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  1. Article ; Online: Disability Bioethics, Social Inclusion, and Whole-Eye Transplantation.

    Mintz, Kevin Todd / Cureton, Adam

    The American journal of bioethics : AJOB

    2024  Volume 24, Issue 5, Page(s) 85–87

    MeSH term(s) Humans ; Social Inclusion ; Human Rights ; Morals ; Bioethics
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2024.2327884
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6814: Show issues Location:
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  2. Article ; Online: An Innovative Use of the Logic Model for a Qualitative Analysis Framework.

    Baucham, Ramona S / Mintz-Binder, Ronda / Baker, Kathy A

    Journal of continuing education in nursing

    2024  , Page(s) 1–5

    Abstract: Background: Qualitative analysis can be a daunting and time-consuming task for those who are attempting to code qualitative data for the first time.: Method: This article presents select secondary data analysis from a previously published study to ... ...

    Abstract Background: Qualitative analysis can be a daunting and time-consuming task for those who are attempting to code qualitative data for the first time.
    Method: This article presents select secondary data analysis from a previously published study to demonstrate the applicability and usefulness of implementing a logic model approach to provide a framework for qualitative analysis.
    Results: The use of the logic model provided systematic organization during the analysis process, efficiency for analytical tasks, and enhanced trustworthiness by documenting each analysis step. The model allowed for easier visualization of data that facilitated a richer and more focused analysis.
    Conclusion: With qualitative data that are focused on processes or outcomes, implementing a logic model framework to categorize and organize data can be useful and efficient, particularly for a novice analyst whether analyzing qualitative text for quality improvement, evidence-based practice, program evaluation, or formal research.
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410520-5
    ISSN 1938-2472 ; 0022-0124
    ISSN (online) 1938-2472
    ISSN 0022-0124
    DOI 10.3928/00220124-20240301-05
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1510: Show issues Location:
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  3. Article: Maternal Outcomes Following Active vs. Expectant Management of Previable Preterm Pre-Labor Rupture of Membranes: A Meta-Analysis.

    Sylvester, Megan A / Mintz, Gabrielle / Sisti, Giovanni

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 8

    Abstract: The diagnosis of previable preterm pre-labor rupture of membranes (PROM) is known to be associated with poor outcomes for both the mother and the fetus. Following previable preterm PROM, patients are generally offered either active management through the ...

    Abstract The diagnosis of previable preterm pre-labor rupture of membranes (PROM) is known to be associated with poor outcomes for both the mother and the fetus. Following previable preterm PROM, patients are generally offered either active management through the termination of the pregnancy or expectant management to increase the chances of fetal survival. It is difficult to counsel patients because there is a lack of data directly comparing maternal outcomes following active vs. expectant management. Using the data in the current literature, the goal of the present meta-analysis was to determine if there were any differences in terms of maternal risks when active versus elective management was chosen. PubMed, Google Scholar, EMBASE, and Scopus were searched. We found four studies accounting for a total of 506 patients. The risk ratio (RR) of chorioamnionitis in active vs. expectant management was 0.30 (with a 95% confidence interval, CI, of 0.09-1.02). The heterogeneity of the study results was 81% (I
    Language English
    Publishing date 2023-08-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10081347
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  4. Article ; Online: An integrated perspective for the diagnosis and therapy of neurodevelopmental disorders - From an engineering point of view.

    Mintz Hemed, Nofar / Melosh, Nicholas A

    Advanced drug delivery reviews

    2023  Volume 194, Page(s) 114723

    Abstract: Neurodevelopmental disorders (NDDs) are complex conditions with largely unknown pathophysiology. While many NDD symptoms are familiar, the cause of these disorders remains unclear and may involve a combination of genetic, biological, psychosocial, and ... ...

    Abstract Neurodevelopmental disorders (NDDs) are complex conditions with largely unknown pathophysiology. While many NDD symptoms are familiar, the cause of these disorders remains unclear and may involve a combination of genetic, biological, psychosocial, and environmental risk factors. Current diagnosis relies heavily on behaviorally defined criteria, which may be biased by the clinical team's professional and cultural expectations, thus a push for new biological-based biomarkers for NDDs diagnosis is underway. Emerging new research technologies offer an unprecedented view into the electrical, chemical, and physiological activity in the brain and with further development in humans may provide clinically relevant diagnoses. These could also be extended to new treatment options, which can start to address the underlying physiological issues. When combined with current speech, language, occupational therapy, and pharmacological treatment these could greatly improve patient outcomes. The current review will discuss the latest technologies that are being used or may be used for NDDs diagnosis and treatment. The aim is to provide an inspiring and forward-looking view for future research in the field.
    MeSH term(s) Humans ; Neurodevelopmental Disorders/genetics ; Neurodevelopmental Disorders/psychology ; Brain ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-02-04
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2023.114723
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2241: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article: Association of Lateral Extra-Articular Tenodesis With Improved Graft Maturity on MRI 2 Years After ACL Reconstruction With Quadriceps Tendon Autograft in Skeletally Immature Athletes.

