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  1. Article ; Online: Acute liver failure after out-of-hospital cardiac arrest: An observational study.

    Delignette, Marie-Charlotte / Stevic, Neven / Lebossé, Fanny / Bonnefoy-Cudraz, Eric / Argaud, Laurent / Cour, Martin

    Resuscitation

    2024  Volume 197, Page(s) 110136

    Abstract: Rationale: Apart from hypoxic hepatitis (HH), the hepatic consequences of out-of-hospital cardiac arrest (OHCA) have been little studied. This cohort study aimed to investigate the characteristics of liver dysfunction resulting from OHCA and its ... ...

    Abstract Rationale: Apart from hypoxic hepatitis (HH), the hepatic consequences of out-of-hospital cardiac arrest (OHCA) have been little studied. This cohort study aimed to investigate the characteristics of liver dysfunction resulting from OHCA and its association with outcomes.
    Methods: Among the conventional static liver function tests used to define acute liver failure (ALF), we determined which one correlated more closely with the reference indocyanine green (ICG) clearance test in a series of OHCA patients from the CYRUS trial (NCT01595958). Subsequently, we assessed whether ALF, in addition to HH (i.e., acute liver injury), was an independent risk factor for death in a large cohort of OHCA patients admitted to two intensive care units between 2007 and 2017.
    Results: ICG clearance, available for 22 patients, was impaired in 17 (77.3%) cases. Prothrombin time (PT) ratio was the only static liver function test that correlated significantly (r = -0.66, p < 0.01) with ICG clearance and was therefore used to define ALF, with the usual cutoff of < 50%. Of the 418 patients included in the analysis (sex ratio: 1.4; median age: 64 [53-75] years; non-shockable rhythm: 73%), 67 (16.0%) presented with ALF, and 61 (14.6%) had HH at admission. On day 28, 337 (80.6%) patients died. Following multivariate analysis, ALF at admission, OHCA occurring at home, absence of bystander, non-cardiac cause of OHCA, low-flow duration ≥ 20 min, and SOFA score excluding liver subscore at admission were independently associated with day 28 mortality.
    Conclusions: ALF occurred frequently after OHCA and, unlike HH, was independently associated with day 28 mortality.
    MeSH term(s) Humans ; Middle Aged ; Out-of-Hospital Cardiac Arrest/therapy ; Out-of-Hospital Cardiac Arrest/complications ; Cohort Studies ; Liver Failure, Acute/complications ; Hepatitis/complications ; Cardiopulmonary Resuscitation
    Language English
    Publishing date 2024-02-08
    Publishing country Ireland
    Document type Observational Study ; Journal Article
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2024.110136
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  2. Article: Delivery of high flow oxygen through nasal vs. tracheal cannulas: A bench study.

    Cour, Martin / Guérin, Claude / Degivry, Florian / Argaud, Laurent / Louis, Bruno

    Frontiers in medicine

    2023  Volume 9, Page(s) 1068428

    Abstract: Background: The use of high flow oxygen therapy (HFOT) has significantly escalated during the COVID-19 pandemic. HFOT can be delivered through both dedicated devices and ICU ventilators. HFOT can be administered to a patient : Methods: Seven HFOT ... ...

    Abstract Background: The use of high flow oxygen therapy (HFOT) has significantly escalated during the COVID-19 pandemic. HFOT can be delivered through both dedicated devices and ICU ventilators. HFOT can be administered to a patient
    Methods: Seven HFOT devices (three dedicated and four ICU ventilators) were connected to a manikin head (Laerdal Medical) through a NC (Optiflow 3S, large size, Fisher and Paykel Healthcare) or a TC (OPT 970 Optiflow+, Fisher and Paykel Healthcare). Each device was also attached to a manikin head that was connected to a lung simulator (ASL5000, Ingmar Medical), set at 40 ml/cmH
    Results: The WOB and its resistive and elastic components were significantly lower with the TC than with the NC for every device, and systematically lower with the reference device than with others. These differences were, however, very small and may be not clinically relevant.
    Conclusion: The WOB is lower with the TC than with the NC and with the reference device, compared with the most recent devices.
    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1068428
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  3. Article ; Online: Factors associated with short- and long-term outcomes in lung cancer patients requiring unplanned invasive mechanical ventilation.

    Chatelain, Emeric / Simon, Marie / Hernu, Romain / Argaud, Laurent / Cour, Martin

    Medicina intensiva

    2023  Volume 48, Issue 1, Page(s) 37–45

    Abstract: Objective: Unplanned invasive mechanical ventilation (IMV) is associated with high mortality in lung cancer patients. We aimed to identify factors associated with weaning from IMV, intensive care unit (ICU) survival and 1-year survival in lung cancer ... ...

