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  1. Article: Multiparametric Measurements of the Eustachian tube and Peritubal Region Using Computed Tomography as a Preoperative Workup for Tuboplasty.

    Varghese, Jerin Kuruvilla / George, Uttam B / Varghese, Ashish

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2023  Volume 75, Issue Suppl 1, Page(s) 851–859

    Abstract: Background: Eustachian tube dysfunction (ETD) is considered a causative factor for middle ear disease as well as treatment failure. The pathogenesis may be a result of chronic infection, allergy, laryngopharyngeal reflux, primary mucosal disease, ... ...

    Abstract Background: Eustachian tube dysfunction (ETD) is considered a causative factor for middle ear disease as well as treatment failure. The pathogenesis may be a result of chronic infection, allergy, laryngopharyngeal reflux, primary mucosal disease, dysfunction of the dilation mechanism and anatomical obstruction. Hence, it becomes essential to know the structure and anatomical variations of the Eustachian tube(ET), particularly with the advent of novel therapeutic options such as tuboplasty to ensure optimal therapeutic outcome.
    Aims: This cross-sectional study is done to perform multiparametric measurements of the ET and peritubal region using computed tomography and develop a structured protocol for pre-tuboplasty workup.
    Materials and methods: This study was done for a period of 20 months, in 100 normal subjects aged between 18 and 60 years, who underwent computed tomography (CT) study of the head and face region, for indications other than nasal/ pharyngeal and sinus disease.
    Results: The mean bony, cartilaginous and overall ET lengths were higher in males. In females, the mean ET angles with Reid's plane were higher. Higher mean craniocaudal diameters of the ET lumen were observed in males. Carotid canal dehiscence was seen in equal prevalence on both sides (5%), with no significant gender differences.
    Conclusion: Therapeutic interventions such as eustachian tuboplasty will benefit from preoperative imaging based planning. This structured protocol provides standardization of pre-operative workup for tuboplasty.
    Language English
    Publishing date 2023-01-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-022-03447-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Qualitative Assessment of Cerebral Perfusion in Post Stroke Seizure Patients using Arterial Spin Labeling

    Anjali B Susan / Uttam B George / Jeyaraj D Pandian

    Journal of Clinical and Diagnostic Research, Vol 16, Iss 6, Pp TC06-TC

    A Case-control Study

    2022  Volume 10

    Abstract: Introduction: Arterial Spin Labeling-Perfusion Weighted Imaging (ASL-PWI) assesses cerebral blood flow using magnetically labeled inflowing arterial blood water protons as freely diffusible tracer without exogenous contrast agent. Seizures are one of the ...

    Abstract Introduction: Arterial Spin Labeling-Perfusion Weighted Imaging (ASL-PWI) assesses cerebral blood flow using magnetically labeled inflowing arterial blood water protons as freely diffusible tracer without exogenous contrast agent. Seizures are one of the sequelae of stroke with its mechanism not well studied. Aim: Qualitative assessment of cerebral perfusion in post stroke seizure patients using ASL-PWI and comparison of perfusion patterns in post stroke seizure patients and stroke patients. Materials and Methods: This was a case-control study among 100 stroke patients who underwent Magnetic Resonance Imaging (MRI) of brain in Department of Radiodiagnosis, from Outpatient and Inpatient Department of Neurology, Christian Medical College, Ludhiana, Punjab, India, from 1st January 2018 till 1st January 2020. Total 50 post stroke seizure patients were included as cases and 50 age-matched post stroke patients without seizure were included as controls. Perfusion pattern was compared qualitatively using ASL-PWI. Qualitative variables were associated using Chi-square test/Fisher’s-Exact test. Results: The mean age of the study subjects were 56.38±16.98 years (age range from 19-87 years) and that of controls were 59.66±11.86 years (age range from 19-89 years) (p-value=0.265). Cerebral hypoperfusion was noted in 39 (78%) of total 50 post stroke seizure patients irrespective of type of stroke. Cortical and subcortical area of frontal and parietal lobes was predominantly involved in post stroke seizure patients. Out of 39, 23 (71.88%) early onset seizure and 16 (88.89%) late onset seizure patients had hypoperfusion. There was no significant association of perfusion abnormality with onset of seizure (p-value=0.241). Hypoperfusion was noted in cases and controls without any statistical difference. Conclusion: Cortical and subcortical area of involvement was noted in post stroke seizure patients. Post stroke seizure patients showed hypoperfusion, irrespective of stroke type and onset of seizure. There was no difference seen in ...
    Keywords hypoperfusion ; magnetic resonance imaging ; neuroimaging ; Medicine ; R
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Photonic reservoir computer using speckle in multimode waveguide ring resonators.

