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  1. Article ; Online: Darbepoetin Alfa: A Viewpoint by Iain C. Macdougall.

    Macdougall, Iain C.

    Drugs

    2001  Volume 61, Issue 14, Page(s) 2105–2106

    Language English
    Publishing date 2001-11-27
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 120316-2
    ISSN 1179-1950 ; 0012-6667
    ISSN (online) 1179-1950
    ISSN 0012-6667
    DOI 10.2165/00003495-200161140-00010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 762: Show issues Location:
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  2. Article ; Online: Anaemia in CKD-treatment standard.

    Macdougall, Iain C

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2024  Volume 39, Issue 5, Page(s) 770–777

    Abstract: Anaemia is one of the most common complications of chronic kidney disease (CKD), having a significant impact on quality of life, and is also associated with a number of adverse clinical outcomes. Its pathogenesis is multifactorial, caused largely by an ... ...

    Abstract Anaemia is one of the most common complications of chronic kidney disease (CKD), having a significant impact on quality of life, and is also associated with a number of adverse clinical outcomes. Its pathogenesis is multifactorial, caused largely by an inadequate production of erythropoietin from the diseased kidneys, with iron deficiency, inflammation, shortened red cell lifespan and enhanced blood loss also being contributory factors. The management of this condition was transformed in the late 1980s by the advent of recombinant human erythropoietin (epoetin), and treatment paradigms have developed over the last three decades, largely focusing on a combination of epoetin or its analogues (erythropoiesis-stimulating agents; ESAs) along with iron supplementation, often administered intravenously due to increased hepcidin levels limiting iron absorption from the gut. Indeed, in patients with early CKD and iron deficiency, iron per se may be sufficient to improve the anaemia, delaying the need for ESA therapy. Other causes of anaemia should be excluded and corrected (if possible) before resorting to treatment with ESAs and iron. More recently, the hypoxia-inducible factor-prolyl hydroxylase inhibitors have entered the therapeutic arena; these are orally active agents that upregulate endogenous erythropoietin production as well as a number of iron-regulatory genes which may also enhance erythropoiesis. The latter drugs are highly efficacious, and may have advantages in inflammatory conditions causing resistance to conventional ESA therapy, but concerns exist regarding their safety, particularly in the longer term. This article reviews the current standards of treatment, as well as recent novel developments in the management of anaemia in CKD.
    MeSH term(s) Humans ; Anemia/etiology ; Anemia/drug therapy ; Renal Insufficiency, Chronic/complications ; Hematinics/therapeutic use ; Erythropoietin/therapeutic use
    Chemical Substances Hematinics ; Erythropoietin (11096-26-7)
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 329: Show issues

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  3. Book: Pocket reference to renal anemia

    Macdougall, Iain C.

    2013  

    Author's details Iain C. MacDougall
    Language English
    Size IX, 62 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Springer Healthcare
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018106462
    ISBN 978-1-908517-74-6 ; 1-908517-74-3
    Database Catalogue ZB MED Medicine, Health

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    2013 A 4191 available for loan (reading room) Lesesaal EG

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  4. Article ; Online: Hypoxia-inducible factor prolyl hydroxylase enzyme inhibitors: ready for primetime?

    Macdougall, Iain C

    Current opinion in nephrology and hypertension

    2022  Volume 31, Issue 5, Page(s) 399–405

    Abstract: Purpose of review: Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors have recently been developed as a new treatment for anemia associated with chronic kidney disease (CKD). Several of these have been approved in Europe (roxadustat), China, ... ...

    Abstract Purpose of review: Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors have recently been developed as a new treatment for anemia associated with chronic kidney disease (CKD). Several of these have been approved in Europe (roxadustat), China, and Japan, but none approved in the United States to date, although daprodustat has been submitted as a new drug application to the Food and Drug Administration. The aim of this review is to critically appraise the available data, particularly the most recent publications, and offer a personal viewpoint on whether or not these drugs are ready for primetime.
    Recent findings: The efficacy of HIF prolyl hydroxylase inhibitors in improving CKD anemia and maintaining a higher hemoglobin is undisputed, but there remain some concerns about safety, particularly in the long term. Some of the safety concerns may result from an exaggerated pharmacological response, while other potential adverse effects could be due to transcriptional effects of these agents beyond genes involved in erythropoiesis.
    Summary: HIF prolyl hydroxylase inhibitors are already being used in clinical practice in several countries of the world, and ongoing research is being conducted to define the role of these drugs not only in the management of anemia but also beyond into other clinical settings.
    MeSH term(s) Anemia/drug therapy ; Anemia/etiology ; Humans ; Hypoxia ; Hypoxia-Inducible Factor-Proline Dioxygenases ; Prolyl-Hydroxylase Inhibitors/adverse effects ; Renal Insufficiency, Chronic/complications
    Chemical Substances Prolyl-Hydroxylase Inhibitors ; Hypoxia-Inducible Factor-Proline Dioxygenases (EC 1.14.11.29)
    Language English
    Publishing date 2022-07-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intravenous Iron Use in the Care of Patients with Kidney Disease.

