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Article ; Online: A G protein-biased S1P

Poirier, Bruno / Briand, Veronique / Kadereit, Dieter / Schäfer, Matthias / Wohlfart, Paulus / Philippo, Marie-Claire / Caillaud, Dominique / Gouraud, Laurent / Grailhe, Patrick / Bidouard, Jean-Pierre / Trellu, Marc / Muslin, Anthony J / Janiak, Philip / Parkar, Ashfaq A

Science signaling

2020 Volume 13, Issue 634

Abstract: Endothelial dysfunction is a hallmark of tissue injury and is believed to initiate the development of vascular diseases. Sphingosine-1 phosphate receptor-1 ( ... ...

Abstract	Endothelial dysfunction is a hallmark of tissue injury and is believed to initiate the development of vascular diseases. Sphingosine-1 phosphate receptor-1 (S1P
MeSH term(s)	Animals ; CHO Cells ; Cricetulus ; Disease Models, Animal ; Endothelial Cells/metabolism ; Humans ; Kidney/metabolism ; Kidney Diseases/drug therapy ; Kidney Diseases/genetics ; Kidney Diseases/metabolism ; Lymphocytes/metabolism ; Rats ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Signal Transduction/drug effects ; Sphingosine-1-Phosphate Receptors/agonists ; Sphingosine-1-Phosphate Receptors/metabolism ; Swine
Chemical Substances	S1PR1 protein, human ; S1PR1 protein, rat ; Sphingosine-1-Phosphate Receptors
Language	English
Publishing date	2020-06-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2417226-1
ISSN	1937-9145 ; 1945-0877
ISSN (online)	1937-9145
ISSN	1945-0877
DOI	10.1126/scisignal.aax8050
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The inhibitory receptor Siglec-G controls the severity of chronic lymphocytic leukemia.

Röder, Bettina / Fahnenstiel, Hannah / Schäfer, Simon / Budeus, Bettina / Dampmann, Maria / Eichhorn, Melanie / Angermüller, Sieglinde / Brost, Claudia / Winkler, Thomas H / Seifert, Marc / Nitschke, Lars

EMBO reports

2023 Volume 24, Issue 8, Page(s) e56420

Abstract: Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in adults in the Western world. B cell receptor (BCR) signaling is known to be crucial for the pathogenesis and maintenance of CLL cells which develop from mature ... ...

Abstract	Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in adults in the Western world. B cell receptor (BCR) signaling is known to be crucial for the pathogenesis and maintenance of CLL cells which develop from mature CD5
MeSH term(s)	Mice ; Animals ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Sialic Acid Binding Immunoglobulin-like Lectins/genetics ; Mice, Transgenic ; Proto-Oncogene Proteins ; B-Lymphocytes/metabolism ; Receptors, Antigen, B-Cell/genetics
Chemical Substances	Sialic Acid Binding Immunoglobulin-like Lectins ; Proto-Oncogene Proteins ; Receptors, Antigen, B-Cell
Language	English
Publishing date	2023-07-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020896-0
ISSN	1469-3178 ; 1469-221X
ISSN (online)	1469-3178
ISSN	1469-221X
DOI	10.15252/embr.202256420
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Zs.A 5433: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Age and sex effects on Super G performance are consistent across internet devices.

Hooyman, Andrew / Schaefer, Sydney Y

International journal of serious games

2023 Volume 10, Issue 2, Page(s) 25–36

Abstract: ... with dementia risk. While this online motor learning assessment (called Super G), along with other computer ... vs. age or sex. This establishes that Super G can now effectively be extended to both computer and ...

