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  1. Article: Lignan-Rich Sesame (

    Kim, Min-Young / Kim, Sungup / Lee, Jeongeun / Kim, Jung-In / Oh, Eunyoung / Kim, Sang-Woo / Lee, Eunsoo / Cho, Kwang-Soo / Kim, Choon-Song / Lee, Myoung-Hee

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 5

    Abstract: ... potential of lignan-rich sesame cultivars. Among the 10 sesame varieties studied, Milyang 74 (M74) extracts ...

    Abstract Alzheimer's disease, a major cause of dementia, is characterized by impaired cholinergic function, increased oxidative stress, and amyloid cascade induction. Sesame lignans have attracted considerable attention owing to their beneficial effects on brain health. This study investigated the neuroprotective potential of lignan-rich sesame cultivars. Among the 10 sesame varieties studied, Milyang 74 (M74) extracts exhibited the highest total lignan content (17.71 mg/g) and in vitro acetylcholinesterase (AChE) inhibitory activity (66.17%, 0.4 mg/mL). M74 extracts were the most effective in improving cell viability and inhibiting reactive oxygen species (ROS) and malondialdehyde (MDA) generation in amyloid-β
    Language English
    Publishing date 2023-05-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12051110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Platelet Rich Plasma (PRP) Treatment in Recalcitrant, Bilateral Phono-traumatic Lesions.

    Woo, Peak / Murry, Thomas

    Journal of voice : official journal of the Voice Foundation

    2024  

    Abstract: ... voice therapy can be challenging. Autologous platelet-rich plasma (PRP) is rich in growth factors and ...

    Abstract Objective: Mature vocal fold nodules and fibrous phono-traumatic lesions that have failed standard voice therapy can be challenging. Autologous platelet-rich plasma (PRP) is rich in growth factors and easily obtained from a simple blood draw. Growth factor injection into the vocal folds may reverse the scar and inflammation in recalcitrant, bilateral phono-traumatic lesions such as mature vocal fold nodules. This study reports the short-term (3months) voice results after PRP injection in 11 subjects with recalcitrant, bilateral phono-traumatic lesions that have failed voice therapy.
    Materials and methods: Serial autologous PRP injections were used to treat 11 patients with recalcitrant, bilateral phono-traumatic lesions in an office setting. All had prior conservative voice therapy or surgery and were deemed failures. Pre and post-treatment video stroboscopy, Voice Handicap Index (VHI-10), and Cepstral Spectral Index of Dysphonia (CSID) before and after treatment (3months) were tabulated and compared. An expert rater blinded to the treatment condition rated the stroboscopy and voice results.
    Results: At 3months postinjection, 9 of the 11 patients reported improved VHI-10 and noted sustained voice improvement after PRP injections. Median VHI-10 changed from 20 to 13 (P < 0.05 paired t test). The CSID scores changed from 17 to 5 (NS P > 0.05, paired t test). Nine of 11 patients reported improved vocal effort and stamina. Stroboscopy ratings were better after treatment than before treatment in 7 of the 11 subjects.
    Conclusion: Short-term improvements in voice may occur in patients with recalcitrant, bilateral phono-traumatic lesions following PRP injection. PRP injections into the vocal folds may be a new treatment for nonsurgical intervention in patients with recalcitrant, bilateral phono-traumatic lesions.
    Level of evidence: II.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 17459-2
    ISSN 1873-4588 ; 1557-8658 ; 0892-1997
    ISSN (online) 1873-4588 ; 1557-8658
    ISSN 0892-1997
    DOI 10.1016/j.jvoice.2024.02.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4034: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Engineering Rich-Cation Vacancies in CuCo

    Reddy, Gutturu Rajasekhara / Sravani, Bathinapatla / Jung, Namgee / Dillip, Gowra Raghupathy / Joo, Sang Woo

    ACS applied materials & interfaces

    2023  Volume 15, Issue 30, Page(s) 36500–36511

    Abstract: Intriguing cationic defects with hollow nano-/microstructures are a critical challenge but a potential strategy to discover electrochemical energy conversion and storage devices with improved electrochemical performances. Herein, we successfully produced ...

    Abstract Intriguing cationic defects with hollow nano-/microstructures are a critical challenge but a potential strategy to discover electrochemical energy conversion and storage devices with improved electrochemical performances. Herein, we successfully produced a highly porous, and large surface area of self-templated CuCo
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c08950
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  4. Article ; Online: Nutraceutical potential of polyphenol-rich

    Seo, Chan / Jeong, Seung Jin / Yun, Hyun Jung / Lee, Hye Ju / Lee, Joo Won / An, Hyun Woo / Han, Nara / Jung, Won-Kyo / Lee, Sang Gil

    Food science and biotechnology

    2022  Volume 31, Issue 8, Page(s) 971–984

    Abstract: Sargassum: Supplementary information: The online version contains supplementary material available at 10.1007/s10068-022-01050-x. ...

