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Article: Efecto del slope tibial en la recuperación funcional, en pacientes sometidos a reconstrucción de ligamento cruzado anterior.

Dobarganes-Barlow, F G / Campos-Flores, D / López-Flores, A / Garcini-Munguía, F / Guevara-Álvarez, A / Gálvez-Romero, J L

Acta ortopedica mexicana

2022 Volume 36, Issue 2, Page(s) 92–96

Abstract: Introduction: the tibial slope has been identified as one of the factors associated with graft failure after anterior cruciate ligament (ACL) reconstruction; however, its relationship with functional results has been little studied. The main purpose of ... ...

Title translation	Effect of tibial slope on functional recovery in patients undergoing anterior cruciate ligament reconstruction.
Abstract	Introduction: the tibial slope has been identified as one of the factors associated with graft failure after anterior cruciate ligament (ACL) reconstruction; however, its relationship with functional results has been little studied. The main purpose of this study is to determine the effect of the tibial slope on functional recovery in patients undergoing reconstruction of the anterior cruciate ligament. Material and methods: we included patients with a diagnosis of anterior cruciate ligament injury undergoing primary reconstruction, from May 2018 to May 2019, who had a complete radiographic and clinical record; also, the scores from questionnaires of the International Knee Documentation Committee (IKDC) and Lysholm scores were collected pre surgical procedures and throughout the one-year follow-up. The measurement of the tibial slope was performed in lateral knee X-rays from the electronic clinical record. A descriptive analysis of first intention was done, and to achieve the objectives, we compared 25 patients who had normal tibial slope that were selected randomly with 25 patients who had increased tibial slope. Results: a total of 98 patients were included, 73 had a normal tibial slope (equal to or less than 12 degrees) and 25 with an increased tibial slope (greater than 12 degrees), the average age in both groups was 28.43 years for the group with normal tibial slope and 28.26 for patients with increased tibial slope. Regarding the functional assessment, the IKDC and Lysholm scores at the end of the follow-up were better for patients with normal tibial slope. Graft failure was only identified in the group with increased tibial slope. On the other hand, the comparative analysis with the control group randomly selected who had normal tibial slope, showed a better functional result assessed by IKDC score at the end of the follow-up for the group with normal tibial slope. Conclusion: patients undergoing ACL reconstruction and increased Tibial Slope have an inferior functional result at one year of follow-up assessed by IKDC, when compared with patients with normal tibial slope.
MeSH term(s)	Humans ; Adult ; Social Group ; Anterior Cruciate Ligament Reconstruction
Language	Spanish
Publishing date	2022-11-26
Publishing country	Mexico
Document type	English Abstract ; Journal Article
ZDB-ID	2205424-8
ISSN	2306-4102
ISSN	2306-4102
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reply letter to: Inhibition of SARS-CoV-2 replication using calcineurin inhibitors: Are concentrations required clinically achievable?

Gálvez-Romero, J L / Deveaux-Homs, J / Real-Ramírez, F A / Palmeros-Rojas, O / Pedraza-Sánchez, S

Journal of internal medicine

2021 Volume 289, Issue 6, Page(s) 928–929

MeSH term(s)	Antiviral Agents ; COVID-19 ; Calcineurin Inhibitors/pharmacology ; Humans ; SARS-CoV-2 ; Virus Replication
Chemical Substances	Antiviral Agents ; Calcineurin Inhibitors
Language	English
Publishing date	2021-04-06
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.13278
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Article: Eficacia de la infiltración periarticular con anestésico local y adyuvantes para control del dolor postquirúrgico en la artroplastía total de rodilla.

Campos-Flores, D / Malpica-Ramírez, L M / Cariño-Cepeda, C / Fernández de Lara-Castilla, L G / Gálvez-Romero, J L

Acta ortopedica mexicana

2021 Volume 35, Issue 2, Page(s) 169–173

Abstract: Introduction: Total knee arthroplasty (TKA) is one of the most successful orthopedic treatments, however, it has been associated with severe postsurgical pain in 30-60% of patients. We propose that infiltration of the articular capsule of the knee ... ...

