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  1. Article ; Online: The multiple sclerosis prodrome is just unspecific symptoms in radiologically isolated syndrome patients - Commentary.

    Makhani, Naila

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2021  Volume 27, Issue 12, Page(s) 1827–1828

    MeSH term(s) Demyelinating Diseases/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Multiple Sclerosis/diagnostic imaging
    Language English
    Publishing date 2021-09-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585211044951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4428: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Treatment Considerations in the Radiologically Isolated Syndrome.

    Makhani, Naila

    Current treatment options in neurology

    2020  Volume 22, Issue 1, Page(s) 3

    Abstract: Purpose of review: This review provides the reader with updated information needed to make an accurate diagnosis of radiologically isolated syndrome (RIS), discusses controversies and considerations related to therapeutic intervention in RIS, and ... ...

    Abstract Purpose of review: This review provides the reader with updated information needed to make an accurate diagnosis of radiologically isolated syndrome (RIS), discusses controversies and considerations related to therapeutic intervention in RIS, and summarizes ongoing clinical intervention trials.
    Recent findings: Individuals with RIS lack clinical neurological symptoms but are at risk for the subsequent development of a first clinical neurological event consistent with a diagnosis of multiple sclerosis. There are two ongoing clinical intervention trials to determine whether disease-modifying treatments for multiple sclerosis can delay or prevent a first clinical event in individuals with RIS. If clinical trials demonstrate a beneficial effect of disease-modifying therapy, such interventions should be considered in individuals with RIS.
    Language English
    Publishing date 2020-02-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057342-X
    ISSN 1534-3138 ; 1092-8480
    ISSN (online) 1534-3138
    ISSN 1092-8480
    DOI 10.1007/s11940-020-0608-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5535: Show issues Location:
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  3. Article ; Online: Radiologically Isolated Syndrome and the Multiple Sclerosis Prodrome in Pediatrics: Early Features of the Spectrum of Demyelination.

    Bower, Aaron / Makhani, Naila

    Seminars in pediatric neurology

    2023  Volume 46, Page(s) 101053

    Abstract: Radiologically isolated syndrome refers to the clinical scenario in which individuals have imaging concerning for multiple sclerosis and would otherwise satisfy radiographic dissemination in space criteria, but do not have any attributable signs or ... ...

    Abstract Radiologically isolated syndrome refers to the clinical scenario in which individuals have imaging concerning for multiple sclerosis and would otherwise satisfy radiographic dissemination in space criteria, but do not have any attributable signs or symptoms. Radiologically isolated syndrome has been increasingly recognized in the pediatric population and it is understood certain individuals will transition to a formal diagnosis of multiple sclerosis over time. This review aims to outline the available data within this unique population including the diagnostic criteria, epidemiology, risk factors associated with transitioning to multiple sclerosis, and the current therapeutic landscape. Radiologically isolated syndrome will also be positioned within a broader spectrum of demyelinating disease as recent data has pointed towards a likely prodromal phase that precedes a first clinical event and diagnosis of multiple sclerosis. Characterizing the radiographic features, clinical symptoms, and biomarkers that constitute this prodromal phase of multiple sclerosis would help identify patients who may most benefit from early intervention in the future.
    MeSH term(s) Humans ; Child ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/epidemiology ; Magnetic Resonance Imaging/methods ; Demyelinating Diseases/diagnostic imaging ; Biomarkers ; Pediatrics
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1290000-x
    ISSN 1558-0776 ; 1071-9091
    ISSN (online) 1558-0776
    ISSN 1071-9091
    DOI 10.1016/j.spen.2023.101053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4772: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The Radiologically Isolated Syndrome: An Opportunity to Prevent Multiple Sclerosis in Children.

    Makhani, Naila

    Pediatric neurology

    2018  Volume 85, Page(s) 13–15

    MeSH term(s) Brain/diagnostic imaging ; Child ; Early Diagnosis ; Humans ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/prevention & control
    Language English
    Publishing date 2018-06-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2018.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Comparing Common Risk Assessment Tools to Predict Outcomes in Total Knee Arthroplasty.

