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  1. Article ; Online: Editorial overview: Introduction to neurobiology of disease.

    Musiek, Erik S / Nestler, Eric J

    Current opinion in neurobiology

    2024  Volume 86, Page(s) 102875

    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Editorial
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2024.102875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3260: Show issues Location:
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  2. Article ; Online: Circadian fragmentation: a harbinger of Alzheimer's disease?

    Musiek, Erik S

    The Lancet. Healthy longevity

    2020  Volume 1, Issue 3, Page(s) e90–e91

    Language English
    Publishing date 2020-11-12
    Publishing country England
    Document type Journal Article
    ISSN 2666-7568
    ISSN (online) 2666-7568
    DOI 10.1016/S2666-7568(20)30021-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Lecanamab Ushers in a New Era of Anti-Amyloid Therapy for Alzheimer's Disease.

    Musiek, Erik S / McDade, Eric / Holtzman, David M

    Annals of neurology

    2023  Volume 93, Issue 5, Page(s) 877–880

    MeSH term(s) Humans ; Alzheimer Disease/therapy ; Amyloid beta-Peptides ; Amyloid
    Chemical Substances Amyloid beta-Peptides ; Amyloid
    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.26643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1370: Show issues Location:
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    Zs.MO 478: Show issues

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  4. Article ; Online: Longer Sleep Duration in Alzheimer's Disease Progression: A Compensatory Response?

    Li, Peng / Gao, Lei / Lucey, Brendan P / Ju, Yo-El S / Musiek, Erik S / Hu, Kun

    Sleep

    2024  

    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsae093
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    Zs.A 1475: Show issues Location:
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  5. Article ; Online: Time-restricted feeding and Alzheimer's disease: you are when you eat.

    King, Melvin W / Chen, Yining / Musiek, Erik S

    Trends in molecular medicine

    2023  Volume 29, Issue 12, Page(s) 974–975

    Abstract: Time-restricted feeding (TRF) has emerged as a means of synchronizing circadian rhythms, which are commonly disrupted in Alzheimer's disease (AD). Whittaker et al. demonstrate that TRF exerts protective effects in two mouse models of AD. We discuss the ... ...

    Abstract Time-restricted feeding (TRF) has emerged as a means of synchronizing circadian rhythms, which are commonly disrupted in Alzheimer's disease (AD). Whittaker et al. demonstrate that TRF exerts protective effects in two mouse models of AD. We discuss the effects of TRF on brain health and mechanisms linking TRF to neurodegeneration.
    MeSH term(s) Mice ; Animals ; Humans ; Alzheimer Disease/etiology ; Circadian Rhythm ; Disease Models, Animal ; Intermittent Fasting
    Language English
    Publishing date 2023-10-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2023.10.004
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    Zs.A 4345: Show issues Location:
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  6. Article ; Online: Aducanumab and the "post-amyloid" era of Alzheimer research?

    Musiek, Erik S / Bennett, David A

    Neuron

    2021  Volume 109, Issue 19, Page(s) 3045–3047

    MeSH term(s) Aged ; Aged, 80 and over ; Alzheimer Disease/drug therapy ; Amyloid ; Antibodies, Monoclonal, Humanized/therapeutic use ; Device Approval ; History, 19th Century ; History, 20th Century ; Humans ; Immunotherapy ; Middle Aged ; Plaque, Amyloid
    Chemical Substances Amyloid ; Antibodies, Monoclonal, Humanized ; aducanumab (105J35OE21)
    Language English
    Publishing date 2021-09-27
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2021.09.007
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    Zs.MG 92: Show issues

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  7. Article ; Online: Targeting Sleep and Circadian Function in the Prevention of Alzheimer Disease.

    Musiek, Erik S / Ju, Yo-El S

    JAMA neurology

    2022  Volume 79, Issue 9, Page(s) 835–836

    MeSH term(s) Alzheimer Disease/prevention & control ; Circadian Rhythm ; Humans ; Sleep ; Sleep Wake Disorders/prevention & control
    Language English
    Publishing date 2022-08-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2022.1732
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    Ui II Zs.191: Show issues Location:
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  8. Article ; Online: Circadian Biology and the Neurovascular Unit.

    Li, Wenlu / Tiedt, Steffen / Lawrence, Jennifer H / Harrington, Mary E / Musiek, Erik S / Lo, Eng H

    Circulation research

    2024  Volume 134, Issue 6, Page(s) 748–769

    Abstract: Mammalian physiology and cellular function are subject to significant oscillations over the course of every 24-hour day. It is likely that these daily rhythms will affect function as well as mechanisms of disease in the central nervous system. In this ... ...

    Abstract Mammalian physiology and cellular function are subject to significant oscillations over the course of every 24-hour day. It is likely that these daily rhythms will affect function as well as mechanisms of disease in the central nervous system. In this review, we attempt to survey and synthesize emerging studies that investigate how circadian biology may influence the neurovascular unit. We examine how circadian clocks may operate in neural, glial, and vascular compartments, review how circadian mechanisms regulate cell-cell signaling, assess interactions with aging and vascular comorbidities, and finally ask whether and how circadian effects and disruptions in rhythms may influence the risk and progression of pathophysiology in cerebrovascular disease. Overcoming identified challenges and leveraging opportunities for future research might support the development of novel circadian-based treatments for stroke.
    MeSH term(s) Animals ; Aging/physiology ; Circadian Clocks ; Circadian Rhythm ; Mammals
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.124.323514
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  9. Article ; Online: Circadian fragmentation

    Erik S Musiek

    The Lancet. Healthy Longevity, Vol 1, Iss 3, Pp e90-e

    a harbinger of Alzheimer's disease?

    2020  Volume 91

    Keywords Geriatrics ; RC952-954.6 ; Medicine ; R
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown.

    Lawrence, Jennifer H / Patel, Asha / King, Melvin W / Nadarajah, Collin J / Daneman, Richard / Musiek, Erik S

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The blood-brain barrier (BBB) is critical for maintaining brain homeostasis but is susceptible to inflammatory dysfunction. Permeability of the BBB to lipophilic molecules shows circadian variation due to rhythmic transporter expression, while basal ... ...

    Abstract The blood-brain barrier (BBB) is critical for maintaining brain homeostasis but is susceptible to inflammatory dysfunction. Permeability of the BBB to lipophilic molecules shows circadian variation due to rhythmic transporter expression, while basal permeability to polar molecules is non-rhythmic. Whether daily timing influences BBB permeability in response to inflammation is unknown. Here, we induced systemic inflammation through repeated lipopolysaccharide (LPS) injections either in the morning (ZT1) or evening (ZT13) under standard lighting conditions, then examined BBB permeability to a polar molecule, sodium fluorescein. We observed clear diurnal variation in inflammatory BBB permeability, with a striking increase in paracellular leak across the BBB specifically following evening LPS injection. Evening LPS led to persisting glia activation and inflammation in the brain that was not observed in the periphery. The exaggerated evening neuroinflammation and BBB disruption were suppressed by microglial depletion or through keeping mice in constant darkness. Our data show that diurnal rhythms in microglial inflammatory responses to LPS drive daily variability in BBB breakdown and reveals time-of-day as a key regulator of inflammatory BBB disruption.
    Language English
    Publishing date 2024-04-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.10.588924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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