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  1. Article: [No title information]

    Cozzio, Antonio / Saulite, Ieva

    Therapeutische Umschau. Revue therapeutique

    2019  Volume 76, Issue 2, Page(s) 55–63

    Title translation Die verschiedenen Gesichter der Ekzeme.
    Language German
    Publishing date 2019-08-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
    DOI 10.1024/0040-5930/a001063
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  2. Article ; Online: Clinical Images: Hydroxychloroquine-associated mucous labial pigmentation in a patient with systemic lupus erythematosus improving under topical treatment with tacrolimus.

    Pirker, Ian / Saulite, Ieva / von Kempis, Johannes

    ACR open rheumatology

    2021  Volume 3, Issue 1, Page(s) 41

    Language English
    Publishing date 2021-01-03
    Publishing country United States
    Document type Journal Article
    ISSN 2578-5745
    ISSN (online) 2578-5745
    DOI 10.1002/acr2.11209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Recurrent Cutaneous Fusariosis in a Kidney Transplant Recipient – a Case Report and Review of the Literature

    Helene Sumer / Regulo Rodriguez / Ieva Saulite / Katia Boggian / Werner Albrich / Johannes Sumer

    healthbook TIMES. Oncology Hematology, Vol 16, Iss

    2023  Volume 2

    Abstract: Introduction:** We report an unusual case of cutaneous fusariosis in a kidney transplant recipient. *Fusarium* species are emerging fungal pathogens that pose diagnostic and therapeutic challenges. In severely immunocompromised patients, fusarial ... ...

    Abstract **Introduction:** We report an unusual case of cutaneous fusariosis in a kidney transplant recipient. *Fusarium* species are emerging fungal pathogens that pose diagnostic and therapeutic challenges. In severely immunocompromised patients, fusarial infections are associated with high mortality in the case of systemic dissemination. **Case presentation:** A 69-year-old black male with a history of renal transplantation presented with recurrent purulent nodules and painful ulcers of the left lower leg. Based on repeated skin biopsies, focally invasive skin infection with *Fusarium solani* was proven histologically and microbiologically. After four months of treatment with oral voriconazole, lesions considerably improved. When the patient died one month later from Covid-19 pneumonia under continued antifungal therapy, there was no evidence of systemic fusariosis or fusarial superinfection. **Conclusion:** Although rare, fusarial infections should be considered in immunocompromised individuals such as solid organ transplant recipients. Therefore, skin lesions in this patient population should be examined accurately. Histopathological and microbiological workups, including fungal cultures, are necessary for diagnosis and timely initiation of targeted therapy. Systemic antifungal therapy with voriconazole is the treatment of choice for focally invasive fusariosis.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher THE HEALTHBOOK COMPANY LTD.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Mycosis fungoides and Sézary syndrome

    Ieva Saulite / Antonio Cozzio / Emmanuella Guenova

    healthbook TIMES. Oncology Hematology, Vol 2, Iss

    2021  Volume 8

    Abstract: Mycosis fungoides (MF) and Sézary syndrome (SS) are two subgroups of cutaneous T-cell lymphomas (CTCL), which belong to the extranodal non-Hodgkin lymphomas. These are rare diseases whose etiology is still not fully understood. Regarding pathogenesis, ... ...

    Abstract Mycosis fungoides (MF) and Sézary syndrome (SS) are two subgroups of cutaneous T-cell lymphomas (CTCL), which belong to the extranodal non-Hodgkin lymphomas. These are rare diseases whose etiology is still not fully understood. Regarding pathogenesis, mycosis fungoides and Sézary syndrome derive from different T-helper cell types and are therefore considered two separate entities according to the current concept. Mycosis fungoides is clinically characterized by patch, plaque and tumor stages, although the disease can also manifest as erythroderma. Sézary syndrome is characterized by the presence of erythroderma, defined as redness of the skin covering >80% of the total body surface area. In the blood count of patients with mycosis fungoides, a T-lymphocytosis, especially with CD4-positive cells, can only be observed in advanced stage IV. One of the typical histological findings is an epidermotropic infiltrate of atypical, CD4-positive T-cells. Characteristic features of Sézary syndrome include atypical T lymphocytes (Sézary cells) in the blood and skin infiltrate. The diagnosis of both mycosis fungoides and Sézary syndrome is based on clinical, histological and hematological examinations as well as imaging techniques. Staging is based on the tumor-node-metastasis-blood (TNMB) classification and is a crucial factor in determining the prognosis. The treatment of mycosis fungoides and Sézary syndrome is carried out according to the stage, whereby local therapies such as UVB phototherapy are used as well as systemic forms of treatment, and in addition, in recent years, targeted therapies have increasingly become part of everyday clinical practice.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher THE HEALTHBOOK COMPANY LTD.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Mycosis fungoides and Sézary syndrome

