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  1. Article ; Online: Declining incidence of intracerebral hemorrhage.

    Del Brutto, O H

    European journal of neurology

    2017  Volume 24, Issue 2, Page(s) e10

    Language English
    Publishing date 2017-02
    Publishing country England
    Document type Letter
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.13221
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  2. Article ; Online: The neglected strokes--cerebrovascular complications of neglected tropical diseases.

    Del Brutto, O H

    International journal of stroke : official journal of the International Stroke Society

    2015  Volume 10, Issue 2, Page(s) E14–5

    MeSH term(s) Humans ; Neglected Diseases/physiopathology ; Neglected Diseases/therapy ; Stroke/physiopathology ; Stroke/therapy ; Tropical Medicine
    Language English
    Publishing date 2015-02
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2303728-3
    ISSN 1747-4949 ; 1747-4930
    ISSN (online) 1747-4949
    ISSN 1747-4930
    DOI 10.1111/ijs.12414
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  3. Article ; Online: First application of a Spanish version simplified modified Rankin Scale questionnaire.

    Bruno, A / Sethuraman, S / Sedler, M J / Gladstone, D / Cagino, K / Del Brutto, V J / Sarmiento-Bobadilla, M / Costa, A F / Del Brutto, O H

    International journal of stroke : official journal of the International Stroke Society

    2019  Volume 14, Issue 5, Page(s) NP12

    MeSH term(s) Case-Control Studies ; Culturally Competent Care ; Female ; Humans ; Male ; Observer Variation ; Spain ; Stroke/diagnosis ; Surveys and Questionnaires ; Translations
    Language English
    Publishing date 2019-02-21
    Publishing country United States
    Document type Letter
    ZDB-ID 2303728-3
    ISSN 1747-4949 ; 1747-4930
    ISSN (online) 1747-4949
    ISSN 1747-4930
    DOI 10.1177/1747493019832983
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  4. Article ; Online: Hemorrhagic stroke in hispanics with severe SARS-CoV2 infection.

    Castillo, P R / Del Brutto, O H / Mautong, H / García, M / Tovar, M / Middlebrooks, E H / Bolona, E

    Journal of the neurological sciences

    2020  Volume 416, Page(s) 117046

    MeSH term(s) COVID-19 ; Hemorrhagic Stroke ; Hispanic Americans ; Humans ; RNA, Viral ; SARS-CoV-2
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2020.117046
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  5. Article: Frailty and Risk of Falls in Community-Dwelling Older Adults Living in a Rural Setting. The Atahualpa Project.

    Del Brutto, O H / Mera, R M / Peinado, C D / Zambrano, M / Sedler, M J

    The Journal of frailty & aging

    2020  Volume 9, Issue 3, Page(s) 150–154

    Abstract: Background: Data supporting a link between frailty and risk of falls is mostly confined to individuals living in urban centers, where risk factors and lifestyles are different from that of rural settings.: Objective: To assess the association between ...

