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  1. Article ; Online: Are contemporary TAVI results influenced by hospital volume?

    Rodés-Cabau, Josep / Nuche, Jorge

    European heart journal

    2022  Volume 44, Issue 10, Page(s) 868–870

    MeSH term(s) Humans ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Transcatheter Aortic Valve Replacement/methods ; Aortic Valve Stenosis/surgery ; Aortic Valve Stenosis/mortality ; Hospitals ; Germany
    Language English
    Publishing date 2022-12-16
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac694
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  2. Article ; Online: Reply to Francisco-Pascual and Rivas-Gándara-Syncope in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.

    Nuche, Jorge / Keller, Lukas S / Rodés-Cabau, Josep

    The Canadian journal of cardiology

    2023  Volume 39, Issue 7, Page(s) 910–911

    MeSH term(s) Humans ; Transcatheter Aortic Valve Replacement ; Aortic Valve/surgery ; Aortic Valve Stenosis/complications ; Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/surgery
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2023.03.026
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2150: Show issues Location:
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  3. Article: Evolving Indications of Transcatheter Aortic Valve Replacement-Where Are We Now, and Where Are We Going.

    Mesnier, Jules / Panagides, Vassili / Nuche, Jorge / Rodés-Cabau, Josep

    Journal of clinical medicine

    2022  Volume 11, Issue 11

    Abstract: Indications for transcatheter aortic valve replacement (TAVR) have steadily increased over the last decade since the first trials including inoperable or very high risk patients. Thus, TAVR is now the most common treatment of aortic valve stenosis in ... ...

    Abstract Indications for transcatheter aortic valve replacement (TAVR) have steadily increased over the last decade since the first trials including inoperable or very high risk patients. Thus, TAVR is now the most common treatment of aortic valve stenosis in elderly patients (vs. surgical aortic valve replacement -SAVR-). In this review, we summarize the current indications of TAVR and explore future directions in which TAVR indications can expand.
    Language English
    Publishing date 2022-05-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11113090
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  4. Article ; Online: Bleeding Events After Transcatheter Aortic Valve Replacement: JACC State-of-the-Art Review.

    Avvedimento, Marisa / Nuche, Jorge / Farjat-Pasos, Julio I / Rodés-Cabau, Josep

    Journal of the American College of Cardiology

    2023  Volume 81, Issue 7, Page(s) 684–702

    Abstract: Transcatheter aortic valve replacement (TAVR) has gained over time a major reduction in procedural complications. Despite this, clinically relevant bleeding still occurs in a non-negligible proportion of patients and adversely affects prognosis. Patients ...

    Abstract Transcatheter aortic valve replacement (TAVR) has gained over time a major reduction in procedural complications. Despite this, clinically relevant bleeding still occurs in a non-negligible proportion of patients and adversely affects prognosis. Patients with severe aortic stenosis are at heightened risk for spontaneous bleeding due to advanced age and a high comorbidity burden. Also, procedural factors and antithrombotic management contribute to define individual bleeding susceptibility. Bleeding prevention represents an emerging area for improving patient care. Because of the tight hemorrhagic/ischemic balance, a tailored approach based on individual bleeding-risk profile, such as a less invasive antithrombotic regimen or appropriate diagnostic preprocedural evaluation, should be pursued to avoid bleeding events. This review aims to provide an in-depth overview of bleeding events in the TAVR field, including definitions, timing and the extent of risk, and clinical impact, as well as updates on antithrombotic management and its potential influence on bleeding complications.
    MeSH term(s) Humans ; Transcatheter Aortic Valve Replacement/adverse effects ; Fibrinolytic Agents/therapeutic use ; Risk Factors ; Treatment Outcome ; Hemorrhage/epidemiology ; Hemorrhage/etiology ; Hemorrhage/drug therapy ; Aortic Valve Stenosis/surgery ; Aortic Valve Stenosis/drug therapy ; Aortic Valve/surgery
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2022.11.050
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    Zs.A 1846: Show issues Location:
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    Zs.MO 196: Show issues

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  5. Article ; Online: Evolving Indications of Transcatheter Aortic Valve Replacement—Where Are We Now, and Where Are We Going

    Jules Mesnier / Vassili Panagides / Jorge Nuche / Josep Rodés-Cabau

    Journal of Clinical Medicine, Vol 11, Iss 3090, p

    2022  Volume 3090

    Abstract: Indications for transcatheter aortic valve replacement (TAVR) have steadily increased over the last decade since the first trials including inoperable or very high risk patients. Thus, TAVR is now the most common treatment of aortic valve stenosis in ... ...

    Abstract Indications for transcatheter aortic valve replacement (TAVR) have steadily increased over the last decade since the first trials including inoperable or very high risk patients. Thus, TAVR is now the most common treatment of aortic valve stenosis in elderly patients (vs. surgical aortic valve replacement -SAVR-). In this review, we summarize the current indications of TAVR and explore future directions in which TAVR indications can expand.
    Keywords transcatheter aortic valve replacement ; aortic stenosis ; aortic regurgitation ; bicuspid valve ; moderate aortic stenosis ; Medicine ; R
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Managing the challenge of a small aortic annulus in patients with severe aortic stenosis.

