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  1. Article ; Online: Correspondence (letter to the editor): Laboratory tests to ascertain tumor resistance to drugs are available.

    Lippert, Theodor H

    Deutsches Arzteblatt international

    2012  Volume 109, Issue 10, Page(s) 188; author reply 188–9

    MeSH term(s) Humans ; Lung Neoplasms/diagnosis ; Molecular Diagnostic Techniques
    Language English
    Publishing date 2012-03-09
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.2012.0188a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Relaxin

    Bongers-Binder, Susanne / Lippert, Theodor H.

    das wiederentdeckte Hormon

    1993  

    Author's details T. H. Lippert ... (Hrsg.). Mit Beitr. von S. Bongers-Binder
    Keywords Relaxin
    Size XII, 166 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book
    HBZ-ID HT004554614
    ISBN 3-540-55894-2 ; 978-3-540-55894-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1993 A 1859 order for loan Magazin

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  3. Article ; Online: Resistance tests were not mentioned.

    Lippert, Theodor H

    Deutsches Arzteblatt international

    2010  Volume 107, Issue 22, Page(s) 399; author reply 399–400

    MeSH term(s) Antineoplastic Agents/therapeutic use ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Drug Resistance, Neoplasm ; Drug Screening Assays, Antitumor ; Humans ; Neoplasm Staging ; Precision Medicine ; Treatment Outcome
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2010-06-04
    Publishing country Germany
    Document type Comment ; Letter
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.2010.0399a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Could a revision of the current guidelines for cancer drug use improve the quality of cancer treatment?

    Lippert, Theodor H / Ruoff, Hans-Jörg / Volm, Manfred

    Therapeutics and clinical risk management

    2014  Volume 10, Page(s) 69–72

    Abstract: Clinical practice guidelines are indispensable for such a variable disease as malignant solid tumors, with the complex possibilities of drug treatment. The current guidelines may be criticized on several points, however. First, there is a lack of ... ...

    Abstract Clinical practice guidelines are indispensable for such a variable disease as malignant solid tumors, with the complex possibilities of drug treatment. The current guidelines may be criticized on several points, however. First, there is a lack of information on the outcome of treatment, such as the expected success and failure rates. Treating not only drug responders but also nonresponders, that is, patients with drug resistance, must result in failures. There is no mention of the possibility of excluding the drug nonresponders, identifiable by special laboratory tests and no consideration is given to the different side effects of the recommended drug regimens. Nor are there any instructions concerning tumor cases for which anticancer drug treatment is futile. In such cases, early palliative care may lead to significant improvements in both life quality and life expectancy. Not least, there is no transparency concerning the preparation of the guidelines: persons cannot be identified who could give a statement of conflicts of interest, and responsibility is assumed only by anonymous medical associations. A revision of the current guidelines could considerably improve cancer treatment.
    Language English
    Publishing date 2014-01-30
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2186560-7
    ISSN 1178-203X ; 1176-6336
    ISSN (online) 1178-203X
    ISSN 1176-6336
    DOI 10.2147/TCRM.S51404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Current status of methods to assess cancer drug resistance.

    Lippert, Theodor H / Ruoff, Hans-Jörg / Volm, Manfred

    International journal of medical sciences

    2011  Volume 8, Issue 3, Page(s) 245–253

    Abstract: Drug resistance is the main cause of the failure of chemotherapy of malignant tumors, resistance being either preexisting (intrinsic resistance) or induced by the drugs (acquired resistance). At present, resistance is usually diagnosed during treatment ... ...

    Abstract Drug resistance is the main cause of the failure of chemotherapy of malignant tumors, resistance being either preexisting (intrinsic resistance) or induced by the drugs (acquired resistance). At present, resistance is usually diagnosed during treatment after a long period of drug administration.In the present paper, methods for a rapid assessment of drug resistance are described. Three main classes of test procedures can be found in the literature, i.e. fresh tumor cell culture tests, cancer biomarker tests and positron emission tomography (PET) tests. The methods are based on the evaluation of molecular processes, i.e. metabolic activities of cancer cells. Drug resistance can be diagnosed before treatment in-vitro with fresh tumor cell culture tests, and after a short time of treatment in-vivo with PET tests. Cancer biomarker tests, for which great potential has been predicted, are largely still in the development stage. Individual resistance surveillance with tests delivering rapid results signifies progress in cancer therapy management, by providing the possibility to avoid drug therapies that are ineffective and only harmful.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/metabolism ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm ; Humans ; Neoplasms/diagnosis ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Positron-Emission Tomography
    Chemical Substances Antineoplastic Agents ; Biomarkers, Tumor
    Language English
    Publishing date 2011-03-23
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.8.245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Current Status of Methods to Assess Cancer Drug Resistance

    Theodor H. Lippert, Hans-Jörg Ruoff, Manfred Volm

    International Journal of Medical Sciences, Vol 8, Iss 3, Pp 245-

    2011  Volume 253

    Abstract: Drug resistance is the main cause of the failure of chemotherapy of malignant tumors, resistance being either preexisting (intrinsic resistance) or induced by the drugs (acquired resistance). At present, resistance is usually diagnosed during treatment ... ...

