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  1. Article ; Online: Cutaneous manifestation of COVID-19 in images: a case report.

    Avellana Moreno, R / Estela Villa, L M / Avellana Moreno, V / Estela Villa, C / Moreno Aparicio, M A / Avellana Fontanella, J A

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2020  Volume 34, Issue 7, Page(s) e307–e309

    MeSH term(s) Adult ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/virology ; Female ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Skin Diseases/complications
    Keywords covid19
    Language English
    Publishing date 2020-05-19
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.16531
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  2. Article: Cutaneous manifestation of COVID-19 in images: a case report

    Avellana Moreno, R / Estela Villa, L M / Avellana Moreno, V / Estela Villa, C / Moreno Aparicio, M A / Avellana Fontanella, J A

    J Eur Acad Dermatol Venereol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #116917
    Database COVID19

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  3. Article ; Online: Cutaneous manifestation of COVID‐19 in images

    Avellana Moreno, R. / Estela Villa, L.M. / Avellana Moreno, V. / Estela Villa, C. / Moreno Aparicio, M.A. / Avellana Fontanella, J.A.

    Journal of the European Academy of Dermatology and Venereology

    a case report

    2020  Volume 34, Issue 7

    Keywords Infectious Diseases ; Dermatology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.16531
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Hepatic reactive lymphoid hyperplasia: a difficult differential diagnosis with hepatocarcinoma.

    Avellana Moreno, Rocío / De la Serna Esteban, Sofía / García-Botella, Alejandra

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2020  Volume 113, Issue 7, Page(s) 552

    Abstract: Hepatic reactive lymphoid hyperplasia (HRLH) is an uncommon lesion. We present the case of a 58-year-old patient with a liver nodule incidentally found by abdominal ultrasonography (US). Liver function, tumor markers, viral serology and immunology were ... ...

    Abstract Hepatic reactive lymphoid hyperplasia (HRLH) is an uncommon lesion. We present the case of a 58-year-old patient with a liver nodule incidentally found by abdominal ultrasonography (US). Liver function, tumor markers, viral serology and immunology were normal. Magnetic resonance imaging (MRI) showed a 16 mm nodule in segment VI-VII, with hypervascular enhancement in the arterial phase, wash-out in late phases, without contrast-retention in the hepatobiliary phase and restriction on diffusion-weighted imaging, suggestive of hepatocellular carcinoma (HCC).
    MeSH term(s) Carcinoma, Hepatocellular/diagnostic imaging ; Contrast Media ; Diagnosis, Differential ; Humans ; Liver Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging ; Middle Aged ; Pseudolymphoma/diagnostic imaging
    Chemical Substances Contrast Media
    Language English
    Publishing date 2020-11-16
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2020.7462/2020
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  5. Article ; Online: Lessons Learned in Elective Surgeries After 6 Pandemic Waves of SARS-CoV-2. A Single European Center Experience.

    García-Botella, Alejandra / De la Serna Esteban, Sofía / López-Antoñanzas, Leyre / Avellana-Moreno, Rocío / Dziakova, Jana / Cano Valderrama, Oscar / Martín-Antona, Esteban / Serrano-García, Irene / Torres García, Antonio José

    World journal of surgery

    2023  Volume 47, Issue 12, Page(s) 2958–2965

    Abstract: Background: The reported high surgical morbidity and mortality in patients with SARS-CoV-2 prompted preoperative screening and modification of surgical protocols. Although vaccination and treatment of COVID-19 have resulted in lower hospitalization ... ...

