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  1. Article: Midodrine - why don't you just work better?

    Anstey, Matthew / Shaefi, Shahzad / Wibrow, Bradley

    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

    2023  Volume 24, Issue 4, Page(s) 296–297

    Language English
    Publishing date 2023-10-16
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2401976-8
    ISSN 1441-2772
    ISSN 1441-2772
    DOI 10.51893/2022.4.E
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Existing Landscape of Practice in Structural Heart Disease Imaging.

    Katsiampoura, Anastasia / Rehman, Taha A / Chen, Guanqing / Shaefi, Shahzad / Mahmood, Feroze / Bose, Ruma R

    Anesthesia and analgesia

    2024  

    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: D-dimer trends in ECMO patients: don't shoot the messenger.

    Seeliger, Benjamin / Bode, Christian / Shaefi, Shahzad / Hofmaenner, Daniel A / David, Sascha

    Intensive care medicine

    2023  Volume 49, Issue 12, Page(s) 1563–1564

    MeSH term(s) Humans ; Extracorporeal Membrane Oxygenation ; Fibrin Fibrinogen Degradation Products
    Chemical Substances fibrin fragment D ; Fibrin Fibrinogen Degradation Products
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Letter
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07258-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Sex Differences in the Incidence of Postoperative Delirium after Cardiac Surgery: A Pooled Analyses of Clinical Trials.

    Wiredu, Kwame / Mueller, Ariel / McKay, Tina B / Behera, Alkananda / Shaefi, Shahzad / Akeju, Oluwaseun

    Anesthesiology

    2023  Volume 139, Issue 4, Page(s) 540–542

    MeSH term(s) Female ; Humans ; Male ; Emergence Delirium/complications ; Incidence ; Sex Characteristics ; Delirium/epidemiology ; Delirium/etiology ; Cardiac Surgical Procedures/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000004656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Proteomics for the Discovery of Clinical Delirium Biomarkers: A Systematic Review of Major Studies.

    Wiredu, Kwame / Aduse-Poku, Edmund / Shaefi, Shahzad / Gerber, Scott A

    Anesthesia and analgesia

    2022  Volume 136, Issue 3, Page(s) 422–432

    Abstract: Delirium represents a significant health care burden, diagnosed in more than 2 million elderly Americans each year. In the surgical population, delirium remains the most common complication among elderly patients, and is associated with longer hospital ... ...

    Abstract Delirium represents a significant health care burden, diagnosed in more than 2 million elderly Americans each year. In the surgical population, delirium remains the most common complication among elderly patients, and is associated with longer hospital stays, higher costs of care, increased mortality, and functional impairment. The pathomechanism of disease is poorly understood, with current diagnostic approaches somewhat subjective and arbitrary, and definitive diagnostic biomarkers are currently lacking. Despite the recent interest in delirium research, biomarker discovery for it remains new. Most attempts to discover biomarkers are targeted studies that seek to assess the involvement of one or more members of a focused panel of candidates in delirium. For a more unbiased, system-biology view, we searched literature from Medical Literature Analysis and Retrieval System Online (MEDLINE), Cochrane Central, Web of Science, SCOPUS, and Dimensions between 2016 and 2021 for untargeted proteomic discovery studies for biomarkers of delirium conducted on human geriatric subjects. Two reviewers conducted an independent review of all search results and resolved discordance by consensus. From an overall search of 1172 publications, 8 peer-reviewed studies met our defined inclusion criteria. The 370 unique perioperative biomarkers identified in these reports are enriched in pathways involving activation of the immune system, inflammatory response, and the coagulation cascade. The most frequently identified biomarker was interleukin-6 (IL-6). By reviewing the distribution of protein biomarker candidates from these studies, we conclude that a panel of proteins, rather than a single biomarker, would allow for discriminating delirium cases from noncases. The paucity of hypothesis-generating studies in the peer-reviewed literature also suggests that a system-biology view of delirium pathomechanisms has yet to fully emerge.
    MeSH term(s) Humans ; Aged ; Delirium/diagnosis ; Proteomics ; Biomarkers ; Length of Stay
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-12-29
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intraoperative plasma proteomic changes in cardiac surgery: In search of biomarkers of post-operative delirium.

