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  1. Article ; Online: Racial and ethnic minority participants in clinical trials of acute respiratory distress syndrome.

    Papoutsi, Eleni / Kremmydas, Panagiotis / Tsolaki, Vasiliki / Kyriakoudi, Anna / Routsi, Christina / Kotanidou, Anastasia / Siempos, Ilias I

    Intensive care medicine

    2023  Volume 49, Issue 12, Page(s) 1479–1488

    Abstract: Purpose: There is growing interest in improving the inclusiveness of racial and ethnic minority participants in trials of acute respiratory distress syndrome (ARDS). With our study we aimed to examine temporal trends of representation and mortality of ... ...

    Abstract Purpose: There is growing interest in improving the inclusiveness of racial and ethnic minority participants in trials of acute respiratory distress syndrome (ARDS). With our study we aimed to examine temporal trends of representation and mortality of racial and ethnic minority participants in randomized controlled trials of ARDS.
    Methods: We performed a secondary analysis of eight ARDS Network and PETAL Network therapeutic clinical trials, published between 2000 and 2019. We classified race/ethnicity into "White", "Black", "Hispanic", or "Other" (including Asian, American Indian or Alaskan Native, Native Hawaiian, or other Pacific Islander participants).
    Results: Of 5375 participants with ARDS, 1634 (30.4%) were Black, Hispanic, or Other race participants. Representation of racial and ethnic minority participants in trials did not change significantly over time (p = 0.257). However, among participants with moderate to severe ARDS (i.e., partial pressure of arterial oxygen to fraction of inspired oxygen ratio < 150), the difference in mortality between racial and ethnic minority participants and White participants decreased over time. In the five most recent trials, including 2923 participants with ARDS, there were no statistically significant differences in mortality between racial/ethnic groups, even after adjusting for potential confounders. In these five most recent trials, mortality was 31% for White, 31.9% for Black, 30.3% for Hispanic, and 37.1% for Other race participants (p = 0.633).
    Conclusion: Representation of racial and ethnic minority participants in ARDS trials from North America, published between 2000 and 2019, did not change over time. Black and Hispanic participants with ARDS may have similar mortality as White participants within trials.
    MeSH term(s) Humans ; United States ; Ethnicity ; Ethnic and Racial Minorities ; Minority Groups ; Respiratory Distress Syndrome/therapy ; Oxygen ; Randomized Controlled Trials as Topic
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07238-x
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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Should age be a criterion for intensive care unit admission in cancer patients?-Still an issue of uncertainty.

    Daganou, Maria / Kyriakoudi, Anna / Koutsoukou, Antonia

    Journal of thoracic disease

    2017  Volume 9, Issue 10, Page(s) 3506–3508

    Language English
    Publishing date 2017-12-18
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2017.08.161
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  3. Article: Modified SCOPE (mSCOPE) Score as a Tool to Predict Mortality in COVID-19 Critically Ill Patients.

    Zanelli, Stavroula / Bakakos, Agamemnon / Sotiropoulou, Zoi / Papaioannou, Andriana I / Koukaki, Evangelia / Potamianou, Efstathia / Kyriakoudi, Anna / Kaniaris, Evangelos / Bakakos, Petros / Giamarellos-Bourboulis, Evangelos J / Koutsoukou, Antonia / Rovina, Nikoletta

    Journal of personalized medicine

    2023  Volume 13, Issue 4

    Abstract: Introduction: Efficient clinical scores predicting the outcome of severe COVID-19 pneumonia may play a pivotal role in patients' management. The aim of this study was to assess the modified Severe COvid Prediction Estimate score (mSCOPE) index as a ... ...