Abstract	There have been recent advances in the application of online games that assess motor skill acquisition/learning and its relationship to age and biological sex, both of which are associated with dementia risk. While this online motor learning assessment (called Super G), along with other computer-based cognitive tests, was originally developed to be completed on a computer, many people (including older adults) have been shown to access the internet through a mobile device. Thus, to improve the generalizability of our online motor skill learning game, it must not only be compatible with mobile devices but also yield replicable effects of various participant characteristics on performance relative to the computer-based version. It is unknown if age and sex differentially affect game performance as a function of device type (keyboard versus touchscreen control). Thus, the purpose of this study was to investigate if device type modifies the established effects of age and sex on performance. Although there was a main effect of device on performance, this effect did not alter the overall relationship between performance vs. age or sex. This establishes that Super G can now effectively be extended to both computer and mobile platforms to further test for dementia risk factors.
Language	English
Publishing date	2023-10-16
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2834858-8
ISSN	2384-8766 ; 2384-8766
ISSN (online)	2384-8766
ISSN	2384-8766
DOI	10.17083/ijsg.v10i2.598
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Article ; Online: Higher risk for chronic graft-versus-host disease (GvHD) in HLA-G mismatched transplants following allogeneic hematopoietic stem cell transplantation: A retrospective study.

Neuchel, Christine / Gowdavally, Sowmya / Tsamadou, Chrysanthi / Platzbecker, Uwe / Sala, Elisa / Wagner-Drouet, Eva / Valerius, Thomas / Kröger, Nicolaus / Wulf, Gerald / Einsele, Hermann / Thurner, Lorenz / Schaefer-Eckart, Kerstin / Freitag, Sebastian / Casper, Jochen / Dürholt, Mareike / Kaufmann, Martin / Hertenstein, Bernd / Klein, Stefan / Ringhoffer, Mark /

Frank, Sandra / Amann, Elisa Maria / Rode, Immanuel / Schrezenmeier, Hubert / Mytilineos, Joannis / Fürst, Daniel

HLA

2022 Volume 100, Issue 4, Page(s) 349–360

Abstract: ... The HLA-class Ib molecule HLA-G has been shown to promote tolerogenicity through its interaction ... HLA-G mismatches may negatively impact the HLA-G-mediated tolerogenicity either due to inefficient ... of mismatched HLA-G on host cells by the immune cells of the donor.: Methods: In order to explore ...

Abstract	Introduction: Graft-versus-host disease (GvHD) is a major complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and is highly influenced by the degree of HLA matching between recipient and donor. The HLA-class Ib molecule HLA-G has been shown to promote tolerogenicity through its interaction with inhibitory receptors found on several immunocompetent cells. We hypothesized that in an allo-HSCT setting, HLA-G mismatches may negatively impact the HLA-G-mediated tolerogenicity either due to inefficient interaction with the inhibitory receptors of the transplanted immune cells or due to direct allorecognition of mismatched HLA-G on host cells by the immune cells of the donor. Methods: In order to explore this hypothesis, we investigated the impact of HLA-G mismatching in 2.083 10/10 matched high resolution HLA-typed allo-HSCT transplants. Results: We found that the risk of chronic GvHD was significantly higher in HLA-G-mismatched transplant cases as compared with the HLA-G-matched control group (HR: 1.46, 95%CI = 1.11-1.91, p = 0.006). Sub-analysis of the mismatch vector revealed that this effect was only detectable in the GvH (HR: 1.89, 95%CI 1.39-2.57, p < 0.001) but not the HvG direction (HR: 1.01, 95%CI = 0.63-1.63, p = 0.967). In addition, the negative impact of HLA-G mismatching on chronic GvHD was only significant in younger patients (<30y HR: 3.02, 95%CI = 1.25-7.28, p = 0.014; >29y HR: 1.28, 95%CI = 0.94-1.72, p = 0.113). Discussion: Our results indicate that HLA-G mismatches may contribute to the onset of chronic GvHD, especially in younger patients and should therefore be avoided when possible.
MeSH term(s)	Alleles ; Graft vs Host Disease ; HLA-G Antigens ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Leukemia, Myeloid, Acute ; Retrospective Studies
Chemical Substances	HLA-G Antigens
Language	English
Publishing date	2022-07-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.14733
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Book ; Thesis: Bedeutung von G-CSF in der Follikelflüssigkeit und Nachweis von G-CSF und seinem Rezeptor auf menschlichen Granulosazellen

Schäfer, Sebastian

2005

Author's details	vorgelegt von Sebastian Schäfer
Language	German
Size	III, 49 S. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Kiel, Univ., Diss., 2005
HBZ-ID	HT014574996
Database	Catalogue ZB MED Medicine, Health

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2004 D 2221	order for loan	Magazin

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Article: G-CSF Infusion for Stem Cell Mobilization Transiently Increases Serum Cell-Free DNA and Protease Concentrations.