    Abstract Objective: Unplanned invasive mechanical ventilation (IMV) is associated with high mortality in lung cancer patients. We aimed to identify factors associated with weaning from IMV, intensive care unit (ICU) survival and 1-year survival in lung cancer patients requiring unplanned IMV.
    Design: Retrospective observational study (2007-2017).
    Setting: University-affiliated ICU.
    Patients: Lung cancer patients requiring unplanned IMV.
    Intervention: None.
    Main variables of interest: Weaning from IMV, ICU and 1-year survival.
    Results: Of the 136 patients included in the analysis (age 64 (9) years, male 110 (81%), metastatic disease 97 (62%)), 52 (38%) were weaned from IMV, 51 (38%) were discharged from ICU and 22 (16%) were alive at 1year. The main indication for intubation was acute respiratory failure. In multivariate analysis, PaO
    Conclusions: A significant proportion of patients with lung cancer treated with unplanned IMV could be weaned from IMV and survived to ICU discharge, especially in the absence of severe hypoxemia at ICU admission. The low one-year survival was mostly driven by metastatic status.
    MeSH term(s) Humans ; Male ; Middle Aged ; Respiration, Artificial ; Lung Neoplasms/therapy ; Hospitalization ; Intensive Care Units ; Patient Discharge
    Language English
    Publishing date 2023-10-06
    Publishing country Spain
    Document type Observational Study ; Journal Article
    ISSN 2173-5727
    ISSN (online) 2173-5727
    DOI 10.1016/j.medine.2023.07.014
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  4. Article ; Online: Response.

    Cour, Martin / Cariou, Alain / Argaud, Laurent

    Chest

    2021  Volume 160, Issue 6, Page(s) e678

    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.07.048
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  5. Article ; Online: Prone Positioning and Neuromuscular Blocking Agents as Adjunctive Therapies in Mechanically Ventilated Patients with Acute Respiratory Distress Syndrome.

    Guérin, Claude / Cour, Martin / Argaud, Laurent

    Seminars in respiratory and critical care medicine

    2022  Volume 43, Issue 3, Page(s) 453–460

    Abstract: Neuromuscular blocking agents (NMBAs) and prone position (PP) are two major adjunctive therapies that can improve outcome in moderate-to-severe acute respiratory distress syndrome. NMBA should be used once lung-protective mechanical ventilation has been ... ...

    Abstract Neuromuscular blocking agents (NMBAs) and prone position (PP) are two major adjunctive therapies that can improve outcome in moderate-to-severe acute respiratory distress syndrome. NMBA should be used once lung-protective mechanical ventilation has been set, for 48 hours or less and as a continuous intravenous infusion. PP should be used as early as possible for long sessions; in COVID-19 its use has exploded. In nonintubated patients, PP might reduce the rate of intubation but not mortality. The goal of this article is to perform a narrative review on the pathophysiological rationale, the clinical effects, and the clinical use and recommendations of both NMBA and PP.
    MeSH term(s) COVID-19/therapy ; Humans ; Neuromuscular Blocking Agents/therapeutic use ; Prone Position ; Respiration, Artificial/adverse effects ; Respiratory Distress Syndrome/drug therapy
    Chemical Substances Neuromuscular Blocking Agents
    Language English
    Publishing date 2022-05-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0042-1744304
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  6. Article: Airway Closure and Expiratory Flow Limitation in Acute Respiratory Distress Syndrome.

    Guérin, Claude / Cour, Martin / Argaud, Laurent

    Frontiers in physiology

    2022  Volume 12, Page(s) 815601

    Abstract: Acute respiratory distress syndrome (ARDS) is mostly characterized by the loss of aerated lung volume associated with an increase in lung tissue and intense and complex lung inflammation. ARDS has long been associated with the histological pattern of ... ...

    Abstract Acute respiratory distress syndrome (ARDS) is mostly characterized by the loss of aerated lung volume associated with an increase in lung tissue and intense and complex lung inflammation. ARDS has long been associated with the histological pattern of diffuse alveolar damage (DAD). However, DAD is not the unique pathological figure in ARDS and it can also be observed in settings other than ARDS. In the coronavirus disease 2019 (COVID-19) related ARDS, the impairment of lung microvasculature has been pointed out. The airways, and of notice the small peripheral airways, may contribute to the loss of aeration observed in ARDS. High-resolution lung imaging techniques found that in specific experimental conditions small airway closure was a reality. Furthermore, low-volume ventilator-induced lung injury, also called as atelectrauma, should involve the airways. Atelectrauma is one of the basic tenet subtending the use of positive end-expiratory pressure (PEEP) set at the ventilator in ARDS. Recent data revisited the role of airways in humans with ARDS and provided findings consistent with the expiratory flow limitation and airway closure in a substantial number of patients with ARDS. We discussed the pattern of airway opening pressure disclosed in the inspiratory volume-pressure curves in COVID-19 and in non-COVID-19 related ARDS. In addition, we discussed the functional interplay between airway opening pressure and expiratory flow limitation displayed in the flow-volume curves. We discussed the individualization of the PEEP setting based on these findings.
    Language English
    Publishing date 2022-01-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.815601
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  7. Article ; Online: Immature neutrophils and myeloid-derived suppressor cells in sepsis: differences in occurrence kinetics.

