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Article ; Online: Long non-coding RNA H19 alleviates hippocampal damage in convulsive status epilepticus rats through the nuclear factor-kappaB signaling pathway.

Xie, Yangmei / Wang, Ming / Deng, Xiaolin / Chen, Yinghui

2022 Volume 13, Issue 5, Page(s) 12783–12793

Abstract: Previous studies have demonstrated that inflammation plays a critical role in hippocampcal damage and cognitive dysfunction induced by convulsive status epilepticus (CSE). Emerging evidence indicated that the long non-coding RNA (lncRNA) H19 acts as an ... ...

Abstract	Previous studies have demonstrated that inflammation plays a critical role in hippocampcal damage and cognitive dysfunction induced by convulsive status epilepticus (CSE). Emerging evidence indicated that the long non-coding RNA (lncRNA) H19 acts as an important regulator of inflammation in various diseases. However, the role of H19 in CSE is still unkonwn. In the present study, pilocarpine-induced SE rat model was used to explore the role of H19 in hippocampal neuron damage in CSE. Our results indicated that the increased level of H19 is positively correlated with the expression of inflammatory cytokines (TNF-α and IL-1β) in hippocampus of SE rats. Moreover, knockdown of H19 could inhibit the activation of microglia and suppress the expression of inflammatory cytokines via nuclear factor-kappaB (NF-κB) signaling pathway. It was further revealed that downregulation of H19 could alleviate hippocampal neuron damage induced by CSE. These findings indicated that H19 modulates inflammatory response and hippocampal damage through the NF-κB signaling pathway in the CSE rats, which provides a promising target to alleviate hippocampcal damage of CSE.
MeSH term(s)	Animals ; Cytokines/metabolism ; Hippocampus/metabolism ; Inflammation/metabolism ; NF-kappa B/genetics ; NF-kappa B/metabolism ; RNA, Long Noncoding/metabolism ; Rats ; Signal Transduction/genetics ; Status Epilepticus/chemically induced ; Status Epilepticus/genetics ; Status Epilepticus/metabolism
Chemical Substances	Cytokines ; H19 long non-coding RNA ; NF-kappa B ; RNA, Long Noncoding
Language	English
Publishing date	2022-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2737830-5
ISSN	2165-5987 ; 2165-5979
ISSN (online)	2165-5987
ISSN	2165-5979
DOI	10.1080/21655979.2022.2074760
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Using Curriculum Learning in Pattern Recognition of 3-dimensional Cryo-electron Microscopy Density Maps.

Deng, Yangmei / Mu, Yongcheng / Sazzed, Salim / Sun, Jiangwen / He, Jing

ACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine

2022 Volume 2020

Abstract: Although Cryo-electron microscopy (cryo-EM) has been successfully used to derive atomic structures for many proteins, it is still challenging to derive atomic structure when the resolution of cryo-EM density maps is in the medium range, e.g., 5-10 Å. ... ...

Abstract	Although Cryo-electron microscopy (cryo-EM) has been successfully used to derive atomic structures for many proteins, it is still challenging to derive atomic structure when the resolution of cryo-EM density maps is in the medium range, e.g., 5-10 Å. Studies have attempted to utilize machine learning methods, especially deep neural networks to build predictive models for the detection of protein secondary structures from cryo-EM images, which ultimately helps to derive the atomic structure of proteins. However, the large variation in data quality makes it challenging to train a deep neural network with high prediction accuracy. Curriculum learning has been shown as an effective learning paradigm in machine learning. In this paper, we present a study using curriculum learning as a more effective way to utilize cryo-EM density maps with varying quality. We investigated three distinct training curricula that differ in whether/how images used for training in past are reused while the network was continually trained using new images. A total of 1,382 3-dimensional cryo-EM images were extracted from density maps of Electron Microscopy Data Bank in our study. Our results indicate learning with curriculum significantly improves the performance of the final trained network when the forgetting problem is properly addressed.
Language	English
Publishing date	2022-07-15
Publishing country	United States
Document type	Journal Article
DOI	10.1145/3388440.3414710
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Association of Outdoor Walking Per Week with Mental Health and Costs of Psychotropic Drugs in Adults.

