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  1. Article ; Online: Assessment of Platelet Function by High-Throughput Screening Light Transmission Aggregometry: Optimul Assay.

    Chan, Melissa V / Lordkipanidzé, Marie / Warner, Timothy D

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2663, Page(s) 627–636

    Abstract: Platelet function testing is critical in the diagnosis of bleeding disorders and allows monitoring of antiplatelet therapy. The gold standard assay, light transmission aggregometry (LTA), was developed 60 years ago and remains widely used worldwide. It ... ...

    Abstract Platelet function testing is critical in the diagnosis of bleeding disorders and allows monitoring of antiplatelet therapy. The gold standard assay, light transmission aggregometry (LTA), was developed 60 years ago and remains widely used worldwide. It requires, however, access to expensive equipment and is time-consuming, and the interpretation of results requires evaluation by an experienced investigator. It also suffers from a lack of standardization, resulting in widely variable results between laboratories. 96-well plate-based Optimul aggregometry utilizes the same principles of LTA and aims to standardize agonist concentrations with the development of 96-well plates which are precoated with 7 concentrations of each lyophilized agonist (arachidonic acid, adenosine diphosphate, collagen, epinephrine, TRAP-6 amide, and U46619) and stored at ambient room temperature (20-25 °C) for up to 12 weeks. For platelet function testing, 40 μL of platelet-rich plasma is added to each well, and the plate is placed onto a plate shaker, after which platelet aggregation is determined by changes in light absorbance. This method reduces the blood volume required and allows for in-depth platelet function analysis without specialist training, or the need to purchase expensive, dedicated equipment.
    MeSH term(s) Humans ; High-Throughput Screening Assays ; Platelet Aggregation ; Platelet Function Tests/methods ; Platelet Aggregation Inhibitors/pharmacology ; Blood Coagulation Disorders ; Blood Platelets
    Chemical Substances Platelet Aggregation Inhibitors
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3175-1_41
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  2. Article: Modelling climate variabilities and global rice production: A panel regression and time series analysis.

    Joseph, Masha / Moonsammy, Stephan / Davis, Harold / Warner, Devin / Adams, Ashley / Timothy Oyedotun, Temitope D

    Heliyon

    2023  Volume 9, Issue 4, Page(s) e15480

    Abstract: Climate change threatens agriculture and it remains a present global challenge to food security and Sustainable Development Goals. The potential impact on the supply of crops such as rice is seen as a major food security issue that requires intervention ... ...

    Abstract Climate change threatens agriculture and it remains a present global challenge to food security and Sustainable Development Goals. The potential impact on the supply of crops such as rice is seen as a major food security issue that requires intervention on several fronts. The literature on rice production, climate variations and climate change show several studies outlining various impacts on rice supply as a result of variations in temperature and rainfall. This study intends to further explore the impacts on rice production caused by temperature changes and rainfall variation by analyzing and modelling the production of rice by the top rice-producing countries globally. A time series of the national rice production and yield along with national average annual temperature and rainfall were sourced for 15 major rice-producing countries. The trends of the time series were then compared between the rice productivity variables and temperature and rainfall. A panel regression model was also developed to further assess the relationship between rice production and temperature and rainfall. The time series showed that rice production and yield are increasing for the majority of the countries analyzed. The panel regression model however showed that continued increase in temperature can result in decreased production of rice and that rainfall volume directly impacts rice output and therefore shows rice production is highly susceptible to flooding and drought events caused by climate variabilities.
    Language English
    Publishing date 2023-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15480
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  3. Article ; Online: What can we learn from senescent platelets, their transcriptomes and proteomes?

    Allan, Harriet E / Vadgama, Ami / Armstrong, Paul C / Warner, Timothy D

    Platelets

    2023  Volume 34, Issue 1, Page(s) 2200838

    Abstract: Research into the natural aging process of platelets has garnered much research interest in recent years, and there have long been associations drawn between the proportion of newly formed platelets in the circulation and the risk of thrombosis. However, ...

