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Article ; Online: Elucidating the dialogue between arbuscular mycorrhizal fungi and polyamines in plants.

Liang, Sheng-Min / Zheng, Feng-Ling / Wu, Qiang-Sheng

World journal of microbiology & biotechnology

2022 Volume 38, Issue 9, Page(s) 159

Abstract: The most dominant arbuscular mycorrhizal (AM) symbiont can be established on roots of most terrestrial plants by beneficial AM fungi. A type of polycationic and aliphatic compounds, polyamines (PAs), are involved in plant physiological activities ... ...

Abstract	The most dominant arbuscular mycorrhizal (AM) symbiont can be established on roots of most terrestrial plants by beneficial AM fungi. A type of polycationic and aliphatic compounds, polyamines (PAs), are involved in plant physiological activities including stress responses. Interestingly, small amounts of PAs such as putrescine (Put) and spermidine (Spd) were found in AM fungal spores, and they are considered to be a component involved in mycorrhizal development, including mycorrhizal colonization, appressoria formation, spore germination and mycelial growth. Thus, PAs are regulatory factors in plant-AM symbiosis. Inoculation of AM fungi also affects the metabolism of endogenous PAs in host plants, including PAs synthesis and catabolism, thus, regulating various physiological events of the host. As a result, there seems to be a dialogue between PAs and AM fungi. Existing knowledge makes us understand that endogenous or exogenous PAs are an important regulator factor in the growth of AM fungi, as well as a key substance to colonize roots, which further enhances mycorrhizal benefits in plant growth responses and root architecture. The presence of AM symbiosis in roots alters the dynamic balance of endogenous PAs, triggering osmotic adjustment and antioxidant defense systems, maintaining charge balance and acting as a stress signalling molecule, which affects various physiological activities, such as plant growth, nutrient acquisition, stress tolerance and improvement of root architecture. This review mainly elucidated (i) what is the role of fungal endogenous PAs in fungal growth and colonization of roots in host plants? (ii) how AM fungi and PAs interact with each other to alter the growth of fungi and plants and subsequent activities, providing the reference for the future combined use of AM fungi and PAs in agricultural production, although there are still many unknown events in the dialogue.
MeSH term(s)	Fungi ; Mycorrhizae/physiology ; Plant Roots/microbiology ; Plants ; Polyamines/metabolism ; Symbiosis
Chemical Substances	Polyamines
Language	English
Publishing date	2022-07-14
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1499109-3
ISSN	1573-0972 ; 0959-3993
ISSN (online)	1573-0972
ISSN	0959-3993
DOI	10.1007/s11274-022-03336-y
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Article: [The Efficacy and Safety of Daratumumab-Based Regimen in Treatment of Multiple Myeloma Patients with Renal Impairment].

Yin, Ling-Ling / Shen, Yang-Ling / Min, Feng-Ling / Gu, Wei-Ying / Wang, Ying / Qi, Kun-Ming / Li, Zhen-Yu / Xu, Kai-Lin

Zhongguo shi yan xue ye xue za zhi

2023 Volume 31, Issue 1, Page(s) 141–147

Abstract: ... IgD-MM and 6 were light chain MM. Median estinated glomerular filtration rate (eGFR) was 22.48 ml/(min ...

Abstract	Objective: To investigate the efficacy and safety of daratumumab in treatment of multiple myeloma (MM) patients with renal impairment (RI). Methods: The clinical data of 15 MM patients with RI who received daratumumab-based regimen from January 2021 to March 2022 in three centers were retrospectively analyzed. Patients were treated with daratumumab or daratumumab combined with dexamethasone or daratumumab combined with bortezomib and dexamethasone and the curative effect and survival were analyzed. Results: The median age of 15 patients was 64 (ranged 54-82) years old. Six patients were IgG-MM, 2 were IgA-MM,1 was IgD-MM and 6 were light chain MM. Median estinated glomerular filtration rate (eGFR) was 22.48 ml/(min·1.73 M Conclusion: Daratumumab-based regimens have good short-term efficacy and safety in the treatment of multiple myeloma patients with renal impairment.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Multiple Myeloma/drug therapy ; Retrospective Studies ; Dexamethasone/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Bortezomib/therapeutic use ; Renal Insufficiency/chemically induced ; Renal Insufficiency/drug therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Chemical Substances	daratumumab (4Z63YK6E0E) ; Dexamethasone (7S5I7G3JQL) ; Antibodies, Monoclonal ; Bortezomib (69G8BD63PP)
Language	Chinese
Publishing date	2023-02-10
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2023.01.023
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Zs.A 6603: Show issues

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Article ; Online: Chronic neutrophilic leukemia complicated with monoclonal gammopathy of undetermined significance: A case report and literature review.