Wang, Meng / Jiang, Caixia / Huang, Yangmei / He, Xiaoyan / Deng, Lamei

Journal of community health

2022 Volume 48, Issue 1, Page(s) 136–140

Abstract: Regular walking confers many physical health benefits, including a reduced risk of disease-specific and all-cause mortality and better physical fitness. However, less is known about its role in mental health. Thus, the aims of this study were to ... ...

Abstract	Regular walking confers many physical health benefits, including a reduced risk of disease-specific and all-cause mortality and better physical fitness. However, less is known about its role in mental health. Thus, the aims of this study were to determine the associations of outdoor walking per week with costs of psychotropic drugs used and mental health in adults. 500 adults aged 18 to 64 years in Hangzhou (China) reported sex, age, the name of the psychotropic drugs used and their dosage, and outdoor walking during the past 7 days. The cost that a person spends on buying psychotropic drugs for a month was considered psychotropic drugs costs. Overall mental health was assessed using the Chinese Version of the 12-Item General Health Questionnaire. The levels of walking in participants taking psychotropic were significantly lower than participants who did not taking psychotropic (p = 0.002). There was a significant negative correlation between mental health scores and minutes of walking per week and a significant positive correlation between the number of psychotropic drugs used and walking per week (p < 0.05). However, no particular associations were found between costs of psychotropic drug used and walking per week. Outdoor walking is prospectively associated with better overall mental health in adults. Then, awareness should be raised about the possible positive effects of outdoor walking on the mental health of adults.
MeSH term(s)	Humans ; Adult ; Infant, Newborn ; Mental Health ; Walking ; Psychotropic Drugs ; China
Chemical Substances	Psychotropic Drugs
Language	English
Publishing date	2022-11-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	426631-6
ISSN	1573-3610 ; 0094-5145
ISSN (online)	1573-3610
ISSN	0094-5145
DOI	10.1007/s10900-022-01157-6
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Article ; Online: Astaxanthin Attenuates Neuroinflammation in Status Epilepticus Rats by Regulating the ATP-P2X7R Signal.

Wang, Ming / Deng, Xiaolin / Xie, Yangmei / Chen, Yinghui

Drug design, development and therapy

2020 Volume 14, Page(s) 1651–1662

Abstract: Background: As a life-threatening neurological emergency, status epilepticus (SE) is often refractory to available treatment. Current studies have shown a causal role of neuroinflammation in patients with lower seizure thresholds and driving seizures. ... ...