    Abstract Background: Data supporting a link between frailty and risk of falls is mostly confined to individuals living in urban centers, where risk factors and lifestyles are different from that of rural settings.
    Objective: To assess the association between frailty and risk of falls in older adults living in rural Ecuador.
    Design: Population-based cross-sectional study.
    Participants: Community-dwellers aged ≥60 years living in a rural Ecuadorian village, in whom frail status and risk of falls were assessed.
    Measurements: Frailty was evaluated by the Edmonton Frailty Scale (EFS) and risk of falls by the Downton Fall Risk Index (DFRI). Multivariate models were fitted to evaluate whether frailty was associated with risk of falls (dependent variable), after adjusting for demographics, alcohol intake, cardiovascular risk factors, sleep quality, symptoms of depression, and history of an overt stroke. Correlation coefficients were constructed to assess confounders modifying this association.
    Results: A total of 324 participants (mean age: 70.5±8 years) were included. The mean EFS score was 4.4±2.5 points, with 180 (56%) participants classified as robust, 76 (23%) as pre-frail and 68 (21%) as frail. The DFRI was positive in 87 (27%) participants. In univariate analysis, the EFS score was higher among participants with a positive DFRI (p<0.001). The number of frail individuals was higher (p<0.001), while that of robust individuals was lower (p<0.001) among those with a positive DFRI. Adjusted logistic regression models showed no association between frailty and the DFRI. Correlation coefficients showed that age, high glucose levels, and history of an overt stroke tempered the association between frailty and the risk of falls found in univariate analyses.
    Conclusions: Frailty is not independently associated with risk of falls in older adults living in a remote rural setting. Further studies are needed to assess the impact of frailty on the risk of falls in these populations.
    MeSH term(s) Accidental Falls/statistics & numerical data ; Aged ; Cross-Sectional Studies ; Ecuador/epidemiology ; Frail Elderly/statistics & numerical data ; Frailty/epidemiology ; Humans ; Independent Living/statistics & numerical data ; Middle Aged ; Risk Assessment ; Rural Population/statistics & numerical data
    Language English
    Publishing date 2020-06-26
    Publishing country France
    Document type Journal Article
    ZDB-ID 2856228-8
    ISSN 2273-4309 ; 2260-1341
    ISSN (online) 2273-4309
    ISSN 2260-1341
    DOI 10.14283/jfa.2019.36
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  6. Article ; Online: Neurological complications of venomous snake bites: a review.

    Del Brutto, O H / Del Brutto, V J

    Acta neurologica Scandinavica

    2012  Volume 125, Issue 6, Page(s) 363–372

    Abstract: Snake bite envenoming is a neglected tropical disease affecting millions of people living in the developing world. According to the offending snake species, the clinical picture may be dominated by swelling and soft tissue necrosis in the bitten limb, or ...

    Abstract Snake bite envenoming is a neglected tropical disease affecting millions of people living in the developing world. According to the offending snake species, the clinical picture may be dominated by swelling and soft tissue necrosis in the bitten limb, or by systemic or neurological manifestations. Serious neurological complications, including stroke and muscle paralysis, are related to the toxic effects of the venom, which contains a complex mixture of toxins affecting the coagulation cascade, the neuromuscular transmission, or both. Metalloproteinases, serine proteases, and C-type lentins (common in viper and colubrid venoms) have anticoagulant or procoagulant activity and may be either agonists or antagonists of platelet aggregation; as a result, ischemic or hemorrhagic strokes may occur. In contrast, the venom of elapids is rich in phospholipase A(2) and three-finger proteins, which are potent neurotoxins affecting the neuromuscular transmission at either presynaptic or post-synaptic levels. Presynaptic-acting neurotoxins (called β-neurotoxins) inhibit the release of acetylcholine, while post-synaptic-acting neurotoxins (called α-neurotoxins) cause a reversible blockage of acetylcholine receptors. Proper management of the envenomed patient, including prompt transport to the hospital, correction of the hemostatic disorder, ventilatory support, and administration of antivenom, significantly reduces the risk of neurological complications which, in turn, reduce the mortality and improve the functional outcome of survivors.
    MeSH term(s) Animals ; Blood Coagulation/drug effects ; Humans ; Nervous System Diseases/etiology ; Neurotoxins/toxicity ; Snake Bites/complications ; Snake Bites/epidemiology ; Snake Bites/therapy ; Snake Venoms/toxicity ; Snakes
    Chemical Substances Neurotoxins ; Snake Venoms
    Language English
    Publishing date 2012-06
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 90-5
    ISSN 1600-0404 ; 0001-6314
    ISSN (online) 1600-0404
    ISSN 0001-6314
    DOI 10.1111/j.1600-0404.2011.01593.x
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    Ui I Zs.142: Show issues Location:
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  7. Article ; Online: The relationship between oily fish intake and arterial stiffness in older adults living in rural coastal Ecuador.

