Article ; Online: Host Cell Entry and Neutralization Sensitivity of SARS-CoV-2 Lineages B.1.620 and R.1.
2022 Volume 14, Issue 11
Abstract: ... while lineage R.1 harbors four mutations in S and infections were observed in several countries, particularly ... Japan and the US. However, the impact of the mutations in B.1.620 and R.1 S proteins on antibody ... by vaccine-induced antibodies. Our results reveal evasion of neutralizing antibodies by B.1.620 and R.1 ...
| Abstract | The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) facilitates viral entry into host cells and is the key target for neutralizing antibodies. The SARS-CoV-2 lineage B.1.620 carries fifteen mutations in the S protein and is spread in Africa, the US and Europe, while lineage R.1 harbors four mutations in S and infections were observed in several countries, particularly Japan and the US. However, the impact of the mutations in B.1.620 and R.1 S proteins on antibody-mediated neutralization and host cell entry are largely unknown. Here, we report that these mutations are compatible with robust ACE2 binding and entry into cell lines, and they markedly reduce neutralization by vaccine-induced antibodies. Our results reveal evasion of neutralizing antibodies by B.1.620 and R.1, which might have contributed to the spread of these lineages. |
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| MeSH term(s) | Humans ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus ; Angiotensin-Converting Enzyme 2 ; Virus Internalization ; Peptidyl-Dipeptidase A/metabolism ; COVID-19 ; Antibodies, Neutralizing ; Antibodies, Viral ; Mutation |
| Chemical Substances | Spike Glycoprotein, Coronavirus ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Antibodies, Neutralizing ; Antibodies, Viral ; spike protein, SARS-CoV-2 |
| Language | English |
| Publishing date | 2022-11-09 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2516098-9 |
| ISSN | 1999-4915 ; 1999-4915 |
| ISSN (online) | 1999-4915 |
| ISSN | 1999-4915 |
| DOI | 10.3390/v14112475 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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