    Kotzur, Travis M / Singh, Aaron / Peng, Lindsey N / Makhani, Ahmed A / Seifi, Ali / Moore, Chance C

    The Journal of arthroplasty

    2024  

    Abstract: Background: A number of tools exist to aid surgeons in risk assessment, including the Charlson Comorbidity Index (CCI), the Elixhauser Comorbidity Index (ECI), and various measures of frailty, such as the Hospital Frailty Risk Score (HFR). While all of ... ...

    Abstract Background: A number of tools exist to aid surgeons in risk assessment, including the Charlson Comorbidity Index (CCI), the Elixhauser Comorbidity Index (ECI), and various measures of frailty, such as the Hospital Frailty Risk Score (HFR). While all of these tools have been validated for general use, the best risk assessment tool is still debated. Risk assessment is particularly important in elective surgery, such as total joint arthroplasty. The aim of this study is to compare the predictive power of the CCI, ECI, and HFR in the setting of total knee arthroplasty (TKA).
    Methods: All patients who underwent TKA were identified via International Statistical Classification of Diseases and Related Health Problems, Tenth Revision code from the National Readmissions Database, years 2016 to 2019. Patient demographics, perioperative complications, and hospital-associated outcomes were recorded. Receiver operating characteristic (ROC) curves were created and area under the curves (AUCs) evaluated to gauge the predictive capabilities of each risk assessment tool (CCI, ECI, and HFR) across a range of outcomes.
    Results: A total of 1,930,803 patients undergoing TKA were included in our analysis. For mortality, ECI was most predictive (0.95 AUC), while HFR and CCI were 0.75 and 0.74 AUC, respectively. For periprosthetic fractures, ECI was 0.78 AUC, HFR was 0.68 AUC, and CCI was 0.66 AUC. For joint infections, the ECI was 0.78 AUC, the HFR was 0.63 AUC, and the CCI was 0.62 AUC. For 30-day readmission, ECI was 0.79 AUC, while HFR and CCI were 0.6 AUC. For 30-day reoperation, ECI was 0.69 AUC, while HFR was 0.58 AUC and CCI was 0.56 AUC.
    Conclusions: Our analysis shows that ECI is superior to CCI and HFR for predicting 30-day postoperative outcomes following TKA. Surgeons should consider assessing patients using ECI prior to TKA.
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2024.01.052
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    Zs.A 2134: Show issues Location:
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  6. Article ; Online: The multiple sclerosis prodrome.

    Makhani, Naila / Tremlett, Helen

    Nature reviews. Neurology

    2021  Volume 17, Issue 8, Page(s) 515–521

    Abstract: A prodrome is an early set of signs, symptoms or other findings that occur before the onset of typical symptoms of a disease. Prodromal phases are well recognized in several neurological and inflammatory diseases, but the possibility of a prodrome in ... ...

    Abstract A prodrome is an early set of signs, symptoms or other findings that occur before the onset of typical symptoms of a disease. Prodromal phases are well recognized in several neurological and inflammatory diseases, but the possibility of a prodrome in multiple sclerosis (MS) has received relatively little attention until the past few years. In this Perspective, we summarize what is currently known about the MS prodrome, including its possible duration, clinical features and potential biomarkers. We also consider what insights and lessons can be learned from knowledge of and research into the prodromal phases of other diseases. A better understanding of the MS prodrome could have profound clinical implications as it could enable earlier recognition of MS and earlier initiation of treatments that reduce relapse rates and long-term disability. Knowledge of the MS prodrome could also affect research into the causes of MS, and putative risk factors must be re-evaluated in light of the MS prodrome. We conclude by outlining the major knowledge gaps and propose future initiatives.
    MeSH term(s) Biomarkers/metabolism ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/psychology ; Humans ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/metabolism ; Multiple Sclerosis/psychology ; Neuroimaging/methods ; Neuroimaging/trends ; Prodromal Symptoms ; Risk Factors
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-06-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-021-00519-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6257: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 88: Show issues

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  7. Article: The Multiple Sclerosis Prodrome: Evidence to Action.