Title translation	Effectiveness of peri-articular infiltration with local anesthetic and adjuvants for post-surgical pain control in total knee replacement.
Abstract	Introduction: Total knee arthroplasty (TKA) is one of the most successful orthopedic treatments, however, it has been associated with severe postsurgical pain in 30-60% of patients. We propose that infiltration of the articular capsule of the knee during surgery will decrease postsurgical pain. Material and methods: Experimental, randomized, double-blind study in patients undergoing unilateral TKA between April 2018 and January 2019. Patients were divided into two groups, the first infiltration with placebo and the second with anesthetic solution and adjuvants (fentanyl, epinephrine and ketorolac). Pain was measured with the visual analog scale (VAS) at 4, 6, 8, 12, 18, 24, 36 and 48 hours postsurgical, as well as the consumption of opioid analgesics and antiemetics. Results: 20 patients in each group, with a follow-up of 4 weeks. There were no significant differences in demographic characteristics between the two groups. Better control of postsurgical pain was observed in the group that received infiltration with anesthetic and adjuvant, as well as a decrease in the consumption of opioid analgesics and antiemetics. There was no difference in bleeding or in the incidence of infections between the two groups. Conclusion: Peri-capsular infiltration is a safe and effective method, as part of multimodal analgesia in total knee arthroplasty, as it decreases postsurgical pain, opioid and antiemetic use and does not increase postsurgical bleeding.
MeSH term(s)	Analgesia ; Analgesics, Opioid/therapeutic use ; Anesthetics, Local ; Arthroplasty, Replacement, Knee ; Double-Blind Method ; Humans ; Pain Management ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control
Chemical Substances	Analgesics, Opioid ; Anesthetics, Local
Language	Spanish
Publishing date	2021-11-03
Publishing country	Mexico
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2205424-8
ISSN	2306-4102
ISSN	2306-4102
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Article ; Online: Viral infections and their relationship with catastrophic antiphospholipid syndrome: a possible pathogenic mechanism of severe COVID-19 thrombotic complications.

Mendoza-Pinto, C / Escárcega, R O / García-Carrasco, M / Bailey, D J O / Gálvez-Romero, J L / Cervera, R

Journal of internal medicine

2020 Volume 288, Issue 6, Page(s) 737–739

MeSH term(s)	Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/virology ; COVID-19/complications ; Humans ; Thrombosis/complications ; Thrombosis/virology
Keywords	covid19
Language	English
Publishing date	2020-06-22
Publishing country	England
Document type	Letter
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.13123
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Article: Viral infections and their relationship with catastrophic antiphospholipid syndrome: a possible pathogenic mechanism of severe COVID-19 thrombotic complications

Mendoza-Pinto, C / Escárcega, R O / García-Carrasco, M / Bailey, D J O / Gálvez-Romero, J L / Cervera, R

J. intern. med

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #620191
Database	COVID19

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Article ; Online: Viral infections and their relationship with catastrophic antiphospholipid syndrome

Mendoza‐Pinto, C. / Escárcega, R. O. / García‐Carrasco, M. / Bailey, D. J. O. / Gálvez‐Romero, J. L. / Cervera, R.

Journal of Internal Medicine ; ISSN 0954-6820 1365-2796

a possible pathogenic mechanism of severe COVID‐19 thrombotic complications

2020

Keywords	Internal Medicine ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
DOI	10.1111/joim.13123
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cyclosporine A plus low-dose steroid treatment in COVID-19 improves clinical outcomes in patients with moderate to severe disease: A pilot study.

Gálvez-Romero, J L / Palmeros-Rojas, O / Real-Ramírez, F A / Sánchez-Romero, S / Tome-Maxil, R / Ramírez-Sandoval, M P / Olivos-Rodríguez, R / Flores-Encarnación, S E / Cabrera-Estrada, A A / Ávila-Morales, J / Cortés-Sánchez, V / Sarmiento-Padilla, G / Tezmol-Ramírez, S E / Aparicio-Hernández, D / Urbina-Sánchez, M I / Gómez-Pluma, M Á / Cisneros-Méndez, S / Rodríguez-Rivas, D I / Reyes-Inurrigarro, S /

Cortés-Díaz, G / Cruz-Delgado, C / Navarro-González, J / Deveaux-Homs, J / Pedraza-Sánchez, S

Journal of internal medicine

2021 Volume 289, Issue 6, Page(s) 906–920

Abstract: Background: COVID-19 pandemic causes high global morbidity and mortality and better medical treatments to reduce mortality are needed.: Objective: To determine the added benefit of cyclosporine A (CsA), to low-dose steroid treatment, in patients with ...

