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  1. Article ; Online: Massive Vulvar Edema: A Sign of Nephrotic Syndrome.

    Zuccaro, Biancamaria / Perillo, Gabriella / De Giorgi, Vincenzo

    The American journal of medicine

    2024  

    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2024.02.011
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.289: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Hidradenoma papilliferum of the vulva: a dermoscopic challenging diagnosis.

    De Giorgi, Vincenzo / Zuccaro, Biancamaria / Silvestri, Flavia / Venturi, Federico

    Anais brasileiros de dermatologia

    2023  Volume 98, Issue 4, Page(s) 546–548

    MeSH term(s) Female ; Humans ; Tubular Sweat Gland Adenomas/diagnostic imaging ; Vulva ; Vulvar Neoplasms/diagnosis ; Sweat Gland Neoplasms
    Language English
    Publishing date 2023-03-24
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 433655-0
    ISSN 1806-4841 ; 0365-0596
    ISSN (online) 1806-4841
    ISSN 0365-0596
    DOI 10.1016/j.abd.2021.11.014
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    Zs.A 359: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 344: Show issues

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  3. Article ; Online: Unveiling hydrochlorothiazide: Skin cancer risk and hidden interactions.

    Magnaterra, Elisabetta / Lambertini, Martina / Scarfì, Federica / Gola, Massimo / Dika, Emi / De Giorgi, Vincenzo

    Journal of the American Academy of Dermatology

    2023  Volume 89, Issue 5, Page(s) e249–e250

    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Letter
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2023.06.061
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    Zs.A 1540: Show issues Location:
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  4. Article: Conceptual Evolution and Current Approach to Spitz Tumors.

    Urso, Carmelo / De Giorgi, Vincenzo / Massi, Daniela

    Dermatopathology (Basel, Switzerland)

    2022  Volume 9, Issue 2, Page(s) 136–142

    Abstract: Over the past several decades, the study of Spitz neoplasms has flourished, with expanded conceptualization and refined terminology, providing a framework for the assessment and classification of Spitz nevi, atypical Spitz Tumors, and Spitz melanoma. ... ...

    Abstract Over the past several decades, the study of Spitz neoplasms has flourished, with expanded conceptualization and refined terminology, providing a framework for the assessment and classification of Spitz nevi, atypical Spitz Tumors, and Spitz melanoma. Cancer genomics have generated concepts such as driver and passenger genes and clonal evolution, which can be applied to Spitz tumors. Herein, we provide a historical perspective, followed by a summary of current knowledge and clinical approaches for these challenging tumors.
    Language English
    Publishing date 2022-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2777118-0
    ISSN 2296-3529
    ISSN 2296-3529
    DOI 10.3390/dermatopathology9020017
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  5. Article ; Online: Metabolic control and clinical outcome in adolescents with phenylketonuria.

    De Giorgi, Agnese / Nardecchia, Francesca / Romani, Cristina / Leuzzi, Vincenzo

    Molecular genetics and metabolism

    2023  Volume 140, Issue 3, Page(s) 107684

    Abstract: The main neurological, cognitive, and behavioural consequences of phenylketonuria have been eradicated thanks to new-born screening and Phe-restricted diet therapy. However, the effects of high phenylalanine levels during adolescence and adulthood on ... ...

    Abstract The main neurological, cognitive, and behavioural consequences of phenylketonuria have been eradicated thanks to new-born screening and Phe-restricted diet therapy. However, the effects of high phenylalanine levels during adolescence and adulthood on neurocognitive functions remain a concern. This systematic review aimed at collecting clinical data suggesting the safest metabolic target for early treated PKU during the second decade of life. Twenty studies met the inclusion criteria for full-text review. Relevant studies included papers that (a) examined the relationship between metabolic control and neurocognitive functions during adolescence or (b) investigated the impact of metabolic control in adolescence on adult outcomes. Most studies showed a positive correlation between metabolic control during adolescence and neurocognitive outcomes across ages. This was true both for IQ and executive functions, although data on executive functions were less clear, and it remains to be established whether they are more vulnerable to Phe than IQ. Taken together present evidence confirm brain vulnerability to Phe during adolescence and suggests that low average Phe levels and low Phe fluctuations should be maintained throughout life. While results are fully compatible with current European recommendations, clinical and methodological limitations coupled with remarkable interindividual variability prevented a clear identification of a safe threshold for Phe blood levels during adolescence.
    MeSH term(s) Adult ; Humans ; Adolescent ; Cognition ; Neuropsychological Tests ; Executive Function ; Brain ; Phenylketonurias/drug therapy ; Phenylalanine
    Chemical Substances Phenylalanine (47E5O17Y3R)
    Language English
    Publishing date 2023-08-12
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1418518-0
    ISSN 1096-7206 ; 1096-7192
    ISSN (online) 1096-7206
    ISSN 1096-7192
    DOI 10.1016/j.ymgme.2023.107684
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    Zs.A 617: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Melanoma and menarche: Exploring the hormonal impact in pediatric cases.

    Magnaterra, Elisabetta / Zuccaro, Biancamaria / Magliulo, Manfredi / Venturi, Federico / Perillo, Gabriella / Gola, Massimo / De Giorgi, Vincenzo

    Pediatric dermatology

    2023  Volume 41, Issue 1, Page(s) 187–188

    MeSH term(s) Female ; Humans ; Child ; Menarche ; Melanoma ; Skin Neoplasms ; Age Factors
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Letter
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.15480
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    Zs.A 1882: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Estrogen could also play a key role in the development of pediatric melanoma.

