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Article ; Online: Angiotensin II-induced cardiomyocyte hypertrophy: A complex response dependent on intertwined pathways.

Consegal, Marta / Valls-Lacalle, Laura / Rodríguez-Sinovas, Antonio

2021 Volume 40, Issue 3, Page(s) 201–203

MeSH term(s)	Angiotensin II ; Cardiomegaly/chemically induced ; Humans ; Myocytes, Cardiac ; Receptor, Angiotensin, Type 1
Chemical Substances	Receptor, Angiotensin, Type 1 ; Angiotensin II (11128-99-7)
Language	Portuguese
Publishing date	2021-01-18
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2646972-8
ISSN	2174-2049 ; 2174-2049
ISSN (online)	2174-2049
ISSN	2174-2049
DOI	10.1016/j.repc.2020.12.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cellular crosstalk in cardioprotection: Where and when do reactive oxygen species play a role?

Martins-Marques, Tania / Rodriguez-Sinovas, Antonio / Girao, Henrique

Free radical biology & medicine

2021 Volume 169, Page(s) 397–409

Abstract: A well-balanced intercellular communication between the different cells within the heart is vital for the maintenance of cardiac homeostasis and function. Despite remarkable advances on disease management and treatment, acute myocardial infarction ... ...

Abstract	A well-balanced intercellular communication between the different cells within the heart is vital for the maintenance of cardiac homeostasis and function. Despite remarkable advances on disease management and treatment, acute myocardial infarction remains the major cause of morbidity and mortality worldwide. Gold standard reperfusion strategies, namely primary percutaneous coronary intervention, are crucial to preserve heart function. However, reestablishment of blood flow and oxygen levels to the infarcted area are also associated with an accumulation of reactive oxygen species (ROS), leading to oxidative damage and cardiomyocyte death, a phenomenon termed myocardial reperfusion injury. In addition, ROS signaling has been demonstrated to regulate multiple biological pathways, including cell differentiation and intercellular communication. Given the importance of cell-cell crosstalk in the coordinated response after cell injury, in this review, we will discuss the impact of ROS in the different forms of inter- and intracellular communication, as well as the role of gap junctions, tunneling nanotubes and extracellular vesicles in the propagation of oxidative damage in cardiac diseases, particularly in the context of ischemia/reperfusion injury.
MeSH term(s)	Gap Junctions ; Humans ; Myocardial Reperfusion Injury/metabolism ; Myocytes, Cardiac ; Oxidative Stress ; Reactive Oxygen Species/metabolism
Chemical Substances	Reactive Oxygen Species
Language	English
Publishing date	2021-04-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2021.03.044
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Zs.A 2109: Show issues

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Article ; Online: Long-Term Protective Effects of Succinate Dehydrogenase Inhibition during Reperfusion with Malonate on Post-Infarction Left Ventricular Scar and Remodeling in Mice.

Valls-Lacalle, Laura / Consegal, Marta / Ganse, Freddy G / Yáñez-Bisbe, Laia / Pastor, Javier / Ruiz-Meana, Marisol / Inserte, Javier / Benito, Begoña / Ferreira-González, Ignacio / Rodríguez-Sinovas, Antonio

International journal of molecular sciences

2024 Volume 25, Issue 8

Abstract: Succinate dehydrogenase inhibition with malonate during initial reperfusion reduces myocardial infarct size in both isolated mouse hearts subjected to global ischemia and in in situ pig hearts subjected to transient coronary ligature. However, the long- ... ...

Abstract	Succinate dehydrogenase inhibition with malonate during initial reperfusion reduces myocardial infarct size in both isolated mouse hearts subjected to global ischemia and in in situ pig hearts subjected to transient coronary ligature. However, the long-term effects of acute malonate treatment are unknown. Here, we investigated whether the protective effects of succinate dehydrogenase inhibition extend to a reduction in scar size and adverse left ventricular remodeling 28 days after myocardial infarction. Initially, ten wild-type mice were subjected to 45 min of left anterior descending coronary artery (LAD) occlusion, followed by 24 h of reperfusion, and were infused during the first 15 min of reperfusion with saline with or without disodium malonate (10 mg/kg/min, 120 μL/kg/min). Malonate-treated mice depicted a significant reduction in infarct size (15.47 ± 3.40% of area at risk vs. 29.34 ± 4.44% in control animals,
MeSH term(s)	Animals ; Malonates/pharmacology ; Myocardial Infarction/drug therapy ; Myocardial Infarction/pathology ; Mice ; Succinate Dehydrogenase/metabolism ; Succinate Dehydrogenase/antagonists & inhibitors ; Male ; Ventricular Remodeling/drug effects ; Myocardial Reperfusion Injury/drug therapy ; Myocardial Reperfusion Injury/pathology ; Cicatrix/pathology ; Cicatrix/drug therapy ; Mice, Inbred C57BL
Chemical Substances	Malonates ; Succinate Dehydrogenase (EC 1.3.99.1) ; malonic acid (9KX7ZMG0MK)
Language	English
Publishing date	2024-04-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25084366
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Article ; Online: Connexins in the Heart: Regulation, Function and Involvement in Cardiac Disease.