    Abstract Introduction: Efficient clinical scores predicting the outcome of severe COVID-19 pneumonia may play a pivotal role in patients' management. The aim of this study was to assess the modified Severe COvid Prediction Estimate score (mSCOPE) index as a predictor of mortality in patients admitted to the ICU due to severe COVID-19 pneumonia.
    Materials and methods: In this retrospective observational study, 268 critically ill COVID-19 patients were included. Demographic and laboratory characteristics, comorbidities, disease severity, and outcome were retrieved from the electronical medical files. The mSCOPE was also calculated.
    Results: An amount of 70 (26.1%) of patients died in the ICU. These patients had higher mSCOPE score compared to patients who survived (
    Conclusion: mSCOPE score could be proved useful in patients' risk stratification, guiding clinical interventions in patients with severe COVID-19.
    Language English
    Publishing date 2023-04-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13040628
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  4. Article: Weaning Failure in Critically Ill Patients Is Related to the Persistence of Sepsis Inflammation.

    Kyriakoudi, Anna / Rovina, Nikoletta / Koltsida, Ourania / Kostakou, Eirini / Konstantelou, Elissavet / Kardara, Matina / Kompoti, Maria / Palamidas, Anastasios / Kaltsakas, Georgios / Koutsoukou, Antonia

    Diagnostics (Basel, Switzerland)

    2021  Volume 12, Issue 1

    Abstract: Introduction: Septic patients undergoing mechanical ventilation (MV) often experience difficulty in weaning. Th aim of this study was to determine whether inflammatory biomarkers of sepsis could be indicative of the failure or success of spontaneous ... ...

    Abstract Introduction: Septic patients undergoing mechanical ventilation (MV) often experience difficulty in weaning. Th aim of this study was to determine whether inflammatory biomarkers of sepsis could be indicative of the failure or success of spontaneous breathing trial (SBT) in these patients.
    Methods: Sixty-five patients on MV (42 septic and 23 intubated for other reasons) fulfilling the criteria for SBT were included in the study. Blood samples were collected right before, at the end of (30 min) and 24 h after the SBT. Serum inflammatory mediators associated with sepsis (IL-18, IL-18BP, TNF) were determined and correlated with the outcome of SBT.
    Results: A successful SBT was achieved in 45 patients (69.2%). Septic patients had a higher percentage of SBT failure as compared to non-septic patients (85% vs. 15%,
    Conclusion: Sustained increased levels of IL-18 and IL-18BP, acknowledged markers of sepsis, were found to be indicative of SBT failure in patients recovering from sepsis. Our results show that, although subclinical, remaining septic inflammation that sustaines for a long time complicates the weaning procedure. Biomarkers for the estimation of the septic burden and the right time for weaning are needed.
    Language English
    Publishing date 2021-12-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12010092
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  5. Article: Pharmacokinetic Characteristics of Nebulized Colistimethate Sodium Using Two Different Types of Nebulizers in Critically Ill Patients with Ventilator-Associated Respiratory Infections.

    Kyriakoudi, Anna / Pontikis, Konstantinos / Valsami, Georgia / Avgeropoulou, Stavrina / Neroutsos, Efthymios / Christodoulou, Eirini / Moraitou, Eleni / Markantonis, Sophia L / Dokoumetzidis, Aristides / Rello, Jordi / Koutsoukou, Antonia

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 11

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-11-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11111528
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  6. Article ; Online: Weaning Failure in Critically Ill Patients Is Related to the Persistence of Sepsis Inflammation

    Anna Kyriakoudi / Nikoletta Rovina / Ourania Koltsida / Eirini Kostakou / Elissavet Konstantelou / Matina Kardara / Maria Kompoti / Anastasios Palamidas / Georgios Kaltsakas / Antonia Koutsoukou

    Diagnostics, Vol 12, Iss 92, p

    2022  Volume 92

    Abstract: Introduction: Septic patients undergoing mechanical ventilation (MV) often experience difficulty in weaning. Th aim of this study was to determine whether inflammatory biomarkers of sepsis could be indicative of the failure or success of spontaneous ... ...