    Abstract Background: The reported high surgical morbidity and mortality in patients with SARS-CoV-2 prompted preoperative screening and modification of surgical protocols. Although vaccination and treatment of COVID-19 have resulted in lower hospitalization rates and infection severity, publications on postoperative results have not been updated. The aim of the study was to analyze the outcomes of patients undergoing surgery in two periods with high incidence of SARS-CoV-2 infection, before and after vaccination.
    Materials and methods: This is a prospective cohort study of patients undergoing surgery in two periods: March-June 2020 (Group2020) and December 2021-February 2022 (Group2022) (after massive vaccination).
    Results: In total, 618 patients who underwent surgery were included in the analysis (Group2020: 343 vs. Group2022: 275). Significantly more oncological procedures were performed in Group2020, and there were no differences in postoperative complications. Nosocomial SARS-CoV-2 infection occurred in 4 patients in Group2020 and 1 patient in Group2022. In Group 2022, 70 patients (25.4%) had COVID-19 prior to surgery, and 68 (97.1%) were vaccinated. Comparative analysis between patients with past COVID-19 and those without showed no difference in postoperative morbidity and mortality. According to the time elapsed between SARS-CoV-2 infection and surgery (≤ 7 or > 7 weeks), comparative analysis showed no significant differences.
    Conclusion: The establishment of preoperative screening protocols for SARS-CoV-2 infection results in a low incidence of nosocomial infection and optimal postoperative outcomes. Preoperative SARS-CoV-2 infection in vaccinated patients was not associated with increased postoperative complications, even in shorter periods after infection. In surgical patients, individualized preoperative evaluation after SARS-CoV-2 infection may be more important than strict time limitation.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/epidemiology ; COVID-19/prevention & control ; Pandemics ; Prospective Studies ; Elective Surgical Procedures ; Postoperative Complications/epidemiology
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-023-07222-y
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  6. Article ; Online: Conversion from Roux-En-Y Gastric Bypass to Single Anastomosis Duodenoileal Bypass (SADI-S) for Weight Regain.

    Avellana Moreno, Rocío / Lasses Martínez, Bibiana / Estela Villa, Luis Miguel / Pérez Aguirre, María E / Sánchez-Pernaute, Andrés / Torres García, Antonio J

    Obesity surgery

    2021  Volume 32, Issue 1, Page(s) 221–222

    Abstract: Background: Revisional bariatric surgery presents a challenge for bariatric surgeons. This procedure can be considered for patients with inadequate weight loss or weight regain after an initial satisfactory response following bariatric surgery. However, ...

    Abstract Background: Revisional bariatric surgery presents a challenge for bariatric surgeons. This procedure can be considered for patients with inadequate weight loss or weight regain after an initial satisfactory response following bariatric surgery. However, the surgical management of weight regain following RYGB remains controversial. We present a case of successful weight gain management after a single anastomosis duodenoileal bypass with sleeve gastrectomy (SADIS) as a revisional procedure for patients with weight regain after RYGB.
    Methods: A 23-year-old female with a body mass index (BMI) of 52 kg/m
    Results: There were no intraoperative complications. An upper gastrointestinal series was obtained on the third postoperative day which resulted normal and oral feedings were resumed. The patient was then discharged on fifth postoperative day. There were no complications within the first 30 postoperative days.
    Conclusions: We attach a video that illustrates the management and technique used to deal with the weight regain after primary bariatric surgery RYGB. We consider that in patients with super morbid obesity refractory to RYGB, conversion to SADIS is an excellent alternative due to its safety and feasibility.
    MeSH term(s) Adult ; Female ; Gastrectomy ; Gastric Bypass/methods ; Humans ; Laparoscopy ; Obesity, Morbid/surgery ; Reoperation/methods ; Retrospective Studies ; Weight Gain ; Weight Loss ; Young Adult
    Language English
    Publishing date 2021-09-16
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-021-05622-4
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  7. Article: Brunneroma: an infrequent duodenal neoplasm.

    Olcina Domínguez, Pablo / Estela Villa, Luis / Villadóniga Sánchez, Arancha / Avellana Moreno, Rocío / Gil Rojas, Sergio / García-Cano Lizcano, Jesús

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2021  Volume 114, Issue 2, Page(s) 124

    Abstract: An 83-year-old male presented to the Emergency Department with long lasting epigastric discomfort, weight loss and diarrhea. Physical exam and basic laboratory tests showed no remarkable findings. Upper endoscopy revealed a sessile lesion (Paris 0-IIa) ... ...

    Abstract An 83-year-old male presented to the Emergency Department with long lasting epigastric discomfort, weight loss and diarrhea. Physical exam and basic laboratory tests showed no remarkable findings. Upper endoscopy revealed a sessile lesion (Paris 0-IIa) in the anterior wall of the duodenal bulb, with smooth surface and slightly ulcerated at the top.
    MeSH term(s) Aged, 80 and over ; Duodenal Neoplasms/diagnostic imaging ; Duodenal Neoplasms/pathology ; Duodenal Neoplasms/surgery ; Duodenum/diagnostic imaging ; Duodenum/pathology ; Gastroscopy ; Humans ; Male
    Language English
    Publishing date 2021-10-05
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2021.8349/2021
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  8. Article ; Online: Exome sequencing of three cases of familial exceptional longevity.