Abstract	Background: COVID-19 pandemic causes high global morbidity and mortality and better medical treatments to reduce mortality are needed. Objective: To determine the added benefit of cyclosporine A (CsA), to low-dose steroid treatment, in patients with COVID-19. Methods: Open-label, non randomized pilot study of patients with confirmed infection of SARS-CoV-2 hospitalized from April to May 2020 at a single centre in Puebla, Mexico. Patients were assigned to receive either steroids or CsA plus steroids. Pneumonia severity was assessed by clinical, laboratory, and lung tomography. The death rate was evaluated at 28 days. Results: A total of 209 adult patients were studied, 105 received CsA plus steroids (age 55.3 ± 13.3; 69% men), and 104 steroids alone (age 54.06 ± 13.8; 61% men). All patients received clarithromycin, enoxaparin and methylprednisolone or prednisone up to 10 days. Patient's death was associated with hypertension (RR = 3.5) and diabetes (RR = 2.3). Mortality was 22 and 35% for CsA and control groups (P = 0.02), respectively, for all patients, and 24 and 48.5% for patients with moderate to severe disease (P = 0.001). Higher cumulative clinical improvement was seen for the CsA group (Nelson Aalen curve, P = 0.001, log-rank test) in moderate to severe patients. The Cox proportional hazard analysis showed the highest HR improvement value of 2.15 (1.39-3.34, 95%CI, P = 0.0005) for CsA treatment in moderate to severe patients, and HR = 1.95 (1.35-2.83, 95%CI, P = 0.0003) for all patients. Conclusion: CsA used as an adjuvant to steroid treatment for COVID-19 patients showed to improve outcomes and reduce mortality, mainly in those with moderate to severe disease. Further investigation through controlled clinical trials is warranted.
MeSH term(s)	COVID-19/drug therapy ; COVID-19/mortality ; COVID-19/pathology ; Cyclosporine/adverse effects ; Cyclosporine/therapeutic use ; Drug Therapy, Combination ; Female ; Glucocorticoids/administration & dosage ; Glucocorticoids/therapeutic use ; Humans ; Lung/pathology ; Male ; Methylprednisolone/administration & dosage ; Methylprednisolone/therapeutic use ; Middle Aged ; Pilot Projects ; Prednisone/administration & dosage ; Prednisone/therapeutic use ; Treatment Outcome
Chemical Substances	Glucocorticoids ; Cyclosporine (83HN0GTJ6D) ; Prednisone (VB0R961HZT) ; Methylprednisolone (X4W7ZR7023)
Language	English
Publishing date	2021-02-02
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.13223
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Article ; Online: Bartonella in dogs and fleas from Tulancingo, Hidalgo, Mexico.

Tobar, B Z / Lapsley, W D / Swain, W L / Jaffe, D A / Setien, A Aguilar / Galvez-Romero, G / Obregon-Morales, C / Olave-Leyva, J I / Chomel, B B

Medical and veterinary entomology

2020 Volume 34, Issue 3, Page(s) 302–308

Abstract: Bartonella sp. infection is quite common in free-roaming dogs in many tropical countries. However, limited information is available of the presence of these pathogens in Mexico. The present study looked at prevalence of Bartonella exposure and/or ... ...

Abstract	Bartonella sp. infection is quite common in free-roaming dogs in many tropical countries. However, limited information is available of the presence of these pathogens in Mexico. The present study looked at prevalence of Bartonella exposure and/or infection in dogs and their fleas in Central Mexico. Blood samples were collected from 31 stray dogs in August 2014 at the municipal pound, Tulancingo, Mexico, as well as fleas on 26 of them. Bartonella seropositivity was 46.9%, including 35.5% for Bartonella henselae, 45% for Bartonella clarridgeiae and 32.2% for Bartonella vinsonii subsp. berkhoffii. Three (9.7%) dogs were polymerase chain reaction (PCR) positive for the Bartonella gltA gene. Partial sequencing of that gene revealed that these three dogs were infected with B. henselae. In total, 86 fleas were collected from 26 dogs (range 1-9 fleas per dog), including 52 Ctenocephalides felis and 34 Ctenocephalides canis. Of 40 pools of fleas (20 pools of C. canis and 20 pools of C. felis), five (12.5%) were PCR positive for the Bartonella sp. gltA gene, including three C. canis pools (five fleas) and two C. felis pools (three fleas). All sequences showed 99.25% to 100% homology with B. henselae Houston I.
MeSH term(s)	Animals ; Bartonella/isolation & purification ; Bartonella Infections/epidemiology ; Bartonella Infections/microbiology ; Bartonella Infections/veterinary ; Bartonella henselae/isolation & purification ; Dog Diseases/epidemiology ; Dog Diseases/microbiology ; Dogs ; Female ; Male ; Mexico/epidemiology ; Polymerase Chain Reaction/veterinary ; Prevalence ; Siphonaptera/microbiology
Language	English
Publishing date	2020-03-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	286021-1
ISSN	1365-2915 ; 0269-283X
ISSN (online)	1365-2915
ISSN	0269-283X
DOI	10.1111/mve.12438
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Article ; Online: The anti-thrombotic effects of vitamin D and their possible relationship with antiphospholipid syndrome.