    Prieto-Lobato, Alicia / Nuche, Jorge / Avvedimento, Marisa / Paradis, Jean-Michel / Dumont, Eric / Kalavrouziotis, Dimitris / Mohammadi, Siamak / Rodés-Cabau, Josep

    Expert review of cardiovascular therapy

    2023  Volume 21, Issue 11, Page(s) 747–761

    Abstract: Introduction: Small aortic annulus (SAA) poses a challenge in the management of patients with severe aortic stenosis requiring aortic valve replacement - both surgical and transcatheter - since it has been associated with worse clinical outcomes.: ... ...

    Abstract Introduction: Small aortic annulus (SAA) poses a challenge in the management of patients with severe aortic stenosis requiring aortic valve replacement - both surgical and transcatheter - since it has been associated with worse clinical outcomes.
    Areas covered: This review aims to comprehensively summarize the available evidence regarding the management of aortic stenosis in patients with SAA and discuss the current controversies as well as future perspectives in this field.
    Expert opinion: It is paramount to agree in a common definition for diagnosing and properly treating SAA patients, and for that purpose, multidetector computer tomography is essential. The results of recent trials led to the expansion of transcatheter aortic valve replacement among patients of all the surgical-risk spectrum, and the choice of treatment (transcatheter, surgical) should be based on patient comorbidities, anatomical characteristics, and patient preferences.
    MeSH term(s) Humans ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Transcatheter Aortic Valve Replacement/methods ; Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis Implantation/methods ; Heart Valve Prosthesis ; Treatment Outcome ; Prosthesis Design
    Language English
    Publishing date 2023-12-10
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1080/14779072.2023.2271395
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6107: Show issues Location:
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  7. Article ; Online: Percutaneous Coronary Intervention Pre-TAVR: Current State of the Evidence.

    Keller, Lukas S / Panagides, Vassili / Mesnier, Jules / Nuche, Jorge / Rodés-Cabau, Josep

    Current cardiology reports

    2022  Volume 24, Issue 8, Page(s) 1011–1020

    Abstract: Purpose of review: This review intends to give an up-to-date overview of the current state of evidence in the treatment of coronary artery disease (CAD) in patients undergoing transcatheter aortic valve replacement (TAVR), focusing on percutaneous ... ...

    Abstract Purpose of review: This review intends to give an up-to-date overview of the current state of evidence in the treatment of coronary artery disease (CAD) in patients undergoing transcatheter aortic valve replacement (TAVR), focusing on percutaneous coronary interventions (PCI) pre-TAVR.
    Recent findings: The recently published ACTIVATION trial is the 1st randomized trial comparing coronary revascularization (PCI) versus medical treatment in patients with significant CAD undergoing TAVR. With the caveat of several major limitations of the trial, the results of this study raised the question about the appropriateness of the common practice to routinely revascularize coronary stenosis before TAVR. Aortic valve stenosis is the most common valvular heart disease among the elderly and it often co-occurs with CAD. TAVR is increasingly considered an alternative to surgical aortic valve replacement not only in the elderly population but also in younger and lower-risk patients. The impact of co-existing CAD on clinical outcomes as well as the optimal timing of PCI in TAVR candidates is still unclear and the subject of ongoing randomized trials. Meanwhile, it is common practice in many centers to routinely perform invasive coronary angiography and PCI for significant coronary disease as part of the TAVR workup. While computed tomography angiography has emerged as a possible alternative to the invasive coronary angiography in patients with low pre-test probability for CAD, the value of functional invasive assessment of coronary lesions in the pre-TAVR setting has still to be clarified. Also, there is an increasing interest in the clinical relevance and optimal management of the potentially challenging coronary access post-TAVR, requiring further research.
    MeSH term(s) Aged ; Aortic Valve/surgery ; Aortic Valve Stenosis/complications ; Aortic Valve Stenosis/surgery ; Coronary Artery Disease/complications ; Coronary Artery Disease/surgery ; Humans ; Percutaneous Coronary Intervention/methods ; Risk Factors ; Transcatheter Aortic Valve Replacement/methods ; Treatment Outcome
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055373-0
    ISSN 1534-3170 ; 1523-3782
    ISSN (online) 1534-3170
    ISSN 1523-3782
    DOI 10.1007/s11886-022-01717-1
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    Zs.A 5524: Show issues Location:
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  8. Article ; Online: Metabolic changes contribute to maladaptive right ventricular hypertrophy in pulmonary hypertension beyond pressure overload: an integrative imaging and omics investigation.