    Cash, Timothy P / Pita, Guillermo / Domínguez, Orlando / Alonso, Maria R / Moreno, Leticia T / Borrás, Consuelo / Rodríguez-Mañas, Leocadio / Santiago, Catalina / Garatachea, Nuria / Lucia, Alejandro / Avellana, Juan A / Viña, Jose / González-Neira, Anna / Serrano, Manuel

    Aging cell

    2014  Volume 13, Issue 6, Page(s) 1087–1090

    Abstract: Exceptional longevity (EL) is a rare phenotype that can cluster in families, and co-segregation of genetic variation in these families may point to candidate genes that could contribute to extended lifespan. In this study, for the first time, we have ... ...

    Abstract Exceptional longevity (EL) is a rare phenotype that can cluster in families, and co-segregation of genetic variation in these families may point to candidate genes that could contribute to extended lifespan. In this study, for the first time, we have sequenced a total of seven exomes from exceptionally long-lived siblings (probands ≥ 103 years and at least one sibling ≥ 97 years) that come from three separate families. We have focused on rare functional variants (RFVs) which have ≤ 1% minor allele frequency according to databases and that are likely to alter gene product function. Based on this, we have identified one candidate longevity gene carrying RFVs in all three families, APOB. Interestingly, APOB is a component of lipoprotein particles together with APOE, and variants in the genes encoding these two proteins have been previously associated with human longevity. Analysis of nonfamilial EL cases showed a trend, without reaching statistical significance, toward enrichment of APOB RFVs. We have also identified candidate longevity genes shared between two families (5-13) or within individual families (66-156 genes). Some of these genes have been previously linked to longevity in model organisms, such as PPARGC1A, NRG1, RAD52, RAD51, NCOR1, and ADCY5 genes. This work provides an initial catalog of genes that could contribute to exceptional familial longevity.
    MeSH term(s) Aged, 80 and over ; Apolipoprotein B-100/genetics ; Exome ; Family Health ; Female ; Gene Frequency ; Genetic Variation ; Humans ; Longevity/genetics ; Male
    Chemical Substances APOB protein, human ; Apolipoprotein B-100
    Language English
    Publishing date 2014-08-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.12261
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  9. Article ; Online: Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection

    Nepogodiev, D / Bhangu, A / Glasbey, JC / Li, E / Omar, OM / Simoes, JFF / Abbott, TEF / Alser, O / Arnaud, AP / Bankhead-Kendall, BK / Breen, KA / Cunha, MF / Davidson, GH / Di Saverio, S / Gallo, G / Griffiths, EA / Gujjuri, RR / Hutchinson, PJ / Kaafarani, HMA /
    Lederhuber, H / Löffler, MW / Mashbari, HN / Minaya-Bravo, A / Morton, DG / Moszkowicz, D / Pata, F / Tsoulfas, G / Venn, ML / Cox, D / Roslani, AC / Alakaloko, F / de Vries, JPPM / Aaraj, MA / Abbott, SJ / Abdalla, MOM / Abdelaal, AS / Ademuyiwa, AO / Aherne, TM / Ali, OM / Alkadeeki, GZ / Almeida, AC / Alrahawy, MM / Ambler, GK / Alameer, E / Andreani, SM / De Andrés-Asenjo, B / Antonanzas, LL / Aoun, SG / Ashoush, FM / Augestad, KM / Avellana, RB / Ayeni, FA / Ayorinde, JOO / Babu, BH / Baig, MMAS / Bajomo, OM / Baker, OJ / Baker, MP / Baldwin, AJ / Ban, VS / Baron, RD / Barranquero, AG / Barry, CP / DI Bartolomeo, A / Bass, GA / Bath, MF / Batjer, HH / Beamish, AJ / Belgaumkar, AP / Bence, MN / Benson, RA / Bernal-Sprekelsen, JC / Bhama, AR / Bhavaraju, AV / Biffl, WL / Blundell, CM / Boddy, AP / Borgstein, ABJ / Bosanquet, DC / Bosch, KD / Bouhuwaish, AEM / Bozkurt, MA / Brathwaite, CEM / Brown, BC / Brown, OD / Brown, AK / Buarque, IL / Bueno-Ca nones, AD / Bulugma, MR / Burke, JR / Byrne, MHV / Cagigal-Ortega, EP / Callcut, RA / DI Candido, F / Canova, ME / Carlos, WJ / Caruana, EJ / Cato, LD / Catton, AB / Ceretti, AP / Chase, TJG / Chiara, FD / Chowdhury, AH / Chung, EA / Cicerchia, PM / Clough, ECS / Coleman, NL / Collins, CG / Collins, ML / Colonna, ET / Comini, LV / Coughlin, PA / Cruzado, LFG / Davidson, BR / Davies, RJ / Davies, EJ / Davis, NF / Dawson, BE / Dean, BJF / Delgado, MGC / Diaz, JJ / Dickson, KE / Diez-Alonso, MM / Dixon, JR / Doe, MJ / Drake, TD / Drake, FT / Duffy, JP / Dunne, DFJ / Dunne, NJM / Durán-Mu noz-Cruzado, VM / Durst, AZE / Eardley, NJ / Edwards, JG / Elfallal, AH / Elfiky, MMA / Elliott, JA / Emile, SH / Emslie, KM / Endorf, FW / Engel, JL / Enjuto, DT / Etchill, EW / Evans, JP / Fahey, BA / Faria, CS / Feo, CV / Ferguson, HJM / Fernandez, BD / Fernandez, AG / Fernández, AJ / Fernández-Pacheco, BC / Fitzgerald, JE / Fonsi, GB / Font, RF / Fowler, AL / Fretwell, KR / Fructuoso, LS / Fusai, GK / Garcia, MH / Garcia-Ure na, MA / Gill, CK / Gisbertz, SS / Del Giudice, R / Giuffrida, MC / Di Giuseppe, M / Gómez, MF / Guariglia, CA / Hainsworth, AJ / Hall, BJ / Hall, JRW / Hammond, JS / Haqqani, MH / Harrison, EM / Hazelton, JP / van Heinsbergen, M / Hill, ADK / Hing, CB / Hirji, SA / Ho, MWS / Holbrook, CM / Holme, TJ / Hopkins, JC / Hopkinson, DN / Hossain, FS / Hudson, VE / Hughes, JL / Hwang, ES / Ibrahim, MAH / Isolani, SM / Jenkinson, MD / Jenny, HE / Jeyaretna, DS / Jones, RP / Jones, AP / Jonker, PKC / Jönsson, ML / Joyce, DP / Kalkwarf, KJ / Kamarajah, SK / El Kassas, M / Kavanagh, DO / Keatley, JM / Khalefa, MA / Khan, JS / Kirmani, BH / Kisiel, AP / Kouris, SM / Kowal, MR / Labib, PL / Larkin, JO / Lauscher, JC / Leclercq, WKG / Ledesma, FSJ / Leite-Moreira, AM / Leung, EYL / Lewis, SE / Lima, MJA / Lin, DJ / Liu, HH / Lowery, AJ / Lozano, SM / Luney, CR / Maia, MMA / Mariani, NM / Marino, MV / Marra, AA / Marsh, CL / Martin, RCG / McCluney, SJ / McIntyre, RC / Mckay, SC / McKevitt, KL / Meagher, AD / Mehdi, MQ / Mehigan, BJ / Gonzalez-De Miguel, M / De Miguel-Ardevines, MC / Mills, SJ / Mohan, HM / Moir, JAG / Monson, JRT / Monteiro, JM / Montella, MT / Montesinos, CS / Morgom, MM / Moura, FS / Muguerza, JM / Murphy, SH / De Nardi, P / Naumann, DN / Neary, PC / Neely, DTA / Ng-Kamstra, JS / Ngu, AWT / Nguyen, TA / Nita, GE / Nunes, QM / Nygaard, RM / O’Meara, LB / O’Neill, JR / Okafor, BU / Olson, SA / Oo, AY / Ormazabal, PC / Osorio, AL / Pachl, MJ / Parry, JT / Patel, PK / Pérez-Sánchez, LE / Pevidal, AN / Pezzuto, AP / Philp, MM / Pinkney, TD / Pollok, JM / Povey, MG / Poza, AA / Rajgor, AD / Rao, JN / Raptis, DA / Rice, HE / Ridgway, PF / Rivas, AM / Rodriguez-Sanjuan, JC / Rogers, LJ / Da Roit, A / Rollett, RA / Romera, JL / Rooney, SM / Roxo, VI / Le Roy, B / Rubio, EE / Ruiz, CC / Ruiz, ML / Ryan, ÉJ / Saad, AR / Saeed, SA / Salama, HA / Salamah, AA / Sampietro, GM / Sarma, DR / Schaffer, KB / Schnitzbauer, AA / Scurrah, RJ / Serevina, OL / Serralheiro, PA / 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S / Al-Masri, M / Al-Najjar, H / Al-Sukaini, A / Alam, R / Alderson, D / Aliyeva, Z / Aljanadi, F / Almasri, M / Alonso-Ortu no, P / Altintoprak, F / Amira, G / Amjad, R / Anania, G / Andabaka, T / Angelou, D / Annamalai, S / Annessi, V / Anthoney, J / Anwar, S / Anwer, M / Aragon-Chamizo, J / Ardito, A / Arigoni, M / Armao, T / Arminio, A / Armstrong, L / Arnaud, A / Asaad, P / Ashcroft, J / Ashmore, C / Asqalan, A / Asti, E / Aubry, E / Aytac, E / Ayuso-Herrera, E / Baeza, M / Bailon-Cuadrado, M / Bakmaz, B / Baldi, C / Baldini, E / Baldo, S / Ballabio, M / Baloyiannis, I / Baltazar, G / Bàmbina, F / Bandiera, A / Barlow, E / Barmasse, R / Barmpagianni, C / Baronio, G / Barra, F / Bartsch, AM / Basgaran, A / Basha, A / Bashkirova, V / Bastazza, M / Baumber, R / Belcher, E / Belvedere, A / Benítez-Linero, I / Bergeat, D / Bernasconi, M / Bhalla, A / Bhutiani, N / Bianco, F / Bisagni, P / Blake, I / Blanco-Colino, R / Blazquez-Martin, A / Boal, M / Bonavina, L / Bonavina, G / 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del Pueblo, C / van Ramshorst, GH / De Salas, MM / De Souza, AC / Dolores Del Toro, M / Archer, JE / Odeh, A / Erridge, S / Salem, HK / Jones, GP / Gardner, A / Tripathi, SS / Gregg, A / Jeganathan, R / Siddique, MH / Lombardi, CP / Martin, B / Leo, CA / Dass, D / Di Franco, G / Jiao, LR / Mari, GM / Capitan-Morales, LC / Connelly, TM / Alanbuki, A / De Virgilio, A / Schilling, C / San Miguel Mendez, C / Kulkarni, G / Nizami, K / Walsh, S / Dean, H / Ruiz-Marin, M / Houston, R / Trompetto, M / Chrastek, D / Kouritas, V / Cannoletta, M / Rosato, F / Kaushal, MV / Costa, PM / Elkadi, HH / Johnstone, JR / Irvine, E / Alvarez, MR / Corbellini, C / Venkatesan, GS / Mateo-Sierra, O / Martínez-Pérez, C / Serrano González, J / Hernández Bartolomé, MÁ / Díaz Pérez, D / Gutiérrez Samaniego, M / Galindo Jara, P / Sharma, N / Smart, NJ / Keller, DS

    an international cohort study

    2020  

    Abstract: Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and ... ...

    Abstract Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
    Keywords covid19
    Language English
    Publisher Elsevier
    Publishing country uk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection

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G.S. / Mateo-Sierra O. / Martinez-Perez C. / Serrano Gonzalez J. / Hernandez Bartolome M.A. / Diaz Perez D. / Gutierrez Samaniego M. / Galindo Jara P. / Sharma N. / Smart N.J. / Keller D.S.

    an international cohort study

    2020  

    Abstract: Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and ... ...

    Abstract Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p<0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p<0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p<0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
    Keywords Adult ; Aged ; Betacoronavirus ; Coronavirus Infections ; Elective Surgical Procedures ; Emergency Medical Services ; Female ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia ; Viral ; Postoperative Complications ; Respiratory Tract Diseases ; Retrospective Studies ; Surgical Procedures ; Operative ; Young Adult ; covid19
    Subject code 610 ; 616
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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