    Retzky, Julia S / Chipman, Danielle E / Mintz, Douglas N / Cordasco, Frank A / Green, Daniel W

    Orthopaedic journal of sports medicine

    2024  Volume 12, Issue 1, Page(s) 23259671231211885

    Abstract: Background: Quadriceps tendon autograft (QTA) has recently gained popularity in the treatment of anterior cruciate ligament (ACL) ruptures in pediatric patients. The addition of lateral extra-articular tenodesis (LET) to an ACL reconstruction (ACLR) has ...

    Abstract Background: Quadriceps tendon autograft (QTA) has recently gained popularity in the treatment of anterior cruciate ligament (ACL) ruptures in pediatric patients. The addition of lateral extra-articular tenodesis (LET) to an ACL reconstruction (ACLR) has been found to reduce the risk of ACL retear in high-risk patients.
    Purpose: To (1) compare ACL graft maturity using signal intensity ratios (SIRs) on magnetic resonance imaging (MRI) scans in skeletally immature patients undergoing ACLR with QTA either with or without concomitant LET and (2) evaluate LET safety by calculating the physeal disturbance-related reoperation rate in the ACLR+LET group.
    Study design: Cohort study; Level of evidence, 3.
    Methods: The records of patients aged ≤18 years who underwent ACLR between 2015 and 2021 were reviewed retrospectively. Patients undergoing ACLR with QTA who had open distal femoral and proximal tibial physes on MRI scans and a minimum 2-year follow-up data were included. SIR values were measured on sagittal MRI scans by averaging the signal at 3 regions of interest along the ACL graft and dividing by the signal of the posterior cruciate ligament at its insertion. Statistical analysis was performed to evaluate differences in SIR values at 6 months, 1 year, and 2 years postoperatively in patients who underwent ACLR alone versus ACLR+LET.
    Results: Overall, 29 patients were included in the study: 16 patients in the ACLR+LET group and 13 patients in the ACLR-only group. There were no significant differences in SIR values between groups at the 6-month or 1-year postoperative timepoints. At 2 years postoperatively, the median SIR of the ACLR+LET group was significantly lower than that of the ACLR-only group on both univariate (1.33 vs 1.86, respectively,
    Conclusion: The addition of LET to an ACLR with QTA was associated with lower average SIR values and thus improved graft maturity at 2 years postoperatively compared with ACLR alone in skeletally immature patients. The addition of LET to an ACLR was found to be safe in skeletally immature patients.
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2706251-X
    ISSN 2325-9671
    ISSN 2325-9671
    DOI 10.1177/23259671231211885
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  6. Article ; Online: All calcified nodules are made equal and require the same approach: pros and cons.

    Guagliumi, Giulio / Pellegrini, Dario / Maehara, Akiko / Mintz, Gary S

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2023  Volume 19, Issue 2, Page(s) e110–e112

    MeSH term(s) Humans ; Calcification, Physiologic
    Language English
    Publishing date 2023-06-05
    Publishing country France
    Document type Journal Article
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJ-E-23-00002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6680: Show issues Location:
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    Zs.MO 571: Show issues

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  7. Article ; Online: Design matters: A comparison of natural versus synthetic skin substitutes across benchtop and porcine wound healing metrics: An experimental study.

    Stefanelli, Victoria L / Mintz, Benjamin / Gandhi, Ankur / Smith, Jason

    Health science reports

    2023  Volume 6, Issue 8, Page(s) e1462

    Abstract: Background and aims: Skin substitutes, essential tools for helping close full thickness wounds with minimal scarring, are available in both collagen-based and synthetic polyurethane constructions. Here we explore fundamental differences between two ... ...