    García-Lunar, Inés / Jorge, Inmaculada / Sáiz, Jorge / Solanes, Núria / Dantas, Ana Paula / Rodríguez-Arias, Juan José / Ascaso, María / Galán-Arriola, Carlos / Jiménez, Francisco Rafael / Sandoval, Elena / Nuche, Jorge / Moran-Garrido, Maria / Camafeita, Emilio / Rigol, Montserrat / Sánchez-Gonzalez, Javier / Fuster, Valentín / Vázquez, Jesús / Barbas, Coral / Ibáñez, Borja /
    Pereda, Daniel / García-Álvarez, Ana

    Basic research in cardiology

    2024  

    Abstract: Right ventricular (RV) failure remains the strongest determinant of survival in pulmonary hypertension (PH). We aimed to identify relevant mechanisms, beyond pressure overload, associated with maladaptive RV hypertrophy in PH. To separate the effect of ... ...

    Abstract Right ventricular (RV) failure remains the strongest determinant of survival in pulmonary hypertension (PH). We aimed to identify relevant mechanisms, beyond pressure overload, associated with maladaptive RV hypertrophy in PH. To separate the effect of pressure overload from other potential mechanisms, we developed in pigs two experimental models of PH (M1, by pulmonary vein banding and M2, by aorto-pulmonary shunting) and compared them with a model of pure pressure overload (M3, pulmonary artery banding) and a sham-operated group. Animals were assessed at 1 and 8 months by right heart catheterization, cardiac magnetic resonance and blood sampling, and myocardial tissue was analyzed. Plasma unbiased proteomic and metabolomic data were compared among groups and integrated by an interaction network analysis. A total of 33 pigs completed follow-up (M1, n = 8; M2, n = 6; M3, n = 10; and M0, n = 9). M1 and M2 animals developed PH and reduced RV systolic function, whereas animals in M3 showed increased RV systolic pressure but maintained normal function. Significant plasma arginine and histidine deficiency and complement system activation were observed in both PH models (M1&M2), with additional alterations to taurine and purine pathways in M2. Changes in lipid metabolism were very remarkable, particularly the elevation of free fatty acids in M2. In the integrative analysis, arginine-histidine-purines deficiency, complement activation, and fatty acid accumulation were significantly associated with maladaptive RV hypertrophy. Our study integrating imaging and omics in large-animal experimental models demonstrates that, beyond pressure overload, metabolic alterations play a relevant role in RV dysfunction in PH.
    Language English
    Publishing date 2024-03-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 189755-x
    ISSN 1435-1803 ; 0300-8428 ; 0175-9418
    ISSN (online) 1435-1803
    ISSN 0300-8428 ; 0175-9418
    DOI 10.1007/s00395-024-01041-5
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    Ui IV Zs.30: Show issues Location:
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  9. Article ; Online: Cardioprotective effect of the short-acting beta-blocker esmolol in experimental ischemia/reperfusion.

    Nuche, Jorge / Huertas, Sergio / Galán-Arriola, Carlos / López-Ayala, Pedro / Lobo, Manuel / Ibáñez, Borja

    Revista espanola de cardiologia (English ed.)

    2021  Volume 75, Issue 6, Page(s) 527–529

    MeSH term(s) Adrenergic beta-Antagonists/therapeutic use ; Humans ; Ischemia ; Propanolamines/therapeutic use ; Reperfusion
    Chemical Substances Adrenergic beta-Antagonists ; Propanolamines ; esmolol (MDY902UXSR)
    Language Spanish
    Publishing date 2021-12-21
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2021.11.009
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  10. Article ; Online: From the Evolut Pro to the Evolut FX self-expanding transcatheter aortic valve replacement systems: current status and future perspectives.

    Panagides, Vassili / Mesnier, Jules / Nuche, Jorge / Delarochellière, Robert / Paradis, Jean-Michel / Kalavrouziotis, Dimitri / Dumont, Eric / Mohammadi, Siamak / Rodes-Cabau, Josep

    Expert review of medical devices

    2022  Volume 19, Issue 7, Page(s) 561–569

    Abstract: Introduction: Since the initial experience with the CoreValve (Medtronic, Minneapolis, Minnesota), there have been continuous iterations of this valve system in order to improve procedural success and reduce periprocedural complications. The Evolut Pro, ...

    Abstract Introduction: Since the initial experience with the CoreValve (Medtronic, Minneapolis, Minnesota), there have been continuous iterations of this valve system in order to improve procedural success and reduce periprocedural complications. The Evolut Pro, Pro+, and FX are the latest generations of this transcatheter heart valve (THV).
    Areas covered: This review paper aims to analyze the main characteristics and clinical evidence about the Evolut Pro THV and summarize the main iterations of the newer generation Evolut FX valve system.
    Expert opinion: The Evolut Pro system has been associated with good clinical outcomes and excellent valve hemodynamic performance including reduced rates of paravalvular leaks. Technical enhancements to improve valve positioning, orientation, and vascular access have been implemented in the newer generation Evolut FX system.
    MeSH term(s) Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis ; Humans ; Prosthesis Design ; Risk Factors ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
    Language English
    Publishing date 2022-08-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2250857-0
    ISSN 1745-2422 ; 1743-4440
    ISSN (online) 1745-2422
    ISSN 1743-4440
    DOI 10.1080/17434440.2022.2113386
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