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Article ; Online: Autoantibodies in ANCA-associated vasculitis.

Wiik, Allan S

Rheumatic diseases clinics of North America

2010 Volume 36, Issue 3, Page(s) 479–489

Abstract: Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides are systemic or more limited conditions characterized by necrotizing destruction of small and medium-sized vessels (eg, capillaries, venules, and arterioles). ANCAs are the most ... ...

Abstract	Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides are systemic or more limited conditions characterized by necrotizing destruction of small and medium-sized vessels (eg, capillaries, venules, and arterioles). ANCAs are the most predominant autoantibodies in patients affected by vasculitis, but other autoantibodies may also occur, probably reflecting pathogenetic events in affected tissue. These autoantibodies are assumed to play a role in the initiation and propagation of chronic inflammation. ANCAs are valuable for clinical diagnosis, follow-up, and guidance in therapy.
MeSH term(s)	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/immunology ; Antibodies, Antineutrophil Cytoplasmic/blood ; Antibodies, Antineutrophil Cytoplasmic/immunology ; Autoantibodies/immunology ; Endothelium, Vascular/immunology ; Humans ; Myeloblastin/immunology ; Peroxidase/immunology
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic ; Autoantibodies ; Peroxidase (EC 1.11.1.7) ; Myeloblastin (EC 3.4.21.76)
Language	English
Publishing date	2010-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	92118-x
ISSN	1558-3163 ; 0889-857X
ISSN (online)	1558-3163
ISSN	0889-857X
DOI	10.1016/j.rdc.2010.05.001
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Article: Guidelines for Antinuclear Antibody Testing.

Wiik, Allan S

EJIFCC

2006 Volume 17, Issue 3, Page(s) 134–140

Language	English
Publishing date	2006-10-01
Publishing country	Italy
Document type	Journal Article
ISSN	1650-3414
ISSN	1650-3414
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Article: The immune response to citrullinated proteins in patients with rheumatoid arthritis: genetic, clinical, technical, and epidemiological aspects.

Wiik, Allan S

Clinical reviews in allergy & immunology

2007 Volume 32, Issue 1, Page(s) 13–22

Abstract: This article reviews data concerning the applicability of anti-citrullinated peptide antibodies in the diagnosis, estimation of prognosis, and follow-up of patients with rheumatoid arthritis (RA). The production of anti-citrullinated peptide antibodies ... ...

Abstract	This article reviews data concerning the applicability of anti-citrullinated peptide antibodies in the diagnosis, estimation of prognosis, and follow-up of patients with rheumatoid arthritis (RA). The production of anti-citrullinated peptide antibodies is closely associated with the presence of the HLA-DRB1 shared epitope, a known risk factor for development of RA, and the production may be influenced by environmental factors such as tobacco smoking. Patients who harbor this antibody from the early stage of their disease develop more severe erosive disease than patients with RA who lack the antibody. The anti-citrullinated peptide antibody level may be a reflection of disease activity, at least in the early phase of the disease. The antibody can sometimes be found several years before the onset of clinical symptoms of RA, which may represent an open window for preventive measures to be taken.
MeSH term(s)	Animals ; Antibody Formation/immunology ; Antigens/immunology ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/pathology ; Biomarkers ; Epitopes/immunology ; Humans ; Peptides, Cyclic/immunology
Chemical Substances	Antigens ; Biomarkers ; Epitopes ; Peptides, Cyclic ; cyclic citrullinated peptide
Language	English
Publishing date	2007-04-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1239045-8
ISSN	1559-0267 ; 1080-0549
ISSN (online)	1559-0267
ISSN	1080-0549
DOI	10.1007/BF02686078
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Article: Missing links in high quality diagnostics of inflammatory systemic rheumatic diseases: It is all about the patient!

Wiik, Allan S / Bizzaro, Nicola

Auto- immunity highlights

2012 Volume 3, Issue 2, Page(s) 35–49

Abstract: The aim of this review is to focus attention on high quality diagnostics of systemic inflammatory rheumatic diseases. Though many steps in the diagnostic process from the first visit in a doctor's office till a final diagnosis have been established a lot ...

