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Article: Anti-osteoporotic effects of Yi Mai Jian on bone metabolism of ovariectomized rats.

Shi, Bin / Lin, Che-Chun / Lee, Chia-Jung / Ning, De-Shan / Lin, Chao-Chi / Zhao, Hong-Wei / Yang, Chang-Syun / Deng, Shun-Xin / Chiu, Yung-Jia / Wang, Ching-Chiung

Frontiers in pharmacology

2024 Volume 15, Page(s) 1326415

Abstract: Yi Mai Jian herbal formula (YMJ) is formulated with Eucommiae Folium, Astragali Radix ...

Abstract	Yi Mai Jian herbal formula (YMJ) is formulated with Eucommiae Folium, Astragali Radix, Ligustri Lucidi Fructus, and Elaeagnus Fructus to improve bone function in traditional Chinese medicine. The anti-osteoporotic effects of YMJ in bone metabolism were evaluated in ovariectomized (OVX) rats. The skeletal structure of the femur and vertebrae was analyzed after treating OVX rats with YMJ for 114 days. The results showed that YMJ significantly increased the bone mineral density (BMD) and trabecular number (Tb. N) of the femur and 5th lumbar vertebrae and reduced trabecular separation (Tb. Sp). Moreover, trabecular bone volume/total tissue volume (BV/TV), bone stiffness, and maximum femur load were significantly increased. The serum concentrations of NTX1 and PYD were significantly decreased. According to these results, YMJ could ameliorate osteoporosis in ovariectomized rats. Eucommiae Folium and Elaeagnus Fructus inhibited osteoclast differentiation, Ligustri Lucidi Fructus inhibited calcium reabsorption, Astragali Radix stimulated osteoblast proliferation, and Astragali Radix and Eucommiae Folium stimulated mineralization. Therefore, the combination of the four herbs into one formula, YMJ, could alleviate bone remodeling caused by low estrogen levels. We suggest that YMJ could be a healthy food candidate for preventing post-menopausal osteoporosis.
Language	English
Publishing date	2024-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1326415
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Article ; Online: Correction for: Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.

Jiang, Xiao-Lin / Tai, He / Kuang, Jin-Song / Zhang, Jing-Yi / Cui, Shi-Chao / Lu, Yu-Xuan / Qi, Shu-Bo / Zhang, Shi-Yu / Li, Shun-Min / Chen, Jian-Ping / Meng, Xian-Sheng

Aging

2023 Volume 15, Issue 6, Page(s) 2358–2360

Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Journal Article ; Published Erratum
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204637
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Article ; Online: Yi Mai granule improve energy supply of endothelial cells in atherosclerosis via miRNA-125a-5p regulating mitochondrial autophagy through Pink1-Mfn2-Parkin pathway.

Kong, De Zhao / Sun, Peng / Lu, Yi / Yang, Ye / Min, Dong Yu / Zheng, Si Cheng / Yang, Yi / Zhang, Zhe / Yang, Guan Lin / Jiang, Jun Wen

Journal of ethnopharmacology

2023 Volume 319, Issue Pt 1, Page(s) 117114

Abstract: Ethnopharmacological relevance: Yi Mai granule (YMG) consists of two classic Chinese medicine ...