Stoikou, Maria / van Breda, Shane V / Schäfer, Günther / Vokalova, Lenka / Giaglis, Stavros / Plattner, Alexandra / Infanti, Laura / Holbro, Andreas / Hahn, Sinuhe / Rossi, Simona W / Buser, Andreas

Frontiers in medicine

2020 Volume 7, Page(s) 155

Abstract: G-CSF for stem cell mobilization increases circulating levels of myeloid cells at different stages ... that G-CSF primes PMNs toward the release of neutrophils extracellular traps (NETs). Since NETs are often ... involved in thrombotic events, we hypothesized that high G-CSF blood concentrations could enhance PMN ...

Abstract	G-CSF for stem cell mobilization increases circulating levels of myeloid cells at different stages of maturation. Polymorphonuclear cells (PMNs) are also mobilized in high numbers. It was previously reported that G-CSF primes PMNs toward the release of neutrophils extracellular traps (NETs). Since NETs are often involved in thrombotic events, we hypothesized that high G-CSF blood concentrations could enhance PMN priming toward NET formation in healthy hematopoietic stem cell donors, predisposing them to thrombotic events. However, we found that G-CSF does not prime PMNs toward NETs formation, but increases the serum concentration of cell-free DNA, proteases like neutrophils elastase and myeloperoxidase, and reactive oxygen species. This could possibly create an environment disposed to induce thrombotic events in the presence of additional predisposing factors.
Language	English
Publishing date	2020-04-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2020.00155
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Book ; Thesis: Untersuchungen zur Zytotoxizität von Extrakten und Inhaltsstoffen der Kavawurzel (Piper methysticum G. Forst.)

Schäfer, Katrien

2006

Author's details	von Katrien Schäfer
Keywords	Piper methysticum ; Inhaltsstoff ; Cytotoxizität
Subject	Zytotoxizität ; Kawa ; Kava ; Kava-Kava ; Rauschpfeffer ; Kawapfeffer
Language	German
Size	IX, 169 S. : Ill., graph. Darst., 21 cm
Edition	1. Aufl.
Publisher	Cuvillier
Publishing place	Göttingen
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Braunschweig, Techn. Univ., Diss., 2006
HBZ-ID	HT014895360
ISBN	3-86537-937-0 ; 978-3-86537-937-5
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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068/1926	available for loan (reading room)	Freihandmagazin (U1)

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Book ; Thesis: Untersuchungen zur Zytotoxizität von Extrakten und Inhaltsstoffen der Kavawurzel (Piper methysticum G. Forst.)

Schäfer, Katrien

2006

Author's details	von Katrien Schäfer
Keywords	Piper methysticum ; Inhaltsstoff ; Cytotoxizität
Subject	Zytotoxizität ; Kawa ; Kava ; Kava-Kava ; Rauschpfeffer ; Kawapfeffer
Language	German
Size	IX, 169 S. : Ill., graph. Darst., 21 cm
Edition	1. Aufl.
Publisher	Cuvillier
Publishing place	Göttingen
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Braunschweig, Techn. Univ., Diss., 2006
HBZ-ID	HT014895360
ISBN	3-86537-937-0 ; 978-3-86537-937-5
Database	Catalogue ZB MED Medicine, Health

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2009 A 4204	order for loan	Magazin

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Article ; Online: Reliability, validity and critical appraisal of the cross-cultural adapted German version of the Mayo Elbow Performance Score (MEPS-G).

