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Article ; Online: Fate restrictions in embryonic neural progenitors.

Fischer, Evelyne / Morin, Xavier

2020 Volume 66, Page(s) 178–185

Abstract: The vertebrate central nervous system (CNS) is a fantastically complex organ composed of dozens of cell types within the neural and glial lineages. Its organization is laid down during development, through the localized and sequential production of ... ...

Abstract	The vertebrate central nervous system (CNS) is a fantastically complex organ composed of dozens of cell types within the neural and glial lineages. Its organization is laid down during development, through the localized and sequential production of subsets of neurons with specific identities. The principles and mechanisms that underlie the timely production of adequate classes of cells are only partially understood. Recent advances in molecular profiling describe the developmental trajectories leading to this amazing cellular diversity and provide us with cell atlases of an unprecedented level of precision. Yet, some long-standing questions pertaining to lineage relationships between neural progenitor cells and their differentiated progeny remain unanswered. Here, we discuss questions related to proliferation potential, timing of fate choices and restriction of neuronal output potential of individual CNS progenitors through the lens of lineage relationship. Unlocking methodological barriers will be essential to accurately describe CNS development at a cellular resolution.
MeSH term(s)	Cell Differentiation ; Cell Lineage ; Central Nervous System ; Neural Stem Cells ; Neuroglia ; Neurons
Language	English
Publishing date	2020-11-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1078046-4
ISSN	1873-6882 ; 0959-4388
ISSN (online)	1873-6882
ISSN	0959-4388
DOI	10.1016/j.conb.2020.10.014
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Article ; Online: Swallowing dysfunctions in patients with disorders of consciousness: Evidence from neuroimaging data, assessment, and management.

Regnier, Amandine / Mélotte, Evelyne / Aubinet, Charlène / Alnagger, Naji / Fischer, David / Lagier, Aude / Thibaut, Aurore / Laureys, Steven / Kaux, Jean-François / Gosseries, Olivia

NeuroRehabilitation

2024 Volume 54, Issue 1, Page(s) 91–107

Abstract: Following severe brain injuries, a subset of patients may remain in an altered state of consciousness; most of these patients require artificial feeding. Currently, a functional oral phase and the presence of exclusive oral feeding may constitute signs ... ...

Abstract	Following severe brain injuries, a subset of patients may remain in an altered state of consciousness; most of these patients require artificial feeding. Currently, a functional oral phase and the presence of exclusive oral feeding may constitute signs of consciousness. Additionally, the presence of pharyngo-laryngeal secretions, saliva aspiration, cough reflex and tracheostomy are related to the level of consciousness. However, the link between swallowing and consciousness is yet to be fully understood. The primary aim of this review is to establish a comprehensive overview of the relationship between an individual's conscious behaviour and swallowing (reflexive and voluntary). Previous studies of brain activation during volitional and non-volitional swallowing tasks in healthy subjects are also reviewed. We demonstrate that the areas activated by voluntary swallowing tasks (primary sensorimotor, cingulate, insula, premotor, supplementary motor, cerebellum, and operculum) are not specific to deglutitive function but are shared with other motor tasks and brain networks involved in consciousness. This review also outlines suitable assessment and treatment methods for dysphagic patients with disorders of consciousness. Finally, we propose that markers of swallowing could contribute to the development of novel diagnostic guidelines for patients with disorders of consciousness.
MeSH term(s)	Humans ; Deglutition/physiology ; Consciousness ; Consciousness Disorders/diagnostic imaging ; Consciousness Disorders/therapy ; Brain/diagnostic imaging ; Brain/physiology ; Deglutition Disorders/diagnostic imaging ; Deglutition Disorders/etiology ; Neuroimaging
Language	English
Publishing date	2024-01-28
Publishing country	Netherlands
Document type	Review ; Journal Article
ZDB-ID	1087912-2
ISSN	1878-6448 ; 1053-8135
ISSN (online)	1878-6448
ISSN	1053-8135
DOI	10.3233/NRE-230135
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Article ; Online: A novel mode of control of nickel uptake by a multifunctional metallochaperone.