Rodríguez-Sinovas, Antonio / Sánchez, Jose Antonio / Valls-Lacalle, Laura / Consegal, Marta / Ferreira-González, Ignacio

International journal of molecular sciences

2021 Volume 22, Issue 9

Abstract: Connexins are a family of transmembrane proteins that play a key role in cardiac physiology. Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes, allowing the existence of electrical coupling. However, in addition to this ... ...

Abstract	Connexins are a family of transmembrane proteins that play a key role in cardiac physiology. Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes, allowing the existence of electrical coupling. However, in addition to this fundamental role, connexins are also involved in cardiomyocyte death and survival. Thus, chemical coupling through gap junctions plays a key role in the spreading of injury between connected cells. Moreover, in addition to their involvement in cell-to-cell communication, mounting evidence indicates that connexins have additional gap junction-independent functions. Opening of unopposed hemichannels, located at the lateral surface of cardiomyocytes, may compromise cell homeostasis and may be involved in ischemia/reperfusion injury. In addition, connexins located at non-canonical cell structures, including mitochondria and the nucleus, have been demonstrated to be involved in cardioprotection and in regulation of cell growth and differentiation. In this review, we will provide, first, an overview on connexin biology, including their synthesis and degradation, their regulation and their interactions. Then, we will conduct an in-depth examination of the role of connexins in cardiac pathophysiology, including new findings regarding their involvement in myocardial ischemia/reperfusion injury, cardiac fibrosis, gene transcription or signaling regulation.
MeSH term(s)	Animals ; Connexins/metabolism ; Heart Diseases/metabolism ; Heart Diseases/physiopathology ; Humans
Chemical Substances	Connexins
Language	English
Publishing date	2021-04-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22094413
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Article ; Online: TRPV4 Channels Promote Pathological, but Not Physiological, Cardiac Remodeling through the Activation of Calcineurin/NFAT and TRPC6.

Yáñez-Bisbe, Laia / Moya, Mar / Rodríguez-Sinovas, Antonio / Ruiz-Meana, Marisol / Inserte, Javier / Tajes, Marta / Batlle, Montserrat / Guasch, Eduard / Mas-Stachurska, Aleksandra / Miró, Elisabet / Rivas, Nuria / Ferreira González, Ignacio / Garcia-Elias, Anna / Benito, Begoña

International journal of molecular sciences

2024 Volume 25, Issue 3

Abstract: TRPV4 channels, which respond to mechanical activation by permeating ... ...

Abstract	TRPV4 channels, which respond to mechanical activation by permeating Ca
MeSH term(s)	Animals ; Mice ; Calcineurin/metabolism ; Cells, Cultured ; Fibrosis ; Heart Failure/metabolism ; Isoproterenol ; Mice, Transgenic ; Myocytes, Cardiac/metabolism ; NFATC Transcription Factors/genetics ; NFATC Transcription Factors/metabolism ; TRPC6 Cation Channel/genetics ; TRPC6 Cation Channel/metabolism ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism ; Ventricular Remodeling/genetics
Chemical Substances	Calcineurin (EC 3.1.3.16) ; Isoproterenol (L628TT009W) ; NFATC Transcription Factors ; TRPC6 Cation Channel ; TRPV Cation Channels
Language	English
Publishing date	2024-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25031541
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Article ; Online: Lysyl oxidase-dependent extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease.

Ballester-Servera, Carme / Alonso, Judith / Cañes, Laia / Vázquez-Sufuentes, Paula / Puertas-Umbert, Lídia / Fernández-Celis, Amaya / Taurón, Manel / Rodríguez-Sinovas, Antonio / López-Andrés, Natalia / Rodríguez, Cristina / Martínez-González, José

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 167, Page(s) 115469

Abstract: Extracellular matrix (ECM) is an active player in cardiovascular calcification (CVC), a major public health issue with an unmet need for effective therapies. Lysyl oxidase (LOX) conditions ECM biomechanical properties; thus, we hypothesized that LOX ... ...

