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Article ; Online: Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach.

Ghigna, Maria-Rosa / Thomas de Montpreville, Vincent

European respiratory review : an official journal of the European Respiratory Society

2021 Volume 30, Issue 162

Abstract: The diagnosis of a mediastinal mass may be challenging for clinicians, since lesions arising within the mediastinum include a variety of disease entities, frequently requiring a multidisciplinary approach. Age and sex represent important information, ... ...

Abstract	The diagnosis of a mediastinal mass may be challenging for clinicians, since lesions arising within the mediastinum include a variety of disease entities, frequently requiring a multidisciplinary approach. Age and sex represent important information, which need to be integrated with imaging and laboratory findings. In addition, the location of the mediastinal lesion is fundamental; indeed, we propose to illustrate mediastinal diseases based on the compartment of origin. We consider that this structured approach may serve as hint to the diagnostic modalities and management of mediastinal diseases. In this review, we present primary mediastinal tumours in the evolving context of new diagnostic and therapeutic tools, with recently described entities, based on our own experience with >900 cases encountered in the past 10 years.
MeSH term(s)	Diagnostic Imaging ; Humans ; Mediastinal Neoplasms/diagnostic imaging ; Mediastinal Neoplasms/therapy ; Mediastinum/diagnostic imaging
Language	English
Publishing date	2021-10-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1077620-5
ISSN	1600-0617 ; 0905-9180
ISSN (online)	1600-0617
ISSN	0905-9180
DOI	10.1183/16000617.0309-2020
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Article: Intimal granulomatous angiitis in sarcoid pulmonary vasculitis: worth remembering.

Bernaudin, Jean-François / Le Pavec, Jérôme / Fadel, Elie / Jeny, Florence / Valeyre, Dominique / Thomas de Montpreville, Vincent

ERJ open research

2023 Volume 9, Issue 3

Abstract: Intimal granulomatous angiitis is a facet of pulmonary sarcoidosis vasculitis that has almost been forgotten. Its observation may offer new understanding of the various patterns of pulmonary hypertension associated with sarcoidosis. ...

Abstract	Intimal granulomatous angiitis is a facet of pulmonary sarcoidosis vasculitis that has almost been forgotten. Its observation may offer new understanding of the various patterns of pulmonary hypertension associated with sarcoidosis.
Language	English
Publishing date	2023-05-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2827830-6
ISSN	2312-0541
ISSN	2312-0541
DOI	10.1183/23120541.00549-2022
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Article: Cysts of the posterior mediastinum showing müllerian differentiation (Hattori's cysts).

Thomas-de-Montpréville, Vincent / Dulmet, Elisabeth

Annals of diagnostic pathology

2007 Volume 11, Issue 6, Page(s) 417–420

Abstract: Cysts of probable müllerian origin have recently been recognized in the mediastinum by Hattori (Virchows Arch. 2005;446:82-84; Chest. 2005;128:3388-3390). In a retrospective study, we found 9 such cases, accounting for 5.5% of a series of 163 consecutive ...

Abstract	Cysts of probable müllerian origin have recently been recognized in the mediastinum by Hattori (Virchows Arch. 2005;446:82-84; Chest. 2005;128:3388-3390). In a retrospective study, we found 9 such cases, accounting for 5.5% of a series of 163 consecutive mediastinal nonneoplastic cysts operated in our institution. These cysts occurred in 9 women aged 40 to 58 years (mean, 50.6 years). These women often had overweight (n=4) or various gynecologic history (n=5). Cysts were paravertebral (n=8) or prevertebral (n=1). They were initially classified as bronchogenic or unspecified benign serous cysts. Their diameter measured 1.3 to 5 cm. Their thin wall contained smooth muscle. They were lined by a simple cylindrical or cuboidal, nonmucinous, and often ciliated epithelium resembling uterine tubal epithelium. This epithelium expressed cytokeratin 7, epithelial membrane antigen and estrogen and progesterone receptors. It was negative for cytokeratin 5/6. In the same series, there were 66 bronchogenic cysts, 6 being paravertebral. In conclusion, cysts with müllerian differentiation account for a small proportion of mediastinal cysts and have a usual but nonspecific paravertebral location.
MeSH term(s)	Adult ; Female ; Humans ; Hysterectomy ; Immunohistochemistry ; Leiomyoma/complications ; Leiomyoma/surgery ; Mediastinal Cyst/metabolism ; Mediastinal Cyst/pathology ; Middle Aged ; Mucin-1/metabolism ; Mullerian Ducts/pathology ; Obesity/complications ; Ovarian Cysts/complications ; Ovarian Cysts/surgery ; Polyps/complications ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Retrospective Studies ; Uterine Cervical Neoplasms/complications ; Uterine Cervical Neoplasms/surgery
Chemical Substances	Mucin-1 ; Receptors, Estrogen ; Receptors, Progesterone
Language	English
Publishing date	2007-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1440011-x
ISSN	1532-8198 ; 1092-9134
ISSN (online)	1532-8198
ISSN	1092-9134
DOI	10.1016/j.anndiagpath.2006.12.011
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Article: Molecular mechanisms of pathological tumor transformation and their clinical implications: predictors of pulmonary adenocarcinoma transformation into small cell carcinoma.