Papen, A / Schöttker-Königer, T / Schäfer, A / Morrison, F / Hollinger, B / Burkhart, K J / Nietschke, R / Zimmerer, A / Maffulli, N / Migliorini, F / Schneider, Marco M

Journal of orthopaedic surgery and research

2022 Volume 17, Issue 1, Page(s) 328

Abstract: ... We determined the validity and reliability of its German version (MEPS-G) after cross-cultural adaptation ... Methods: Six investigators examined 57 patients with elbow pathologies. The MEPS-G was compared ... of the MEPS-G score was moderate (ICC (2.1) = 0.65). The IRR of the four individual dimensions was moderate ...

Abstract	Background: The Mayo Elbow Performance Score (MEPS) is a rating system consisting of four dimensions to evaluate elbow performance. It is a common tool for assessment of elbow impairments worldwide. We determined the validity and reliability of its German version (MEPS-G) after cross-cultural adaptation. Methods: Six investigators examined 57 patients with elbow pathologies. The MEPS-G was compared to validated elbow scores such as the German versions of DASH, the Oxford Elbow Score, pain level and subjective elbow performance on a VAS. Inter-rater reliability (IRR) and validity of the score and its dimensions were also reviewed. Verification was performed using the intraclass correlation coefficient (ICC), the prevalence and bias with adjusted Kappa (PABAK) and the Spearman correlation. Results: The IRR of the MEPS-G score was moderate (ICC (2.1) = 0.65). The IRR of the four individual dimensions was moderate to high (K Conclusion: The MEPS-G is not sufficiently valid, which is consistent with its English version. The patient-based dimensions were a weakness, demonstrating high risk of bias. There is no general recommendation for the utilization of the MEPS-G as outcome measurement for patients with elbow pathologies.
MeSH term(s)	Cross-Cultural Comparison ; Elbow ; Humans ; Pain ; Reproducibility of Results ; Surveys and Questionnaires
Language	English
Publishing date	2022-06-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-022-03210-5
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Article ; Online: Contribution of Coronavirus-Specific Immunoglobulin G Responses to Complement Overactivation in Patients with Severe Coronavirus Disease 2019.

The Journal of infectious diseases

2022 Volume 226, Issue 5, Page(s) 766–777

Abstract: ... with higher immunoglobulin (Ig) G titers, greater complement activation, and higher disease severity score ...

Abstract	Background: Excessive complement activation has been implicated in the pathogenesis of coronavirus disease 2019 (COVID-19), but the mechanisms leading to this response remain unclear. Methods: We measured plasma levels of key complement markers, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA and antibodies against SARS-CoV-2 and seasonal human common cold coronaviruses (CCCs) in hospitalized patients with COVID-19 of moderate (n = 18) and critical severity (n = 37) and in healthy controls (n = 10). Results: We confirmed that complement activation is systemically increased in patients with COVID-19 and is associated with a worse disease outcome. We showed that plasma levels of C1q and circulating immune complexes were markedly increased in patients with severe COVID-19 and correlated with higher immunoglobulin (Ig) G titers, greater complement activation, and higher disease severity score. Additional analyses showed that the classical pathway was the main arm responsible for augmented complement activation in severe patients. In addition, we demonstrated that a rapid IgG response to SARS-CoV-2 and an anamnestic IgG response to the nucleoprotein of the CCCs were strongly correlated with circulating immune complex levels, complement activation, and disease severity. Conclusions: These findings indicate that early, nonneutralizing IgG responses may play a key role in complement overactivation in severe COVID-19. Our work underscores the urgent need to develop therapeutic strategies to modify complement overactivation in patients with COVID-19.
MeSH term(s)	Antibodies, Viral ; COVID-19 ; Coronavirus Nucleocapsid Proteins ; Humans ; Immunoglobulin G ; SARS-CoV-2
Chemical Substances	Antibodies, Viral ; Coronavirus Nucleocapsid Proteins ; Immunoglobulin G
Language	English
Publishing date	2022-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiac091
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Uh II Zs.50: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 445: Show issues

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