Milica Denic / Evelyne Turlin / Valérie Michel / Frédéric Fischer / Mozhgan Khorasani-Motlagh / Deborah Zamble / Daniel Vinella / Hilde de Reuse

PLoS Pathogens, Vol 17, Iss 1, p e

2021 Volume 1009193

Abstract: Cellular metal homeostasis is a critical process for all organisms, requiring tight regulation. In the major pathogen Helicobacter pylori, the acquisition of nickel is an essential virulence determinant as this metal is a cofactor for the acid-resistance ...

Abstract	Cellular metal homeostasis is a critical process for all organisms, requiring tight regulation. In the major pathogen Helicobacter pylori, the acquisition of nickel is an essential virulence determinant as this metal is a cofactor for the acid-resistance enzyme, urease. Nickel uptake relies on the NixA permease and the NiuBDE ABC transporter. Till now, bacterial metal transporters were reported to be controlled at their transcriptional level. Here we uncovered post-translational regulation of the essential Niu transporter in H. pylori. Indeed, we demonstrate that SlyD, a protein combining peptidyl-prolyl isomerase (PPIase), chaperone, and metal-binding properties, is required for the activity of the Niu transporter. Using two-hybrid assays, we found that SlyD directly interacts with the NiuD permease subunit and identified a motif critical for this contact. Mutants of the different SlyD functional domains were constructed and used to perform in vitro PPIase activity assays and four different in vivo tests measuring nickel intracellular accumulation or transport in H. pylori. In vitro, SlyD PPIase activity is down-regulated by nickel, independently of its C-terminal region reported to bind metals. In vivo, a role of SlyD PPIase function was only revealed upon exposure to high nickel concentrations. Most importantly, the IF chaperone domain of SlyD was shown to be mandatory for Niu activation under all in vivo conditions. These data suggest that SlyD is required for the active functional conformation of the Niu permease and regulates its activity through a novel mechanism implying direct protein interaction, thereby acting as a gatekeeper of nickel uptake. Finally, in agreement with a central role of SlyD, this protein is essential for the colonization of the mouse model by H. pylori.
Keywords	Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A novel mode of control of nickel uptake by a multifunctional metallochaperone.

Denic, Milica / Turlin, Evelyne / Michel, Valérie / Fischer, Frédéric / Khorasani-Motlagh, Mozhgan / Zamble, Deborah / Vinella, Daniel / de Reuse, Hilde