    Del Brutto, O H / Mera, R M / Peñaherrera, E / Peñaherrera, R / Costa, A F

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2018  Volume 28, Issue 11, Page(s) 1173–1174

    MeSH term(s) Age Factors ; Aged ; Animals ; Cross-Sectional Studies ; Diet ; Ecuador/epidemiology ; Female ; Fish Oils/administration & dosage ; Fishes ; Humans ; Male ; Middle Aged ; Nutritive Value ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/epidemiology ; Peripheral Arterial Disease/physiopathology ; Peripheral Arterial Disease/prevention & control ; Portion Size ; Protective Factors ; Recommended Dietary Allowances ; Risk Factors ; Rural Health ; Vascular Stiffness
    Chemical Substances Fish Oils
    Language English
    Publishing date 2018-08-02
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2018.07.010
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    Zs.A 3149: Show issues Location:
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  9. Article ; Online: Hemorrhagic stroke in hispanics with severe SARS-CoV2 infection

    Castillo, P.R. / Del Brutto, O.H. / Mautong, H. / García, M. / Tovar, M. / Middlebrooks, E.H. / Bolona, E.

    Journal of the Neurological Sciences

    2020  Volume 416, Page(s) 117046

    Keywords Neurology ; Clinical Neurology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2020.117046
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  10. Article: Neurocisticercosis: actualización en diagnóstico y tratamiento.

    Del Brutto, O H

    Neurologia (Barcelona, Spain)

    2005  Volume 20, Issue 8, Page(s) 412–418

    Abstract: Cysticercosis occurs when humans become intermediate hosts of Taenia solium after ingesting its eggs. It is the most common helminthic infection of the nervous system, and is endemic in Latin America, Asia and Africa, as well as in industrialized nations ...

    Title translation Neurocysticercosis: up-dating in diagnosis and treatment.
    Abstract Cysticercosis occurs when humans become intermediate hosts of Taenia solium after ingesting its eggs. It is the most common helminthic infection of the nervous system, and is endemic in Latin America, Asia and Africa, as well as in industrialized nations with a high immigrant influx of people coming from endemic areas. Neurocysticercosis is a pleomorphic disease due to individual differences in the number and location of the parasites within the nervous system as well as to differences in the severity of the host's immune reaction against the parasite. Common clinical manifestations include epilepsy, focal neurological signs, intracranial hypertension, and cognitive decline. Diagnosis require proper interpretation of clinical, neuroimaging, and serologic data, in the correct epidemiological context. Neuroimaging studies show the parasites as well as the changes they induce in the nervous system. Tests developed to detect anticysticercal antibodies in serum or cerebrospinal fluid present problems inherent to lack of specificity or sensibility, and should not be used by themselves to confirm or exclude the diagnosis. Cysticidal drugs (albendazole and praziquantel) have improved the prognosis of this condition. However, some patients have torpid clinical courses despite therapy. Surgery plays an important role in the management of some forms of the disease, particularly hydrocephalus and intraventricular cysts.
    MeSH term(s) Albendazole/therapeutic use ; Animals ; Anthelmintics/therapeutic use ; Antibodies/blood ; Antibodies/cerebrospinal fluid ; Humans ; Neurocysticercosis/diagnosis ; Neurocysticercosis/pathology ; Neurocysticercosis/physiopathology ; Neurocysticercosis/therapy ; Praziquantel/therapeutic use ; Taenia solium/immunology ; Taenia solium/metabolism
    Chemical Substances Anthelmintics ; Antibodies ; Praziquantel (6490C9U457) ; Albendazole (F4216019LN)
    Language Spanish
    Publishing date 2005-10
    Publishing country Spain
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 1056021-x
    ISSN 1578-1968 ; 0213-4853
    ISSN (online) 1578-1968
    ISSN 0213-4853
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