García-Carrasco, M / Jiménez-Herrera, E A / Gálvez-Romero, J L / Mendoza-Pinto, C / Méndez-Martínez, S / Etchegaray-Morales, I / Munguía-Realpozo, P / Vázquez de Lara-Cisneros, L / Santa Cruz, F J / Cervera, R

Lupus

2018 Volume 27, Issue 14, Page(s) 2181–2189

Abstract: The importance of the immunomodulatory effects of vitamin D has recently been associated with autoimmune and chronic inflammatory diseases. Vitamin D deficiency has been linked to the development of autoimmune conditions. Antiphospholipid syndrome is an ... ...

Abstract	The importance of the immunomodulatory effects of vitamin D has recently been associated with autoimmune and chronic inflammatory diseases. Vitamin D deficiency has been linked to the development of autoimmune conditions. Antiphospholipid syndrome is an autoimmune disease characterized by thrombotic events and obstetric complications in patients with antiphospholipid antibodies. Current data show that patients with antiphospholipid syndrome have a high prevalence of vitamin D deficiency even without classic risk factors. Several studies have suggested vitamin D may have anti-thrombotic functions. In antiphospholipid syndrome, low vitamin D serum levels have been associated with thrombotic manifestations, suggesting a possible protective role of vitamin D in antiphospholipid syndrome. This literature review presents current evidence on the haemostatic functions of vitamin D and their possible relationship with the clinical manifestations of antiphospholipid syndrome.
MeSH term(s)	Antibodies, Antiphospholipid/blood ; Anticoagulants/therapeutic use ; Antiphospholipid Syndrome/complications ; Female ; Humans ; Pregnancy ; Pregnancy Complications, Hematologic/etiology ; Thrombosis/drug therapy ; Thrombosis/etiology ; Vitamin D/metabolism ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/drug therapy
Chemical Substances	Antibodies, Antiphospholipid ; Anticoagulants ; Vitamin D (1406-16-2)
Language	English
Publishing date	2018-10-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1154407-7
ISSN	1477-0962 ; 0961-2033
ISSN (online)	1477-0962
ISSN	0961-2033
DOI	10.1177/0961203318801520
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Article ; Online: Factors of the epidemiological triad that influence the persistence of human papilloma virus infection in women with systemic lupus erythematosus.

Méndez-Martínez, S / García-Carrasco, M / Jiménez-Herrera, E A / Mendoza-Pinto, C / Etchegaray-Morales, I / Barahona-Rubio, P W / Gálvez-Romero, J L / Munguía-Realpozo, P / Muñóz-Guarneros, C O / Cedillo-Ramírez, M L / Silva-Gómez, S E / Linares-Fleites, G / Rojas-Vallaraga, A

Lupus

2018 Volume 27, Issue 9, Page(s) 1542–1546

Abstract: We studied the epidemiologic triad-related factors influencing human papilloma virus (HPV) persistence in Mexican women with systemic lupus erythematosus (SLE). Patients aged ≥18 years with SLE (American College of Rheumatology criteria), with and ... ...

Abstract	We studied the epidemiologic triad-related factors influencing human papilloma virus (HPV) persistence in Mexican women with systemic lupus erythematosus (SLE). Patients aged ≥18 years with SLE (American College of Rheumatology criteria), with and without HPV persistence, were selected. Groups were analyzed by (1) host: clinical disease characteristics; (2) agent: (I) infectious (prevalence, incidence, HPV genotype and co-infections (≥2 HPV genotypes or mycoplasmas)), (II) chemical (contraceptives and immunosuppressive drugs) and (III) physical (vitamin D deficiency) and (3) environment. A total of 121 SLE patients were selected over a two-year period. (1) Host: mean age 45.8 years and disease duration 12.7 years. (2) Agent: (I) infectious. HPV infection prevalence in the second sample was 26.4%, high-risk HPV genotypes 21.5% and co-infections 7.4%. HPV infection incidence was 13.2%, persistence 13.2% and clearance 15.7%. (II) Chemical: use of oral hormonal contraceptives 5% and immunosuppressive treatment 97.5%. (III) Physical: Vitamin D levels were similar in both groups. (3) Environment: (I) natural. A total of 60.6% of patients were residents of Puebla City. (II) Social: The mean education level was 10.9. Poverty levels were: III degree 52.4%, IV degree 28% and II degree 17%. (III) Cultural behavioral: Onset of sexual life was 20.5 years, 10% had ≥3 sexual partners and 51.2% were postmenopausal. In conclusion, no factor of the epidemiologic triad was associated with HPV infection prevalence.
MeSH term(s)	Adult ; Aged ; Cohort Studies ; Environment ; Female ; Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/epidemiology ; Mexico/epidemiology ; Middle Aged ; Papillomavirus Infections/complications ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/virology ; Young Adult
Language	English
Publishing date	2018-05-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1154407-7
ISSN	1477-0962 ; 0961-2033
ISSN (online)	1477-0962
ISSN	0961-2033
DOI	10.1177/0961203318773176
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