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Article ; Online: Blue-brownish Nodule in the Umbilical Area: A Quiz.

Krajewski, Piotr K / Szepietowski, Jacek C

2023 Volume 103, Page(s) adv18368

Language	English
Publishing date	2023-09-28
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	80007-7
ISSN	1651-2057 ; 0001-5555
ISSN (online)	1651-2057
ISSN	0001-5555
DOI	10.2340/actadv.v103.18368
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Ui VI Zs.101: Show issues

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Article ; Online: Psoriasis: An inflammatory skin disease affecting the mind.

Szepietowski, Jacek C / Krajewski, Piotr K / Pacan, Przemysław

Journal of the European Academy of Dermatology and Venereology : JEADV

2024 Volume 38, Issue 3, Page(s) 460–461

MeSH term(s)	Humans ; Psoriasis ; Dermatitis ; Skin
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.19740
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Zs.A 3492: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Secukinumab for the treatment of moderate-to-severe plaque psoriasis in paediatric patients aged six years and older.

Krajewski, Piotr K / Szepietowski, Jacek C

Expert review of clinical immunology

2023 Volume 19, Issue 7, Page(s) 711–716

Abstract: Introduction: Psoriasis (PSO) is a chronic, recurrent, inflammatory skin disorder that significantly influences patients' quality of life. The prevalence of PSO among children varies depending on the age and ranges from 0.12% at one year to 2% at 18 ... ...

Abstract	Introduction: Psoriasis (PSO) is a chronic, recurrent, inflammatory skin disorder that significantly influences patients' quality of life. The prevalence of PSO among children varies depending on the age and ranges from 0.12% at one year to 2% at 18 years. Due to systemic inflammation, PSO is associated with obesity, hypertension, inflammatory bowel disease, and cardiovascular incidences.Secukinumab is a fully human monoclonal antibody selectively targeting IL-17A. The drug has been approved for children aged 6-18 with moderate to severe plaque psoriasis. Nevertheless, only a few reports thoroughly describe its efficacy and safety in the pediatric population. Areas covered: This review aims to describe the efficacy and safety of secukinumab for the treatment of moderate-to-severe plaque PSO in pediatric patients aged six years and older. Expert opinion: Although there are only two clinical trials assessing the efficacy and safety of secukinumab in the pediatric population with plaque PSO, this therapy seems to be a significant advancement in managing those patients. Both dose regimens (depending on the weight, low-dose, 75/75/150 mg, and high-dose 75/150/300 mg) of secukinumab were more effective in achieving significant clinical improvement (PASI 75/90 and IGA response) than placebo or active-comparator. Both regimens showed good safety and tolerability profiles, with mostly mild AEs and no SAEs observed.
MeSH term(s)	Humans ; Child ; Quality of Life ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal/adverse effects ; Psoriasis/drug therapy ; Chronic Disease ; Severity of Illness Index ; Treatment Outcome
Chemical Substances	secukinumab (DLG4EML025) ; Antibodies, Monoclonal, Humanized ; Antibodies, Monoclonal
Language	English
Publishing date	2023-05-23
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2274260-8
ISSN	1744-8409 ; 1744-666X
ISSN (online)	1744-8409
ISSN	1744-666X
DOI	10.1080/1744666X.2023.2214365
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Article ; Online: The NLRP3 Inflammasome Gene Is Overexpressed in Hidradenitis Suppurativa Lesions: A Preliminary Study on the Role of Pyroptosis in Disease Pathogenesis.

Krajewski, Piotr K / Szukała, Weronika / Szepietowski, Jacek C

Current issues in molecular biology

2024 Volume 46, Issue 3, Page(s) 2544–2552

Abstract: Hidradenitis suppurativa (HS) is a debilitating inflammatory skin disorder, and its pathogenesis remains incompletely understood. This study aimed to investigate the role of the P2X7 receptor (P2X7R) and NLRP3 inflammasome in HS pathogenesis. RNA ... ...