    Abstract Introduction: Septic patients undergoing mechanical ventilation (MV) often experience difficulty in weaning. Th aim of this study was to determine whether inflammatory biomarkers of sepsis could be indicative of the failure or success of spontaneous breathing trial (SBT) in these patients. Methods: Sixty-five patients on MV (42 septic and 23 intubated for other reasons) fulfilling the criteria for SBT were included in the study. Blood samples were collected right before, at the end of (30 min) and 24 h after the SBT. Serum inflammatory mediators associated with sepsis (IL-18, IL-18BP, TNF) were determined and correlated with the outcome of SBT. Results: A successful SBT was achieved in 45 patients (69.2%). Septic patients had a higher percentage of SBT failure as compared to non-septic patients (85% vs. 15%, p = 0.026), with an odds ratio for failing 4.5 times (OR = 4.5 95%CI: 1.16–17.68, p 0.022). IL-18 levels and the relative mRNA expression in serum were significantly higher in septic as compared to non-septic patients ( p < 0.05). Sepsis was independently associated with higher serum IL-18 and TNF levels in two time-point GEE models (53–723, p = 0.023 and 0.3–64, p = 0.048, respectively). IL-18BP displayed independent negative association with rapid shallow breathing index (RSBI) (95% CI: −17.6 to −4, p = 0.002). Conclusion: Sustained increased levels of IL-18 and IL-18BP, acknowledged markers of sepsis, were found to be indicative of SBT failure in patients recovering from sepsis. Our results show that, although subclinical, remaining septic inflammation that sustaines for a long time complicates the weaning procedure. Biomarkers for the estimation of the septic burden and the right time for weaning are needed.
    Keywords sepsis ; inflammation ; IL-18 ; IL-18BP ; critically ill patients ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Acute life-threatening cardiac tamponade in a mechanically ventilated patient with COVID-19 pneumonia.

    Derveni, Vaia / Kaniaris, Evangelos / Toumpanakis, Dimitris / Potamianou, Efstathia / Ioannidou, Ilianna / Theodoulou, Danai / Kyriakoudi, Anna / Kyriakopoulou, Magda / Pontikis, Konstantinos / Daganou, Maria

    IDCases

    2020  Volume 21, Page(s) e00898

    Abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently evolved as a pandemic disease. Although the respiratory system is predominantly affected, cardiovascular complications have been ... ...

    Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently evolved as a pandemic disease. Although the respiratory system is predominantly affected, cardiovascular complications have been frequently identified, including acute myocarditis, myocardial infarction, acute heart failure, arrhythmias and venous thromboembolic events. Pericardial disease has been rarely reported. We present a case of acute life-threatening cardiac tamponade caused by a small pericardial effusion in a mechanically ventilated patient with severe COVID-19 associated pneumonia. The patient presented acute circulatory collapse with hemodynamic features of cardiogenic or obstructive shock. Bedside echocardiography permitted prompt diagnosis and life-saving pericardiocentesis. Further investigation revealed no other apparent cause of pericardial effusion except for SARS-CoV-2 infection. Cardiac tamponade may complicate COVID-19 and should be included in the differential diagnosis of acute hemodynamic deterioration in mechanically ventilated COVID-19 patients.
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2020.e00898
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  8. Article: Cutaneous Vasculopathy in a COVID-19 Critically Ill Patient: A Histologic, Immunohistochemical, and Electron Microscopy Study.

    Kyriakoudi, Anna / Pontikis, Konstantinos / Tsaraklis, Athanasios / Soura, Efthymia / Vourlakou, Christine / Kossyvakis, Athanasios / Potamianou, Efstathia / Kaniaris, Evangelos / Ioannidou, Iliana / Mentis, Andreas / Kloukina, Ismini / Daganou, Maria / Koutsoukou, Antonia

    Case reports in critical care

    2021  Volume 2021, Page(s) 6644853

    Abstract: We describe a critically ill, SARS-CoV-2 positive patient with respiratory failure and thrombotic/livedoid skin lesions, appearing during the course of the disease. The biopsy of the lesions revealed an occlusive, pauci-inflammatory vasculopathy of the ... ...