Abstract	Ethnopharmacological relevance: Yi Mai granule (YMG) consists of two classic Chinese medicine formulas used to treat cardiovascular disease for centuries. The Pink1-Mfn2-Parkin pathway, a well-recognized mechanism that mediates mitochondrial autophagy, plays a big part in mitochondrial quality control and the maintenance of heart function. However, the effects of YMG on endothelial dysfunction and mitochondrial autophagy remain unknown. Aim of the study: Here, we focused on the therapeutic effects of YMG in improving mitochondrial autophagy and the mechanism of YMG against cardiovascular disease. Materials and methods: In this study, rats were fed high-fat diet (HFD) for 21 weeks and were given high, medium, and low doses of YMG in stomach. The open field test was used to evaluate the rats' behavior. Atherosclerotic plaques, blood lipids, and cytokine levels were measured. Mitochondrial autophagy changes were observed by Transmission electron microscope (TEM). Human umbilical vein endothelial cells (HUVECs) were injured by angiotensinⅡ(AngⅡ) and were given high, medium, and low doses of YMG medicated serum in cell culture medium. Pink1-Mfn2-Parkin expression and miRNA 125a-5p expression were measured by RT-PCR and Western blot. Results: We demonstrated that the atherosclerosis model group tended to exhibit reduced vitality behaviors. We proved that the atherosclerosis model group showed obvious atherosclerotic plaques, endothelial cells destruction, and high level of blood lipid and cytokines (including hs-CRP, ET). Mitochondria were reduced, and mitophagy was inhibited in aortic cells of the model group. MiRNA-125a-5p was up-regulated; at the same time, Pink1-Mfn2-Parkin-mediated mitochondrial autophagy was prevented. We also proved that AngⅡinjured HUVEC showed obviously low mRNA levels of Pink1, Mfn2, and Parkin. Interestingly, we found that miRNA-125a-5p was significantly down regulated in Ang II-induced HUVECs. In addition, miRNA-125a-5p significantly reduced the protective effect of YiMai Granules against Ang II injury. Conclusion: Our finding indicated that Pink1-Mfn2-Parkin-mediated mitochondrial autophagy plays a crucial role in alleviating atherosclerosis. YMG alleviated atherosclerosis by potentially activating mitochondrial autophagy may via miRNA-125a-5p, regulating Pink1-Mfn2-Parkin pathway, and regulating proinflammatory factors, vasoconstriction cytokine, and blood lipids.
MeSH term(s)	Rats ; Humans ; Animals ; Endothelial Cells/metabolism ; Plaque, Atherosclerotic/metabolism ; Cardiovascular Diseases ; Protein Kinases/metabolism ; Autophagy ; Mitochondria ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Atherosclerosis/drug therapy ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Cytokines/metabolism ; Lipids/pharmacology ; MicroRNAs/genetics ; MicroRNAs/metabolism
Chemical Substances	Protein Kinases (EC 2.7.-) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Cytokines ; Lipids ; MicroRNAs
Language	English
Publishing date	2023-09-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117114
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Article ; Online: Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.

Jiang, Xiao-Lin / Tai, He / Kuang, Jin-Song / Zhang, Jing-Yi / Cui, Shi-Chao / Lu, Yu-Xuan / Qi, Shu-Bo / Zhang, Shi-Yu / Li, Shun-Min / Chen, Jian-Ping / Meng, Xian-Sheng

Aging

2022 Volume 14, Issue 20, Page(s) 8321–8345

Abstract: As a widely applied traditional Chinese medicine (TCM), Jian-Pi-Yi-Shen (JPYS) decoction maybe ...

Abstract	As a widely applied traditional Chinese medicine (TCM), Jian-Pi-Yi-Shen (JPYS) decoction maybe applied in curing premature ovarian failure (POF) besides chronic kidney disease (CKD).
MeSH term(s)	Rats ; Female ; Humans ; Animals ; Primary Ovarian Insufficiency/metabolism ; Triptorelin Pamoate/metabolism ; Triptorelin Pamoate/pharmacology ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Apoptosis ; Granulosa Cells/metabolism ; Mitochondria/metabolism
Chemical Substances	Triptorelin Pamoate (08AN7WA2G0) ; Drugs, Chinese Herbal
Language	English
Publishing date	2022-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204320
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Article ; Online: Two Novel Flavonoids with Lipid-Lowering Activity from Yi Medicine Shekaqi.

Lin, Yu-Ping / Fu, Sheng-Nan / Li, Xin-Ping / Wang, Meng-Meng / Fang, Qiong-Lian / Qiao, Xue / Yan, Qi / Hua, Yan

Chemistry & biodiversity

2022 Volume 19, Issue 9, Page(s) e202200363

Abstract: Yi medicine Shekaqi is the most attractive traditional ethnic medicine due to its significant and ... isolated from Yi medicine Shekaqi. Their structures were elucidated based on the analysis ...

Abstract	Yi medicine Shekaqi is the most attractive traditional ethnic medicine due to its significant and diverse pharmacological activities. Two novel flavonoids, including 5,2'-dihydroxy-6-methoxy-7-decyloxyflavone and tenaxin II-7-O-β-D-glucuronopyranosyl acid butyl ester, along with six known flavonoids, were isolated from Yi medicine Shekaqi. Their structures were elucidated based on the analysis of their comprehensive spectral data. The in vitro lipid-lowering activities of the eight compounds showed that all the compounds significantly inhibited the lipopolysaccharide (LPS)-induced increase in the total cholesterol (TC) level, while compounds 1, 4, 6, 7, and 8 significantly inhibited the LPS-induced increase in the triglyceride (TG) level.
MeSH term(s)	Cholesterol ; Esters ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Lipopolysaccharides/pharmacology ; Triglycerides
Chemical Substances	Esters ; Flavonoids ; Lipopolysaccharides ; Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2022-08-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202200363
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Article ; Online: The Tibetan-Yi region is both a corridor and a barrier for human gene flow.