    Abstract Background and aims: Skin substitutes, essential tools for helping close full thickness wounds with minimal scarring, are available in both collagen-based and synthetic polyurethane constructions. Here we explore fundamental differences between two frequently used skin substitutes and discuss how these differences may impact in vivo performance.
    Methods: Polyurethane- and collagen-based matrices were characterized in vitro for pore size via scanning electron microscopy, hydrophobicity via liquid contact angle, conformability via bending angle, and biocompatibility via fibroblast and keratinocyte adhesion and proliferation. These matrices were then evaluated in a full-thickness excisional pig wound study followed by histological analysis. Statistical analysis was performed using
    Results: Average pore diameter in the tested polyurethane matrix was over four times larger than that of the collagen matrix (589 ± 297 µm vs. 132 ± 91 µm). Through liquid contact angle measurement, the collagen matrix (not measurable) was found to be hydrophilic compared to the hydrophobic polyurethane matrix (>90°). The collagen matrix was significantly more conformable than the polyurethane matrix (9 ± 2° vs. 84 ± 5° bending angle, respectively). Fibroblast and keratinocyte adhesion and proliferation assays elucidated a significantly greater ability of both cell types to attach and proliferate on collagen versus polyurethane. While the porcine study showed minimal contraction of either matrix material, histological findings between the two treatments were markedly different. Collagen matrices were associated with early fibroblast infiltration and fibroplasia, whereas polyurethane matrices elicited a strong multinucleated giant cell response and produced a network of comparatively aligned collagen fibrils.
    Conclusions: The more favorable in vitro properties of the collagen matrix led to less inflammation and better overall tissue response in vivo. Overall, our findings demonstrate how the choice of biomaterial and its design directly translate to differing in vivo mechanisms of action and overall tissue quality.
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.1462
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  8. Article ; Online: Data assimilation in operator algebras.

    Freeman, David / Giannakis, Dimitrios / Mintz, Brian / Ourmazd, Abbas / Slawinska, Joanna

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 8, Page(s) e2211115120

    Abstract: We develop an algebraic framework for sequential data assimilation of partially observed dynamical systems. In this framework, Bayesian data assimilation is embedded in a nonabelian operator algebra, which provides a representation of observables by ... ...

    Abstract We develop an algebraic framework for sequential data assimilation of partially observed dynamical systems. In this framework, Bayesian data assimilation is embedded in a nonabelian operator algebra, which provides a representation of observables by multiplication operators and probability densities by density operators (quantum states). In the algebraic approach, the forecast step of data assimilation is represented by a quantum operation induced by the Koopman operator of the dynamical system. Moreover, the analysis step is described by a quantum effect, which generalizes the Bayesian observational update rule. Projecting this formulation to finite-dimensional matrix algebras leads to computational schemes that are i) automatically positivity-preserving and ii) amenable to consistent data-driven approximation using kernel methods for machine learning. Moreover, these methods are natural candidates for implementation on quantum computers. Applications to the Lorenz 96 multiscale system and the El Niño Southern Oscillation in a climate model show promising results in terms of forecast skill and uncertainty quantification.
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2211115120
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    Zs.A 1148: Show issues Location:
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  9. Article: Behavioral Analytics for Myopic Agents.

    Mintz, Yonatan / Aswani, Anil / Kaminsky, Philip / Flowers, Elena / Fukuoka, Yoshimi

    European journal of operational research

    2023  Volume 310, Issue 2, Page(s) 793–811

    Abstract: Many multi-agent systems have a single coordinator providing incentives to a large number of agents. Two challenges faced by the coordinator are a finite budget from which to allocate incentives, and an initial lack of knowledge about the utility ... ...

    Abstract Many multi-agent systems have a single coordinator providing incentives to a large number of agents. Two challenges faced by the coordinator are a finite budget from which to allocate incentives, and an initial lack of knowledge about the utility function of the agents. Here, we present a behavioral analytics approach for solving the coordinator's problem when the agents make decisions by maximizing utility functions that depend on prior system states, inputs, and other parameters that are initially unknown. Our behavioral analytics framework involves three steps: first, we develop a model that describes the decision-making process of an agent; second, we use data to estimate the model parameters for each agent and predict their future decisions; and third, we use these predictions to optimize a set of incentives that will be provided to each agent. The framework and approaches we propose in this paper can then adapt incentives as new information is collected. Furthermore, we prove that the incentives computed by this approach are asymptotically optimal with respect to a loss function that describes the coordinator's objective. We optimize incentives with a decomposition scheme, where each sub-problem solves the coordinator's problem for a single agent, and the master problem is a pure integer program. We conclude with a simulation study to evaluate the effectiveness of our approach for designing a personalized weight loss program. The results show that our approach maintains efficacy of the program while reducing its costs by up to 60%, while adaptive heuristics provide substantially less savings.
    Language English
    Publishing date 2023-03-31
    Publishing country Netherlands
    Document type Journal Article
    ISSN 0377-2217
    ISSN 0377-2217
    DOI 10.1016/j.ejor.2023.03.034
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  10. Article: Student Reflections on the Paucity of Psychotherapy Education in U.S. Medical Schools.

    Rosewater, Jacob B / Kollipara, Sai A / Mintz, Mika D

    American journal of psychotherapy

    2022  , Page(s) appipsychotherapy20210033

    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2950-6
    ISSN 0002-9564
    ISSN 0002-9564
    DOI 10.1176/appi.psychotherapy.20210033
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