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  1. Book: The mitoribosome

    Barrientos, Antonio / Fontanesi, Flavia

    methods and protocols

    (Methods in molecular biology ; 2661 ; Springer protocols)

    2023  

    Author's details edited by Antonio Barrientos and Flavia Fontanesi
    Series title Methods in molecular biology ; 2661
    Springer protocols
    DNA and RNA origami
    Collection DNA and RNA origami
    Keywords Mitochondria
    Subject code 571.657
    Language English
    Size xi, 346 Seiten, Illustrationen, 26 cm
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT030017894
    ISBN 978-1-071-63170-6 ; 9781071631713 ; 1-071-63170-5 ; 1071631713
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 7042 -2661- not available for loan Lesesaal EG

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  2. Article ; Online: IUBMB Life special issue: Mitochondrial biology and the yeast paradigm.

    Fontanesi, Flavia

    IUBMB life

    2024  

    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1492141-8
    ISSN 1521-6551 ; 1521-6543
    ISSN (online) 1521-6551
    ISSN 1521-6543
    DOI 10.1002/iub.2820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Metabolic Labeling of Mitochondrial Translation Products in Whole Cells and Isolated Organelles.

    Maiti, Priyanka / Fontanesi, Flavia

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2661, Page(s) 193–215

    Abstract: Mitochondria retain their own genome and translational apparatus that is highly specialized in the synthesis of a handful of proteins, essential components of the oxidative phosphorylation system. During evolution, the players and mechanisms involved in ... ...

    Abstract Mitochondria retain their own genome and translational apparatus that is highly specialized in the synthesis of a handful of proteins, essential components of the oxidative phosphorylation system. During evolution, the players and mechanisms involved in mitochondrial translation have acquired some unique features, which we have only partially disclosed. The study of the mitochondrial translation process has been historically hampered by the lack of an in vitro translational system and has largely relied on the analysis of the incorporation rate of radiolabeled amino acids into mitochondrial proteins in cellulo or in organello. In this chapter, we describe methods to monitor mitochondrial translation by labeling newly synthesized mitochondrial polypeptides with [S
    MeSH term(s) Animals ; Protein Biosynthesis ; Mitochondria/metabolism ; Methionine/metabolism ; Amino Acids/metabolism ; Mitochondrial Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Mammals/genetics
    Chemical Substances Methionine (AE28F7PNPL) ; Amino Acids ; Mitochondrial Proteins
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3171-3_12
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  4. Article ; Online: Mitochondrial respiratory supercomplexes of the yeast Saccharomyces cerevisiae.

    Eldeeb, Mazzen H / Camacho Lopez, Lizeth J / Fontanesi, Flavia

    IUBMB life

    2024  

    Abstract: The functional and structural relationship among the individual components of the mitochondrial respiratory chain constitutes a central aspect of our understanding of aerobic catabolism. This interplay has been a subject of intense debate for over 50 ... ...

    Abstract The functional and structural relationship among the individual components of the mitochondrial respiratory chain constitutes a central aspect of our understanding of aerobic catabolism. This interplay has been a subject of intense debate for over 50 years. It is well established that individual respiratory enzymes associate into higher-order structures known as respiratory supercomplexes, which represent the evolutionarily conserved organizing principle of the mitochondrial respiratory chain. In the yeast Saccharomyces cerevisiae, supercomplexes are formed by a complex III homodimer flanked by one or two complex IV monomers, and their high-resolution structures have been recently elucidated. Despite the wealth of structural information, several proposed supercomplex functions remain speculative and our understanding of their physiological relevance is still limited. Recent advances in the field were made possible by the construction of yeast strains where the association of complex III and IV into supercomplexes is impeded, leading to diminished respiratory capacity and compromised cellular competitive fitness. Here, we discuss the experimental evidence and hypotheses relative to the functional roles of yeast respiratory supercomplexes. Moreover, we review the current models of yeast complex III and IV assembly in the context of supercomplex formation and highlight the data scattered throughout the literature suggesting the existence of cross talk between their biogenetic processes.
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1492141-8
    ISSN 1521-6551 ; 1521-6543
    ISSN (online) 1521-6551
    ISSN 1521-6543
    DOI 10.1002/iub.2817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The DEAD Box Protein Mrh4 Functions in the Assembly of the Mitochondrial Large Ribosomal Subunit.