    Ashner, Matthew N / Paudel, Uttam / Luengo-Kovac, Marta / Pilawa, Jacob / Valley, George C

    Optics express

    2021  Volume 29, Issue 13, Page(s) 19262–19277

    Abstract: Photonic reservoir computers (RC) come in single mode ring and multimode array geometries. We propose and simulate a photonic RC architecture using speckle in a multimode waveguide ring resonator that requires neither the ultra-high-speed analog-digital ... ...

    Abstract Photonic reservoir computers (RC) come in single mode ring and multimode array geometries. We propose and simulate a photonic RC architecture using speckle in a multimode waveguide ring resonator that requires neither the ultra-high-speed analog-digital conversion nor the spatial light modulator used in other designs. We show that the equations for propagation around a multimode (MM) ring resonator along with an optical nonlinearity, and optical feedback can be cast exactly in the standard RC form with speckle mixing performing the pseudo-random matrix multiplications. The hyperparameters are the outcoupling efficiency, the nonlinearity saturation intensity, the input bias, and the waveguide properties. In particular, the number of waveguide modes is a measure of the number of effective neurons in the RC. Simulations show a ring using a strongly guiding 50-µm planar waveguide gives 206 effective neurons and excellent predictions of Mackey-Glass waveforms for a broad range of the hyperparameters, while a weakly guiding MM 200-µm diameter fiber gives 4,238 effective neurons and excellent predictions of chaotic solutions of the Kuramoto-Sivashinsky equation. We discuss physical realizations for implementing the system with a chip-scale device or with discrete components and a MM optical fiber.
    Language English
    Publishing date 2021-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.425062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Supramolecularly Bonded Layered Heterostructures Exhibiting HER Activity.

    Kaur, Manjodh / Singh, Navin Kumar / Gupta, Uttam / Sarkar, Aritra / George, Subi J / Rao, C N R

    Chemistry, an Asian journal

    2019  Volume 14, Issue 9, Page(s) 1523–1529

    Abstract: van der Waals heterostructures formed by 2D materials have attracted much attention in the last few years. Recently, 2D nanosheets linked by covalent bonds have been found to exhibit novel properties. In the present study we have investigated ... ...

    Abstract van der Waals heterostructures formed by 2D materials have attracted much attention in the last few years. Recently, 2D nanosheets linked by covalent bonds have been found to exhibit novel properties. In the present study we have investigated supramolecular layered heterostructures formed by nanosheets of MoS
    Language English
    Publishing date 2019-03-13
    Publishing country Germany
    Document type Journal Article
    ISSN 1861-471X
    ISSN (online) 1861-471X
    DOI 10.1002/asia.201801503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Classification of time-domain waveforms using a speckle-based optical reservoir computer.

    Paudel, Uttam / Luengo-Kovac, Marta / Pilawa, Jacob / Shaw, T Justin / Valley, George C

    Optics express

    2020  Volume 28, Issue 2, Page(s) 1225–1237

    Abstract: Reservoir computing is a recurrent machine learning framework that expands the dimensionality of a problem by mapping an input signal into a higher-dimension reservoir space that can capture and predict features of complex, non-linear temporal dynamics. ... ...