Abstract	Background: As a life-threatening neurological emergency, status epilepticus (SE) is often refractory to available treatment. Current studies have shown a causal role of neuroinflammation in patients with lower seizure thresholds and driving seizures. The ATP-gated purinergic P2X7 receptor (P2X7R) is mainly expressed on the microglia, which function as gatekeepers of inflammation. Although emerging evidence has demonstrated significant anti-inflammatory effects of astaxanthin (AST) in SE, the associated mechanism remains unclear. Therefore, this study aimed to clarify the effects of AST on P2X7R-related inflammation in SE. Methods: SE was induced in rats using lithium-pilocarpine, and AST was administered 1 h after SE induction. Rat microglia were treated with lipopolysaccharide (LPS), AST, ATP, 2,3-O-4-benzoyl-4-benzoyl-ATP (BzATP) and oxidized ATP (oxATP). The Morris water maze, immunohistochemistry, and Nissl staining were performed in rats. Expressions of P2X7R and inflammatory cytokines (such as cycloxygenase-2 (Cox-2), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α)) were detected using real-time polymerase chain reaction (RT-PCR) and Western blot (WB) both in rats and microglia. ATP concentration in the microglia was evaluated using ELISA. Results: The AST alleviated hippocampal injury and improved cognitive dysfunction induced by SE. AST also effectively inhibited inflammation and downregulated P2X7R expression in both rat brain and microglia. The results also showed that AST reduced the extracellular ATP levels and that P2X7R expression could be increased by extracellular ATP. In addition, BzATP upregulates the expression of P2X7R and inflammatory factors in microglia. Conversely, it downregulates the expression of P2X7R and inflammatory factors. Conclusion: Our study suggests that AST attenuated ATP-P2X7R mediated inflammation in SE.
MeSH term(s)	Adenosine Triphosphate/metabolism ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Dose-Response Relationship, Drug ; Inflammation/drug therapy ; Inflammation/metabolism ; Lipopolysaccharides ; Male ; Rats ; Rats, Wistar ; Receptors, Purinergic P2X7/metabolism ; Signal Transduction/drug effects ; Status Epilepticus/chemically induced ; Status Epilepticus/drug therapy ; Status Epilepticus/metabolism ; Structure-Activity Relationship ; Xanthophylls/administration & dosage ; Xanthophylls/pharmacology
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Lipopolysaccharides ; Receptors, Purinergic P2X7 ; Xanthophylls ; Adenosine Triphosphate (8L70Q75FXE) ; astaxanthine (8XPW32PR7I)
Language	English
Publishing date	2020-04-30
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S249162
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Changes in Metal Distribution, Vegetative Growth, Reactive Oxygen and Nutrient Absorption of Tagetes patula under Soil Cadmium Stress

Shi, Hongzhou / Wang, Yangmei / Chen, Hong / Deng, Fuxiang / Liu, Yongan / Cao, Guoxing

Horticulturae. 2022 Jan. 12, v. 8, no. 1

2022

Abstract: Phytoremediation with hyperaccumulator plants has been recognized as a potential way for the clearing of cadmium (Cd)-contaminated soil. In this study, hyperaccumulator Tagetes patula was treated with seven concentrations of Cd, ranging from 0 to 300 mg ... ...

Abstract	Phytoremediation with hyperaccumulator plants has been recognized as a potential way for the clearing of cadmium (Cd)-contaminated soil. In this study, hyperaccumulator Tagetes patula was treated with seven concentrations of Cd, ranging from 0 to 300 mg kg⁻¹. The Cd enrichment and nutrient contents in different organs during different growth phases were investigated. Under Cd concentrations ≤75 mg kg⁻¹, the morphological growth of T. patula did not change significantly regardless of growth stage. However, when Cd concentration exceeded 150 mg kg⁻¹, the morphological growth was remarkedly inhibited. The root/shoot ratio remained unchanged except for at 300 mg kg⁻¹. In addition, Cd negatively influenced the flowering process at the concentration of 300 mg kg⁻¹. Cd content increased significantly in Cd-treated plants. Nitrogen absorption was increased under Cd treatments, and phosphorus content was also increased under concentration ≤150 mg·kg⁻¹. However, the potassium content in the flower was decreased under 300 mg kg⁻¹. Furthermore, the contents of H₂O₂, O²⁻ and malondialdehyde were increased during the seedling phase, especially when Cd concentration was ≥150 mg kg⁻¹. In summary, T. patula showed a strong ability to tolerate Cd, and such ability might be explained by nutrient absorption and reactive oxygen clearness.
Keywords	Tagetes patula ; absorption ; cadmium ; flowers ; hyperaccumulators ; malondialdehyde ; nitrogen ; nutrient uptake ; oxygen ; phosphorus content ; phytoremediation ; potassium ; seedlings ; vegetative growth
Language	English
Dates of publication	2022-0112
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2813983-5
ISSN	2311-7524
ISSN	2311-7524
DOI	10.3390/horticulturae8010069
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of Neuroinflammation on ABC Transporters: Possible Contribution to Refractory Epilepsy.