    Abstract Sargassum
    Supplementary information: The online version contains supplementary material available at 10.1007/s10068-022-01050-x.
    Language English
    Publishing date 2022-03-19
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2000008-X
    ISSN 2092-6456 ; 1226-7708
    ISSN (online) 2092-6456
    ISSN 1226-7708
    DOI 10.1007/s10068-022-01050-x
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    In stock of ZB MED Bonn / Germany

    Z 7438: Show issues

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  5. Article: Platelet-rich plasma in treatment of scar, atrophy, and sulcus: Short- and long-term results.

    Woo, Peak

    Laryngoscope investigative otolaryngology

    2023  Volume 8, Issue 5, Page(s) 1304–1311

    Abstract: Objective: Platelet-rich plasma (PRP) is rich in growth factors and is easily obtained ...

    Abstract Objective: Platelet-rich plasma (PRP) is rich in growth factors and is easily obtained from blood samples. Long-term data after PRP injection into the larynx should be improved. This study reports the short-term (3 months) and long-term (12 months) voice results after PRP injection.
    Materials and methods: Sixty-three patients with scars (
    Results: VHI-10 changed from 19.5 to 14 at 3 months and 21 to 15 in the long term. The CSID scores improved from 31 to 21 in the short term and 31 to 26 in the long term (
    Conclusion: Both short- and long-term improvements in voice following PRP injection have been reported. Patients with mild-to-moderate dysphonia had better outcomes. PRP injection is an alternative treatment for patients with mild-to-moderate dysphonia due to vocal fold scarring, sulcus, and atrophy.
    Level of evidence: II Prospective case series treatment.
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Journal Article
    ISSN 2378-8038
    ISSN 2378-8038
    DOI 10.1002/lio2.1143
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  6. Article ; Online: Colloidal Synthesis of Ultrathin and Se-Rich V

    Oh, Seungbae / Woo, Chaeheon / Ahn, Jungyoon / Kim, Tae Yeong / Dong, Xue / Kim, Yeongjin / Choi, Kyung Hwan / Chae, Sudong / Zhang, Xiaojie / Bang, Hyeon-Seok / Kang, Jinsu / Jeon, Jiho / Oh, Hyung-Suk / Yoon, Won-Sub / Yu, Hak Ki / Choi, Jae-Young

    ACS applied materials & interfaces

    2023  Volume 15, Issue 48, Page(s) 55745–55752

    Abstract: In this study, the one-dimensional (1D) material ... ...

    Abstract In this study, the one-dimensional (1D) material V
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c12430
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  7. Article ; Online: Upregulation of epithelial metallothioneins by metal-rich ultrafine particulate matter from an underground railway.

    Loxham, Matthew / Woo, Jeongmin / Singhania, Akul / Smithers, Natalie P / Yeomans, Alison / Packham, Graham / Crainic, Alina M / Cook, Richard B / Cassee, Flemming R / Woelk, Christopher H / Davies, Donna E

    Metallomics : integrated biometal science

    2020  Volume 12, Issue 7, Page(s) 1070–1082

    Abstract: ... in underground railways is rich in metals, especially iron. In the ultrafine (UFPM; <0.1 μm diameter) fraction ... or ROS scavenging. These data suggest differential regulation of responses to metal-rich UFPM ...

    Abstract Airborne particulate matter (PM) is a leading cause of mortality and morbidity. However, understanding of the range and mechanisms of effects of PM components is poor. PM generated in underground railways is rich in metals, especially iron. In the ultrafine (UFPM; <0.1 μm diameter) fraction, the combination of small size and metal enrichment poses an unknown health risk. This study aimed to analyse transcriptomic responses to underground UFPM in primary bronchial epithelial cells (PBECs), a key site of PM deposition. The oxidation state of iron in UFPM from an underground station was determined by X-ray absorption near edge structure (XANES) spectroscopy. Antioxidant response was assayed using a reporter cell line transfected with an antioxidant response element (ARE)-luciferase construct. Differentiated PBECs were exposed to UFPM for 6 h or 24 h for RNA-Seq and RT-qPCR analysis. XANES showed predominance of redox-active Fe3O4, with ROS generation confirmed by induction of ARE-luciferase expression. 6 h exposure of PBECs to UFPM identified 52 differentially expressed genes (DEGs), especially associated with epithelial maintenance, whereas 24 h exposure yielded 23 DEGs, particularly involved with redox homeostasis and metal binding. At both timepoints, there was upregulation of members of the metallothionein family, low molecular weight proteins with antioxidant activity whose main function is binding and homeostasis of zinc and copper ions, but not iron ions. This upregulation was partially inhibited by metal chelation or ROS scavenging. These data suggest differential regulation of responses to metal-rich UFPM depending on exposure period, and highlight novel pathways and markers of PM exposure, with the role of metallothioneins warranting further investigation.
    MeSH term(s) Antioxidants/chemistry ; Antioxidants/metabolism ; Copper/metabolism ; Metallothionein/chemistry ; Metallothionein/metabolism ; Oxidation-Reduction ; Particulate Matter/chemistry ; Reactive Oxygen Species/metabolism ; X-Ray Absorption Spectroscopy ; Zinc/metabolism
    Chemical Substances Antioxidants ; Particulate Matter ; Reactive Oxygen Species ; Copper (789U1901C5) ; Metallothionein (9038-94-2) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2020-04-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2474317-3
    ISSN 1756-591X ; 1756-5901
    ISSN (online) 1756-591X
    ISSN 1756-5901
    DOI 10.1039/d0mt00014k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Surface modification of Ni-rich LiNi

    Kim, Hong Ki / Kang, Hyeong Seop / Santhoshkumar, P / Park, Jae Woo / Ho, Chang Won / Sim, Gyu Sang / Lee, Chang Woo

    RSC advances

    2021  Volume 11, Issue 35, Page(s) 21685–21694

    Abstract: Ni-rich LiNi ...