Ghigna, Maria-Rosa / Thomas De Montpréville, Vincent

Journal of thoracic disease

2017 Volume 9, Issue 10, Page(s) 3469–3472

Language	English
Publishing date	2017-12-18
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd.2017.09.15
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Article ; Online: Unexpected Cardiotoxicity in Patients With

Riudavets, Mariona / Azarine, Arshid / Smaali, Sondes / Kim, Young-Wouk / Thomas de Montpréville, Vincent / Grecea, Alina Miruna / Naltet, Charles / Gazzah, Annas / Planchard, David

JTO clinical and research reports

2022 Volume 3, Issue 12, Page(s) 100432

Abstract: Antibody-drug conjugates targeting receptor tyrosine-protein kinase erbB-2 ( ...

Abstract	Antibody-drug conjugates targeting receptor tyrosine-protein kinase erbB-2 (
Language	English
Publishing date	2022-11-10
Publishing country	United States
Document type	Case Reports
ISSN	2666-3643
ISSN (online)	2666-3643
DOI	10.1016/j.jtocrr.2022.100432
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Article: Heart tumors in children and adults: clinicopathological study of 59 patients from a surgical center.

Thomas-de-Montpréville, Vincent / Nottin, Rémi / Dulmet, Elisabeth / Serraf, Alain

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

2007 Volume 16, Issue 1, Page(s) 22–28

Abstract: Background: Heart tumors are rare lesions with variegated histological types. Their clinicopathological features could be more comprehensively categorized.: Methods: This is a 19-year retrospective study of 17 infants/toddlers (<2 years of age) and ... ...

Abstract	Background: Heart tumors are rare lesions with variegated histological types. Their clinicopathological features could be more comprehensively categorized. Methods: This is a 19-year retrospective study of 17 infants/toddlers (<2 years of age) and 42 patients aged between 14 and 79 years (mean = 51.5) in a surgical center. Results: Congenital tumors (n = 17; 29%), including rhabdomyomas (n = 9), ventricular fibromas (n = 6), and hemangiomas (n = 1), required surgery mainly because of mass effect. Familial myofibromatosis was the only embolic congenital lesion. Acquired benign tumors (n = 28; 47%) included myxomas (n = 21), fibroelastomas (n = 3), myofibroblastic inflammatory tumors (n = 2), and lipomas (n = 2). Eight (29%) were revealed by systemic embolization. These benign noncongenital tumors were all treated by complete resection, except for an incompletely resected lipoma of the mitral valve. Postoperative arrhythmia (n = 1) and pericardial effusion (n = 3) were the only complications. Primary sarcomas (n = 8; 14%) were mostly vascular tumors (five of eight), and patients with high-grade tumors had a mean survival of 15 months (n = 5). Cardiac metastases (n = 6; 10%) were from carcinomas (n = 3) or sarcomas (n = 3); apart from a necrotic metastasis, all patients died (mean survival of 6 months). Conclusions: This study shows that, regardless of patients' age, heart tumors can be classified as: (a) congenital lesions, which are spontaneously nonprogressive or regressive lesions possibly requiring surgery mainly because of mass effect; (b) acquired benign tumors, which are lesions requiring surgery often because of embolization risk; and (c) primary and secondary malignant tumors, which are lesions with globally poor prognosis but with some indications for resection.
MeSH term(s)	Adolescent ; Adult ; Aged ; Echocardiography ; Female ; Fibroma/congenital ; Fibroma/pathology ; Fibroma/surgery ; Heart Neoplasms/congenital ; Heart Neoplasms/pathology ; Heart Neoplasms/surgery ; Humans ; Infant ; Infant, Newborn ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Myxoma/pathology ; Myxoma/surgery ; Neoplasm Metastasis ; Neoplasm Regression, Spontaneous ; Retrospective Studies ; Rhabdomyoma/congenital ; Rhabdomyoma/pathology ; Rhabdomyoma/surgery ; Rhabdomyosarcoma/congenital ; Rhabdomyosarcoma/pathology ; Sarcoma/congenital ; Sarcoma/pathology ; Sarcoma/surgery
Language	English
Publishing date	2007-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1134600-0
ISSN	1054-8807
ISSN	1054-8807
DOI	10.1016/j.carpath.2006.05.008
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Article: Doppler echocardiography for surveillance of acute cardiac allograft rejection: a 28-year single-center experience.