Abstract	The aim of this review is to focus attention on high quality diagnostics of systemic inflammatory rheumatic diseases. Though many steps in the diagnostic process from the first visit in a doctor's office till a final diagnosis have been established a lot of things still must be done to improve quality assurance and secure fast and safe transmission of data from one step to the next. Some procedures inherent in early high quality diagnostics need to be worked out. A number of elements can be improved, some stumble stones can be removed, and a tighter collaboration between actors at different levels in the line of action in clinical and laboratory medicine can be organized. Several proposals have been made by international working groups such as the IUIS International Autoantibody Standardization Committee, and the EASI steering group in collaboration with their national EASI teams. Practical exercises carried out for more than three decades by the European Consensus Finding Study Group have proven to very useful. The review points at several principles worked out by these international expert groups can be useful in actual daily practice also in rheumatology. The hope is that the presentation will give rise to a continued discussion on how to link different parts of the diagnostic process together and strengthen collaboration between all teams involved in the diagnostic chain. The ultimate measure of success will be better clinical outcomes for patients and increased satisfaction in their families.
Language	English
Publishing date	2012-04-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2563376-4
ISSN	2038-3274 ; 2038-0305
ISSN (online)	2038-3274
ISSN	2038-0305
DOI	10.1007/s13317-012-0029-0
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Article: Appropriateness of autoantibody testing in clinical medicine.

Wiik, Allan S

Clinica chimica acta; international journal of clinical chemistry

2003 Volume 333, Issue 2, Page(s) 177–180

Abstract: Background: Pathologically expressed autoantibodies reflect ongoing immune-mediated inflammation in patients and may even be regarded as surrogate markers of disease prognosis and clinical outcome in certain clinical settings.: Materials and methods: ...

Abstract	Background: Pathologically expressed autoantibodies reflect ongoing immune-mediated inflammation in patients and may even be regarded as surrogate markers of disease prognosis and clinical outcome in certain clinical settings. Materials and methods: The most appropriate way to decide about autoantibody testing is to set a tentative diagnosis before ordering a few clinically relevant autoantibody screening tests and then follow locally agreed rules for continued testing. Results: Different algorithms were applied considering both the possibility to obtain an initial tentative diagnosis by the clinician and another strategy to be adopted when the clinical information cannot be obtained. Conclusions: Guidelines can only be formulated by close collaboration between clinical and laboratory experts that reach agreement on testing and reporting strategies and thereby ensure the highest possible compliance with both local and international recommendations for diagnostics.
MeSH term(s)	Autoantibodies/analysis ; Clinical Laboratory Techniques/methods ; Clinical Laboratory Techniques/standards ; Clinical Medicine/methods ; Clinical Medicine/standards ; Humans ; Program Evaluation/methods ; Program Evaluation/standards
Chemical Substances	Autoantibodies
Language	English
Publishing date	2003-07-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80228-1
ISSN	1873-3492 ; 0009-8981
ISSN (online)	1873-3492
ISSN	0009-8981
DOI	10.1016/s0009-8981(03)00182-7
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Article: Serum levels of lipoprotein(a) and E-selectin are reduced in rheumatoid arthritis patients treated with methotrexate or methotrexate in combination with TNF-α-inhibitor.

Hjeltnes, Gunnbjørg / Hollan, Ivana / Førre, Oystein / Wiik, Allan / Lyberg, Torstein / Mikkelsen, Knut / Agewall, Stefan

Clinical and experimental rheumatology

2013 Volume 31, Issue 3, Page(s) 415–421

Abstract: ... without tumor necrosis factor alpha (TNF-α)-inhibitors on serum lipoprotein(a) (s-Lp(a)), and to explore a possible relationship ... between s-Lp(a) and endothelial function (EF) in terms of serum levels of adhesion molecules and reactive ... Results: Compared to baseline values, s-Lp(a) was significantly reduced after 6 weeks (p=0.001) and 6 ...