Abstract	Hidradenitis suppurativa (HS) is a debilitating inflammatory skin disorder, and its pathogenesis remains incompletely understood. This study aimed to investigate the role of the P2X7 receptor (P2X7R) and NLRP3 inflammasome in HS pathogenesis. RNA sequencing and real-time PCR were performed to assess the gene expression levels of P2X7R and NLRP3 in the skin biopsies of HS patients and healthy controls (HC). The results of our study revealed a significantly increased expression of the NLRP3 gene in both the lesional and perilesional skin of HS patients compared to healthy controls. Moreover, the mRNA levels of NLRP3 were significantly higher in lesional skin compared to non-lesional skin in HS patients, indicating the spread of inflammation to adjacent tissues. In contrast, no significant differences in P2X7R gene expression were observed between the three groups. These findings suggest the involvement of NLRP3 inflammasomes in HS pathogenesis, while P2X7R may not play a significant role in the disease. This research sheds light on the complex inflammatory pathways in HS, highlighting the potential of NLRP3 as a therapeutic target. Understanding the molecular mechanisms underlying HS is crucial for the development of targeted treatment modalities for this debilitating condition.
Language	English
Publishing date	2024-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb46030161
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Zs.A 5122: Show issues

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Article ; Online: Pathological and Therapeutical Implications of Pyroptosis in Psoriasis and Hidradenitis Suppurativa: A Narrative Review.

Krajewski, Piotr K / Tsoukas, Maria / Szepietowski, Jacek C

Current issues in molecular biology

2024 Volume 46, Issue 1, Page(s) 663–676

Abstract: This manuscript explores the role of pyroptosis, an inflammatory programmed cell death, in the pathogenesis of two chronic dermatoses, psoriasis and hidradenitis suppurativa (HS). The diseases, though clinically diverse, share common pathogenetic ... ...

Abstract	This manuscript explores the role of pyroptosis, an inflammatory programmed cell death, in the pathogenesis of two chronic dermatoses, psoriasis and hidradenitis suppurativa (HS). The diseases, though clinically diverse, share common pathogenetic pathways involving the unbalanced interaction between the adaptive and innate immune systems. This review focuses on the molecular changes in psoriatic and HS skin, emphasizing the activation of dendritic cells, secretion of interleukins (IL-17, IL-22, and TNF-α), and the involvement of inflammasomes, particularly NLRP3. This manuscript discusses the role of caspases, especially caspase-1, in driving pyroptosis and highlights the family of gasdermins (GSDMs) as key players in the formation of pores leading to cell rupture and the release of proinflammatory signals. This study delves into the potential therapeutic implications of targeting pyroptosis in psoriasis and HS, examining existing medications like biologics and Janus kinase inhibitors. It also reviews the current limitations and challenges in developing therapies that selectively target pyroptosis. Additionally, the manuscript explores the role of pyroptosis in various inflammatory disorders associated with psoriasis and HS, such as inflammatory bowel disease, diabetes mellitus, and cardiovascular disorders. The review concludes by emphasizing the need for further research to fully elucidate the pathomechanisms of these dermatoses and develop effective, targeted therapies.
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb46010043
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Article ; Online: Acne influences life-changing decisions among young adults.

Bień, Beata / Krajewski, Piotr K / Szepietowski, Jacek C

Italian journal of dermatology and venereology

2024 Volume 159, Issue 2, Page(s) 174–181

Abstract: Background: Acne is a chronic inflammatory disease predominantly affecting young people. This study was undertaken to assess the impact of acne in young adults on their major life-changing decisions (MLCD), paying attention to the relationships between ... ...