Deng, Xiaolin / Xie, Yangmei / Chen, Yinghui

CNS & neurological disorders drug targets

2018 Volume 17, Issue 10, Page(s) 728–735

Abstract: Background & objective: Epilepsy is a common and serious chronic neurological disorder that is mainly treated with antiepileptic drugs. Although current antiepileptic drugs used in clinical practice have advanced to the third generation, approximately ... ...

Abstract	Background & objective: Epilepsy is a common and serious chronic neurological disorder that is mainly treated with antiepileptic drugs. Although current antiepileptic drugs used in clinical practice have advanced to the third generation, approximately one-third of patients are refractory to these treatments. More efficacious treatments for refractory epilepsy are therefore needed. A better understanding of the mechanism underlying refractory epilepsy is likely to facilitate the development of a more effective therapy. The abnormal expression and/or dysfunction of efflux transporters, particularly ABC transporters, might contribute to certain cases of refractory epilepsy. Inflammation in the brain has recently been shown to regulate the expression and/or function of ABC transporters in the cerebral vascular endothelial cells and glia of the blood-brain barrier by activating intracellular signalling pathways. Conclusion: Therefore, in this review, we will briefly summarize recent research advances regarding the possible role of neuroinflammation in regulating ABC transporter expression in epilepsy.
MeSH term(s)	ATP-Binding Cassette Transporters/metabolism ; Animals ; Anticonvulsants/therapeutic use ; Drug Resistant Epilepsy/drug therapy ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Humans ; Neuroglia/drug effects ; Neuroglia/metabolism
Chemical Substances	ATP-Binding Cassette Transporters ; Anticonvulsants
Language	English
Publishing date	2018-09-12
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2228394-8
ISSN	1996-3181 ; 1871-5273
ISSN (online)	1996-3181
ISSN	1871-5273
DOI	10.2174/1871527317666180828121820
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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Long Non-coding RNA KCNQ1OT1 Contributes to Antiepileptic Drug Resistance Through the miR-138-5p/ABCB1 Axis

Xie, Yangmei / Wang, Ming / Shao, Yiye / Deng, Xiaolin / Chen, Yinghui

Frontiers in neuroscience

2019 Volume 13, Page(s) 1358

Abstract: Compelling evidence has verified that long non-coding RNAs (lncRNAs) play a critical role on drug resistance in various diseases, especially cancer. However, the role of lncRNAs underlying multidrug resistance in epilepsy remains to be clarified. In the ... ...

Abstract	Compelling evidence has verified that long non-coding RNAs (lncRNAs) play a critical role on drug resistance in various diseases, especially cancer. However, the role of lncRNAs underlying multidrug resistance in epilepsy remains to be clarified. In the present study, we investigated the potential regulatory mechanism of the lncRNA KCNQ1OT1 in regulating antiepileptic drug (AED) resistance in human brain microvascular endothelial cells (HBMECs). The results revealed that expression of P-glycoprotein (P-gp) and KCNQ1OT1 was significantly elevated in phenytoin-resistant HBMECs (HBMEC/PHT). Meanwhile, the activity of nuclear factor-kappa B (NF-κB) was increased in HBMECs/PHT cells. Microarray analysis indicated that miR-138-5p was downregulated in HBMEC/PHT cells. Interestingly, bioinformatics prediction tools indicated miR-138-5p could directly target the transcripts of KCNQ1OT1 and NF-κB p65, and these results were confirmed by luciferase assays. Moreover, KCNQ1OT1 downregulation or miR-138-5p upregulation
Language	English
Publishing date	2019-12-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2019.01358
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: HAP1 Modulates Epileptic Seizures by Regulating GABA

Li, Rong / Wu, Bing / He, Miaoqing / Zhang, Peng / Zhang, Qinbin / Deng, Jing / Yuan, Jinxian / Chen, Yangmei

Neurochemical research

2020 Volume 45, Issue 9, Page(s) 1997–2008

Abstract: The number of γ-aminobutyric acid type A receptors ( ... ...