Gao, Jia-Pei / Zhai, Li-Jia / Gao, Xiao-Hui / Min, Feng-Ling

Journal of clinical laboratory analysis

2022 Volume 36, Issue 4, Page(s) e24287

Abstract: Background: Study of the molecular biological characteristics of chronic neutrophilic leukemia complicated with plasma cell disorder (CNL-PCD) and lymphocytic proliferative disease (CNL-LPD).: Methods: The clinical data of a patient with chronic ... ...

Abstract	Background: Study of the molecular biological characteristics of chronic neutrophilic leukemia complicated with plasma cell disorder (CNL-PCD) and lymphocytic proliferative disease (CNL-LPD). Methods: The clinical data of a patient with chronic neutrophilic leukemia complicated with monoclonal gammopathy of undetermined significance (CNL-MGUS) in our hospital were reviewed, and the Chinese and/or English literature about CNL-PCD and CNL-LPD in PubMed and the Chinese database CNKI in the past 10 years was searched to analyze the molecular biological characteristics of this disease. Results: A 73-year-old male had persistent leukocytosis for 18 months. The white blood cell count was 46.77 × 109/L and primarily composed of mature neutrophils; hemoglobin: 77 g/L; platelet count: 189 × 109/L. Serum immunofixation electrophoresis showed IgG-λ monoclonal M protein. A CT scan showed splenomegaly. Next-generation sequencing (NGS) showed that CSF3R T618I, ASXL1 and RUNX1 mutations were positive. It was diagnosed as CNL-MGUS. We summarized 10 cases of CNL-PCD and 1 case of CNL-LPD who underwent genetic mutation detection reported in the literature. The CSF3R mutational frequency (7/11, 63.6%) was lower than that of isolated CNL. The ASXL1 mutations were all positive (3/3), which may represent a poor prognostic factor. The SETBP1 mutation may promote the progression of CNL-PCD. We also found JAK2, RUNX1, NRAS, etc. in CNL-PCD. Conclusions: Chronic neutrophilic leukemia may be more inclined to coexist with plasma cell disorder. The CSF3R mutation in CNL-PCD is still the most common mutated gene compared with isolated CNL. Mutations in SETBP1 and ASXL1 may be poor prognostic factors for CNL-PCD.
MeSH term(s)	Aged ; Core Binding Factor Alpha 2 Subunit/genetics ; Humans ; Leukemia, Neutrophilic, Chronic/complications ; Leukemia, Neutrophilic, Chronic/diagnosis ; Leukemia, Neutrophilic, Chronic/genetics ; Male ; Monoclonal Gammopathy of Undetermined Significance/complications ; Monoclonal Gammopathy of Undetermined Significance/genetics ; Mutation/genetics ; Paraproteinemias/complications ; Paraproteinemias/genetics
Chemical Substances	Core Binding Factor Alpha 2 Subunit
Language	English
Publishing date	2022-02-16
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	645095-7
ISSN	1098-2825 ; 0887-8013
ISSN (online)	1098-2825
ISSN	0887-8013
DOI	10.1002/jcla.24287
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Zs.A 2471: Show issues

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Article ; Online: Toxicity interactions of azole fungicide mixtures on Chlorella pyrenoidosa.

Huang, Feng-Ling / Liu, Min / Qin, Li-Tang / Mo, Ling-Yun / Liang, Yan-Peng / Zeng, Hong-Hu / Deng, Zhen-Gui

Environmental toxicology

2023 Volume 38, Issue 7, Page(s) 1509–1519

Abstract: It is acknowledged that azole fungicides may release into the environment and pose potential toxic risks. The combined toxicity interactions of azole fungicide mixtures, however, are still not fully understood. The combined toxicities and its toxic ... ...

Abstract	It is acknowledged that azole fungicides may release into the environment and pose potential toxic risks. The combined toxicity interactions of azole fungicide mixtures, however, are still not fully understood. The combined toxicities and its toxic interactions of 225 binary mixtures and 126 multi-component mixtures on Chlorella pyrenoidosa were performed in this study. The results demonstrated that the negative logarithm 50% effect concentration (pEC
MeSH term(s)	Fungicides, Industrial/toxicity ; Azoles/toxicity ; Chlorella ; Epoxy Compounds/toxicity
Chemical Substances	Fungicides, Industrial ; Azoles ; epoxiconazole (U80T84L776) ; Epoxy Compounds
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.23782
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Zs.A 2676: Show issues

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Article: Effects of drip irrigation frequency on the yield and nutrient utilization efficiency of tomato under long-season cultivation in solar greenhouse.