    Abstract Research into the natural aging process of platelets has garnered much research interest in recent years, and there have long been associations drawn between the proportion of newly formed platelets in the circulation and the risk of thrombosis. However, these observations have largely been demonstrated in patient groups in which there may be underlying systemic changes that effect platelet function. Recent advances in technology have allowed in-depth analysis of differently aged platelets isolated from the peripheral blood of healthy individuals and have demonstrated that aged platelets, often referred to as senescent platelets, undergo extensive changes in the transcriptome and proteome. Ultimately, these changes result in platelets whose functions have deteriorated such that they cannot partake in hemostatic responses to the same extent as newly formed platelets. Here, we review transcriptomic and proteomic research in platelet aging in the context of health and how this research sheds light upon alterations in platelet structure and function.
    MeSH term(s) Humans ; Aged ; Transcriptome ; Proteome ; Proteomics ; Blood Platelets/physiology ; Aging/genetics
    Chemical Substances Proteome
    Language English
    Publishing date 2023-04-18
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2023.2200838
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    Zs.A 2888: Show issues Location:
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  4. Book: Endothelin and its inhibitors

    Battistini, Bruno / Warner, Timothy D.

    (Handbook of experimental pharmacology ; 152)

    2001  

    Author's details contributors B. Battistini ... Ed. Timothy D. Warner
    Series title Handbook of experimental pharmacology ; 152
    Collection
    Keywords Endothelins ; Receptors, Endothelin / antagonists & inhibitors ; Receptors, Endothelin / physiology ; Endothelin ; Pharmakologischer Antagonist ; Rezeptor
    Language English
    Size XXIV, 532 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT012993106
    ISBN 3-540-67985-5 ; 978-3-540-67985-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  5. Article ; Online: Platelet ageing: A review.

    Allan, Harriet E / Vadgama, Ami / Armstrong, Paul C / Warner, Timothy D

    Thrombosis research

    2022  Volume 231, Page(s) 214–222

    Abstract: Platelet ageing is an area of research which has gained much interest in recent years. Newly formed platelets, often referred to as reticulated platelets, young platelets or immature platelets, are defined as RNA-enriched and have long been thought to be ...

    Abstract Platelet ageing is an area of research which has gained much interest in recent years. Newly formed platelets, often referred to as reticulated platelets, young platelets or immature platelets, are defined as RNA-enriched and have long been thought to be hyper-reactive. This latter view is largely rooted in associations and observations in patient groups with shortened platelet half-lives who often present with increased proportions of newly formed platelets. Evidence from such groups suggests that an increased proportion of newly formed platelets is associated with an increased risk of thrombotic events and a reduced effectiveness of standard anti-platelet therapies. Whilst research has highlighted the existence of platelet subpopulations based on function, size and age within patient groups, the common intrinsic changes which occur as platelets age within the circulation are only just being explored. By understanding the changes that occur during the natural ageing processes of platelets, we may be able to identify the triggers for alterations in platelet life span and platelet reactivity. Here we review research on platelet ageing in the context of health and disease, paying particular attention to the experimental approaches taken and the robustness of conclusions that can be drawn.
    MeSH term(s) Humans ; Blood Platelets ; Aging
    Language English
    Publishing date 2022-12-16
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2022.12.004
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  6. Article ; Online: Modelling climate variabilities and global rice production

    Masha Joseph / Stephan Moonsammy / Harold Davis / Devin Warner / Ashley Adams / Temitope D. Timothy Oyedotun

    Heliyon, Vol 9, Iss 4, Pp e15480- (2023)

    A panel regression and time series analysis

    2023  

    Abstract: Climate change threatens agriculture and it remains a present global challenge to food security and Sustainable Development Goals. The potential impact on the supply of crops such as rice is seen as a major food security issue that requires intervention ... ...

    Abstract Climate change threatens agriculture and it remains a present global challenge to food security and Sustainable Development Goals. The potential impact on the supply of crops such as rice is seen as a major food security issue that requires intervention on several fronts. The literature on rice production, climate variations and climate change show several studies outlining various impacts on rice supply as a result of variations in temperature and rainfall. This study intends to further explore the impacts on rice production caused by temperature changes and rainfall variation by analyzing and modelling the production of rice by the top rice-producing countries globally. A time series of the national rice production and yield along with national average annual temperature and rainfall were sourced for 15 major rice-producing countries. The trends of the time series were then compared between the rice productivity variables and temperature and rainfall. A panel regression model was also developed to further assess the relationship between rice production and temperature and rainfall. The time series showed that rice production and yield are increasing for the majority of the countries analyzed. The panel regression model however showed that continued increase in temperature can result in decreased production of rice and that rainfall volume directly impacts rice output and therefore shows rice production is highly susceptible to flooding and drought events caused by climate variabilities.
    Keywords Climate variability ; Precipitation ; Rice production ; Temperature ; Trend analysis ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Anti-platelet drugs and their necessary interaction with endothelial mediators and platelet cyclic nucleotides for therapeutic efficacy.