    Abstract Drug resistance is the main cause of the failure of chemotherapy of malignant tumors, resistance being either preexisting (intrinsic resistance) or induced by the drugs (acquired resistance). At present, resistance is usually diagnosed during treatment after a long period of drug administration. In the present paper, methods for a rapid assessment of drug resistance are described. Three main classes of test procedures can be found in the literature, i.e. fresh tumor cell culture tests, cancer biomarker tests and positron emission tomography (PET) tests. The methods are based on the evaluation of molecular processes, i.e. metabolic activities of cancer cells. Drug resistance can be diagnosed before treatment in-vitro with fresh tumor cell culture tests, and after a short time of treatment in-vivo with PET tests. Cancer biomarker tests, for which great potential has been predicted, are largely still in the development stage. Individual resistance surveillance with tests delivering rapid results signifies progress in cancer therapy management, by providing the possibility to avoid drug therapies that are ineffective and only harmful.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Ivyspring International Publisher
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Book ; Conference proceedings: Sex steroids and the cardiovascular system

    Lippert, Theodore H.

    the proceedings of the 1st interdisciplinary workshop, Tuebingen, Germany, October 1996

    1998  

    Author's details ed. by Theodore H. Lippert
    Keywords Cardiovascular System / drug effects / congresses ; Sex Hormones / physiology / congresses ; Östrogene ; Arzneimittelnebenwirkung ; Kardiovaskuläre Krankheit ; Kardiovaskuläres System
    Subject Herz-Kreislauf-Krankheit ; Herz-Kreislauf-Erkrankung ; Kardiovaskuläres System ; Cardiovasculäre Krankheit ; Kardiovaskuläre Krankheiten ; Arzneimittel ; Unerwünschte Arzneimittelwirkung ; UAW ; Herz-Kreislauf-System ; Cardiovasculäres System ; Follikelhormone ; Estrogene ; Östrogen
    Language English
    Size XII, 243 S. : Ill., graph. Darst.
    Publisher Parthenon Publ. Group
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    Note Includes index
    HBZ-ID HT009215412
    ISBN 1-85070-956-4 ; 978-1-85070-956-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 7407 order for loan Magazin

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  8. Article: Intrinsic and acquired drug resistance in malignant tumors. The main reason for therapeutic failure.

    Lippert, Theodor H / Ruoff, Hans-Jörg / Volm, Manfred

    Arzneimittel-Forschung

    2008  Volume 58, Issue 6, Page(s) 261–264

    Abstract: Drug resistance is the major reason for failure in cancer chemotherapy. Resistance may be either pre-existent (intrinsic resistance), or induced by drugs (acquired resistance), So far, no strategy has been found to overcome resistance, which is based on ... ...

    Abstract Drug resistance is the major reason for failure in cancer chemotherapy. Resistance may be either pre-existent (intrinsic resistance), or induced by drugs (acquired resistance), So far, no strategy has been found to overcome resistance, which is based on highly complex and individually variable biological mechanisms. In present clinical practice, drug resistance can only be recognized during treatment, after long lag times. Thus diagnostic tests are re quired, indicating resistance at an earlier stage, in order to avoid unnecessary medication, frequently associated with toxic side-effects. A number of new anti-cancer drugs are now available. In contrast to the unspecifically acting cytostatic chemotherapy, these compounds have targeted actions. However, as recent studies have shown, resistances and severe side-effects can also be found with targeted drugs. With the increasing number of new treatment regimens, the early diagnosis of resistance will optimize therapy, and indeed will be indispensable for individual cancer therapy. The resistance assays available for use in clinical practice should be integrated into cancer therapy. Research into this neglected area needs to be intensified.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Chemotherapy, Adjuvant ; Drug Delivery Systems ; Drug Resistance, Neoplasm/genetics ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Treatment Failure
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2008
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 502081-5
    ISSN 1616-7066 ; 0004-4172
    ISSN (online) 1616-7066
    ISSN 0004-4172
    DOI 10.1055/s-0031-1296504
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.151: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    1990 A 260: Show issues

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  9. Article: Intrinsic and Acquired Drug Resistance in Malignant Tumors

    Lippert, Theodor H / Ruoff, Hans-Jörg / Volm, Manfred

    Arzneimittelforschung

    2008  Volume 58, Issue 06, Page(s) 261–264

    Abstract: Drug resistance is the major reason for failure in cancer chemotherapy. Resistance may be either pre-existent (intrinsic resistance), or induced by drugs (acquired resistance). So far, no strategy has been found to overcome resistance, which is based on ... ...