Abstract	Extracellular matrix (ECM) is an active player in cardiovascular calcification (CVC), a major public health issue with an unmet need for effective therapies. Lysyl oxidase (LOX) conditions ECM biomechanical properties; thus, we hypothesized that LOX might impact on mineral deposition in calcific aortic valve disease (CAVD) and atherosclerosis. LOX was upregulated in calcified valves from two cohorts of CAVD patients. Strong LOX immunostaining was detected surrounding calcified foci in calcified human valves and atherosclerotic lesions colocalizing with RUNX2 on valvular interstitial cells (VICs) or vascular smooth muscle cells (VSMCs). Both LOX secretion and organized collagen deposition were enhanced in calcifying VICs exposed to osteogenic media. β-aminopropionitrile (BAPN), an inhibitor of LOX, attenuated collagen deposition and calcification. VICs seeded onto decellularized matrices from BAPN-treated VICs calcified less than cells cultured onto control scaffolds; instead, VICs exposed to conditioned media from cells over-expressing LOX or cultured onto LOX-crosslinked matrices calcified more. Atherosclerosis was induced in WT and transgenic mice that overexpress LOX in VSMC (TgLOX
Language	English
Publishing date	2023-09-18
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115469
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Ud II Zs.198: Show issues

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Article ; Online: Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction.

Jakobsson, Gabriel / Papareddy, Praveen / Andersson, Henrik / Mulholland, Megan / Bhongir, Ravi / Ljungcrantz, Irena / Engelbertsen, Daniel / Björkbacka, Harry / Nilsson, Jan / Manea, Adrian / Herwald, Heiko / Ruiz-Meana, Marisol / Rodríguez-Sinovas, Antonio / Chew, Michelle / Schiopu, Alexandru

Critical care (London, England)

2023 Volume 27, Issue 1, Page(s) 374

Abstract: Background and aims: The triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly understood and are not addressed by current treatments. S100A8/A9 is a pro-inflammatory alarmin abundantly secreted by activated neutrophils during ... ...

Abstract	Background and aims: The triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly understood and are not addressed by current treatments. S100A8/A9 is a pro-inflammatory alarmin abundantly secreted by activated neutrophils during infection and inflammation. We investigated the efficacy of S100A8/A9 blockade as a potential new treatment in SIMD. Methods: The relationship between plasma S100A8/A9 and cardiac dysfunction was assessed in a cohort of 62 patients with severe sepsis admitted to the intensive care unit of Linköping University Hospital, Sweden. We used S100A8/A9 blockade with the small-molecule inhibitor ABR-238901 and S100A9 Results: In sepsis patients, elevated plasma S100A8/A9 was associated with left-ventricular (LV) systolic dysfunction and increased SOFA score. In wild-type mice, 5 mg/kg of bacterial lipopolysaccharide (LPS) induced rapid plasma S100A8/A9 increase and acute LV dysfunction. Two ABR-238901 doses (30 mg/kg) administered intraperitoneally with a 6 h interval, starting directly after LPS or at a later time-point when LV dysfunction is fully established, efficiently prevented and reversed the phenotype, respectively. In contrast, dexamethasone did not improve cardiac function compared to PBS-treated endotoxemic controls. S100A8/A9 inhibition potently reduced systemic levels of inflammatory mediators, prevented upregulation of inflammatory genes and restored mitochondrial function in the myocardium. The S100A9 Conclusion: Elevated S100A8/A9 is associated with the development of LV dysfunction in severe sepsis patients and in a mouse model of endotoxemia. Pharmacological blockade of S100A8/A9 with ABR-238901 has potent anti-inflammatory effects, mitigates myocardial dysfunction and might represent a novel therapeutic strategy for patients with severe sepsis.
MeSH term(s)	Animals ; Humans ; Mice ; Calgranulin A/antagonists & inhibitors ; Calgranulin B/metabolism ; Endotoxemia/complications ; Endotoxemia/drug therapy ; Heart Diseases/drug therapy ; Inflammation/drug therapy ; Lipopolysaccharides ; Myocardium/pathology ; Ventricular Dysfunction, Left/drug therapy
Chemical Substances	ABR-238901 ; Calgranulin A ; Calgranulin B ; Lipopolysaccharides
Language	English
Publishing date	2023-09-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-023-04652-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5517: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Human Lysyl Oxidase Over-Expression Enhances Baseline Cardiac Oxidative Stress but Does Not Aggravate ROS Generation or Infarct Size Following Myocardial Ischemia-Reperfusion.