Abstract	Objectives: To examine the effect of methotrexate (MTX) with or without tumor necrosis factor alpha (TNF-α)-inhibitors on serum lipoprotein(a) (s-Lp(a)), and to explore a possible relationship between s-Lp(a) and endothelial function (EF) in terms of serum levels of adhesion molecules and reactive hyperaemic index (RHI) in patients with rheumatoid arthritis (RA). Methods: Serum levels of Lp(a), endothelial adhesion molecules, RHI and inflammatory markers were studied in 64 RA patients, starting with either MTX (n=34) or MTX+TNF-α-inhibitor treatment (n=30) at baseline and after 6 weeks and 6 months. Results: Compared to baseline values, s-Lp(a) was significantly reduced after 6 weeks (p=0.001) and 6 months (p=0.001) in RA patients treated with MTX, and after 6 weeks (p=0.001) in the MTX+TNF-α-inhibitor group. A non-significant reduction was found after 6 months (p=0.102) in the MTX+TNFα-inhibitor group. Serum E-selectin (s-E-selectin) was significantly reduced in both RA treatment groups at both control points. S-Lp(a) correlated positively with s-E-selectin at baseline (p=0.004), and change in s-E-selectin correlated with the change in s-Lp(a) during follow-up (p6weeks= 0.008, p 6months=0.009). No association was found between s-Lp(a) and the other adhesion molecules and RHI. Conclusions: MTX or MTX combined with a TNFα-inhibitor appears to significantly reduce Lp(a). This finding indicate that s-Lp(a) might be related to systemic inflammation, or that the examined drugs might reduce s-Lp(a) by other mechanisms. Anti-inflammatory treatment might be a novel therapeutic option to decrease s-Lp(a). The associations between s-E-selectin and s-Lp(a) suggest an interaction between these factors, or a common cause.
MeSH term(s)	Adalimumab ; Adult ; Aged ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/physiopathology ; Cohort Studies ; Drug Therapy, Combination ; E-Selectin/blood ; E-Selectin/physiology ; Etanercept ; Female ; Humans ; Immunoglobulin G/therapeutic use ; Infliximab ; Intercellular Adhesion Molecule-1/blood ; Intercellular Adhesion Molecule-1/drug effects ; Intercellular Adhesion Molecule-1/physiology ; Lipoprotein(a)/blood ; Lipoprotein(a)/physiology ; Male ; Methotrexate/therapeutic use ; Middle Aged ; Receptors, Tumor Necrosis Factor/therapeutic use ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Vascular Cell Adhesion Molecule-1/blood ; Vascular Cell Adhesion Molecule-1/physiology
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antirheumatic Agents ; E-Selectin ; ICAM1 protein, human ; Immunoglobulin G ; Lipoprotein(a) ; Receptors, Tumor Necrosis Factor ; SELE protein, human ; Tumor Necrosis Factor-alpha ; Vascular Cell Adhesion Molecule-1 ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Infliximab (B72HH48FLU) ; Adalimumab (FYS6T7F842) ; Etanercept (OP401G7OJC) ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2013-05
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
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Article ; Online: All you wanted to know about anti-CCP but were afraid to ask.

Wiik, Allan S / van Venrooij, Walther J / Pruijn, Ger J M

Autoimmunity reviews

2010 Volume 10, Issue 2, Page(s) 90–93

Abstract: The most specific biomarker associated with the diagnosis of rheumatoid arthritis (RA) is autoantibodies to citrullinated peptides/proteins (ACPA). Though recognized as an important marker of progressive erosive disease its use has been hampered by doubt ...

Abstract	The most specific biomarker associated with the diagnosis of rheumatoid arthritis (RA) is autoantibodies to citrullinated peptides/proteins (ACPA). Though recognized as an important marker of progressive erosive disease its use has been hampered by doubt about what is a positive versus a negative reaction in the several assays that have become available commercially. This review intends to indicate that the CCP2 assay has the highest specificity and sensitivity in stratified studies that encompass sera from RA patients and non-RA inflammatory controls compared to other ACPA tests. Still, larger and strictly stratified studies are highly warranted to substantiate this conclusion.
MeSH term(s)	Animals ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/immunology ; Autoantibodies/blood ; Autoantigens/immunology ; Citrulline/immunology ; Humans ; Peptides, Cyclic/immunology ; Rats ; Sensitivity and Specificity
Chemical Substances	Autoantibodies ; Autoantigens ; Peptides, Cyclic ; Citrulline (29VT07BGDA)
Language	English
Publishing date	2010-12
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2144145-5
ISSN	1873-0183 ; 1568-9972
ISSN (online)	1873-0183
ISSN	1568-9972
DOI	10.1016/j.autrev.2010.08.009
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Article: Relations of serum COMP to cardiovascular risk factors and endothelial function in patients with rheumatoid arthritis treated with methotrexate and TNF-α inhibitors.