    Knowles, Rebecca B / Warner, Timothy D

    Pharmacology & therapeutics

    2018  Volume 193, Page(s) 83–90

    Abstract: For many millions of patients at secondary risk of coronary thrombosis pharmaceutical protection is supplied by dual anti-platelet therapy. Despite substantial therapeutic developments over the last decade recurrent thrombotic events occur, highlighting ... ...

    Abstract For many millions of patients at secondary risk of coronary thrombosis pharmaceutical protection is supplied by dual anti-platelet therapy. Despite substantial therapeutic developments over the last decade recurrent thrombotic events occur, highlighting the need for further optimisation of therapies. Importantly, but often ignored, anti-platelet drugs interact with cyclic nucleotide systems in platelets and these are the same systems that mediate key endogenous pathways of platelet regulation, notably those dependent upon the vascular endothelium. The aim of this review is to highlight interactions between the anti-platelet drugs, aspirin and P2Y
    MeSH term(s) Animals ; Aspirin/pharmacology ; Blood Platelets/drug effects ; Blood Platelets/metabolism ; Endothelium, Vascular/drug effects ; Humans ; Nucleotides, Cyclic/metabolism ; Platelet Aggregation Inhibitors/pharmacology ; Purinergic P2Y Receptor Antagonists/pharmacology
    Chemical Substances Nucleotides, Cyclic ; Platelet Aggregation Inhibitors ; Purinergic P2Y Receptor Antagonists ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2018-08-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2018.08.004
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    Zs.A 1183: Show issues Location:
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  8. Article ; Online: Modelling climate variabilities and global rice production: A panel regression and time series analysis

    Joseph, Masha / Moonsammy, Stephan / Davis, Harold / Warner, Devin / Adams, Ashley / Timothy Oyedotun, Temitope D.

    Heliyon. 2023 Apr., v. 9, no. 4 p.e15480-

    2023  

    Abstract: Climate change threatens agriculture and it remains a present global challenge to food security and Sustainable Development Goals. The potential impact on the supply of crops such as rice is seen as a major food security issue that requires intervention ... ...

    Abstract Climate change threatens agriculture and it remains a present global challenge to food security and Sustainable Development Goals. The potential impact on the supply of crops such as rice is seen as a major food security issue that requires intervention on several fronts. The literature on rice production, climate variations and climate change show several studies outlining various impacts on rice supply as a result of variations in temperature and rainfall. This study intends to further explore the impacts on rice production caused by temperature changes and rainfall variation by analyzing and modelling the production of rice by the top rice-producing countries globally. A time series of the national rice production and yield along with national average annual temperature and rainfall were sourced for 15 major rice-producing countries. The trends of the time series were then compared between the rice productivity variables and temperature and rainfall. A panel regression model was also developed to further assess the relationship between rice production and temperature and rainfall. The time series showed that rice production and yield are increasing for the majority of the countries analyzed. The panel regression model however showed that continued increase in temperature can result in decreased production of rice and that rainfall volume directly impacts rice output and therefore shows rice production is highly susceptible to flooding and drought events caused by climate variabilities.
    Keywords climate ; climate change ; drought ; food security ; rain ; regression analysis ; rice ; sustainable development ; temperature ; time series analysis ; Climate variability ; Precipitation ; Rice production ; Trend analysis
    Language English
    Dates of publication 2023-04
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15480
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: A Review of Prevalence Estimation Methods for Human Trafficking Populations.