    Abstract Ni-rich LiNi
    Language English
    Publishing date 2021-06-18
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d1ra00857a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Case of Neutrophil-Rich Anaplastic Large-Cell Lymphoma with Relapse.

    Seol, Jung Eun / Hong, Seong Min / Ahn, Sang Woo / Kim, Jong Uk / Cho, Gyeong Je / Jin, Woo Jung / Park, So Hee / Kim, Hyojin

    Annals of dermatology

    2023  Volume 35, Issue Suppl 1, Page(s) S76–S78

    Abstract: ... rich ALCL. A 63-year-old male patient presented with erythematous exophytic mass on the left lower leg ... and a few lymphocytes. Neutrophil-rich ALCL is a rare histological variant of ALCL. It is ... Neutrophil-rich ALCL responds well to treatment but tends to recur. There were four cases reported to have ...

    Abstract After anaplastic large-cell lymphoma (ALCL) was first described by Stain in 1985, there have been several histological variants of ALCL reported. There are classified histological subtypes of ALCL, such as lymphohistiocytic, small cell, Hodgkin-like, composite pattern, and other less common variants including neutrophil-rich ALCL. A 63-year-old male patient presented with erythematous exophytic mass on the left lower leg. In the past, his condition had been diagnosed as abdominal primary cutaneous ALCL (pcALCL), which recurred as systemic ALCL (sALCL) in the left bronchus. After treatment, he achieved complete remission. Histopathologic examination showed large-sized pleomorphic, anaplastic mitotic tumor cells, several neutrophils, and a few lymphocytes. Neutrophil-rich ALCL is a rare histological variant of ALCL. It is characterized by the presence of CD30-positive anaplastic tumor cells with numerous neutrophil infiltrations. Neutrophil-rich ALCL responds well to treatment but tends to recur. There were four cases reported to have recurrent neutrophil-rich ALCL. All cases were diagnosed with neutrophil-rich pcALCL prior to recurrence. Three cases had local recurrence, and only one case relapsed as sALCL. Herein, we present the first case of neutrophil-rich ALCL recurring as sALCL twice.
    Language English
    Publishing date 2023-10-28
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 1012662-4
    ISSN 2005-3894 ; 1013-9087
    ISSN (online) 2005-3894
    ISSN 1013-9087
    DOI 10.5021/ad.21a.028
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2800: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Noncanonical usage of stop codons in ciliates expands proteins with structurally flexible Q-rich motifs.

    Chuang, Chi-Ning / Liu, Hou-Cheng / Woo, Tai-Ting / Chao, Ju-Lan / Chen, Chiung-Ya / Hu, Hisao-Tang / Hsueh, Yi-Ping / Wang, Ting-Fang

    eLife

    2024  Volume 12

    Abstract: ... polyglutamine/asparagine (polyQ/N) tracts are Q-rich motifs found in many proteins. SCDs often are intrinsically ... to their high percentages of STQ or STQN amino acid content, four SCDs and three prion-causing Q/N-rich motifs ... of yeast proteins possess autonomous protein expression-enhancing activities. Since these Q-rich motifs ...

    Abstract Serine(S)/threonine(T)-glutamine(Q) cluster domains (SCDs), polyglutamine (polyQ) tracts and polyglutamine/asparagine (polyQ/N) tracts are Q-rich motifs found in many proteins. SCDs often are intrinsically disordered regions that mediate protein phosphorylation and protein-protein interactions. PolyQ and polyQ/N tracts are structurally flexible sequences that trigger protein aggregation. We report that due to their high percentages of STQ or STQN amino acid content, four SCDs and three prion-causing Q/N-rich motifs of yeast proteins possess autonomous protein expression-enhancing activities. Since these Q-rich motifs can endow proteins with structural and functional plasticity, we suggest that they represent useful toolkits for evolutionary novelty. Comparative Gene Ontology (GO) analyses of the near-complete proteomes of 26 representative model eukaryotes reveal that Q-rich motifs prevail in proteins involved in specialized biological processes, including
    MeSH term(s) Animals ; Mice ; Codon, Terminator/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Dictyostelium/genetics ; Fungal Proteins/metabolism ; Glutamine/metabolism
    Chemical Substances Codon, Terminator ; Fungal Proteins ; Glutamine (0RH81L854J)
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.91405
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