Valls-Lacalle, Laura / Puertas-Umbert, Lídia / Varona, Saray / Martínez-González, José / Rodríguez, Cristina / Rodríguez-Sinovas, Antonio

Antioxidants (Basel, Switzerland)

2021 Volume 11, Issue 1

Abstract: Lysyl oxidase (LOX) is an enzyme critically involved in collagen maturation, whose activity releases ... ...

Abstract	Lysyl oxidase (LOX) is an enzyme critically involved in collagen maturation, whose activity releases H
Language	English
Publishing date	2021-12-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11010075
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Article ; Online: NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond.

Martínez-González, José / Cañes, Laia / Alonso, Judith / Ballester-Servera, Carme / Rodríguez-Sinovas, Antonio / Corrales, Irene / Rodríguez, Cristina

International journal of molecular sciences

2021 Volume 22, Issue 21

Abstract: The mechanisms committed in the activation and response of vascular and inflammatory immune cells play a major role in tissue remodeling in cardiovascular diseases (CVDs) such as atherosclerosis, pulmonary arterial hypertension, and abdominal aortic ... ...

Abstract	The mechanisms committed in the activation and response of vascular and inflammatory immune cells play a major role in tissue remodeling in cardiovascular diseases (CVDs) such as atherosclerosis, pulmonary arterial hypertension, and abdominal aortic aneurysm. Cardiovascular remodeling entails interrelated cellular processes (proliferation, survival/apoptosis, inflammation, extracellular matrix (ECM) synthesis/degradation, redox homeostasis, etc.) coordinately regulated by a reduced number of transcription factors. Nuclear receptors of the subfamily 4 group A (NR4A) have recently emerged as key master genes in multiple cellular processes and vital functions of different organs, and have been involved in a variety of high-incidence human pathologies including atherosclerosis and other CVDs. This paper reviews the major findings involving NR4A3 (Neuron-derived Orphan Receptor 1, NOR-1) in the cardiovascular remodeling operating in these diseases.
MeSH term(s)	Animals ; Atherosclerosis ; Atrial Remodeling ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/pathology ; Cardiovascular System/metabolism ; Cardiovascular System/pathology ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/physiology ; Humans ; Inflammation ; Nerve Tissue Proteins/metabolism ; Nerve Tissue Proteins/physiology ; Pulmonary Arterial Hypertension ; Receptors, Steroid/metabolism ; Receptors, Steroid/physiology ; Receptors, Thyroid Hormone/metabolism ; Receptors, Thyroid Hormone/physiology
Chemical Substances	DNA-Binding Proteins ; NR4A3 protein, human ; Nerve Tissue Proteins ; Nr4a3 protein, mouse ; Receptors, Steroid ; Receptors, Thyroid Hormone
Language	English
Publishing date	2021-10-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222111371
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Article ; Online: Citric Acid Cycle Metabolites Predict Infarct Size in

Consegal, Marta / Núñez, Norberto / Barba, Ignasi / Benito, Begoña / Ruiz-Meana, Marisol / Inserte, Javier / Ferreira-González, Ignacio / Rodríguez-Sinovas, Antonio

International journal of molecular sciences

2021 Volume 22, Issue 8

Abstract: Succinate dehydrogenase (SDH) inhibition with malonate during reperfusion reduced myocardial infarction in animals, whereas its endogenous substrate, succinate, is detected in plasma from STEMI patients. We investigated whether protection by SDH ... ...

Abstract	Succinate dehydrogenase (SDH) inhibition with malonate during reperfusion reduced myocardial infarction in animals, whereas its endogenous substrate, succinate, is detected in plasma from STEMI patients. We investigated whether protection by SDH inhibition is additive to that of remote ischemic perconditioning (RIC) in
MeSH term(s)	Animals ; Biomarkers/blood ; Biomarkers/metabolism ; Citric Acid Cycle ; Coronary Occlusion/metabolism ; Coronary Occlusion/pathology ; Coronary Occlusion/therapy ; Dicarboxylic Acids/blood ; Dicarboxylic Acids/metabolism ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Heart/drug effects ; Ischemic Preconditioning/methods ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardial Infarction/therapy ; Myocardium/metabolism ; Succinate Dehydrogenase/antagonists & inhibitors ; Swine
Chemical Substances	Biomarkers ; Dicarboxylic Acids ; Enzyme Inhibitors ; Succinate Dehydrogenase (EC 1.3.99.1)
Language	English
Publishing date	2021-04-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22084151
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