    Abstract Reservoir computing is a recurrent machine learning framework that expands the dimensionality of a problem by mapping an input signal into a higher-dimension reservoir space that can capture and predict features of complex, non-linear temporal dynamics. Here, we report on a bulk electro-optical demonstration of a reservoir computer using speckles generated by propagating a laser beam modulated with a spatial light modulator through a multimode waveguide. We demonstrate that the hardware can successfully perform a multivariate audio classification task performed using the Japanese vowel speakers public data set. We perform full wave optical calculations of this architecture implemented in a chip-scale platform using an SiO
    Language English
    Publishing date 2020-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.379264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correlation between high-resolution computed tomography temporal bone findings and surgical findings in patients with inflammatory diseases of the middle ear

    Jeslean Jose / Uttam B George / Ashish Varghese / Shubhra Rathore

    CHRISMED Journal of Health and Research, Vol 6, Iss 3, Pp 140-

    2019  Volume 145

    Abstract: Background: With the advent of high-resolution computed tomography (HRCT), more information can be obtained about the anatomy of the middle ear, soft tissue pathologies, and the complications of middle ear disease process as compared to the conventional ... ...

    Abstract Background: With the advent of high-resolution computed tomography (HRCT), more information can be obtained about the anatomy of the middle ear, soft tissue pathologies, and the complications of middle ear disease process as compared to the conventional diagnostic methods. Aims: This study aims to study the spectrum of HRCT temporal bone findings in inflammatory middle ear diseases as well as correlate computed tomography (CT) with intraoperative findings. Settings and Design: This is a cross-sectional study including all consecutive patients presenting to the ear, nose, and throat department with a provisional diagnosis of inflammatory middle ear disease requiring surgical management and referred to department of radiodiagnosis for HRCT temporal bone. Materials and Methods: The HRCT findings of 58 such patients were compared with the intraoperative findings. Statistical Analysis Used: Interrater agreement Kappa was used to find agreement between CT and surgical findings. Diagnostic test was used to find out sensitivity, specificity, negative predictive value, and positive predictive value of CT taking surgery as gold standard. P < 0.05 was considered as statistically significant. Results: HRCT had high sensitivity for delineating the disease at most of the sites except for the facial canal and integrity of stapes. Correlative accuracy was highest in the region of the incus, labyrinth, scutum, sinus plate, inner ear, and jugular bulb. Conclusions: Our study showed moderate to very good correlation between HRCT temporal bone and operative findings. It also allowed early identification of complications enabling a better surgical approach and treatment plan.
    Keywords Cholesteatoma ; high-resolution computed tomography ; inflammatory middle ear diseases ; Medicine ; R ; Nursing ; RT1-120
    Subject code 610 ; 616
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Spinal Epidural Bleed in Hemophilia: A Rare Site of Bleeding With Complete Resolution With Nonsurgical Management.

    Singh, Suvir / Philip, Chepsy C / George, Uttam / John, Manthanathu J

    Journal of pediatric hematology/oncology

    2018  Volume 41, Issue 3, Page(s) 215–217

    Abstract: Hemophilia A is an inherited bleeding disorder, seen in 1 in 10,000 live births. It is characterized by an increased risk of bleeding, especially involving the musculoskeletal system. Central nervous system bleeding, including brain and spinal cord bleed ...

    Abstract Hemophilia A is an inherited bleeding disorder, seen in 1 in 10,000 live births. It is characterized by an increased risk of bleeding, especially involving the musculoskeletal system. Central nervous system bleeding, including brain and spinal cord bleed is rare in the absence of overt trauma, seen in <5% patients. Epidural spinal bleeding in hemophilia is even rarer, and described in <20 patients so far in literature. We describe a young boy who presented with a cervical spine epidural bleed, and was managed conservatively without any sequelae. We also look at the controversies and recent evidence weighing surgical and conservative management of such bleeds.
    MeSH term(s) Child ; Disease Management ; Hematoma, Epidural, Spinal/diet therapy ; Hematoma, Epidural, Spinal/etiology ; Hemophilia A/complications ; Hemorrhage/etiology ; Humans ; Male ; Spine/pathology ; Treatment Outcome
    Language English
    Publishing date 2018-10-19
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000001335
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  8. Article ; Online: Central pontine myelinolysis following hypoglycemia

    Rufus Demel / Pratish George / Uttam George / Jeyaraj Pandian

    CHRISMED Journal of Health and Research, Vol 1, Iss 3, Pp 214-

    2014  Volume 215

    Keywords Medicine ; R ; Nursing ; RT1-120
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Low occurrence of “spot sign” on computed tomography angiography in acute intracerebral hemorrhage