PLoS pathogens

2021 Volume 17, Issue 1, Page(s) e1009193

Abstract	Cellular metal homeostasis is a critical process for all organisms, requiring tight regulation. In the major pathogen Helicobacter pylori, the acquisition of nickel is an essential virulence determinant as this metal is a cofactor for the acid-resistance enzyme, urease. Nickel uptake relies on the NixA permease and the NiuBDE ABC transporter. Till now, bacterial metal transporters were reported to be controlled at their transcriptional level. Here we uncovered post-translational regulation of the essential Niu transporter in H. pylori. Indeed, we demonstrate that SlyD, a protein combining peptidyl-prolyl isomerase (PPIase), chaperone, and metal-binding properties, is required for the activity of the Niu transporter. Using two-hybrid assays, we found that SlyD directly interacts with the NiuD permease subunit and identified a motif critical for this contact. Mutants of the different SlyD functional domains were constructed and used to perform in vitro PPIase activity assays and four different in vivo tests measuring nickel intracellular accumulation or transport in H. pylori. In vitro, SlyD PPIase activity is down-regulated by nickel, independently of its C-terminal region reported to bind metals. In vivo, a role of SlyD PPIase function was only revealed upon exposure to high nickel concentrations. Most importantly, the IF chaperone domain of SlyD was shown to be mandatory for Niu activation under all in vivo conditions. These data suggest that SlyD is required for the active functional conformation of the Niu permease and regulates its activity through a novel mechanism implying direct protein interaction, thereby acting as a gatekeeper of nickel uptake. Finally, in agreement with a central role of SlyD, this protein is essential for the colonization of the mouse model by H. pylori.
MeSH term(s)	Animals ; Bacterial Proteins/metabolism ; Helicobacter Infections/metabolism ; Helicobacter Infections/microbiology ; Helicobacter pylori/metabolism ; Metallochaperones/metabolism ; Mice ; Nickel/metabolism ; Peptidylprolyl Isomerase/metabolism ; Urease/metabolism
Chemical Substances	Bacterial Proteins ; Metallochaperones ; Nickel (7OV03QG267) ; Urease (EC 3.5.1.5) ; Peptidylprolyl Isomerase (EC 5.2.1.8)
Language	English
Publishing date	2021-01-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7366
ISSN (online)	1553-7374
ISSN	1553-7366
DOI	10.1371/journal.ppat.1009193
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Article ; Online: Expansion of nickel binding- and histidine-rich proteins during gastric adaptation of Helicobacter species.

Fischer, Frédéric / Vorontsov, Egor / Turlin, Evelyne / Malosse, Christian / Garcia, Camille / Tabb, David L / Chamot-Rooke, Julia / Percudani, Riccardo / Vinella, Daniel / De Reuse, Hilde

Metallomics : integrated biometal science

2022 Volume 14, Issue 9

Abstract: Acquisition and homeostasis of essential metals during host colonization by bacterial pathogens rely on metal uptake, trafficking, and storage proteins. How these factors have evolved within bacterial pathogens is poorly defined. Urease, a nickel enzyme, ...

Abstract	Acquisition and homeostasis of essential metals during host colonization by bacterial pathogens rely on metal uptake, trafficking, and storage proteins. How these factors have evolved within bacterial pathogens is poorly defined. Urease, a nickel enzyme, is essential for Helicobacter pylori to colonize the acidic stomach. Our previous data suggest that acquisition of nickel transporters and a histidine-rich protein (HRP) involved in nickel storage in H. pylori and gastric Helicobacter spp. have been essential evolutionary events for gastric colonization. Using bioinformatics, proteomics, and phylogenetics, we extended this analysis to determine how evolution has framed the repertoire of HRPs among 39 Epsilonproteobacteria; 18 gastric and 11 non-gastric enterohepatic (EH) Helicobacter spp., as well as 10 other Epsilonproteobacteria. We identified a total of 213 HRPs distributed in 22 protein families named orthologous groups (OGs) with His-rich domains, including 15 newly described OGs. Gastric Helicobacter spp. are enriched in HRPs (7.7 ± 1.9 HRPs/strain) as compared to EH Helicobacter spp. (1.9 ± 1.0 HRPs/strain) with a particular prevalence of HRPs with C-terminal histidine-rich domains in gastric species. The expression and nickel-binding capacity of several HRPs was validated in five gastric Helicobacter spp. We established the evolutionary history of new HRP families, such as the periplasmic HP0721-like proteins and the HugZ-type heme oxygenases. The expansion of histidine-rich extensions in gastric Helicobacter spp. proteins is intriguing but can tentatively be associated with the presence of the urease nickel enzyme. We conclude that this HRP expansion is associated with unique properties of organisms that rely on large intracellular nickel amounts for their survival.
MeSH term(s)	Bacterial Proteins/metabolism ; Helicobacter/metabolism ; Helicobacter pylori/metabolism ; Histidine/metabolism ; Nickel/metabolism ; Proteins ; Stomach ; Urease/metabolism
Chemical Substances	Bacterial Proteins ; Proteins ; histidine-rich proteins ; Histidine (4QD397987E) ; Nickel (7OV03QG267) ; Urease (EC 3.5.1.5)
Language	English
Publishing date	2022-08-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2474317-3
ISSN	1756-591X ; 1756-5901
ISSN (online)	1756-591X
ISSN	1756-5901
DOI	10.1093/mtomcs/mfac060
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Article ; Online: Differential Routing of Mindbomb1 via Centriolar Satellites Regulates Asymmetric Divisions of Neural Progenitors.