Hjeltnes, Gunnbjørg / Hollan, Ivana / Førre, Øystein / Wiik, Allan / Lyberg, Torstein / Mikkelsen, Knut / Agewall, Stefan

The Journal of rheumatology

2012 Volume 39, Issue 7, Page(s) 1341–1347

Abstract: Objective: To examine whether serum level of cartilage oligomeric matrix protein (S-COMP) is ... for rheumatoid arthritis (RA); and to investigate whether S-COMP is related to cardiovascular risk factors ... with RA.: Methods: Clinical and laboratory measures, including S-COMP and reactive hyperemic index (RHI ...

Abstract	Objective: To examine whether serum level of cartilage oligomeric matrix protein (S-COMP) is related to methotrexate (MTX) or to MTX and tumor necrosis factor-α (TNF-α) combination treatment for rheumatoid arthritis (RA); and to investigate whether S-COMP is related to cardiovascular risk factors including endothelial dysfunction and level of anticitrullinated protein antibodies (ACPA) in patients with RA. Methods: Clinical and laboratory measures, including S-COMP and reactive hyperemic index (RHI), were examined in 55 consecutive patients with RA starting with either MTX (n = 34) or MTX and anti-TNF-α treatment (n = 21) at baseline, and after 6 weeks and 6 months. Results: S-COMP was similar in the 2 treatment regimens during followup. We found a positive relationship between S-COMP at baseline and the use of disease-modifying antirheumatic drugs the last year preceding the study (p = 0.001), and a negative relation to current use of systemic glucocorticosteroids (p = 0.044). The nonsignificant change in S-COMP between baseline and the 6-month followup was positively and independently related to change in ACPA level (p = 0.009). There was no significant association between RHI and level of S-COMP at baseline. Conclusion: The cartilage turnover marker S-COMP did not change significantly after 6 months' treatment with MTX with or without a TNF-α inhibitor in patients with RA. The positive association between S-COMP and ACPA suggests that these factors might interact, and could both be contributors to an unknown link between inflammation and cartilage destruction in patients with RA. S-COMP was not related to endothelial function in patients with RA, or to other cardiovascular risk factors studied. Clinical Trials registration number NCT00902005.
MeSH term(s)	Adult ; Aged ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/etiology ; Cartilage Oligomeric Matrix Protein ; Drug Therapy, Combination ; Endothelium, Vascular/drug effects ; Extracellular Matrix Proteins/blood ; Female ; Glucocorticoids/therapeutic use ; Glycoproteins/blood ; Humans ; Hyperemia/blood ; Hyperemia/drug therapy ; Male ; Matrilin Proteins ; Methotrexate/therapeutic use ; Middle Aged ; Risk Factors ; Treatment Outcome ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
Chemical Substances	Antirheumatic Agents ; Cartilage Oligomeric Matrix Protein ; Extracellular Matrix Proteins ; Glucocorticoids ; Glycoproteins ; Matrilin Proteins ; TSP5 protein, human ; Tumor Necrosis Factor-alpha ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2012-07
Publishing country	Canada
Document type	Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.111401
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Zs.A 1168: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Antinuclear antibodies: a contemporary nomenclature using HEp-2 cells.

Wiik, Allan S / Høier-Madsen, Mimi / Forslid, Jan / Charles, Peter / Meyrowitsch, Jan

Journal of autoimmunity

2010 Volume 35, Issue 3, Page(s) 276–290

Abstract: The choice of terms used to describe indirect immunofluorescence (IIF) staining patterns of autoantibodies binding to HEp-2 cells is at present quite varied and disordered because no accurate consensus on names and descriptions exist. The aim of our ... ...