    Vineeth Jaison / Paramdeep Kaur / Yashpal Singh / Uttam Braino George / Jeyaraj Durai Pandian

    CHRISMED Journal of Health and Research, Vol 6, Iss 4, Pp 248-

    A single-center prospective study from India

    2019  Volume 253

    Abstract: Background: Intracerebral hemorrhage (ICH) has high mortality and morbidity. The “spot sign” on three-dimensional computerized tomography angiography (3D-CTA) has been associated with hematoma expansion and poorer outcomes. The occurrence of “spot sign” ... ...

    Abstract Background: Intracerebral hemorrhage (ICH) has high mortality and morbidity. The “spot sign” on three-dimensional computerized tomography angiography (3D-CTA) has been associated with hematoma expansion and poorer outcomes. The occurrence of “spot sign” in the Indian population is poorly studied. This study was done to explore the occurrence of “spot sign” in Indian patients with ICH and their outcomes. Methods: Patients with ICH presenting within 48 h from onset to the stroke unit were recruited. They underwent noncontrast computerized tomography (NCCT) head followed by 3D-CTA and a repeat NCCT head before discharge, surgery, or with clinical worsening within 7 days of presentation. Hematoma volume was calculated using the ABC/2 method. The primary outcome was modified Rankin Scale at 3 months. Results were analyzed using descriptive statistics, Fisher's exact test, independent t- test, and Mann–Whitney U-test. The analysis was performed using SPSS version 21. P < 0.05 was taken as statistically significant. Results: Fifty-four patients were recruited during the study period, and only three patients (5.6%) had “spot sign.” All patients with “spot sign” had poor outcome without hematoma expansion. Conclusion: This study shows a low occurrence of “spot sign” in patients with ICH than previously reported. All patients with “spot sign” showed poor outcome.
    Keywords hematoma expansion ; intracerebral hemorrhage ; spot sign ; Medicine ; R ; Nursing ; RT1-120
    Subject code 616
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Spectrum of mandibular and maxillary pathologies as assessed with dentascan

    Gurleen Kaur / Uttam B George / Subhash Singla / Sumir Gandhi / Shubhra Rathore

    CHRISMED Journal of Health and Research, Vol 6, Iss 2, Pp 102-

    A pictorial essay

    2019  Volume 107

    Abstract: Introduction: Dentascan is a CT imaging software that provides three dimensional display and high resolution panoramic views of the jaw. It has become an important aspect of evaluation of mandibular and maxillary pathologies due to its advantages over ... ...

    Abstract Introduction: Dentascan is a CT imaging software that provides three dimensional display and high resolution panoramic views of the jaw. It has become an important aspect of evaluation of mandibular and maxillary pathologies due to its advantages over two dimensional techniques and conventional CT. Materials and Methods: 60 patients presenting with jaw lesions, were studied using Dentascan software. The aim of the study was to explore the spectrum of findings in various mandibular and maxillary pathologies as well as define their extent and involvement using DentaScan. Results: Impacted mandibular molars constituted 45% of cases followed by tumors and inflammatory lesions (36.6 %). Of the 22 tumors and inflammatory lesions, giant cell granulomas and radicular cysts, accounted for 22.7% each while osteomyelitis constituted 18%. Other lesions included osteosarcoma, buccal space infection, ameloblastoma, adenomatoid odontogenic tumor, dentigerous cysts and carcinoma alveolus. Trauma leading to facial fractures and TMJ pathologies constituted 8.3% and 10% of cases respectively. Conclusion: DentaScan is a valuable tool in evaluation of maxillary and mandibular pathologies including tumors/cysts, inflammatory /infectious lesions, TMJ ankylosis and facial fractures. By providing information superior to radiographs and conventional computed tomography, it plays a valuable role in pre-operative assessment of various pathologies.
    Keywords DentaScan ; mandibular pathologies ; maxillary pathologies ; Medicine ; R ; Nursing ; RT1-120
    Subject code 616
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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