Tozer, Samuel / Baek, Chooyoung / Fischer, Evelyne / Goiame, Rosette / Morin, Xavier

Neuron

2017 Volume 93, Issue 3, Page(s) 542–551.e4

Abstract: Unequal centrosome maturation correlates with asymmetric division in multiple cell types. Nevertheless, centrosomal fate determinants have yet to be identified. Here, we show that the Notch pathway regulator Mindbomb1 co-localizes asymmetrically with ... ...

Abstract	Unequal centrosome maturation correlates with asymmetric division in multiple cell types. Nevertheless, centrosomal fate determinants have yet to be identified. Here, we show that the Notch pathway regulator Mindbomb1 co-localizes asymmetrically with centriolar satellite proteins PCM1 and AZI1 at the daughter centriole in interphase. Remarkably, while PCM1 and AZI1 remain asymmetric during mitosis, Mindbomb1 is associated with either one or both spindle poles. Asymmetric Mindbomb1 correlates with neurogenic divisions and Mindbomb1 is inherited by the prospective neuron. By contrast, in proliferative divisions, a supplementary pool of Mindbomb1 associated with the Golgi apparatus in interphase is released during mitosis and compensates for Mindbomb1 centrosomal asymmetry. Finally, we show that preventing Mindbomb1 centrosomal association induces reciprocal Notch activation between sister cells and promotes symmetric divisions. Thus, we uncover a link between differential centrosome maturation and Notch signaling and reveal an unexpected compensatory mechanism involving the Golgi apparatus in restoring symmetry in proliferative divisions.
MeSH term(s)	Animals ; Cell Cycle Proteins/metabolism ; Cell Division ; Centrioles/metabolism ; Centrosome/metabolism ; Chick Embryo ; Golgi Apparatus/metabolism ; Mitosis ; Neural Stem Cells/metabolism ; Neurogenesis ; Receptors, Notch/metabolism ; Signal Transduction ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	Cell Cycle Proteins ; Receptors, Notch ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2017-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2016.12.042
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Zs.A 2496: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Divergence of developmental trajectories is triggered interactively by early social and ecological experience in a cooperative breeder.

Fischer, Stefan / Bohn, Lena / Oberhummer, Evelyne / Nyman, Cecilia / Taborsky, Barbara

Proceedings of the National Academy of Sciences of the United States of America

2017 Volume 114, Issue 44, Page(s) E9300–E9307

Abstract: Cooperative breeders feature the highest level of social complexity among vertebrates. Environmental constraints foster the evolution of this form of social organization, selecting for both well-developed social and ecological competences. Cooperative ... ...

Abstract	Cooperative breeders feature the highest level of social complexity among vertebrates. Environmental constraints foster the evolution of this form of social organization, selecting for both well-developed social and ecological competences. Cooperative breeders pursue one of two alternative social trajectories: delaying reproduction to care for the offspring of dominant breeders or dispersing early to breed independently. It is yet unclear which ecological and social triggers determine the choice between these alternatives and whether diverging developmental trajectories exist in cooperative vertebrates predisposing them to dispersal or philopatry. Here we experimentally reared juveniles of cooperatively breeding cichlid fish by varying the social environment and simulated predation threat in a two-by-two factorial long-term experiment. First, we show that individuals develop specialized behavioral competences, originating already in the early postnatal phase. Second, these specializations predisposed individuals to pursue different developmental trajectories and either to disperse early or to extend philopatry in adulthood. Thus, our results contrast with the proposition that social specializations in early ontogeny should be restricted to eusocial species. Importantly, social and ecological triggers were both required for the generation of divergent life histories. Our results thus confirm recent predictions from theoretical models that organisms should combine relevant information from different environmental cues to develop integrated phenotypes.
MeSH term(s)	Animals ; Behavior, Animal/physiology ; Breeding/methods ; Cichlids/physiology ; Cooperative Behavior ; Ecology/methods ; Ecosystem ; Female ; Male ; Phenotype ; Predatory Behavior/physiology ; Reproduction/physiology
Language	English
Publishing date	2017-10-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1705934114
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Article: Smell or vision? The use of different sensory modalities in predator discrimination.