Abstract	The choice of terms used to describe indirect immunofluorescence (IIF) staining patterns of autoantibodies binding to HEp-2 cells is at present quite varied and disordered because no accurate consensus on names and descriptions exist. The aim of our study was to propose a logical and ordered IIF classification taxonomy based on 29 different selected IIF patterns. In a preliminary project carried out at Statens Serum Institut it was first shown by use of a software programme named DOORS developed by Percepton Ltd, that reading of digitized images of HEp-2 patterns on an LCD monitor could be used instead of traditional microscopy. Digitized images of HEp-2 patterns were then used in the EU supported project named CANTOR (June 1998-July 2000) aiming to reach consensus among three clinical immunology expert centres and collaborating to attain a classification version that could be used to qualitatively and quantitatively test and train image recognitions skills of laboratory technicians against expert consensus. The usability of this classification version was then tested in a course consisting of training and certification. The conclusion was that participants in the training programme clearly increased their perceptive skills using images, terms, descriptions and the graphic and statistic tools in the self-administered DOORS programme and that software-assisted training could achieve a common and accurate level of visual pattern interpretation. All results from this project were reported to the European Commission but have not previously been published in scientific literature. This communication presents the final results of agreed image classifications.
MeSH term(s)	Antibodies, Antinuclear/classification ; Antibodies, Antinuclear/immunology ; Antibodies, Antinuclear/metabolism ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/immunology ; Biomarkers/metabolism ; Cell Line, Tumor ; Diagnosis, Computer-Assisted/methods ; Europe ; Fluorescent Antibody Technique, Indirect ; Humans ; Pattern Recognition, Automated ; Protein Binding ; Protein Transport ; Terminology as Topic
Chemical Substances	Antibodies, Antinuclear ; Biomarkers
Language	English
Publishing date	2010-11
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639452-8
ISSN	1095-9157 ; 0896-8411
ISSN (online)	1095-9157
ISSN	0896-8411
DOI	10.1016/j.jaut.2010.06.019
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Article: The influence of pregnancy on the development of autoimmunity in chronic lymphocytic leukemia.

Jønsson, Viggo / Bock, Johannes E / Hilden, Jørgen / Houlston, Richard S / Wiik, Allan

Leukemia & lymphoma

2006 Volume 47, Issue 8, Page(s) 1481–1487

Abstract: To examine whether pregnancy influences the development of autoimmunity in chronic lymphocytic leukemia (CLL), we studied 591 consecutive CLL patients (202 post-menopausal women and 389 men). The mean observation time for all patients was 3.8 years, ... ...

Abstract	To examine whether pregnancy influences the development of autoimmunity in chronic lymphocytic leukemia (CLL), we studied 591 consecutive CLL patients (202 post-menopausal women and 389 men). The mean observation time for all patients was 3.8 years, corresponding to approximately 2200 person-years of follow-up. Autoimmune manifestations were analyzed in 194 women with known obstetric history and known number of long-term sexual partners, and in the 389 male CLL patients for comparison. One hundred and fifty-nine of the CLL patients exhibited autoimmune manifestations, 38% in females and 21% in men. In female CLL patients, the frequency of autoimmunity and the number of pregnancies and the number of partners were strongly correlated. Each of the major autoimmune types approximately doubled in frequency for each additional pregnancy. The impact of pregnancy on expressed autoimmunity increased with each additional sexual partner (the odds of autoimmunity increased 11 times with each long-term sexual partner). The average numbers of pregnancies in female CLL patients with and without autoimmunity were 4.92 and 2.24, respectively (P < 0.001). Coombs' positive autoimmune anemia, a gastric ulcer with parietal cell autoantibodies and idiopathic thrombocytopenic purpura were equally common in women and men, whereas autoimmune thyroiditis, Sjögren's syndrome, rheumatoid arthritis and systemic lupus erythematosus were seen in higher rates in women than in men. The spectrum of autoimmunity suggests that pregnancy-related alloimmunization may be involved in the development of autoimmunity in CLL.
MeSH term(s)	Autoantibodies/blood ; Autoimmune Diseases/etiology ; Autoimmunity ; Female ; Follow-Up Studies ; Gravidity ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Male ; Pregnancy ; Pregnancy Complications, Neoplastic/immunology ; Sexual Behavior
Chemical Substances	Autoantibodies
Language	English
Publishing date	2006-08-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428190600634135
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