    Wiredu, Kwame / O'Connor, Sean / Naseem, Heba / Brauer, Brooke L / Kettenbach, Arminja N / Frost, Hildreth R / Shaefi, Shahzad / Gerber, Scott A

    Proteomics. Clinical applications

    2023  Volume 17, Issue 4, Page(s) e2200066

    Abstract: Purpose: Delirium presents a significant healthcare burden. It complicates post-operative care in up to 50% of cardiac surgical patients with worse outcomes, longer hospital stays and higher cost of care. Moreover, the nature of delirium following ... ...

    Abstract Purpose: Delirium presents a significant healthcare burden. It complicates post-operative care in up to 50% of cardiac surgical patients with worse outcomes, longer hospital stays and higher cost of care. Moreover, the nature of delirium following cardiac surgery with cardiopulmonary bypass (CPB) remains unclear, the underlying pathobiology is poorly understood, status quo diagnostic methods are subjective, and diagnostic biomarkers are currently lacking.
    Objective: To identify diagnostic biomarkers of delirium and for insights into possible neuronal pathomechanisms.
    Experimental design: Comparative proteomic analyses were performed on plasma samples from a nested matched cohort of patients who underwent cardiac surgery. Validation by targeted proteomics was performed in an independent set of samples. Biomarkers were assessed for biological functions and diagnostic accuracy.
    Results: Forty-seven percent of subjects demonstrated delirium. Of 3803 proteins identified from patient samples by multiplexed quantitative proteomics, 16 were identified as signatures of exposure to CPB, and 11 biomarkers distinguished delirium cases from non-cases (AuROC = 93%). Notable among these biomarkers are C-reactive protein, serum amyloid A-1 and cathepsin-B.
    Conclusions and clinical relevance: The interplay of systemic and central inflammatory markers sheds new light on delirium pathogenesis. This work suggests that accurate identification of cases may be achievable using panels of biomarkers.
    MeSH term(s) Biomarkers/blood ; Proteomics ; Humans ; Cardiac Surgical Procedures ; Emergence Delirium/blood ; Emergence Delirium/diagnosis ; Case-Control Studies ; Male ; Aged ; Randomized Controlled Trials as Topic ; Deep Learning ; Workflow
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-01-04
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2261788-7
    ISSN 1862-8354 ; 1862-8346
    ISSN (online) 1862-8354
    ISSN 1862-8346
    DOI 10.1002/prca.202200066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Anesthetic Preferences for Cardiac Anesthesia: A Survey of the Society of Cardiovascular Anesthesiologists.

    O'Gara, Brian P / Beydoun, Najla Y / Mueller, Ariel / Kumaresan, Abirami / Shaefi, Shahzad

    Anesthesia and analgesia

    2022  Volume 136, Issue 1, Page(s) 51–59

    Abstract: Background: Volatile anesthetics have been historically preferred for cardiac anesthesia, but the evidence for their superiority to intravenous agents is mixed. We conducted a survey to better understand the current state of practice and the rationale ... ...