Abstract	Background: Acne is a chronic inflammatory disease predominantly affecting young people. This study was undertaken to assess the impact of acne in young adults on their major life-changing decisions (MLCD), paying attention to the relationships between major life-changing decisions profile (MLCDP) and Quality of Life (QoL), feeling of stigmatization and acceptance of the disease. Methods: The study was performed on 213 young people diagnosed with acne. A variety of questionnaires were employed to measure the clinical and psychological aspects of acne. Results: The majority of patients (N.=148, 73.3%) reported at least one MLCD that acne affected in any way (mean number 2.9±3.2, range: 0-18). The most common MLCD influenced by acne appeared to be a decision of changing eating habits (N.=132, 65.3%), followed by changing habits associated with smoking and alcohol (N.=85, 42.1%) and deciding to be more active physically (N.=61, 30.2%). The total score of MLCDP ranged from 0 to 33 points (mean 5.41±6.23 points). MLCDP total score significantly correlated with clinical acne severity (P=0.006), QoL (P<0.001), stigmatization (P<0.001) and illness acceptance (P<0.001). Conclusions: Acne has an important impact on life-changing decisions in young adults. MLCDP correlates with impaired QoL, level of stigmatization and degree of illness acceptance. This should be taken into consideration in the holistic approach to acne patients.
MeSH term(s)	Humans ; Acne Vulgaris/psychology ; Quality of Life/psychology ; Male ; Female ; Young Adult ; Adolescent ; Adult ; Surveys and Questionnaires ; Decision Making ; Feeding Behavior/psychology ; Severity of Illness Index ; Smoking/psychology
Language	English
Publishing date	2024-04-23
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3065415-4
ISSN	2784-8450
ISSN (online)	2784-8450
DOI	10.23736/S2784-8671.24.07754-5
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Zs.B 119: Show issues

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Article ; Online: Erythematous Lesion with Small Arciform Pattern Erosions: A Quiz.

Krajewski, Piotr K / Szepietowski, Jacek C

Acta dermato-venereologica

2021 Volume 101, Issue 9, Page(s) adv00542

Language	English
Publishing date	2021-09-08
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	80007-7
ISSN	1651-2057 ; 0001-5555
ISSN (online)	1651-2057
ISSN	0001-5555
DOI	10.2340/00015555-3900
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Article: Anhedonia in Acne Vulgaris: A Cross-Sectional Study of 104 Consecutive Acne Patients.

Szepietowska, Marta / Stefaniak, Aleksandra A / Krajewski, Piotr K / Matusiak, Łukasz

Clinical, cosmetic and investigational dermatology

2024 Volume 17, Page(s) 349–357

Abstract: Background: Anhedonia is defined as a reduced ability to experience or even a total loss of pleasure.: Purpose: This study was undertaken to evaluate anhedonia in 104 consecutive acne patients.: Material and methods: Acne severity was assessed ... ...

Abstract	Background: Anhedonia is defined as a reduced ability to experience or even a total loss of pleasure. Purpose: This study was undertaken to evaluate anhedonia in 104 consecutive acne patients. Material and methods: Acne severity was assessed with Investigator Global Assessment (IGA), anhedonia was studied with the Snaith-Hamilton Pleasure Scale (SHAPS), Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS) and Temporal Experience of Pleasure Scale (TEPS). Moreover, the quality of life (QoL) and stigmatization, as well as depression and anxiety (Hospital Anxiety and Depression Scale - HADS), were additionally evaluated. Results: Anhedonia was found in 20.19% of acne patients and was more common (p=0.007) in males (34.29%) than in females (13.04%). Based on SHAPS, males with acne showed significantly (p=0.049) higher levels of anhedonia (2.39 ± 3.18 points) than acne females (1.26 ± 2.36 points). Anhedonia significantly correlated with the clinical acne severity (SHAPS: r=0.205, p=0.038 and ACIPS: r=-0.222, p=0.026). Although the intensity of anhedonia did not show any relationship with QoL and stigmatization assessments, there was a significant correlation between anhedonia and depressive symptoms (SHAPS: r=0.310, p<0.001; ACIPS: r=-0.364, p<0.001). Such dependency was not documented for anxiety. Conclusion: Anhedonia seems to be a common phenomenon in acne and should be considered in the holistic approach to acne patients.
Language	English
Publishing date	2024-02-07
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494852-4
ISSN	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S451927
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Article ; Online: Ruxolitinib cream for the short-term treatment of mild-moderate atopic dermatitis.

