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  1. Article ; Online: Lupus miliaris disseminatus faciei in a 10-year-old child: A case report and literature review.

    Tang, Keyun / Jin, Hongzhong

    Journal of cosmetic dermatology

    2022  

    Language English
    Publishing date 2022-06-24
    Publishing country England
    Document type Letter
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15176
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6539: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: An Updated Review of Recent Advances in Neurosyphilis.

    Zhou, Jia / Zhang, Hanlin / Tang, Keyun / Liu, Runzhu / Li, Jun

    Frontiers in medicine

    2022  Volume 9, Page(s) 800383

    Abstract: Neurosyphilis is caused ... ...

    Abstract Neurosyphilis is caused by
    Language English
    Publishing date 2022-09-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.800383
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  3. Article: Clinical Characteristics and Management of Patients With Clinical Amyopathic Dermatomyositis: A Retrospective Study of 64 Patients at a Tertiary Dermatology Department.

    Tang, Keyun / Zhang, Hanlin / Jin, Hongzhong

    Frontiers in medicine

    2021  Volume 8, Page(s) 783416

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-12-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.783416
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  4. Article ; Online: DBPP-Predictor

    Yaxin Gu / Yimeng Wang / Keyun Zhu / Weihua Li / Guixia Liu / Yun Tang

    Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-

    a novel strategy for prediction of chemical drug-likeness based on property profiles

    2024  Volume 15

    Abstract: Abstract Evaluation of chemical drug-likeness is essential for the discovery of high-quality drug candidates while avoiding unwarranted biological and clinical trial costs. A high-quality drug candidate should have promising drug-like properties, ... ...

    Abstract Abstract Evaluation of chemical drug-likeness is essential for the discovery of high-quality drug candidates while avoiding unwarranted biological and clinical trial costs. A high-quality drug candidate should have promising drug-like properties, including pharmacological activity, suitable physicochemical and ADMET properties. Hence, in silico prediction of chemical drug-likeness has been proposed while being a challenging task. Although several prediction models have been developed to assess chemical drug-likeness, they have such drawbacks as sample dependence and poor interpretability. In this study, we developed a novel strategy, named DBPP-Predictor, to predict chemical drug-likeness based on property profile representation by integrating physicochemical and ADMET properties. The results demonstrated that DBPP-Predictor exhibited considerable generalization capability with AUC (area under the curve) values from 0.817 to 0.913 on external validation sets. In terms of application feasibility analysis, the results indicated that DBPP-Predictor not only demonstrated consistent and reasonable scoring performance on different data sets, but also was able to guide structural optimization. Moreover, it offered a new drug-likeness assessment perspective, without significant linear correlation with existing methods. We also developed a free standalone software for users to make drug-likeness prediction and property profile visualization for their compounds of interest. In summary, our DBPP-Predictor provided a valuable tool for the prediction of chemical drug-likeness, helping to identify appropriate drug candidates for further development.
    Keywords Information technology ; T58.5-58.64 ; Chemistry ; QD1-999
    Subject code 006
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: DBPP-Predictor: a novel strategy for prediction of chemical drug-likeness based on property profiles.

    Gu, Yaxin / Wang, Yimeng / Zhu, Keyun / Li, Weihua / Liu, Guixia / Tang, Yun

    Journal of cheminformatics

    2024  Volume 16, Issue 1, Page(s) 4

    Abstract: Evaluation of chemical drug-likeness is essential for the discovery of high-quality drug candidates while avoiding unwarranted biological and clinical trial costs. A high-quality drug candidate should have promising drug-like properties, including ... ...

    Abstract Evaluation of chemical drug-likeness is essential for the discovery of high-quality drug candidates while avoiding unwarranted biological and clinical trial costs. A high-quality drug candidate should have promising drug-like properties, including pharmacological activity, suitable physicochemical and ADMET properties. Hence, in silico prediction of chemical drug-likeness has been proposed while being a challenging task. Although several prediction models have been developed to assess chemical drug-likeness, they have such drawbacks as sample dependence and poor interpretability. In this study, we developed a novel strategy, named DBPP-Predictor, to predict chemical drug-likeness based on property profile representation by integrating physicochemical and ADMET properties. The results demonstrated that DBPP-Predictor exhibited considerable generalization capability with AUC (area under the curve) values from 0.817 to 0.913 on external validation sets. In terms of application feasibility analysis, the results indicated that DBPP-Predictor not only demonstrated consistent and reasonable scoring performance on different data sets, but also was able to guide structural optimization. Moreover, it offered a new drug-likeness assessment perspective, without significant linear correlation with existing methods. We also developed a free standalone software for users to make drug-likeness prediction and property profile visualization for their compounds of interest. In summary, our DBPP-Predictor provided a valuable tool for the prediction of chemical drug-likeness, helping to identify appropriate drug candidates for further development.
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2486539-4
    ISSN 1758-2946
    ISSN 1758-2946
    DOI 10.1186/s13321-024-00800-9
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  6. Article: The Relationship Between Alzheimer's Disease and Skin Diseases: A Review.

