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  1. Article ; Online: Cutaneous community-associated methicillin-resistant staphylococcus aureus among all skin and soft-tissue infections in two geographically distant pediatric emergency departments.

    Hasty, Molly B / Klasner, Ann / Kness, Sean / Denmark, T Kent / Ellis, Don / Herman, Martin I / Brown, Lance

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    2007  Volume 14, Issue 1, Page(s) 35–40

    Abstract: Objectives: To describe the culture results of cutaneous infections affecting otherwise healthy children presenting to two pediatric emergency departments (EDs) in the southeastern United States and southern California.: Methods: Medical records of ... ...

    Abstract Objectives: To describe the culture results of cutaneous infections affecting otherwise healthy children presenting to two pediatric emergency departments (EDs) in the southeastern United States and southern California.
    Methods: Medical records of 920 children who presented to the pediatric EDs with skin infections and abscesses (International Classification of Diseases, Ninth Revision codes 680.0-686.9) during 2003 were reviewed. Chronically ill children with previously described risk factors for community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) were excluded. Data abstracted included the type of infection; the site of infection; and, if a culture was obtained, the organism grown, along with their corresponding sensitivities.
    Results: Of the 270 children who had bacterial cultures obtained, 60 (22%) were CA-MRSA-positive cultures, most cultured from abscesses (80%). Of all abscesses cultured, CA-MRSA grew in more than half (53%). All CA-MRSA isolates tested were sensitive to vancomycin, trimethoprim-sulfamethoxazole, rifampin, and gentamicin. One isolate at each center was resistant to clindamycin. The sensitivities at both institutions were similar.
    Conclusions: The authors conclude that CA-MRSA is responsible for most abscesses and that the pattern of CA-MRSA infections in these geographically distant pediatric EDs is similar. These data suggest that optimal diagnostic and management strategies for CA-MRSA will likely be widely applicable if results from a larger, more collaborative study yield similar findings.
    MeSH term(s) Abscess/microbiology ; Adolescent ; Buttocks/microbiology ; California/epidemiology ; Child ; Child, Preschool ; Community-Acquired Infections ; Emergency Service, Hospital ; Female ; Humans ; Infant ; Infant, Newborn ; Leg/microbiology ; Male ; Methicillin Resistance ; Microbial Sensitivity Tests ; Retrospective Studies ; Soft Tissue Infections/drug therapy ; Soft Tissue Infections/epidemiology ; Soft Tissue Infections/microbiology ; Southeastern United States/epidemiology ; Staphylococcal Skin Infections/drug therapy ; Staphylococcal Skin Infections/epidemiology
    Language English
    Publishing date 2007-01
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1197/j.aem.2006.08.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice.

    Hurez, Vincent / Dao, Vinh / Liu, Aijie / Pandeswara, Srilakshmi / Gelfond, Jonathan / Sun, Lishi / Bergman, Molly / Orihuela, Carlos J / Galvan, Veronica / Padrón, Álvaro / Drerup, Justin / Liu, Yang / Hasty, Paul / Sharp, Zelton Dave / Curiel, Tyler J

    Aging cell

    2015  Volume 14, Issue 6, Page(s) 945–956

    Abstract: ... cell death, and inflammation in distinct T- and B-lymphocyte and myeloid cell subpopulations. Immune ...

    Abstract The mammalian (mechanistic) target of rapamycin (mTOR) regulates critical immune processes that remain incompletely defined. Interest in mTOR inhibitor drugs is heightened by recent demonstrations that the mTOR inhibitor rapamycin extends lifespan and healthspan in mice. Rapamycin or related analogues (rapalogues) also mitigate age-related debilities including increasing antigen-specific immunity, improving vaccine responses in elderly humans, and treating cancers and autoimmunity, suggesting important new clinical applications. Nonetheless, immune toxicity concerns for long-term mTOR inhibition, particularly immunosuppression, persist. Although mTOR is pivotal to fundamental, important immune pathways, little is reported on immune effects of mTOR inhibition in lifespan or healthspan extension, or with chronic mTOR inhibitor use. We comprehensively analyzed immune effects of rapamycin as used in lifespan extension studies. Gene expression profiling found many and novel changes in genes affecting differentiation, function, homeostasis, exhaustion, cell death, and inflammation in distinct T- and B-lymphocyte and myeloid cell subpopulations. Immune functions relevant to aging and inflammation, and to cancer and infections, and innate lymphoid cell effects were validated in vitro and in vivo. Rapamycin markedly prolonged lifespan and healthspan in cancer- and infection-prone mice supporting disease mitigation as a mechanism for mTOR suppression-mediated longevity extension. It modestly altered gut metagenomes, and some metagenomic effects were linked to immune outcomes. Our data show novel mTOR inhibitor immune effects meriting further studies in relation to longevity and healthspan extension.
    MeSH term(s) Aging/drug effects ; Animals ; Antibiotics, Antineoplastic/pharmacology ; B-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Differentiation/drug effects ; Dendritic Cells/immunology ; Female ; Flagellin/immunology ; Gastrointestinal Microbiome ; Gene Expression Profiling ; Immunologic Memory/immunology ; Interleukins/metabolism ; Longevity/drug effects ; Longevity/immunology ; Male ; Melanoma, Experimental ; Mice ; Mice, Inbred C57BL ; Myeloid Cells/immunology ; Programmed Cell Death 1 Receptor/biosynthesis ; Sirolimus/pharmacology ; Spleen/cytology ; Spleen/immunology ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/immunology ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/immunology ; Interleukin-22
    Chemical Substances Antibiotics, Antineoplastic ; Interleukins ; Pdcd1 protein, mouse ; Programmed Cell Death 1 Receptor ; Flagellin (12777-81-0) ; mTOR protein, mouse (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2015-08-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.12380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Characteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States