Zhang, Zhe / Zhang, Yanlin / Wang, Yinan / Zhao, Zicheng / Yang, Melinda / Zhang, Lin / Zhou, Bin / Xu, Bingying / Zhang, Hongbo / Chen, Teng / Dai, Wenkui / Zhou, Yong / Shi, Shuo / Nielsen, Rasmus / Li, Shuai Cheng / Li, Shengbin

Cell reports

2022 Volume 39, Issue 4, Page(s) 110720

Abstract: The Tibetan-Yi Corridor (TYC) region between Tibet and the rest of east Asia has served ...

Abstract	The Tibetan-Yi Corridor (TYC) region between Tibet and the rest of east Asia has served as a crossroads for human migrations for thousands of years. The lack of whole-genome sequencing data specific to the TYC populations has hindered the understanding of the fundamental patterns of migration and divergence between humans in east Asia and southeast Asia. Here, we provide 248 individual whole genomes from the 16 TYC and 3 outgroup populations to elucidate historical relationships. We find that the Tibetan plateau forms an important barrier to gene flow, with a more Tibetan-like ancestry in northern populations and a southern east Asian-related ancestry in south populations. An isolated population, Achang, shows a prolonged isolation and genetic drift compared to other TYC populations. We also note that previous claims regarding the history and structure of TYC populations inferred by linguistics are incompatible with the genetic evidence.
MeSH term(s)	Asians/genetics ; Ethnicity ; Gene Flow ; Genetics, Population ; Humans ; Tibet
Language	English
Publishing date	2022-04-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2022.110720
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Article ; Online: Ecological and human health hazards of soil heavy metals after wildfire: A case study of Liangshan Yi autonomous prefecture, China.

Rao, Lin / Zheng, Chao / Chen, Jian-Bin / Cai, Jun-Zhuo / Yang, Zhan-Biao / Xu, Xiao-Xun / Lv, Guo-Chun / Xu, Chang-Lian / Wang, Gui-Yin / Man, Yu-Bon / Wong, Ming-Hung / Cheng, Zhang

Chemosphere

2024 Volume 352, Page(s) 141506

Abstract: Soil samples were collected in at different depths from the conflagration area in Liangshan Yi ...

Abstract	Soil samples were collected in at different depths from the conflagration area in Liangshan Yi Autonomous Region, China, to investigate the distribution characteristics and ecological and human health risks of heavy metals after a wildfire. The samples collected comprise wildfire ash (WA) above the soil surface, ash soil (AS) 0-5 cm, and plain soil (PS) 5-15 cm below the soil surface. Additionally, reference soil (RS) was collected from a nearby unburned area at the same latitude as the conflagration area. The results showed that the concentrations of zinc (Zn), copper (Cu), lead (Pb), and cadmium (Cd) in the WA and AS were significantly higher than in reference soil (RS) (p < 0.05). Concentrations of Pb in the PS were 2.52 times higher than that in RS (17.9 mg kg
MeSH term(s)	Humans ; Soil ; Environmental Monitoring ; Cadmium ; Lead ; Wildfires ; Risk Assessment ; Soil Pollutants/analysis ; Metals, Heavy/analysis ; China ; Neoplasms
Chemical Substances	Soil ; Cadmium (00BH33GNGH) ; Lead (2P299V784P) ; Soil Pollutants ; Metals, Heavy
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141506
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Zs.A 2540: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Reduction in gefitinib resistance mediated by Yi-Fei San-Jie pill in non-small cell lung cancer through regulation of tyrosine metabolism, cell cycle, and the MET/EGFR signaling pathway.

Yang, Cai-Zhi / Guo, Wei / Wang, Yi-Fan / Hu, Lei-Hao / Wang, Jing / Luo, Jia-Min / Yao, Xiao-Hui / Liu, Shan / Tao, Lan-Ting / Sun, Ling-Ling / Lin, Li-Zhu

Journal of ethnopharmacology

2023 Volume 314, Page(s) 116566

Abstract: Ethnopharmacological relevance: The Chinese herbal prescription Yi-Fei San-Jie pill (YFSJ) has ...