    Schroeder, Elyssa / Edgemon, Timothy G / Aletraris, Lydia / Kagotho, Njeri / Clay-Warner, Jody / Okech, David

    Public health reports (Washington, D.C. : 1974)

    2022  Volume 137, Issue 1_suppl, Page(s) 46S–52S

    Abstract: Human trafficking has long-lasting implications for the well-being of trafficked people, families, and affected communities. Prevention and intervention efforts, however, have been stymied by a lack of information on the scale and scope of the problem. ... ...

    Abstract Human trafficking has long-lasting implications for the well-being of trafficked people, families, and affected communities. Prevention and intervention efforts, however, have been stymied by a lack of information on the scale and scope of the problem. Because trafficked people are mostly hidden from view, traditional methods of establishing prevalence can be prohibitively expensive in the recruitment, participation, and retention of survey participants. Also, trafficked people are not randomly distributed in the general population. Researchers have therefore begun to apply methods previously used in public health research and other fields on hard-to-reach populations to measure the prevalence of human trafficking. In this topical review, we examine how these prevalence methods used for hard-to-reach populations can be used to measure the prevalence of human trafficking. These methods include network-based approaches, such as respondent-driven sampling and the network scale-up method, and venue-based methods. Respondent-driven sampling is useful, for example, when little information about the trafficked population has been produced and when an adequate sampling frame does not exist. The network scale-up method is unique in that it does not target the hidden population directly. The implications of our work internationally include the need for documenting and validating the various prevalence estimation methods in the United States in a more robust way than was done in existing efforts. In providing this roadmap for estimating the prevalence of human trafficking, our overarching goal is to promote the equitable treatment and overall well-being of the socially disadvantaged populations who disproportionately experience human trafficking.
    MeSH term(s) HIV Infections/epidemiology ; Human Trafficking ; Humans ; Prevalence ; Public Health ; Research Design ; United States/epidemiology
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120953-x
    ISSN 1468-2877 ; 0033-3549
    ISSN (online) 1468-2877
    ISSN 0033-3549
    DOI 10.1177/00333549211044010
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  10. Article ; Online: Using mobile technology to influence alcohol-impaired driving risk perceptions and decisions.

    Haney, Alison M / Warner, Olivia M / McMullin, Sara D / Motschman, Courtney A / Trull, Timothy J / McCarthy, Denis M

    Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors

    2023  Volume 38, Issue 1, Page(s) 47–55

    Abstract: Objective: Despite significant individual and societal risk, alcohol-impaired driving (AID) remains prevalent in the United States. Our aim was to determine whether breathalyzer-cued warning messages administered via mobile devices in the natural ... ...

    Abstract Objective: Despite significant individual and societal risk, alcohol-impaired driving (AID) remains prevalent in the United States. Our aim was to determine whether breathalyzer-cued warning messages administered via mobile devices in the natural drinking environment could influence real-world AID cognitions and behaviors.
    Method: One hundred twenty young adults (53% women; mean age = 24.7) completed 6 weeks of ecological momentary assessment (EMA) and provided breathalyzer samples using a BACtrack Mobile Pro linked to their mobile device. On mornings after drinking episodes, participants reported their driving activities from the previous evening (787 episodes). Participants were randomly assigned to receive warning messages if they reached a breath alcohol concentration (BrAC) ≥ .05, or no messages. Participants in the warnings condition reported their willingness to drive and perceived danger of driving at EMA prompts (1,541 reports).
    Results: We observed a significant effect of condition, such that the association between cumulative AID engagement and driving after reaching a BrAC of .05 was dampened among individuals in the warnings condition, compared to those in the no warnings condition. Receiving a warning message was associated with increased momentary perceived danger of driving and decreased willingness to drive.
    Conclusions: We found that BrAC-cued warning messages reduced the probability of AID and willingness to drive while impaired, and increased the perceived danger of driving after drinking. These results serve as proof-of-concept for the use of mobile technology to deliver an adaptive just-in-time intervention to reduce the probability of AID. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
    MeSH term(s) Young Adult ; Humans ; Female ; Adult ; Male ; Alcohol Drinking ; Driving Under the Influence ; Cues ; Computers, Handheld ; Breath Tests/methods ; Automobile Driving
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2101111-4
    ISSN 1939-1501 ; 0893-164X
    ISSN (online) 1939-1501
    ISSN 0893-164X
    DOI 10.1037/adb0000929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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