Vallée, Aurélien / Houyel, Lucile / To, Ngoc Tram / Fels, Audrey / Kloeckner, Martin / Blanchard, David / Lemann, Thomas / Gaillard, Maïra / Ramadan, Ramzi / Genty, Thibaut / Thomas de Montpreville, Vincent / Beaussier, Hélène / Chatellier, Gilles / Deleuze, Philippe / Haulon, Stephan / Guihaire, Julien

Cardiovascular diagnosis and therapy

2024 Volume 14, Issue 1, Page(s) 59–71

Abstract: Background: Endomyocardial biopsies (EMB) are recommended for the detection of acute cardiac rejection (ACR) despite limited sensitivity. We report the long-term post-transplant results of Doppler echocardiography as a noninvasive alternative of routine ...

Abstract	Background: Endomyocardial biopsies (EMB) are recommended for the detection of acute cardiac rejection (ACR) despite limited sensitivity. We report the long-term post-transplant results of Doppler echocardiography as a noninvasive alternative of routine EMB. Methods: Two cohorts of heart transplantation (HT) recipients were chronologically defined as follows: the Dual Monitoring Cohort (DMC) from January 1990 to December 1997 included patients who underwent routine EMB and Doppler echocardiography within 24 hours for ACR surveillance; and the "Echo-First Cohort" (EFC), including patients transplanted from January 1998 to December 2018 with Doppler echocardiography as first-line approach for ACR surveillance. Echocardiographic measurements of interest were collected: early diastolic (E) wave peak velocity; pressure half time (PHT) and isovolumetric relaxation time (IVRT). Post-transplant outcomes were reviewed and the Kaplan-Meier approach was used for survival estimates. Inter-operator variability for ultrasound measurements was investigated. Data were collected from medical records from January 2019 to December 2020. Results: A total of 228 patients were included, 99 patients in the DMC and 129 in the EFC. Overall, 5-, 10- and 15-year survival rates were 65.4%, 55.5% and 44.1% respectively, without any significant difference between the two cohorts (log rank test, P=0.71). Echocardiography variables and EMB findings were associated with a mean area under the receiver operating characteristic curve (AUC-ROC) of 0.73 [95% confidence interval (CI): 0.54-0.91], 0.74 (95% CI: 0.54-0.94) and 0.75 (95% CI: 0.57-0.94) respectively for E wave, PHT and IVRT. IVRT and PHT were significantly decreased, and E wave significantly increased, in case of histologically proven ACR. Inter-operator variability was not significant for E wave and IVRT measurements (P=0.13 and 0.30 respectively). Conclusions: Doppler echocardiography as a first-line method for surveillance of ACR did not impair long-term results after HT. These findings suggest that this non-invasive approach might be a reasonable alternative to systematic EMB, limiting risk and improving the quality of life.
Language	English
Publishing date	2024-01-31
Publishing country	China
Document type	Journal Article
ZDB-ID	2685043-6
ISSN	2223-3660 ; 2223-3652
ISSN (online)	2223-3660
ISSN	2223-3652
DOI	10.21037/cdt-23-305
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Article: Involvement of SUR2/Kir6.1 channel in the physiopathology of pulmonary arterial hypertension.