    Tremlett, Helen / Munger, Kassandra L / Makhani, Naila

    Frontiers in neurology

    2022  Volume 12, Page(s) 761408

    Abstract: A growing body of work points toward the existence of a clinically symptomatic prodromal phase in multiple sclerosis (MS) that might span 5-10 years or more. A prodrome is an early set of signs or symptoms predating the onset of classical disease, which ... ...

    Abstract A growing body of work points toward the existence of a clinically symptomatic prodromal phase in multiple sclerosis (MS) that might span 5-10 years or more. A prodrome is an early set of signs or symptoms predating the onset of classical disease, which in turn predates a definitive diagnosis. Evidence for a prodromal phase in MS could have major implications for prevention, earlier recognition and treatment, as well as an improved disease course or prognosis. This Perspective provides a succinct overview of the recent advances in our understanding of the MS prodrome and current key challenges. Many of the MS prodromal features characterized thus far are non-specific and are common in the general population; no single feature alone is sufficient to identify an individual with prodromal MS. Biomarkers may increase specificity and accuracy for detecting individuals in the MS prodromal phase, but are yet to be discovered or formally validated. Progress made in the elucidation of prodromal phases in other neurological and immune-mediated diseases suggests that these barriers can be overcome. Therefore, while knowledge of a prodromal phase in MS remains nascent, how best to move from the rapidly growing evidence to research-related action is critical. Immediate implications include refining the concept of the MS continuum to include a prodromal phase. This will help inform the true "at risk" period when considering exposures that might cause MS. Major long-term implications include the earlier recognition of MS, improved prognosis, through earlier disease management, and the future possibility of MS disease prevention.
    Language English
    Publishing date 2022-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.761408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Inflammatory bowel disease later diagnosed as strongyloides colitis in migrants to Canada: a case series.

    Raheel, Hira / Kopalakrishnan, Swana / Bhasker, Shveta / Makhani, Leila / Clarke, Shareese / Nicholas, Mathew N / Mufti, Asfandyar / Boggild, Andrea K

    Therapeutic advances in infectious disease

    2023  Volume 10, Page(s) 20499361231162719

    Abstract: ... ...

    Abstract Strongyloides
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Case Reports
    ZDB-ID 2728410-4
    ISSN 2049-937X ; 2049-9361
    ISSN (online) 2049-937X
    ISSN 2049-9361
    DOI 10.1177/20499361231162719
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  9. Article ; Online: E-cigarette exposure causes early pro-atherogenic changes in an inducible murine model of atherosclerosis.

    Alakhtar, Bayan / Guilbert, Cynthia / Subramaniam, Nivetha / Caruana, Vincenza / Makhani, Kiran / Baglole, Carolyn J / Mann, Koren K

    Frontiers in toxicology

    2023  Volume 5, Page(s) 1244596

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-12-18
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3080
    ISSN (online) 2673-3080
    DOI 10.3389/ftox.2023.1244596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Abnormal Fluid-Attenuated Inversion Recovery Signal in the Internal Capsule: A Novel Brain Magnetic Resonance Imaging Finding in a Child With Acute Flaccid Myelitis.

    Makhani, Naila / Mahajan, Amit

    Pediatric neurology

    2017  Volume 73, Page(s) 108–109

    MeSH term(s) Child ; Facial Muscles/physiopathology ; Female ; Humans ; Internal Capsule/diagnostic imaging ; Magnetic Resonance Imaging ; Myelitis/diagnostic imaging
    Language English
    Publishing date 2017-02-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2017.01.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2260: Show issues Location:
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