    Abstract We describe a critically ill, SARS-CoV-2 positive patient with respiratory failure and thrombotic/livedoid skin lesions, appearing during the course of the disease. The biopsy of the lesions revealed an occlusive, pauci-inflammatory vasculopathy of the cutaneous small vessels characterized by complement and fibrinogen deposition on vascular walls, pointing to a thrombotic vasculopathy. Transmission electron microscopy of the affected skin failed to reveal any viral inclusions. Clinical evaluation and laboratory findings ruled out systemic coagulopathies and disseminated intravascular coagulation, drug-induced skin reaction, and common viral rashes. Our hypothesis is that the, herein evidenced, microvascular occlusive injury might constitute a significant pathologic mechanism in COVID-19, being a common denominator between cutaneous and pulmonary manifestations.
    Language English
    Publishing date 2021-04-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2927720-6
    ISSN 2090-6439 ; 2090-6420
    ISSN (online) 2090-6439
    ISSN 2090-6420
    DOI 10.1155/2021/6644853
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  9. Article ; Online: The lung microbiome dynamics between stability and exacerbation in chronic obstructive pulmonary disease (COPD): Current perspectives.

    Dima, Efrosini / Kyriakoudi, Anna / Kaponi, Maria / Vasileiadis, Ioannis / Stamou, Panagiota / Koutsoukou, Antonia / Koulouris, Nikolaos G / Rovina, Nikoletta

    Respiratory medicine

    2019  Volume 157, Page(s) 1–6

    Abstract: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder with a course that is not uniform for all COPD patients. Although smoking is considered as the major cause of the disease, persistent or recurrent infections seem to play a ... ...

    Abstract Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder with a course that is not uniform for all COPD patients. Although smoking is considered as the major cause of the disease, persistent or recurrent infections seem to play a particular role in the disease establishment and progression. COPD is characterized by dysregulated immunity that has been associated with the bacterial colonization and infections. The establishment of culture-independent techniques has shed new light on the relationships between bacterial ecology and health status and expanded our knowledge on the lung microbiome. Interactions between the host and lung microbiome result in inflammation and activation of resident cells. The lung microbiome contains populations of symbionts and pathobionts in balance which lose their equilibrium and disturb the balance of T-helper and regulatory T-cells (Treg) upon infection, or lung disease. In COPD factors such as disease severity, exacerbations, degree of inflammation, and type of treatment used (e.g inhaled or systemic steroids and antibiotics) affect the composition of lung microbiota. Recent data indicate that the presence of specific bacterial taxa in the airways has the potential to influence the host immune response and possibly to interfere with disease phenotype. Although, there is a growing body of evidence for the role of microbiome in COPD several unanswered questions still exist for its clinical relevance.
    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Case-Control Studies ; Disease Progression ; Health Status ; Humans ; Inflammation/immunology ; Inflammation/physiopathology ; Lung/drug effects ; Lung/immunology ; Lung/microbiology ; Lung/physiopathology ; Microbiota/genetics ; Phenotype ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/immunology ; Pulmonary Disease, Chronic Obstructive/microbiology ; Pulmonary Disease, Chronic Obstructive/physiopathology ; RNA, Ribosomal, 16S/genetics ; Smoking/adverse effects ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances Anti-Bacterial Agents ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2019-08-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2019.08.012
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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.19: Show issues Location:
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  10. Article ; Online: Acute life-threatening cardiac tamponade in a mechanically ventilated patient with COVID-19 pneumonia

    Derveni, Vaia / Kaniaris, Evangelos / Toumpanakis, Dimitris / Potamianou, Efstathia / Ioannidou, Ilianna / Theodoulou, Danai / Kyriakoudi, Anna / Kyriakopoulou, Magda / Pontikis, Konstantinos / Daganou, Maria

    IDCases

    2020  Volume 21, Page(s) e00898

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2020.e00898
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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