    Zhang, Hanlin / Zhang, Dingyue / Tang, Keyun / Sun, Qiuning

    Clinical, cosmetic and investigational dermatology

    2021  Volume 14, Page(s) 1551–1560

    Abstract: Alzheimer's disease is the most common type of dementia placing a heavy burden on the healthcare system worldwide. Skin diseases are also one of the most common health problems. Several skin diseases are associated with Alzheimer's disease through ... ...

    Abstract Alzheimer's disease is the most common type of dementia placing a heavy burden on the healthcare system worldwide. Skin diseases are also one of the most common health problems. Several skin diseases are associated with Alzheimer's disease through different mechanisms. This review summarizes the relationship between Alzheimer's disease and several types of skin diseases, including bullous pemphigoid, hidradenitis suppurativa, psoriasis, skin cancer, and cutaneous amyloidosis, and provides suggestions based on these associations. Neurologists, dermatologists, and general practitioners should be aware of the relationship between Alzheimer's disease and skin diseases. Dermatology/neurology consultation or referral is necessary when needed.
    Language English
    Publishing date 2021-10-24
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494852-4
    ISSN 1178-7015
    ISSN 1178-7015
    DOI 10.2147/CCID.S322530
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  7. Article ; Online: Thiazolidinedione enhances the efficacy of anti-PD-1 monoclonal antibody in murine melanoma.

    Zhang, Xinyi / Gao, Yuan / Tang, Keyun / Li, Zongyu / Halberstam, Alexandra A / Zhou, Liqun / Perry, Rachel J

    American journal of physiology. Endocrinology and metabolism

    2024  Volume 326, Issue 3, Page(s) E341–E350

    Abstract: Several clinical studies observed a surprising beneficial effect of obesity on enhancing immunotherapy responsiveness in patients with melanoma, highlighting an as-yet insufficiently understood relationship between metabolism and immunogenicity. Here, we ...

    Abstract Several clinical studies observed a surprising beneficial effect of obesity on enhancing immunotherapy responsiveness in patients with melanoma, highlighting an as-yet insufficiently understood relationship between metabolism and immunogenicity. Here, we demonstrate that the thiazolidinedione (TZD) rosiglitazone, a drug commonly used to treat diabetes by sequestering fatty acids in metabolically inert subcutaneous adipose tissue, improved sensitivity to anti-programmed cell death protein 1 (PD-1) treatment in YUMMER1.7 tumor-bearing mice, an initially immunotherapy-sensitive murine melanoma model. We observed a transition from high to intermediate PD-1 expression in tumor-infiltrating CD8+ T cells. Moreover, TZD inhibited PD-1 expression in mouse and human T cells treated in vitro. In addition to its direct impact on immune cells, TZD also decreased circulating insulin concentrations, while insulin induced T cell exhaustion in culture. In TZD-treated mice, we observed higher fatty acid concentrations in the tumor microenvironment, with fatty acids protecting against exhaustion in culture. Together, these data are consistent with an indirect mechanism of TZD inhibiting T cell exhaustion. Finally, we analyzed imaging data from patients with melanoma before and after anti-PD-1 treatment, confirming the beneficial effect of increased subcutaneous fat on anti-PD-1 responsiveness in patients. We also found that the expression of peroxisome proliferator-activated receptor gamma (PPARγ), the canonical activator of lipid uptake and adipogenesis activated by TZD, correlated with overall survival time. Taken together, these data identify a new adjuvant to enhance immunotherapy efficacy in YUMMER1.7 melanoma mice, and discover a new metabolism-based prognostic marker in human melanoma.
    MeSH term(s) Humans ; Animals ; Mice ; Melanoma/drug therapy ; Rosiglitazone ; Programmed Cell Death 1 Receptor ; PPAR gamma ; Thiazolidinediones/pharmacology ; Thiazolidinediones/therapeutic use ; Antibodies, Monoclonal ; Insulin ; Diabetes Mellitus ; Fatty Acids ; Tumor Microenvironment
    Chemical Substances Rosiglitazone (05V02F2KDG) ; Programmed Cell Death 1 Receptor ; PPAR gamma ; 2,4-thiazolidinedione (AA68LXK93C) ; Thiazolidinediones ; Antibodies, Monoclonal ; Insulin ; Fatty Acids
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    DOI 10.1152/ajpendo.00346.2023
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article ; Online: Rosacea and its comorbidities: Should be emphasized but should not be overemphasized.