    Macdougall, Iain C

    Clinical journal of the American Society of Nephrology : CJASN

    2019  Volume 14, Issue 10, Page(s) 1528–1530

    MeSH term(s) Adult ; Anemia, Iron-Deficiency/complications ; Anemia, Iron-Deficiency/drug therapy ; Female ; Ferric Compounds/administration & dosage ; Ferric Oxide, Saccharated/administration & dosage ; Hematinics/administration & dosage ; Humans ; Infusions, Intravenous ; Male ; Maltose/administration & dosage ; Maltose/analogs & derivatives ; Middle Aged ; Renal Insufficiency, Chronic/complications
    Chemical Substances Ferric Compounds ; Hematinics ; ferric carboxymaltose (6897GXD6OE) ; Maltose (69-79-4) ; Ferric Oxide, Saccharated (FZ7NYF5N8L)
    Language English
    Publishing date 2019-06-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.00510119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6584: Show issues Location:
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  6. Book ; Conference proceedings: Managing renal anaemia: what are the issues in 2003?

    Macdougall, Iain C.

    (Nephrology, dialysis, transplantation ; 18, Suppl. 8)

    2003  

    Event/congress Masterclass in Nephrology (4, 2003, Genf)
    Author's details Masterclass in Nephrology, 21 - 22 March 2003, Geneva, Switzerland. Ed. Iain C. Macdougall
    Series title Nephrology, dialysis, transplantation ; 18, Suppl. 8
    Collection
    Language English
    Size viii41 S. : graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT013865848
    Database Catalogue ZB MED Medicine, Health

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  7. Book: An overview of the development and clinical efficacy of novel erythropoiesis stimulating protein (NESP), and practical guidelines for its use in treating renal anaemia

    Macdougall, Iain C.

    (Nephrology, dialysis, transplantation ; 16, Suppl. 3)

    2001  

    Author's details ed. Iain C. Macdougall
    Series title Nephrology, dialysis, transplantation ; 16, Suppl. 3
    Collection
    Language English
    Size 28 S. : graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT013069320
    Database Catalogue ZB MED Medicine, Health

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  8. Article ; Online: Authors' Reply.

    Macdougall, Iain C / Ford, Ian

    Journal of the American Society of Nephrology : JASN

    2020  Volume 31, Issue 7, Page(s) 1654

    MeSH term(s) Administration, Intravenous ; Disease Susceptibility ; Humans ; Infections ; Iron ; Renal Dialysis
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2020050624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3344: Show issues Location:
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  9. Article ; Online: Iron therapy for managing anaemia in chronic kidney disease.

    Macdougall, Iain C

    Current opinion in nephrology and hypertension

    2018  Volume 27, Issue 5, Page(s) 358–363

    Abstract: Purpose of review: Iron deficiency is a major contributory cause to the development of anaemia in chronic kidney disease (CKD), and thus, iron replacement therapy plays a critical role in the management of this condition. The two main routes for ... ...

    Abstract Purpose of review: Iron deficiency is a major contributory cause to the development of anaemia in chronic kidney disease (CKD), and thus, iron replacement therapy plays a critical role in the management of this condition. The two main routes for administering iron are oral and intravenous, and there have been a number of new publications relevant to both routes of administration.
    Recent findings: Recent developments on the topic of iron management in CKD include the introduction of new oral iron preparations, as well as two recent meta-analyses on iron therapy in CKD (one on oral versus intravenous iron, and one on high- versus low-dose intravenous iron in haemodialysis patients). There is also increasing interest in other strategies to improve iron availability, such as intradialytic iron, hypoxia-inducible factor stabilization and antihepcidin strategies.
    Summary: Even despite the latest publications in this field, we are still left with serious gaps in our evidence base on how best to provide supplemental iron to CKD patients. Most of the evidence suggests that intravenous iron is superior to oral iron in increasing haemoglobin and minimizing the use of erythropoiesis-stimulating agents, but the safety of intravenous iron remains a controversy. The PIVOTAL study will hopefully provide informative data to fill some of the gap in the evidence-base and inform best clinical practice.
    MeSH term(s) Administration, Intravenous ; Administration, Oral ; Anemia, Iron-Deficiency/drug therapy ; Anemia, Iron-Deficiency/etiology ; Hematinics/pharmacology ; Hematinics/therapeutic use ; Hepcidins/antagonists & inhibitors ; Humans ; Iron Compounds/administration & dosage ; Prolyl-Hydroxylase Inhibitors/pharmacology ; Prolyl-Hydroxylase Inhibitors/therapeutic use ; Renal Dialysis ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy
    Chemical Substances Hematinics ; Hepcidins ; Iron Compounds ; Prolyl-Hydroxylase Inhibitors
    Language English
    Publishing date 2018-06-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Conference proceedings: 2nd European Epoetin Symposium Optimizing Anaemia Therapy in CRF

    Macdougall, Iain C.

    17 -19 April 1998, Crete, Greece

    (Nephrology, dialysis, transplantation ; 14, Suppl. 2)

    1999  

    Event/congress European Epoetin Symposium (2, 1998)
    Author's details co-chairmen: I. C. Macdougall
    Series title Nephrology, dialysis, transplantation ; 14, Suppl. 2
    Collection
    Language English
    Size 92 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT010186511
    Database Catalogue ZB MED Medicine, Health

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    Zs A 2198 -14,Suppl.2- not available for loan Zeitschriften-Lesesaal

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