    Magnaterra, Elisabetta / Zuccaro, Biancamaria / Magliulo, Manfredi / Venturi, Federico / Silvestri, Flavia / Gola, Massimo / De Giorgi, Vincenzo

    Journal of the American Academy of Dermatology

    2023  Volume 89, Issue 2, Page(s) e95–e96

    MeSH term(s) Humans ; Child ; Melanoma/epidemiology ; Estrogens ; Skin Neoplasms/epidemiology
    Chemical Substances Estrogens
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2023.01.051
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    Zs.A 1540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Improvement of Movement Disorder and Neurodevelopment under Selegiline in a CLTC-Deficient Patient.

    Nardecchia, Francesca / Bove, Rossella / Pollini, Luca / Giannini, Maria Teresa / Manti, Filippo / De Giorgi, Agnese / Papoff, Paola / Martinelli, Simone / Leuzzi, Vincenzo

    Movement disorders clinical practice

    2023  Volume 10, Issue 9, Page(s) 1430–1432

    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13834
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  9. Article ; Online: Tolerance of sonidegib after intolerance of vismodegib-Experience in two patients with nevoid basal cell carcinoma syndrome (Gorlin syndrome).

    Venturi, Federico / Trane, Luciana / Silvestri, Flavia / Zuccaro, Biancamaria / Magnaterra, Elisabetta / De Giorgi, Vincenzo

    Skin health and disease

    2023  Volume 3, Issue 5, Page(s) e260

    Abstract: Nevoid basal cell carcinoma syndrome (NBCCS, Gorlin syndrome) is a rare genetic condition characterized by the early development of numerous cutaneous basal cell carcinomas (BCCs). Although most BCCs are surgically treated with total resection, some of ... ...

    Abstract Nevoid basal cell carcinoma syndrome (NBCCS, Gorlin syndrome) is a rare genetic condition characterized by the early development of numerous cutaneous basal cell carcinomas (BCCs). Although most BCCs are surgically treated with total resection, some of the lesions may proceed to a locally advanced or metastatic stage. Systemic treatment with a hedgehog inhibitors (HHIs) such as Vismodegib or Sonidegib is indicated in this population. We report cases of two patients with confirmed diagnoses of NBCCS. Both patients had undergone multiple surgical excisions and had been treated with oral Vismodegib 150 mg/day for a locally advanced tumour. They both discontinued the therapy due to its specific adverse effects (AEs) and are now being treated with oral Sonidegib, which has had better tolerability and a complete response. The aims of this report was to demonstrate the efficacy of HHI treatment with Sonidegib in patients with NCBBS who had previously treated with Vismodegib but discontinued it because of its specific AEs. Our experience in two patients shows that Sonidegib can be considered in Gorlin patients intolerant but responding to Vismodegib.
    Language English
    Publishing date 2023-06-14
    Publishing country England
    Document type Case Reports
    ISSN 2690-442X
    ISSN (online) 2690-442X
    DOI 10.1002/ski2.260
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  10. Article ; Online: The importance of caregivers for patients with advanced basal cell carcinoma treated with hedgehog-pathway inhibitors: an observational prospective study.

    Trane, Luciana / Salvati, Lorenzo / Silvestri, Flavia / Venturi, Federico / Zuccaro, Biancamaria / Perillo, Gabriella / De Giorgi, Vincenzo

    European journal of dermatology : EJD

    2024  Volume 34, Issue 1, Page(s) 68–72

    Abstract: Oral targeted therapy with hedgehog pathway inhibitors has revolutionized the standard of care for patients with advanced basal cell carcinoma (BCC). These patients are frail and elderly, have various comorbidities, and receive pharmacological ... ...

    Abstract Oral targeted therapy with hedgehog pathway inhibitors has revolutionized the standard of care for patients with advanced basal cell carcinoma (BCC). These patients are frail and elderly, have various comorbidities, and receive pharmacological polytherapy. Moreover, adverse events may have a significant impact on therapeutic adherence, which must be managed by the clinician. We evaluated the impact of caregivers on the treatment of patients with advanced BCC in terms of continuation of therapy over time. All patients included in this observational prospective study had histologically confirmed metastatic or locally advanced BCC (LaBCC) and were treated with hedgehog pathway inhibitors from January 2016 to December 2021 at the Department of Dermatology at the University of Florence, Italy. The collected patient data included: age, sex, BCC site and area of spread; number of cycles, dose, duration and tolerability of therapy; marital status (single, divorced, married/living with a partner, widow/widower); and information such as living with someone, and the presence of any caregivers. Of the 34 patients included, 33 had LaBCC and one metastatic BCC. There were 11 females (32.4%) and 23 males (67.6%). Patients who were married or living with a caregiver -tolerated therapy better than single patients who lived alone. Indeed, patients with married/live-in caregivers and/or those with an adequate caregiver experienced greater therapeutic adherence and tolerance of adverse events. Given the greater therapeutic adherence of patients with live-in caregivers as partners, it is essential to consider patients' marital status. It is advisable to involve the caregiver early on, and there should be a training discussion on the various possible adverse events and the best way to mitigate them. Therapeutic success is linked not only to patients being informed but also to training of caregivers.
    MeSH term(s) Male ; Female ; Humans ; Aged ; Skin Neoplasms/pathology ; Prospective Studies ; Caregivers ; Hedgehog Proteins/metabolism ; Pyridines/adverse effects ; Carcinoma, Basal Cell/pathology ; Antineoplastic Agents/therapeutic use ; Anilides/therapeutic use
    Chemical Substances Hedgehog Proteins ; Pyridines ; Antineoplastic Agents ; Anilides
    Language English
    Publishing date 2024-04-09
    Publishing country France
    Document type Observational Study ; Journal Article
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2024.4608
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    Zs.A 3484: Show issues Location:
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