Le Ribeuz, Hélène / Masson, Bastien / Dutheil, Mary / Boët, Angèle / Beauvais, Antoine / Sabourin, Jessica / De Montpreville, Vincent Thomas / Capuano, Véronique / Mercier, Olaf / Humbert, Marc / Montani, David / Antigny, Fabrice

Frontiers in cardiovascular medicine

2023 Volume 9, Page(s) 1066047

Abstract: Aims: We hypothesized that the ATP-sensitive K: Methods and results: Using : Conclusion: We showed that SUR2A, SUR2B, and Kir6.1 are presented in hPASMCs and hPAECs of controls and PAH patients. ...

Abstract	Aims: We hypothesized that the ATP-sensitive K Methods and results: Using Conclusion: We showed that SUR2A, SUR2B, and Kir6.1 are presented in hPASMCs and hPAECs of controls and PAH patients.
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.1066047
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Article ; Online: Retrospective study of outcomes after extended resection for tracheobronchial adenoid cystic carcinoma.

Estephan, Jérôme / Mercier, Olaf / Thomas de Montpreville, Vincent / Hanna, Amir / Leymarie, Nicolas / Le Pechoux, Cecile / Fadel, Elie

The Journal of thoracic and cardiovascular surgery

2022 Volume 165, Issue 6, Page(s) 1954–1964.e5

Abstract: Objective: Tracheobronchial adenoid cystic carcinoma is a rare, slow-growing malignancy with a considerable propensity for local extension that may require complex airway resection to achieve tumor-free margins. The objective of this study was to assess ...

Abstract	Objective: Tracheobronchial adenoid cystic carcinoma is a rare, slow-growing malignancy with a considerable propensity for local extension that may require complex airway resection to achieve tumor-free margins. The objective of this study was to assess whether our experience supports complex airway resection for tracheobronchial adenoid cystic carcinoma. Methods: Consecutive patients who underwent curative resection for tracheobronchial adenoid cystic carcinoma at our institution between 1970 and 2019 were included retrospectively and classified as having had complex or standard resection. Complex surgery included total tracheal replacement, associated esophageal resection, pneumonectomy, total laryngectomy with tracheal resection, and carinal resection. Standard surgery included tracheal resection, bronchoplastic resection, lobectomy, and bilobectomy. We obtained data from medical records, referring physicians, patients, relatives, and public death records. Results: Of 59 included patients, 38 had complex and 21 had standard surgery. All 4 (6.8%) patients who died postoperatively had undergone complex surgery. Postoperative morbidity was 32.2% overall and was significantly higher after complex surgery (P = .043). Overall 5- and 10-year survival rates were 81.5% and 60.2%, with no significant differences between groups (P = .31). By univariate analysis, T4 tumor and microscopically detectable tumor in the operative specimen margins and gross tumor in the operative specimen margins were associated with poorer survival (P < .05). In the subgroup with microscopically detectable tumor resection, survival was significantly better with adjuvant radiotherapy (P < .05). Conclusions: Complex resection for extended tracheobronchial adenoid cystic carcinoma may achieve local control and satisfying long-term survival. However, this demanding procedure is associated with high postoperative morbidity and mortality rates. Because adjuvant radiotherapy improved outcomes after resection resulting in microscopically detectable tumor in the operative specimen margins, expected outcomes after resection with no detectable tumor in the margins must be compared to those after resection resulting in microscopically detectable tumor in the margins plus radiotherapy, according to the operative risk.
MeSH term(s)	Humans ; Retrospective Studies ; Carcinoma, Adenoid Cystic/surgery ; Carcinoma, Adenoid Cystic/pathology ; Follow-Up Studies ; Tracheal Neoplasms/pathology ; Thoracic Surgical Procedures/methods
Language	English
Publishing date	2022-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2022.10.048
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Article ; Online: Outcome of unexplained acute respiratory distress syndrome with diffuse alveolar damage after lung transplantation.

Stéphan, François / de Montpréville, Vincent Thomas / Diarra, Coumba / Pilorge, Catherine / Fadel, Elie / Ghigna, Maria-Rosa

Intensive care medicine

2018 Volume 44, Issue 4, Page(s) 525–527

MeSH term(s)	Humans ; Lung Transplantation ; Pulmonary Alveoli/pathology ; Respiratory Distress Syndrome, Adult
Language	English
Publishing date	2018-01-20
Publishing country	United States
Document type	Letter
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-018-5050-y
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