Meng, Qing-Qing / Wu, Feng-Ling / Song, Jian-Li / Wei, Min / Meng, Lun / Li, Jing / Yang, Feng-Juan

Ying yong sheng tai xue bao = The journal of applied ecology

2023 Volume 34, Issue 5, Page(s) 1297–1304

Abstract: To improve the utilization efficiency of nutrients and water and determine the best drip irrigation frequency for long-season tomato cultivation in solar greenhouses, we cultivated tomato grafted seedlings in soil using an integrated water and fertilizer ...

Title translation	滴灌频次对温室长季节栽培番茄产量和养分利用效率的影响.
Abstract	To improve the utilization efficiency of nutrients and water and determine the best drip irrigation frequency for long-season tomato cultivation in solar greenhouses, we cultivated tomato grafted seedlings in soil using an integrated water and fertilizer technology: drip irrigation under mulch. Seedlings drip-irrigated with balanced fertilizer (containing 20% N, 20% P
MeSH term(s)	Solanum lycopersicum ; Fertilizers/analysis ; Seasons ; Nitrogen/analysis ; Soil ; Water ; Nutrients ; Agricultural Irrigation/methods
Chemical Substances	Fertilizers ; Nitrogen (N762921K75) ; Soil ; Water (059QF0KO0R)
Language	English
Publishing date	2023-05-26
Publishing country	China
Document type	Journal Article
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
DOI	10.13287/j.1001-9332.202305.014
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Article ; Online: Unveiling the Potential of

Zheng, Youle / Yu, Yixin / Feng, Jin / Ling, Min / Wang, Xu

Journal of agricultural and food chemistry

2024 Volume 72, Issue 4, Page(s) 2240–2249

Abstract: Muscle atrophy refers to a decline in muscle mass and function, which has become a global concern due to the aging population. Various clinical trials have investigated the inhibitors of myostatin (MSTN). They have shown promising improvements in muscle ... ...

Abstract	Muscle atrophy refers to a decline in muscle mass and function, which has become a global concern due to the aging population. Various clinical trials have investigated the inhibitors of myostatin (MSTN). They have shown promising improvements in muscle function and quality of life. However, there are no drugs specifically targeting MSTN that have been approved for clinical use. In this study, we virtually screened liensinine (LIE), a food (
MeSH term(s)	Humans ; Aged ; Nelumbo ; Myostatin/genetics ; Myostatin/metabolism ; Quality of Life ; Muscular Atrophy/drug therapy ; Muscular Atrophy/metabolism ; Proteins/metabolism ; Muscle, Skeletal/metabolism ; Isoquinolines ; Phenols
Chemical Substances	liensinine (2586-96-1) ; Myostatin ; Proteins ; Isoquinolines ; Phenols
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c09002
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Zs.A 1172: Show issues

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Article ; Online: Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies.

Zheng, Youle / Feng, Jin / Yu, Yixin / Ling, Min / Wang, Xu

Archives of pharmacal research

2024 Volume 47, Issue 4, Page(s) 301–324

Abstract: Sarcopenia is a multifactorial condition characterized by loss of muscle mass. It poses significant health risks in older adults worldwide. Both pharmacological and non-pharmacological approaches are reported to address this disease. Certain dietary ... ...

Abstract	Sarcopenia is a multifactorial condition characterized by loss of muscle mass. It poses significant health risks in older adults worldwide. Both pharmacological and non-pharmacological approaches are reported to address this disease. Certain dietary patterns, such as adequate energy intake and essential amino acids, have shown positive outcomes in preserving muscle function. Various medications, including myostatin inhibitors, growth hormones, and activin type II receptor inhibitors, have been evaluated for their effectiveness in managing sarcopenia. However, it is important to consider the variable efficacy and potential side effects associated with these treatments. There are currently no drugs approved by the Food and Drug Administration for sarcopenia. The ongoing research aims to develop more effective strategies in the future. Our review of research on disease mechanisms and drug development will be a valuable contribution to future research endeavors.
MeSH term(s)	Sarcopenia/drug therapy ; Sarcopenia/metabolism ; Sarcopenia/therapy ; Humans ; Animals ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Myostatin/antagonists & inhibitors ; Myostatin/metabolism ; Drug Development/methods
Chemical Substances	Myostatin
Language	English
Publishing date	2024-04-09
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	447623-2
ISSN	1976-3786 ; 0253-6269
ISSN (online)	1976-3786
ISSN	0253-6269
DOI	10.1007/s12272-024-01493-2
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Zs.B 3229: Show issues

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Article: Elucidating the dialogue between arbuscular mycorrhizal fungi and polyamines in plants