    Abstract Background: Volatile anesthetics have been historically preferred for cardiac anesthesia, but the evidence for their superiority to intravenous agents is mixed. We conducted a survey to better understand the current state of practice and the rationale behind provider preferences for anesthesia for cardiac surgery with cardiopulmonary bypass. We hypothesized that anesthetic preference would vary considerably among surveyed providers without a clear majority, as would the rationale behind those preferences.
    Methods: Email invitations were sent to members of the Society of Cardiovascular Anesthesiologists, who were asked to identify the anesthetics or sedatives they typically prefer to administer during induction, prebypass, bypass, postbypass, and postoperative periods and why they prefer those agents. Members' beliefs regarding the importance of anesthetics on postoperative outcomes were also assessed.
    Results: Invitations were sent on 2 separate dates to 3328 and 3274 members, of whom 689 (21%) responded. The median (interquartile range [IQR]) respondent age was 45 (37-56) years, 79% were men, and 75% were fellowship trained. The most frequently chosen drug for induction was propofol (80%). Isoflurane was the most frequently selected primary agent for the prebypass (57%), bypass (62%), and postbypass periods (50%). Sevoflurane was the second most frequently selected (30%; 17%, and 24%, respectively). Propofol was the third most frequently selected agent for the bypass (14%) and postbypass periods (17%). Ease of use was the most frequently selected reason for administering isoflurane and sevoflurane for each period. During bypass, the second most frequently selected rationale for using isoflurane and sevoflurane was institutional practice. A total of 76% responded that the perfusionist typically delivers the bypass anesthetic. Ischemic preconditioning, organ protection, and postoperative cognitive function were infrequently selected as rationales for preferring the volatile anesthetics. Most respondents (73%) think that anesthetics have organ-protective properties, especially isoflurane (74%) and sevoflurane (59%), and 72% believed that anesthetic choice contributes to patient outcome. The median (IQR) agreement (0 = strongly disagree to 100 = strongly agree) was 72 (63-85) for the statement that "inhaled anesthetics are an optimal maintenance anesthetic for cardiac surgery."
    Conclusions: In a survey of cardiac anesthesiologists, a majority of respondents indicated that they prefer volatile anesthetics for maintenance of anesthesia, that anesthetic selection impacts patient outcomes, and that volatile anesthetics have organ-protective properties. The members' rationales for preferring these agents possibly reflect that practical considerations, such as ease of use, effectiveness, and institutional practice, also influence anesthetic selection during cardiac surgery in addition to considerations such as organ protection.
    MeSH term(s) Male ; Humans ; Middle Aged ; Female ; Isoflurane/pharmacology ; Sevoflurane ; Propofol ; Anesthetics, Inhalation ; Anesthesiologists ; Anesthesia, Cardiac Procedures ; Methyl Ethers/pharmacology ; Methyl Ethers/therapeutic use
    Chemical Substances Isoflurane (CYS9AKD70P) ; Sevoflurane (38LVP0K73A) ; Propofol (YI7VU623SF) ; Anesthetics, Inhalation ; Methyl Ethers
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: HO-1 and CD39: It Takes Two to Protect the Realm.

    Lee, Ghee Rye / Shaefi, Shahzad / Otterbein, Leo E

    Frontiers in immunology

    2019  Volume 10, Page(s) 1765

    Abstract: Cellular protective mechanisms exist to ensure survival of the cells and are a fundamental feature of all cells that is necessary for adapting to changes in the environment. Indeed, evolution has ensured that each cell is equipped with multiple ... ...

    Abstract Cellular protective mechanisms exist to ensure survival of the cells and are a fundamental feature of all cells that is necessary for adapting to changes in the environment. Indeed, evolution has ensured that each cell is equipped with multiple overlapping families of genes that safeguard against pathogens, injury, stress, and dysfunctional metabolic processes. Two of the better-known enzymatic systems, conserved through all species, include the heme oxygenases (HO-1/HO-2), and the ectonucleotidases (CD39/73). Each of these systems generates critical bioactive products that regulate the cellular response to a stressor. Absence of these molecules results in the cell being extremely predisposed to collapse and, in most cases, results in the death of the cell. Recent reports have begun to link these two metabolic pathways, and what were once exclusively stand-alone are now being found to be intimately interrelated and do so through their innate ability to generate bioactive products including adenosine, carbon monoxide, and bilirubin. These simple small molecules elicit profound cellular physiologic responses that impact a number of innate immune responses, and participate in the regulation of inflammation and tissue repair. Collectively these enzymes are linked not only because of the mitochondria being the source of their substrates, but perhaps more importantly, because of the impact of their products on specific cellular responses. This review will provide a synopsis of the current state of the field regarding how these systems are linked and how they are now being leveraged as therapeutic modalities in the clinic.
    MeSH term(s) Adenosine/metabolism ; Adenosine Triphosphate/metabolism ; Animals ; Apyrase/metabolism ; Heme/metabolism ; Heme Oxygenase-1/metabolism ; Humans ; Immunity, Innate
    Chemical Substances Heme (42VZT0U6YR) ; Adenosine Triphosphate (8L70Q75FXE) ; Heme Oxygenase-1 (EC 1.14.14.18) ; Apyrase (EC 3.6.1.5) ; ENTPD1 protein, human (EC 3.6.1.5) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2019-07-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.01765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Prevalence of