Abstract	Ethnopharmacological relevance: The Chinese herbal prescription Yi-Fei San-Jie pill (YFSJ) has been used for adjuvant treatment in patients with lung cancer for a long time. Aim of the study: Reports have indicated that the combination of gefitinib (Gef) with YFSJ inhibits the proliferation of EGFR-TKI-resistant cell lines by enhancing cellular apoptosis and autophagy in non-small cell lung cancer (NSCLC). However, the molecular mechanisms underlying the effect of YFSJ on EGFR-TKI resistance and related metabolic pathways remain to be explored. Materials and methods: In our report, ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), metabolomics, network pharmacology, bioinformatics, and biological analysis methods were used to investigate the mechanism. Results: The UPLC-MS/MS data identified 42 active compounds of YFSJ extracts. YFSJ extracts can enhance the antitumor efficacy of Gef without hepatic and renal toxicity in vivo. The analysis of the metabolomics pathway enrichment revealed that YFSJ mainly affected the tyrosine metabolism pathway in rat models. Moreover, YFSJ has been shown to reverse Gef resistance and improve the effects of Gef on the cellular viability, migration capacity, and cell cycle arrest of NSCLC cell lines with EGFR mutations. The results of network pharmacology and molecular docking analyses revealed that tyrosine metabolism-related active compounds of YFSJ affect EGFR-TKIs resistance in NSCLC by targeting cell cycle and the MET/EGFR signaling pathway; these findings were validated by western blotting and immunohistochemistry. Conclusions: YFSJ inhibits NSCLC by inducing cell cycle arrest in the G1/S phase to suppress tumor growth, cell viability, and cell migration through synergistic effects with Gef via the tyrosine metabolic pathway and the EGFR/MET signaling pathway. To summarize, the findings of the current study indicate that YFSJ is a prospective complementary treatment for Gef-resistant NSCLC.
MeSH term(s)	Rats ; Animals ; Carcinoma, Non-Small-Cell Lung/pathology ; Gefitinib/pharmacology ; Gefitinib/therapeutic use ; Lung Neoplasms/pathology ; Molecular Docking Simulation ; Chromatography, Liquid ; Prospective Studies ; ErbB Receptors/metabolism ; Drug Resistance, Neoplasm ; Tandem Mass Spectrometry ; Signal Transduction ; Cell Cycle ; Cell Line, Tumor ; Protein Kinase Inhibitors/pharmacology ; Cell Proliferation
Chemical Substances	Gefitinib (S65743JHBS) ; ErbB Receptors (EC 2.7.10.1) ; Protein Kinase Inhibitors
Language	English
Publishing date	2023-05-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116566
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Zs.A 1494: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Protective effects and regulatory mechanisms of Shen-shuai-yi recipe on renal fibrosis in unilateral ureteral obstruction-induced mice.

Lin, Ping-Lan / Weng, Tao-Tao / Duan, Lian-Xiang / Zhang, Lin-Zhang / Wei, Xia / Qi, Sheng-Lan / You, Jia-Wen / Cao, Yu / Ge, Guang-Bo / Liu, Wei / He, Xiao-Li / Hu, Jing

Heliyon

2023 Volume 9, Issue 7, Page(s) e17908

Abstract: ... Shen-shuai-yi Recipe (SSYR) is a classical Chinese herbal formula for the treatment of CKD ...

Abstract	Renal fibrosis (RF) is a common pathological feature of chronic kidney disease (CKD), which remains a major public health problem. As now, there is still lack of chemical or biological drugs to reverse RF. Shen-shuai-yi Recipe (SSYR) is a classical Chinese herbal formula for the treatment of CKD. However, the effects and mechanisms of SSYR in treating RF are still not clear. In this study, the active constituents SSYR for treating RF were explored by UHPLC-Q-Orbitrap HRMS. Bioinformatics analyses were employed to analyze the key pharmacological targets and the core active constituents of SSYR in the treatment of RF. In experimental validation, vehicle or SSYR at doses of 2.12 g/kg/d and 4.25 g/kg/d were given by orally to unilateral ureteric obstruction (UUO) mice. 13 days after treatment, we detected the severity of renal fibrosis, extracellular collagen deposition and pre-fibrotic signaling pathways. Bioinformatics analysis suggested that signal transducer and activator of transcription 3 (STAT3) was the core target and lenticin, luteolin-7-O-rutinoside, hesperidin, kaempferol-3-O-rutinoside, and 3,5,6,7,8,3',4'-heptamethoxyflavone were the key constituents in SSYR for treating RF. SSYR significantly reduced the expressions of fibronectin (FN), α-smooth muscle actin (α-SMA), collagen-I and alleviated renal interstitial collagen deposition in UUO kidneys. In mechanism, SSYR potently blocked the phosphorylation of STAT3 and Smad3 and suppressed the expression of connective tissue growth factor (CTGF). Collectively, SSYR can ameliorate RF
Language	English
Publishing date	2023-07-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e17908
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Article ; Online: Ameliorative effect and mechanism of Yi-Suan-Cha against hyperuricemia in rats.