    Coudereau, Rémy / Haem Rahimi, Muzhda / Lukaszewicz, Anne-Claire / Cour, Martin / Bidar, Frank / Argaud, Laurent / Venet, Fabienne / Monneret, Guillaume

    Critical care (London, England)

    2024  Volume 28, Issue 1, Page(s) 7

    MeSH term(s) Humans ; Neutrophils ; Myeloid-Derived Suppressor Cells ; Sepsis
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04781-3
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  8. Article: Effects on mechanical power of different devices used for inhaled sedation in a bench model of protective ventilation in ICU.

    Pellet, Pierre-Louis / Stevic, Neven / Degivry, Florian / Louis, Bruno / Argaud, Laurent / Guérin, Claude / Cour, Martin

    Annals of intensive care

    2024  Volume 14, Issue 1, Page(s) 18

    Abstract: Background: Inhaled sedation during invasive mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) has received increasing attention. However, inhaled sedation devices increase dead-space ventilation and an undesirable ... ...

    Abstract Background: Inhaled sedation during invasive mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) has received increasing attention. However, inhaled sedation devices increase dead-space ventilation and an undesirable effect is the increase in minute ventilation needed to maintain CO
    Methods: We conducted a bench study to assess and compare the effects of three devices delivering inhaled sevoflurane currently available in ICU (AnaConDa-50 mL (ANA-50), AnaConDa-100 mL (ANA-100), and MIRUS) on MP by using a test lung model set with three compliances (20, 40, and 60 mL/cmH
    Results: Following device insertion, the EtCO
    Conclusion: Inhaled sedation devices substantially increased MP in this bench model of protective ventilation, which might limit their benefits in ARDS.
    Language English
    Publishing date 2024-01-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-024-01245-x
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  9. Article ; Online: Remote ischaemic conditioning: in search of a suitable match.

    Cour, Martin / Lecour, Sandrine

    Nature reviews. Cardiology

    2019  Volume 16, Issue 12, Page(s) 704–705

    MeSH term(s) Humans ; Ischemic Preconditioning, Myocardial/methods ; Percutaneous Coronary Intervention ; ST Elevation Myocardial Infarction/mortality ; ST Elevation Myocardial Infarction/surgery ; Treatment Outcome
    Language English
    Publishing date 2019-10-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-019-0296-9
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  10. Article ; Online: A Bench Comparison of the Effect of High-Flow Oxygen Devices on Work of Breathing.

    Guérin, Claude / Cour, Martin / Degivry, Florian / Argaud, Laurent / Louis, Bruno

    Respiratory care

    2022  Volume 67, Issue 9, Page(s) 1129–1137

    Abstract: Background: Oxygen therapy via high-flow nasal cannula (HFNC) has been extensively used during the COVID-19 pandemic. The number of devices has also increased. We conducted this study to answer the following questions: Do HFNC devices differ from the ... ...

    Abstract Background: Oxygen therapy via high-flow nasal cannula (HFNC) has been extensively used during the COVID-19 pandemic. The number of devices has also increased. We conducted this study to answer the following questions: Do HFNC devices differ from the original device for work of breathing (WOB) and generated PEEP?
    Methods: Seven devices were tested on ASL 5000 lung model. Compliance was set to 40 mL/cm H
    Results: Baseline WOB and PEEP were comparable between devices. Over all the conditions tested, WOB was 4.2 (1.0-9.4) J/min with the reference device, and the relative variations from it were 0, -3 (2-4), 1 (0-1), -2 (1-2), -1 (1-2), and -1 (1-2)% with Airvo 2, G5, HM80, T60, V500, and V60 Plus devices, respectively, (
    Conclusions: WOB was marginally higher and PEEP marginally lower with devices as compared to the reference device.
    MeSH term(s) COVID-19 ; Cannula ; Humans ; Oxygen ; Oxygen Inhalation Therapy ; Pandemics ; Work of Breathing
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603252-7
    ISSN 1943-3654 ; 0098-9142 ; 0020-1324
    ISSN (online) 1943-3654
    ISSN 0098-9142 ; 0020-1324
    DOI 10.4187/respcare.09889
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