    Abstract Drug resistance is the major reason for failure in cancer chemotherapy. Resistance may be either pre-existent (intrinsic resistance), or induced by drugs (acquired resistance). So far, no strategy has been found to overcome resistance, which is based on highly complex and individually variable biological mechanisms. In present clinical practice, drug resistance can only be recognized during treatment, after long lag times. Thus diagnostic tests are required, indicating resistance at an earlier stage, in order to avoid unnecessary medication, frequently associated with toxic side-effects. A number of new anti-cancer drugs are now available. In contrast to the unspecifically acting cytostatic chemotherapy, these compounds have targeted actions. However, as recent studies have shown, resistances and severe side-effects can also be found with targeted drugs. With the increasing number of new treatment regimens, the early diagnosis of resistance will optimize therapy, and indeed will be indispensable for individual cancer therapy. The resistance assays available for use in clinical practice should be integrated into cancer therapy. Research into this neglected area needs to be intensified.
    Keywords Cancer drug therapy ; Drug resistance, resistance mechanisms, resistance reversal ; Individualised cancer therapy ; Predictive tests
    Language German
    Publishing date 2008-06-01
    Publisher Editio Cantor Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 502081-5
    ISSN 1616-7066 ; 0004-4172
    ISSN (online) 1616-7066
    ISSN 0004-4172
    DOI 10.1055/s-0031-1296504
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Estradiol metabolism and malignant disease.

    Mueck, Alfred O / Seeger, Harald / Lippert, Theodor H

    Maturitas

    2002  Volume 43, Issue 1, Page(s) 1–10

    Abstract: Endogenous estradiol metabolism results in metabolic products that are still capable of exerting various biological, partially estrogen-antagonistic actions. This indicates that the effects of estradiol in carcinogenesis may depend on individual ... ...

    Abstract Endogenous estradiol metabolism results in metabolic products that are still capable of exerting various biological, partially estrogen-antagonistic actions. This indicates that the effects of estradiol in carcinogenesis may depend on individual variations of metabolic breakdown of estradiol. The aim of this paper is to review and discuss the available data relating to stimulatory and inhibitory properties of estradiol metabolites on carcinogenesis. Results of main D-ring metabolites and main A-ring metabolites are presented. There are indications that the endogenous production of growth influencing estradiol metabolites may be elevated in neoplasias. Some results in this respect are available for stimulating tumor growth for the D-ring metabolite 16-hydroxyestrone and the A-ring metabolites 4-hydroxyestrone and 4-hydroxyestradiol. Inhibitory effects exist for the A-ring metabolite 2-methoxyestradiol (2-ME). So far, only a few metabolites have been studied closely for their influence on carcinogenesis. There is also a dearth of data on the intracellular metabolism of estradiol in neoplastic tissues. Knowledge of the metabolites may reveal new approaches to diagnosis and treatment of malignant diseases. 2-ME has already shown actions in pharmacological dosages which led already to a first trial to prove its suitability for treating human breast cancer.
    MeSH term(s) 2-Methoxyestradiol ; Anticarcinogenic Agents/chemistry ; Anticarcinogenic Agents/metabolism ; Estradiol/analogs & derivatives ; Estradiol/chemistry ; Estradiol/metabolism ; Estriol/chemistry ; Estriol/metabolism ; Estrogens, Catechol/chemistry ; Estrogens, Catechol/metabolism ; Female ; Humans ; Hydroxyestrones/chemistry ; Hydroxyestrones/metabolism ; Molecular Structure ; Neoplasms/metabolism
    Chemical Substances Anticarcinogenic Agents ; Estrogens, Catechol ; Hydroxyestrones ; Estradiol (4TI98Z838E) ; 2-Methoxyestradiol (6I2QW73SR5) ; Estriol (FB33469R8E) ; 2-hydroxyestrone (UQS3A06ILY)
    Language English
    Publishing date 2002-07-10
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 80460-5
    ISSN 1873-4111 ; 0378-5122
    ISSN (online) 1873-4111
    ISSN 0378-5122
    DOI 10.1016/s0378-5122(02)00141-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 575: Show issues

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