Qin, Yuanyuan / Zhang, Xuan / Tao, Hui / Wu, Yangyang / Yan, Jie / Liao, Lin / Meng, Jianjun / Lin, Faquan

Journal of clinical laboratory analysis

2021 Volume 35, Issue 8, Page(s) e23859

Abstract: Background: This study aimed to evaluate the urate-lowering effects of Yi-Suan-Cha and explore ... were randomly allocated into normal control, model, allopurinol, benzbromarone, low-dose Yi-Suan-Cha (0 ... 2 g/ml), and high-dose Yi-Suan-Cha (0.4 g/ml) groups (n = 8 rats per group). Rat models ...

Abstract	Background: This study aimed to evaluate the urate-lowering effects of Yi-Suan-Cha and explore its underlying mechanisms in experimental hyperuricemia induced in rats. Methods: Forty-eight male SD rats were randomly allocated into normal control, model, allopurinol, benzbromarone, low-dose Yi-Suan-Cha (0.2 g/ml), and high-dose Yi-Suan-Cha (0.4 g/ml) groups (n = 8 rats per group). Rat models of hyperuricemia were established through intragastric administration of adenine 25 mg/kg + potassium oxalate 300 mg/kg for 3 weeks. After the last administration, serum uric acid, creatinine, and urea nitrogen levels were measured. Renal histopathology was observed by hematoxylin-eosin staining. Xanthine oxidase level in serum and liver homogenates was measured by ELISA. The protein and mRNA expression of URAT1, ABCG2, OAT1, and GLUT9 in the kidney was detected by Western blotting and RT-PCR, respectively. Results: The serum uric acid levels were significantly lowered in all medication groups than in the model group. The benzbromarone and both Yi-Suan-Cha groups showed clear kidney structures with no obvious abnormalities. Compared with the normal control group, the model group showed increased URAT1/GLUT9 protein expression and decreased ABCG2/OAT1 protein expression. Compared with the model group, both Yi-Suan-Cha groups showed decreased URAT1/GLUT9 protein expression and increased ABCG2/OAT1 protein expression. Compared with that in the normal control group, URAT1/GLUT9 mRNA expression increased in the model group. Compared with the model group, the low-dose and high-dose Yi-Suan-Cha groups showed decreased URAT1/GLUT9 mRNA expression and increased ABCG2/OAT1 mRNA expression. Conclusion: Yi-Suan-Cha may lower uric acid level by downregulating URAT1/GLUT9 expression and upregulating ABCG2/OAT1 expression.
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Animals ; Anion Transport Proteins/genetics ; Anion Transport Proteins/metabolism ; Blood Urea Nitrogen ; Creatinine/blood ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Gene Expression Regulation/drug effects ; Hyperuricemia/drug therapy ; Hyperuricemia/metabolism ; Hyperuricemia/pathology ; Kidney/drug effects ; Kidney/metabolism ; Kidney/pathology ; Male ; Monosaccharide Transport Proteins/genetics ; Monosaccharide Transport Proteins/metabolism ; Organic Anion Transport Protein 1/genetics ; Organic Anion Transport Protein 1/metabolism ; Rats, Sprague-Dawley ; Uric Acid/blood ; Xanthine Oxidase/blood ; Xanthine Oxidase/metabolism ; Rats
Chemical Substances	ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Abcg2 protein, rat ; Anion Transport Proteins ; Drugs, Chinese Herbal ; GLUT6 protein, rat ; Monosaccharide Transport Proteins ; Organic Anion Transport Protein 1 ; Slc22a12 protein, rat ; Slc22a6 protein, rat ; Uric Acid (268B43MJ25) ; Creatinine (AYI8EX34EU) ; Xanthine Oxidase (EC 1.17.3.2)
Language	English
Publishing date	2021-07-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	645095-7
ISSN	1098-2825 ; 0887-8013
ISSN (online)	1098-2825
ISSN	0887-8013
DOI	10.1002/jcla.23859
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