    Ieva Saulite / Antonio Cozzio / Emmanuella Guenova

    healthbook TIMES. Oncology Hematology, Vol 2, Iss 8, Pp 22-

    2021  Volume 31

    Abstract: Mycosis fungoides (MF) and Sézary syndrome (SS) are two subgroups of cutaneous T-cell lymphomas (CTCL), which belong to the extranodal non-Hodgkin lymphomas. These are rare diseases whose etiology is still not fully understood. Regarding pathogenesis, ... ...

    Abstract Mycosis fungoides (MF) and Sézary syndrome (SS) are two subgroups of cutaneous T-cell lymphomas (CTCL), which belong to the extranodal non-Hodgkin lymphomas. These are rare diseases whose etiology is still not fully understood. Regarding pathogenesis, mycosis fungoides and Sézary syndrome derive from different T-helper cell types and are therefore considered two separate entities according to the current concept. Mycosis fungoides is clinically characterized by patch, plaque and tumor stages, although the disease can also manifest as erythroderma. Sézary syndrome is characterized by the presence of erythroderma, defined as redness of the skin covering >80% of the total body surface area. In the blood count of patients with mycosis fungoides, a T-lymphocytosis, especially with CD4-positive cells, can only be observed in advanced stage IV. One of the typical histological findings is an epidermotropic infiltrate of atypical, CD4-positive T-cells. Characteristic features of Sézary syndrome include atypical T lymphocytes (Sézary cells) in the blood and skin infiltrate. The diagnosis of both mycosis fungoides and Sézary syndrome is based on clinical, histological and hematological examinations as well as imaging techniques. Staging is based on the tumor-node-metastasis-blood (TNMB) classification and is a crucial factor in determining the prognosis. The treatment of mycosis fungoides and Sézary syndrome is carried out according to the stage, whereby local therapies such as UVB phototherapy are used as well as systemic forms of treatment, and in addition, in recent years, targeted therapies have increasingly become part of everyday clinical practice.
    Keywords sézary syndrome ; mycosis fungoides ; extranodal non-hodgkin’s lymphoma ; cutaneous t-cell lymphoma ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher THE HEALTHBOOK COMPANY LTD.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Warnsymptome Haut : kutane Manifestation der Arzneimittelallergie

    Saulite, Ieva / Hötzenecker, Wolfram / Cozzio, Antonio

    Therapeutische Umschau

    2019  Volume 76, Issue 1, Page(s) 43–48

    Keywords Allergie ; Haut ; Arzneimittelwirkung
    Language German
    Document type Article
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
    Database bibnet.org

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  7. Article: Warnsymptome Haut: kutane Manifestation der Arzneimittelallergie.

    Saulite, Ieva / Hötzenecker, Wolfram / Cozzio, Antonio

    Therapeutische Umschau. Revue therapeutique

    2019  Volume 75, Issue 1, Page(s) 43–48

    Abstract: Warning symptoms skin: cutaneous manifestation of drug ... ...

    Title translation Warning symptoms skin: cutaneous manifestation of drug allergy.
    Abstract Warning symptoms skin: cutaneous manifestation of drug allergy
    MeSH term(s) Drug Hypersensitivity ; Humans ; Skin ; Stevens-Johnson Syndrome
    Language German
    Publishing date 2019-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
    DOI 10.1024/0040-5930/a001054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Level of 25-Hydroxyvitamin D in Pediatric Arthritis Patients

    Laizāne Marta / Saulīte Ieva / Feierābende Sandra / Rumba-Rozenfelde Ingrīda

    Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences, Vol 73, Iss 5, Pp 425-

    2019  Volume 432

    Abstract: Vitamin D deficiency is common and widespread globally. Vitamin D has an immunomodulatory effect, but it is still unclear whether its deficiency is associated with higher disease activity. The aim of this retrospective study was to determine the serum ... ...