Fischer, Stefan / Oberhummer, Evelyne / Cunha-Saraiva, Filipa / Gerber, Nina / Taborsky, Barbara

Behavioral ecology and sociobiology

2017 Volume 71, Issue 10, Page(s) 143

Abstract: Abstract: Theory predicts that animals should adjust their escape responses to the perceived predation risk. The information animals obtain about potential predation risk may differ qualitatively depending on the sensory modality by which a cue is ... ...

Abstract	Abstract: Theory predicts that animals should adjust their escape responses to the perceived predation risk. The information animals obtain about potential predation risk may differ qualitatively depending on the sensory modality by which a cue is perceived. For instance, olfactory cues may reveal better information about the presence or absence of threats, whereas visual information can reliably transmit the position and potential attack distance of a predator. While this suggests a differential use of information perceived through the two sensory channels, the relative importance of visual vs. olfactory cues when distinguishing between different predation threats is still poorly understood. Therefore, we exposed individuals of the cooperatively breeding cichlid Significance statement: The ability to rapidly discriminate between dangerous predators and harmless heterospecifics is crucial for the survival of prey animals. In seasonally fluctuating environment, sensory conditions may change over the year and may make the use of multiple sensory modalities for heterospecific discrimination highly beneficial. Here we compared the efficacy of visual and olfactory senses in the discrimination ability of the cooperatively breeding cichlid
Language	English
Publishing date	2017-09-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	194510-5
ISSN	1432-0762 ; 0340-5443
ISSN (online)	1432-0762
ISSN	0340-5443
DOI	10.1007/s00265-017-2371-8
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Article ; Online: Engineering of a fluorescent chemogenetic reporter with tunable color for advanced live-cell imaging

Hela Benaissa / Karim Ounoughi / Isabelle Aujard / Evelyne Fischer / Rosette Goïame / Julie Nguyen / Alison G. Tebo / Chenge Li / Thomas Le Saux / Giulia Bertolin / Marc Tramier / Lydia Danglot / Nicolas Pietrancosta / Xavier Morin / Ludovic Jullien / Arnaud Gautier

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 17

Abstract: Fluorescent reporters spanning the visible spectrum are needed for imaging live cells and organisms. Here the authors report a collection of fluorogenic chromophores that cover the visible spectrum from blue to red using a single engineered and optimised ...

Abstract	Fluorescent reporters spanning the visible spectrum are needed for imaging live cells and organisms. Here the authors report a collection of fluorogenic chromophores that cover the visible spectrum from blue to red using a single engineered and optimised protein tag.
Keywords	Science ; Q
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Audio / Video ; Thesis: Katheterinterventioneller Verschluss des persistierenden Foramen ovale mit neuem Okklusionssystem

Fischer, Evelyn

2009

Author's details	vorgelegt von Evelyn Fischer
Subject code	617.41
Language	German
Size	1 CD-ROM, 12 cm
Publishing country	Germany
Document type	Book ; Audio / Video ; Thesis
Thesis / German Habilitation thesis	Frankfurt (Main), Univ., Diss., 2010
Accompanying material	Beil. ([2] Bl.)
HBZ-ID	HT016484006
Database	Catalogue ZB MED Medicine, Health

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