Liang, Sheng-Min / Zheng, Feng-Ling / Wu, Qiang-Sheng

World journal of microbiology & biotechnology. 2022 Sept., v. 38, no. 9

2022

Abstract	The most dominant arbuscular mycorrhizal (AM) symbiont can be established on roots of most terrestrial plants by beneficial AM fungi. A type of polycationic and aliphatic compounds, polyamines (PAs), are involved in plant physiological activities including stress responses. Interestingly, small amounts of PAs such as putrescine (Put) and spermidine (Spd) were found in AM fungal spores, and they are considered to be a component involved in mycorrhizal development, including mycorrhizal colonization, appressoria formation, spore germination and mycelial growth. Thus, PAs are regulatory factors in plant-AM symbiosis. Inoculation of AM fungi also affects the metabolism of endogenous PAs in host plants, including PAs synthesis and catabolism, thus, regulating various physiological events of the host. As a result, there seems to be a dialogue between PAs and AM fungi. Existing knowledge makes us understand that endogenous or exogenous PAs are an important regulator factor in the growth of AM fungi, as well as a key substance to colonize roots, which further enhances mycorrhizal benefits in plant growth responses and root architecture. The presence of AM symbiosis in roots alters the dynamic balance of endogenous PAs, triggering osmotic adjustment and antioxidant defense systems, maintaining charge balance and acting as a stress signalling molecule, which affects various physiological activities, such as plant growth, nutrient acquisition, stress tolerance and improvement of root architecture. This review mainly elucidated (i) what is the role of fungal endogenous PAs in fungal growth and colonization of roots in host plants? (ii) how AM fungi and PAs interact with each other to alter the growth of fungi and plants and subsequent activities, providing the reference for the future combined use of AM fungi and PAs in agricultural production, although there are still many unknown events in the dialogue.
Keywords	antioxidant activity ; appressoria ; biotechnology ; catabolism ; fungal growth ; mycelium ; plant growth ; putrescine ; spermidine ; spore germination ; stress tolerance ; symbionts ; vesicular arbuscular mycorrhizae
Language	English
Dates of publication	2022-09
Size	p. 159.
Publishing place	Springer Netherlands
Document type	Article
Note	Review
ZDB-ID	1499109-3
ISSN	1573-0972 ; 0959-3993
ISSN (online)	1573-0972
ISSN	0959-3993
DOI	10.1007/s11274-022-03336-y
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Toxicity interactions of azole fungicide mixtures on Chlorella pyrenoidosa

Huang, Feng‐Ling / Liu, Min / Qin, Li‐Tang / Mo, Ling‐Yun / Liang, Yan‐Peng / Zeng, Hong‐Hu / Deng, Zhen‐Gui

Environmental Toxicology. 2023 July, v. 38, no. 7 p.1509-1519

2023

Abstract	It is acknowledged that azole fungicides may release into the environment and pose potential toxic risks. The combined toxicity interactions of azole fungicide mixtures, however, are still not fully understood. The combined toxicities and its toxic interactions of 225 binary mixtures and 126 multi‐component mixtures on Chlorella pyrenoidosa were performed in this study. The results demonstrated that the negative logarithm 50% effect concentration (pEC₅₀) of 10 azole fungicides to Chlorella pyrenoidosa at 96 h ranged from 4.23 (triadimefon) to 7.22 (ketoconazole), while the pEC₅₀ values of the 351 mixtures ranged from 3.91 to 7.44. The high toxicities were found for the mixtures containing epoxiconazole. According to the results of the model deviation ratio (MDR) calculated from the concentration addition (MDRCA), 243 out of 351 (69.23%) mixtures presented additive effect at the 10% effect, while the 23.08% and 7.69% of mixtures presented synergistic and antagonistic effects, respectively. At the 30% effect, 47.29%, 29.34%, and 23.36% of mixtures presented additive effects, synergism, and antagonism, respectively. At the 50% effect, 44.16%, 34.76%, and 21.08% of mixtures presented additive effects, synergism, and antagonism, respectively. Thus, the toxicity interactions at low concentration (10% effect) were dominated by additive effect (69.23%), whereas 55.84% of mixtures induced synergism and antagonism at high concentration (50% effect). Climbazole and imazalil were the most frequency of components presented in the additive mixtures. Epoxiconazole was the key component induced the synergistic effects, while clotrimazole was the key component in the antagonistic mixtures.
Keywords	Chlorella pyrenoidosa ; additive effect ; antagonism ; clotrimazole ; ecotoxicology ; epoxiconazole ; imazalil ; ketoconazole ; synergism ; toxicity ; triadimefon
Language	English
Dates of publication	2023-07
Size	p. 1509-1519.
Publishing place	John Wiley & Sons, Inc.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.23782
Database	NAL-Catalogue (AGRICOLA)

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Article: Basophils Predict Mite Sensitization in Patients with Kawasaki Disease.

Chang, Ling-Sai / Huang, Ying-Hsien / Chang, Hsin-Yu / Lee, Zon-Min / Feng, Wei-Ling / Kuo, Ho-Chang

Children (Basel, Switzerland)

2023 Volume 10, Issue 7

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2023-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10071209
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