    Abstract Vitamin D deficiency is common and widespread globally. Vitamin D has an immunomodulatory effect, but it is still unclear whether its deficiency is associated with higher disease activity. The aim of this retrospective study was to determine the serum concentration of vitamin D in children with paediatric arthritis (juvenile idiopathic arthritis and reactive arthritis). Prevalence of hypo-vitaminosis D among 98 children with juvenile idiopathic arthritis and reactive arthritis was determined and association between serum concentration of vitamin D and disease activity markers was found. Prevalence of vitamin D deficiency among children included in this study was 69.07%. Children with juvenile idiopathic arthritis had a significantly lower vitamin D level than children with reactive arthritis. There was a statistically significant moderate negative correlation between serum concentration of vitamin D and patient age, as well as a weak negative correlation between vitamin D level and patient body mass index. The significant correlations found between vitamin D level and inflammatory markers indicate that further research on the role of vitamin D in disease activity is needed.
    Keywords vitamin d ; juvenile idiopathic arthritis ; reactive arthritis ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Leucine-Rich Alpha-2-Glycoprotein (LRG-1) as a Potential Kidney Injury Marker in Kidney Transplant Recipients.

    Popova, Anna / Vasiļvolfa, Aiga / Rācenis, Kārlis / Erts, Renārs / Šlisere, Baiba / Saulīte, Anna Jana / Ziedina, Ieva / Folkmane, Inese / Čerņevskis, Harijs / Kroiča, Juta / Pētersons, Aivars / Kuzema, Viktorija

    Annals of transplantation

    2022  Volume 27, Page(s) e936751

    Abstract: BACKGROUND Kidney transplantation is the treatment of choice for most patients with end-stage renal disease. To improve patient and transplant survival, non-invasive diagnostic methods for different pathologies are important. Leucine-rich alpha-2- ... ...

    Abstract BACKGROUND Kidney transplantation is the treatment of choice for most patients with end-stage renal disease. To improve patient and transplant survival, non-invasive diagnostic methods for different pathologies are important. Leucine-rich alpha-2-glycoprotein (LRG-1) is an innovative biomarker that is elevated in cases of angiogenesis, inflammation, and kidney injury. However, there are limited data about the diagnostic role of LRG-1 in kidney transplant recipients. The aim of this study was to evaluate the association between serum LRG-1, urine LRG-1, and kidney transplant function and injury. MATERIAL AND METHODS We enrolled 35 kidney transplant recipients in the study. LRG-1 in the serum and urine was detected using ELISA. We evaluated the correlation of serum and urine LRG-1 with traditional serum and urine kidney injury markers. RESULTS A higher level of serum LRG-1 correlates with a higher level of urine LRG-1. Serum LRG-1 has a positive correlation with transplant age, serum urea, serum creatinine, serum cystatin C, proteinuria, and fractional excretion of sodium (FENa) and a negative correlation with hemoglobin and estimated glomerular filtration rate (eGFR). Urine LRG-1 has a positive correlation with serum cystatin C, proteinuria, and urine neutrophil gelatinase-associated lipocalin (NGAL). CONCLUSIONS Higher levels of serum and urine LRG-1 are associated with kidney transplant injury and functional deterioration. Thus, LRG-1 might be also as a biomarker for tubular dysfunction in patients after kidney transplantation.
    MeSH term(s) Biomarkers ; Cystatin C ; Glycoproteins/analysis ; Glycoproteins/urine ; Humans ; Kidney ; Kidney Transplantation/adverse effects ; Leucine ; Proteinuria
    Chemical Substances Biomarkers ; Cystatin C ; Glycoproteins ; LRG1 protein, human ; Leucine (GMW67QNF9C)
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484710-3
    ISSN 2329-0358 ; 1425-9524
    ISSN (online) 2329-0358
    ISSN 1425-9524
    DOI 10.12659/AOT.936751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Expression of Antimicrobial Peptides in Nail Psoriasis and Normal Nails.

    Saulite, Ieva / Pilmane, Mara / Kisis, Janis

    Acta dermato-venereologica

    2016  Volume 97, Issue 5, Page(s) 644–645

    MeSH term(s) Adolescent ; Adult ; Aged ; Antimicrobial Cationic Peptides/metabolism ; Case-Control Studies ; Humans ; Middle Aged ; Nails/metabolism ; Psoriasis/metabolism ; Young Adult ; beta-Defensins/metabolism
    Chemical Substances Antimicrobial Cationic Peptides ; DEFB103A protein, human ; DEFB4A protein, human ; beta-Defensins ; ropocamptide (3DD771JO2H)
    Language English
    Publishing date 2016-12-14
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-2605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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