    Teja, Bijan / Alibhai, Nafeesa / Rubenfeld, Gordon D / Taggart, Linda R / Jivraj, Naheed / Hirji, Sameer A / O'Gara, Brian P / Shaefi, Shahzad

    Infectious disease reports

    2021  Volume 13, Issue 1, Page(s) 18–22

    Abstract: While early empiric antibiotic therapy is beneficial for patients presenting with sepsis, the presentation of sepsis ... ...

    Abstract While early empiric antibiotic therapy is beneficial for patients presenting with sepsis, the presentation of sepsis from
    Language English
    Publishing date 2021-01-01
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr13010003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Rapid Weight Gain Following Weight Cutting in Male and Female Professional Mixed Martial Artists.

    Murugappan, Kadhiresan R / Mueller, Ariel / Walsh, Daniel P / Shaefi, Shahzad / Leibowitz, Akiva / Sarge, Todd

    International journal of sport nutrition and exercise metabolism

    2021  Volume 31, Issue 3, Page(s) 259–267

    Abstract: Rapid weight loss or "weight cutting" is a common but potentially harmful practice used in mixed martial arts competition. Following the official weigh-in, competitors refeed and rehydrate themselves in a process known as rapid weight gain (RWG) to ... ...

    Abstract Rapid weight loss or "weight cutting" is a common but potentially harmful practice used in mixed martial arts competition. Following the official weigh-in, competitors refeed and rehydrate themselves in a process known as rapid weight gain (RWG) to realize a potential competitive advantage. While data from surveys and small series have indicated the majority of mixed martial arts athletes engage in rapid weight loss, there is a lack of officially collected data from sanctioning organizations describing its prevalence. The present investigation represents a summary of the data collected between December 2015 and January 2018 by the California State Athletic Commission. In total, 512 professional mixed martial artists (455 males and 57 females) were included. Of these, 503 (98%) athletes gained body mass between weigh-in and their bouts. Total RWG between weigh-in and competition was 5.5 ± 2.5 kg, corresponding to an 8.1% ± 3.6% body mass increase. Total RWG was 5.6 ± 2.5 kg (8.1% ± 3.6%) for males and 4.5 ± 2.3 kg (8.0% ± 3.8%) for females. More than one quarter of men and one third of women gained >10% body mass between weigh-in and competition. Athletes from leading international promotions gained more absolute, but not relative, body mass than those from regional promotions. Our findings indicate RWG is nearly ubiquitous in professional , with a similar prevalence in male and female athletes. Trends based on promotion suggest a larger magnitude of RWG in presumably more experienced and/or successful mixed martial artists from leading international promotions.
    MeSH term(s) Athletic Performance ; Body Mass Index ; California ; Data Anonymization ; Eating ; Female ; Fluid Therapy/methods ; Humans ; Internationality ; Male ; Martial Arts/classification ; Martial Arts/physiology ; Martial Arts/statistics & numerical data ; Retrospective Studies ; Sex Factors ; Sports Nutritional Physiological Phenomena ; Weight Gain ; Weight Loss
    Language English
    Publishing date 2021-02-24
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 1101115-4
    ISSN 1543-2742 ; 1050-1606 ; 1526-484X
    ISSN (online) 1543-2742
    ISSN 1050-1606 ; 1526-484X
    DOI 10.1123/ijsnem.2020-0369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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