinized and nonhyalinized variety--is now an accepted subtype of malignant salivary gland tumors. Despite this, the underlying cellular differentiation process leading to the typical histomorphology of this neoplasm remains unclear. This review summarizes and illustrates the histologic, ultrastructural, and immunohistochemical evidence for the underlying squamous cell nature of clear cell carcinoma. Squamous cell differentiation is not an uncommon feature of nonneoplastic and neoplastic lesions of the salivary glands. Clear cell carcinoma needs to be added to this list as a unique but specific variety of clear cell squamous carcinoma.
MeSH term(s)	Adenocarcinoma, Clear Cell/classification ; Adenocarcinoma, Clear Cell/pathology ; Adenocarcinoma, Clear Cell/ultrastructure ; Carcinoma, Squamous Cell/classification ; Carcinoma, Squamous Cell/pathology ; Cell Differentiation ; Epithelial Cells/pathology ; Epithelial Cells/ultrastructure ; Humans ; Immunohistochemistry ; Salivary Gland Neoplasms/classification ; Salivary Gland Neoplasms/pathology ; Salivary Gland Neoplasms/ultrastructure
Language	English
Publishing date	2009-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	202468-8
ISSN	1528-395X ; 0030-4220 ; 1079-2104
ISSN (online)	1528-395X
ISSN	0030-4220 ; 1079-2104
DOI	10.1016/j.tripleo.2009.03.033
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Ul III Zs.121: Show issues

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Article ; Online: Craniotomy versus craniectomy for traumatic acute subdural hematoma-coarsened exact matched analysis of outcomes.

Ran, Kathleen R / Vattipally, Vikas N / Giwa, Ganiat A / Myneni, Saket / Raj, Divyaansh / Dardick, Joseph M / Rincon-Torroella, Jordina / Ye, Xiaobu / Byrne, James P / Suarez, Jose I / Lin, Shih-Chun / Jackson, Christopher M / Mukherjee, Debraj / Gallia, Gary L / Huang, Judy / Weingart, Jon D / Azad, Tej D / Bettegowda, Chetan

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2023 Volume 119, Page(s) 52–58

Abstract: Background and objectives: Acute subdural hematoma (aSDH) after traumatic brain injury frequently requires emergent craniotomy (CO) or decompressive craniectomy (DC). We sought to determine the variables associated with either surgical approach and to ... ...

Abstract	Background and objectives: Acute subdural hematoma (aSDH) after traumatic brain injury frequently requires emergent craniotomy (CO) or decompressive craniectomy (DC). We sought to determine the variables associated with either surgical approach and to compare outcomes between matched patients. Methods: A multi-center retrospective review was used to identify traumatic aSDH patients who underwent CO or DC. Patient variables independently associated with surgical approach were used for coarsened exact matching.Multivariate logistic regression and multivariate Cox proportional-hazards regression wereconducted on matched patients to determine independent predictors of mortality. Results: Seventy-six patients underwent CO and sixty-two underwent DC for aSDH evacuation. DC patients were21.4 years younger (P < 0.001), more likely to be male (80.6 % vs 60.5 %,P = 0.011), and present with GCS ≤ 8 (64.5 % vs 36.8 %,P = 0.001). Age (P < 0.001), epidural hematoma (P = 0.01), skull fracture (P = 0.001), and cisternal effacement (P = 0.02) were independently associated with surgical approach. After coarsened exact matching, DC (P = 0.008), older age (P = 0.007), male sex (P = 0.04), and intraventricular hemorrhage (P = 0.02), were independently associated with inpatient mortality. Multivariate Cox proportional-hazards regression demonstrated that DC was independently associated with mortality at 90-days (P = 0.001) and 1-year post-operation (P = 0.003). Conclusion: aSDH patients who receive surgical evacuation via DC as opposed to CO are younger, more likely to be male, and have worse clinical exam. After controlling for patient differences via coarsened exact matching, DC is independently associated with mortality.
MeSH term(s)	Humans ; Male ; Female ; Hematoma, Subdural, Acute/surgery ; Decompressive Craniectomy ; Craniotomy/adverse effects ; Hematoma, Subdural/etiology ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/surgery ; Brain Injuries/complications ; Retrospective Studies ; Hematoma, Subdural, Intracranial/surgery ; Treatment Outcome
Language	English
Publishing date	2023-11-18
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2023.11.021
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Zs.A 3999: Show issues

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Article ; Online: Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells.

Jiang, Ruoyi / Meng, Hailong / Raddassi, Khadir / Fleming, Ira / Hoehn, Kenneth B / Dardick, Kenneth R / Belperron, Alexia A / Montgomery, Ruth R / Shalek, Alex K / Hafler, David A / Kleinstein, Steven H / Bockenstedt, Linda K

JCI insight

2021 Volume 6, Issue 12

Abstract: The skin lesion erythema migrans (EM) is an initial sign of the Ixodes tick-transmitted Borreliella spirochetal infection known as Lyme disease. T cells and innate immune cells have previously been shown to predominate the EM lesion and promote the ... ...

Abstract	The skin lesion erythema migrans (EM) is an initial sign of the Ixodes tick-transmitted Borreliella spirochetal infection known as Lyme disease. T cells and innate immune cells have previously been shown to predominate the EM lesion and promote the reaction. Despite the established importance of B cells and antibodies in preventing infection, the role of B cells in the skin immune response to Borreliella is unknown. Here, we used single-cell RNA-Seq in conjunction with B cell receptor (BCR) sequencing to immunophenotype EM lesions and their associated B cells and BCR repertoires. We found that B cells were more abundant in EM in comparison with autologous uninvolved skin; many were clonally expanded and had circulating relatives. EM-associated B cells upregulated the expression of MHC class II genes and exhibited preferential IgM isotype usage. A subset also exhibited low levels of somatic hypermutation despite a gene expression profile consistent with memory B cells. Our study demonstrates that single-cell gene expression with paired BCR sequencing can be used to interrogate the sparse B cell populations in human skin and reveals that B cells in the skin infection site in early Lyme disease expressed a phenotype consistent with local antigen presentation and antibody production.
MeSH term(s)	Adult ; Aged ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Erythema Chronicum Migrans/immunology ; Erythema Chronicum Migrans/pathology ; Female ; Histocompatibility Antigens Class II/genetics ; Histocompatibility Antigens Class II/immunology ; Histocompatibility Antigens Class II/metabolism ; Humans ; Immunoglobulin M/genetics ; Immunoglobulin M/metabolism ; Immunophenotyping/methods ; Lyme Disease ; Male ; Middle Aged ; RNA-Seq ; Single-Cell Analysis/methods ; Skin/cytology ; Transcriptome/genetics ; Transcriptome/immunology
Chemical Substances	Histocompatibility Antigens Class II ; Immunoglobulin M
Language	English
Publishing date	2021-06-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.148035
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