Abstract	The number of γ-aminobutyric acid type A receptors (GABA
MeSH term(s)	Adolescent ; Adult ; Animals ; Child ; Child, Preschool ; Epilepsy, Temporal Lobe/chemically induced ; Epilepsy, Temporal Lobe/physiopathology ; Female ; GABA Antagonists/pharmacology ; Gene Knockout Techniques ; Humans ; Inhibitory Postsynaptic Potentials/physiology ; Male ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Pentylenetetrazole ; Picrotoxin/pharmacology ; Rats, Sprague-Dawley ; Receptors, GABA-A/metabolism ; Up-Regulation/drug effects ; Young Adult
Chemical Substances	GABA Antagonists ; GABRB2 protein, human ; Gabrb2 protein, rat ; HAP1 protein, human ; Hap1 protein, rat ; Nerve Tissue Proteins ; Receptors, GABA-A ; Picrotoxin (124-87-8) ; Pentylenetetrazole (WM5Z385K7T)
Language	English
Publishing date	2020-05-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	199335-5
ISSN	1573-6903 ; 0364-3190
ISSN (online)	1573-6903
ISSN	0364-3190
DOI	10.1007/s11064-020-03052-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1368: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: MicroRNA-298 Reverses Multidrug Resistance to Antiepileptic Drugs by Suppressing MDR1/P-gp Expression

Xie, Yangmei / Shao, Yiye / Deng, Xiaolin / Wang, Ming / Chen, Yinghui

Frontiers in neuroscience

2018 Volume 12, Page(s) 602

Abstract: P-glycoprotein (P-gp), a critical multidrug transporter, recognizes and transports various antiepileptic drugs (AEDs) through the blood-brain barrier (BBB). This may decrease the concentrations of AEDs in brain tissues and cause multidrug resistance (MDR) ...

Abstract	P-glycoprotein (P-gp), a critical multidrug transporter, recognizes and transports various antiepileptic drugs (AEDs) through the blood-brain barrier (BBB). This may decrease the concentrations of AEDs in brain tissues and cause multidrug resistance (MDR) in patients with refractory epilepsy. Compelling evidence indicates that microRNAs (miRNAs) modulate MDR in various cancers by regulating P-gp expression. Furthermore, a previous study showed that miR-298 mediates MDR in breast cancer cells by downregulating P-gp expression. Based on the therapeutic results obtained from tumor cells, we aimed to determine whether miR-298 reverses MDR to AEDs by regulating P-gp expression in the BBB. We first established different drug-resistant cell lines, including PHT-resistant HBMECs (human brain microvascular endothelial cells) and doxorubicin (DOX)-resistant U87-MG (human malignant glioma) cells, by inducing P-gp overexpression. Quantitative real-time PCR (qRT-PCR) analysis revealed reduced expression of miR-298 in both HBMEC/PHT and U87-MG/DOX cells, and the luciferase reporter assay identified the direct binding of miR-298 to the 3'-untranslated region (3'-UTR) of P-gp. Moreover, ectopic expression of miR-298 downregulated P-gp expression at the mRNA and protein levels, thereby increasing the intracellular accumulation of AEDs in drug-resistant HBMEC/PHT and U87-MG/DOX cells. Thus, our findings suggest that miR-298 reverses MDR to AEDs by inhibiting P-gp expression, suggesting a potential target for overcoming MDR in refractory epilepsy.
Language	English
Publishing date	2018-08-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2018.00602
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: MicroRNA-146a: A Comprehensive Indicator of Inflammation and Oxidative Stress Status Induced in the Brain of Chronic T2DM Rats.

Xie, Yangmei / Chu, Aiqun / Feng, Yonghao / Chen, Long / Shao, Yiye / Luo, Qiong / Deng, Xiaolin / Wu, Men / Shi, Xiaohong / Chen, Yinghui

Frontiers in pharmacology

2018 Volume 9, Page(s) 478

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2018-05-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2018.00478
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