    Zhang, Hanlin / Tang, Keyun / Wang, Yuchen / Fang, Rouyu / Sun, Qiuning

    Journal of cosmetic dermatology

    2020  Volume 19, Issue 12, Page(s) 3414–3415

    MeSH term(s) Comorbidity ; Humans ; Rosacea/epidemiology
    Language English
    Publishing date 2020-10-27
    Publishing country England
    Document type Letter
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.13793
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6539: Show issues Location:
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  9. Article ; Online: Pregnancy in adult-onset dermatomyositis/polymyositis: A systematic review.

    Tang, Keyun / Zhou, Jia / Lan, Yining / Zhang, Hanlin / Jin, Hongzhong

    American journal of reproductive immunology (New York, N.Y. : 1989)

    2022  Volume 88, Issue 5, Page(s) e13603

    Abstract: Background: Idiopathic inflammatory myopathy (IIM) in pregnancy is uncommon but may result in complications for both mother and the fetus.: Aim: In this systematic review, we summarized the current literature investigating outcomes of pregnancy ... ...

    Abstract Background: Idiopathic inflammatory myopathy (IIM) in pregnancy is uncommon but may result in complications for both mother and the fetus.
    Aim: In this systematic review, we summarized the current literature investigating outcomes of pregnancy related to the dermatomyositis/polymyositis (DM/PM) process.
    Content: We searched PubMed, Embase, Cochrane Library, and Web of Science databases and included 61 studies reporting the disease course, pregnancy outcomes, and management of both pregnancy and DM/PM in the final analysis.The specific information of 221 pregnancies was extracted and these pregnancies were divided into three distinct forms: pregnancies after disease onset (n = 159), pregnancies with new disease onset (n = 37), and pregnancies followed by postpartum onset (n = 25). In most cases, DM/PM disease activity remained stable or improved throughout pregnancy (80.2%) and the postpartum period (83.9%). Active DM/PM during pregnancy significantly increased the risk of stillbirth or neonatal death (12% vs. 1%, P = .005) and preterm birth (34.7% vs. 11%, P < .001). The rates of other poor outcomes (total fetal loss, low birth weight, and intrauterine growth retardation) were also increased in pregnancies with active disease. Mainstay treatments for active DM/PM during pregnancy are glucocorticoids and intravenous immunoglobins.
    Implications: The present results underline the importance of good control of myopathy in optimizing the pregnancy outcomes of women with DM/PM.
    MeSH term(s) Pregnancy ; Adult ; Infant, Newborn ; Female ; Humans ; Dermatomyositis/complications ; Premature Birth ; Polymyositis/complications ; Pregnancy Outcome ; Glucocorticoids
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2022-08-23
    Publishing country Denmark
    Document type Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 604542-x
    ISSN 1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
    ISSN (online) 1600-0897
    ISSN 0271-7352 ; 8755-8920 ; 1046-7408
    DOI 10.1111/aji.13603
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1653: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: Resuming work gradually in the context of COVID-19: Experience from a tertiary dermatology department in China.

    Tang, Keyun / Zhang, Hanlin / Jin, Hongzhong

    Dermatologic therapy

    2020  Volume 33, Issue 4, Page(s) e13554

    MeSH term(s) Betacoronavirus ; COVID-19 ; China/epidemiology ; Comorbidity ; Coronavirus Infections/epidemiology ; Dermatology/organization & administration ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Skin Diseases/epidemiology ; Skin Diseases/therapy
    Keywords covid19
    Language English
    Publishing date 2020-06-15
    Publishing country United States
    Document type Letter
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.13554
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5181: Show issues Location:
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