Krajewski, Piotr K / Szepietowski, Jacek C

Expert review of clinical immunology

2022 Volume 19, Issue 4, Page(s) 349–356

Abstract: Introduction: Atopic dermatitis (AD) is a chronic, recurrent, itchy inflammatory skin disease with a vast influence on a patient's quality of life (QoL). Mild-moderate AD was classically managed with the use of topical corticosteroid (TCS) and ... ...

Abstract	Introduction: Atopic dermatitis (AD) is a chronic, recurrent, itchy inflammatory skin disease with a vast influence on a patient's quality of life (QoL). Mild-moderate AD was classically managed with the use of topical corticosteroid (TCS) and calcineurin inhibitors (TCI). It was proven that the JAK pathway plays an important role in the development of AD. The introduction of topical JAK inhibitors may revolutionize the classical approach to the management of mild-to-moderate atopic dermatitis. Areas covered: This review discussed the role of the JAK pathway in the development and exacerbations of AD with an emphasis on the newly introduced, topical selective JAK1 and JAK2 inhibitor - Ruxolitinib (RUX) cream. It provides an extensive review of pharmacokinetics and pharmacodynamics, efficacy, and safety of RUX cream in clinical trials. Expert opinion: Results from phase II and two phase III clinical trials have shown that RUX cream could be a promising topical treatment of mild-moderate AD. Its favorable safety profile and good efficacy make RUX cream a beneficial modality for patients with chronic TCSs and TCIs use. Future studies on younger patients and with a longer observational period are necessary to adequately assess the efficacy and safety of RUX cream in the whole AD population.
MeSH term(s)	Humans ; Dermatitis, Atopic/drug therapy ; Quality of Life ; Nitriles/therapeutic use ; Pyrimidines/therapeutic use ; Janus Kinase Inhibitors/therapeutic use ; Treatment Outcome
Chemical Substances	ruxolitinib (82S8X8XX8H) ; Nitriles ; Pyrimidines ; Janus Kinase Inhibitors
Language	English
Publishing date	2022-12-26
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2274260-8
ISSN	1744-8409 ; 1744-666X
ISSN (online)	1744-8409
ISSN	1744-666X
DOI	10.1080/1744666X.2023.2161511
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Article ; Online: Adipokines as an important link between hidradenitis suppurativa and obesity: a narrative review.

Krajewski, Piotr K / Matusiak, Łukasz / Szepietowski, Jacek C

The British journal of dermatology

2023 Volume 188, Issue 3, Page(s) 320–327

Abstract: Hidradenitis suppurativa (HS) is a chronic, recurrent, debilitating disorder of the pilosebaceous unit. Although its pathophysiology is not fully explained, inflammation seems to play an essential role in the development of HS. A link between obesity - ... ...

Abstract	Hidradenitis suppurativa (HS) is a chronic, recurrent, debilitating disorder of the pilosebaceous unit. Although its pathophysiology is not fully explained, inflammation seems to play an essential role in the development of HS. A link between obesity - often considered a state of chronic inflammation - and a higher prevalence of HS has been described. Nevertheless, the exact association is not well understood. Adipose tissue is a highly active endocrine organ that produces and secretes a variety of metabolically and immunologically active molecules called adipokines. The imbalances in concentrations of several adipokines in patients with HS have already been described. A shift towards the overproduction of proinflammatory adipokines (including leptin, resistin and visfatin) with the suppression of anti-inflammatory ones (adiponectin) has been noted. We conducted a review of the available data on adipokines in HS, concentrating on the described imbalances in adipokine concentrations, as well as possible implications in HS pathogenesis. Moreover, new, unstudied adipokines with possible implications in the development of HS are proposed.
MeSH term(s)	Humans ; Adipokines ; Adiponectin ; Hidradenitis Suppurativa/metabolism ; Inflammation ; Leptin ; Obesity/metabolism
Chemical Substances	Adipokines ; Adiponectin ; Leptin
Language	English
Publishing date	2023-01-26
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1093/bjd/ljac107
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