    Flythe, Jennifer E. / Assimon, Magdalene M. / Tugman, Matthew J. / Chang, Emily H. / Gupta, Shruti / Shah, Jatan / Sosa, Marie Anne / Renaghan, Amanda DeMauro / Melamed, Michal L. / Wilson, F. Perry / Neyra, Javier A. / Rashidi, Arash / Boyle, Suzanne M. / Anand, Shuchi / Christov, Marta / Thomas, Leslie F. / Edmonston, Daniel / Leaf, David E. / Walther, Carl P. /
    Anumudu, Samaya J. / Arunthamakun, Justin / Kopecky, Kathleen F. / Milligan, Gregory P. / McCullough, Peter A. / Nguyen, Thuy-Duyen / Shaefi, Shahzad / Krajewski, Megan L. / Shankar, Sidharth / Pannu, Ameeka / Valencia, Juan D. / Waikar, Sushrut S. / Kibbelaar, Zoe A. / Athavale, Ambarish M. / Hart, Peter / Upadhyay, Shristi / Vohra, Ishaan / Green, Adam / Rachoin, Jean-Sebastien / Schorr, Christa A. / Shea, Lisa / Edmonston, Daniel L. / Mosher, Christopher L. / Shehata, Alexandre M. / Cohen, Zaza / Allusson, Valerie / Bambrick-Santoyo, Gabriela / Bhatti, Noor ul aain / Mehta, Bijal / Williams, Aquino / Brenner, Samantha K. / Walters, Patricia / Go, Ronaldo C. / Rose, Keith M. / Chan, Lili / Mathews, Kusum S. / Coca, Steven G. / Altman, Deena R. / Saha, Aparna / Soh, Howard / Wen, Huei Hsun / Bose, Sonali / Leven, Emily A. / Wang, Jing G. / Mosoyan, Gohar / Nadkarni, Girish N. / Pattharanitima, Pattharawin / Gallagher, Emily J. / Friedman, Allon N. / Guirguis, John / Kapoor, Rajat / Meshberger, Christopher / Kelly, Katherine J. / Parikh, Chirag R. / Garibaldi, Brian T. / Corona-Villalobos, Celia P. / Wen, Yumeng / Menez, Steven / Malik, Rubab F. / Cervantes, Carmen Elena / Gautam, Samir C. / Mallappallil, Mary C. / Ouyang, Jie / John, Sabu / Yap, Ernie / Melaku, Yohannes / Mohamed, Ibrahim / Bajracharya, Siddhartha / Puri, Isha / Thaxton, Mariah / Bhattacharya, Jyotsna / Wagner, John / Boudourakis, Leon / Nguyen, H. Bryant / Ahoubim, Afshin / Kashani, Kianoush / Tehranian, Shahrzad / Sirganagari, Dheeraj Reddy / Guru, Pramod K. / Zhou, Yan / Bergl, Paul A. / Rodriguez, Jesus / Shah, Jatan A. / Gupta, Mrigank S. / Kumar, Princy N. / Lazarous, Deepa G. / Kassaye, Seble G. / Johns, Tanya S. / Mocerino, Ryan / Prudhvi, Kalyan / Zhu, Denzel / Levy, Rebecca V. / Azzi, Yorg / Fisher, Molly / Yunes, Milagros / Sedaliu, Kaltrina / Golestaneh, Ladan / Brogan, Maureen / Kumar, Neelja / Chang, Michael / Thakkar, Jyotsana / Raichoudhury, Ritesh / Athreya, Akshay / Farag, Mohamed / Schenck, Edward J. / Cho, Soo Jung / Plataki, Maria / Alvarez-Mulett, Sergio L. / Gomez-Escobar, Luis G. / Pan, Di / Lee, Stefi / Krishnan, Jamuna / Whalen, William / Charytan, David / Macina, Ashley / Chaudhry, Sobaata / Wu, Benjamin / Modersitzki, Frank / Srivastava, Anand / Leidner, Alexander S. / Martinez, Carlos / Kruser, Jacqueline M. / Wunderink, Richard G. / Hodakowski, Alexander J. / Velez, Juan Carlos Q. / Price-Haywood, Eboni G. / Matute-Trochez, Luis A. / Hasty, Anna E. / Mohamed, Muner M.B. / Avasare, Rupali S. / Zonies, David / Sise, Meghan E. / Newman, Erik T. / Abu Omar, Samah / Pokharel, Kapil K. / Sharma, Shreyak / Singh, Harkarandeep / Correa, Simon / Shaukat, Tanveer / Kamal, Omer / Wang, Wei / Yang, Heather / Boateng, Jeffery O. / Lee, Meghan / Strohbehn, Ian A. / Li, Jiahua / Mueller, Ariel L. / Redfern, Roberta / Cairl, Nicholas S. / Naimy, Gabriel / Abu-Saif, Abeer / Hall, Danyell / Bickley, Laura / Rowan, Chris / Madhani-Lovely, Farah / Peev, Vasil / Reiser, Jochen / Byun, John J. / Vissing, Andrew / Kapania, Esha M. / Post, Zoe / Patel, Nilam P. / Hermes, Joy-Marie / Sutherland, Anne K. / Patrawalla, Amee / Finkel, Diana G. / Danek, Barbara A. / Arikapudi, Sowminya / Paer, Jeffrey M. / Cangialosi, Peter / Liotta, Mark / Radbel, Jared / Puri, Sonika / Sunderram, Jag / Scharf, Matthew T. / Ahmed, Ayesha / Berim, Ilya / Vatson, Jayanth S. / Levitt, Joseph E. / Garcia, Pablo / Song, Rui / Zhang, Jingjing / Woo, Sang Hoon / Deng, Xiaoying / Katz-Greenberg, Goni / Senter, Katharine / Sharshir, Moh’d A. / Rusnak, Vadym V. / Ali, Muhammad Imran / Bansal, Anip / Podoll, Amber S. / Chonchol, Michel / Sharma, Sunita / Burnham, Ellen L. / Hejal, Rana / Judd, Eric / Latta, Laura / Tolwani, Ashita / Albertson, Timothy E. / Adams, Jason Y. / Reagan, Ronald / Chang, Steven Y. / Beutler, Rebecca M. / Monica, Santa / Schulze, Carl E. / Macedo, Etienne / Rhee, Harin / Liu, Kathleen D. / Jotwani, Vasantha K. / Koyner, Jay L. / Kunczt, Alissa / Shah, Chintan V. / Jaikaransingh, Vishal / Toth-Manikowski, Stephanie M. / Joo, Min J. / Lash, James P. / Chaaban, Nourhan / Dy, Rajany / Iardino, Alfredo / Au, Elizabeth H. / Sharma, Jill H. / Taldone, Sabrina / Contreras, Gabriel / De La Zerda, David / Gershengorn, Hayley B. / Hayek, Salim S. / Blakely, Pennelope / Berlin, Hanna / Azam, Tariq U. / Shadid, Husam / Pan, Michael / Hayer, Patrick O’ / Meloche, Chelsea / Feroze, Rafey / Kaakati, Rayan / Perry, Danny / Bitar, Abbas / Anderson, Elizabeth / Padalia, Kishan J. / Donnelly, John P. / Admon, Andrew J. / Brown, Brent R. / Leonberg-Yoo, Amanda K. / Spiardi, Ryan C. / Miano, Todd A. / Roche, Meaghan S. / Vasquez, Charles R. / Bansal, Amar D. / Ernecoff, Natalie C. / Kapoor, Sanjana / Verma, Siddharth / Chen, Huiwen / Kovesdy, Csaba P. / Molnar, Miklos Z. / Azhar, Ambreen / Hedayati, S. Susan / Nadamuni, Mridula V. / Shastri, Shani / Willett, Duwayne L. / Short, Samuel A.P. / Renaghan, Amanda D. / Enfield, Kyle B. / Bhatraju, Pavan K. / Malik, A. Bilal / Semler, Matthew W. / Vijayan, Anitha / Mariyam Joy, Christina / Li, Tingting / Goldberg, Seth / Kao, Patricia F. / Schumaker, Greg L. / Goyal, Nitender / Faugno, Anthony J. / Hsu, Caroline M. / Tariq, Asma / Meyer, Leah / Kshirsagar, Ravi K. / Weiner, Daniel E. / Jose, Aju / Griffiths, Jennifer / Gupta, Sanjeev / Kapoor, Aromma / Wilson, Perry / Arora, Tanima / Ugwuowo, Ugochukwu

    American Journal of Kidney Diseases ; ISSN 0272-6386

    2020  

    Keywords Nephrology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1053/j.ajkd.2020.09.003
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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