    De Silva, Dasmanthie / Fontanesi, Flavia / Barrientos, Antoni

    Cell metabolism

    2023  Volume 36, Issue 1, Page(s) 222

    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2023.11.016
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  6. Article ; Online: The functional significance of mitochondrial respiratory chain supercomplexes.

    Kohler, Andreas / Barrientos, Antoni / Fontanesi, Flavia / Ott, Martin

    EMBO reports

    2023  Volume 24, Issue 11, Page(s) e57092

    Abstract: The mitochondrial respiratory chain (MRC) is a key energy transducer in eukaryotic cells. Four respiratory chain complexes cooperate in the transfer of electrons derived from various metabolic pathways to molecular oxygen, thereby establishing an ... ...

    Abstract The mitochondrial respiratory chain (MRC) is a key energy transducer in eukaryotic cells. Four respiratory chain complexes cooperate in the transfer of electrons derived from various metabolic pathways to molecular oxygen, thereby establishing an electrochemical gradient over the inner mitochondrial membrane that powers ATP synthesis. This electron transport relies on mobile electron carries that functionally connect the complexes. While the individual complexes can operate independently, they are in situ organized into large assemblies termed respiratory supercomplexes. Recent structural and functional studies have provided some answers to the question of whether the supercomplex organization confers an advantage for cellular energy conversion. However, the jury is still out, regarding the universality of these claims. In this review, we discuss the current knowledge on the functional significance of MRC supercomplexes, highlight experimental limitations, and suggest potential new strategies to overcome these obstacles.
    MeSH term(s) Mitochondrial Membranes/metabolism ; Electron Transport ; Mitochondria/metabolism
    Language English
    Publishing date 2023-10-12
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202357092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 41: Show issues

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  7. Article: The human mitochondrial mRNA structurome reveals mechanisms of gene expression.

    Conor Moran, J / Brivanlou, Amir / Brischigliaro, Michele / Fontanesi, Flavia / Rouskin, Silvi / Barrientos, Antoni

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The mammalian mitochondrial genome encodes thirteen oxidative phosphorylation system proteins, crucial in aerobic energy transduction. These proteins are translated from 9 monocistronic and 2 bicistronic transcripts, whose native structures remain ... ...

    Abstract The mammalian mitochondrial genome encodes thirteen oxidative phosphorylation system proteins, crucial in aerobic energy transduction. These proteins are translated from 9 monocistronic and 2 bicistronic transcripts, whose native structures remain unexplored, leaving fundamental molecular determinants of mitochondrial gene expression unknown. To address this gap, we developed a mitoDMS-MaPseq approach and used DREEM clustering to resolve the native human mitochondrial mt-mRNA structurome. We gained insights into mt-mRNA biology and translation regulatory mechanisms, including a unique programmed ribosomal frameshifting for the
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.31.564750
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  8. Article ; Online: Spin-dependent electrochemistry and electrochemical enantioselective recognition with chiral methylated bis(ethylenedithio)-tetrathiafulvalenes.

    Stefani, Andrea / Bogdan, Alexandra / Pop, Flavia / Tassinari, Francesco / Pasquali, Luca / Fontanesi, Claudio / Avarvari, Narcis

    The Journal of chemical physics

    2023  Volume 159, Issue 20

    Abstract: Enantio-discrimination and spin-dependent electrochemistry (SDE), as a manifestation of the chirality-induced spin selectivity (CISS) effect, are important phenomena that can be probed by "chiral" electrochemistry. Here, we prepared chiralized surfaces ... ...

    Abstract Enantio-discrimination and spin-dependent electrochemistry (SDE), as a manifestation of the chirality-induced spin selectivity (CISS) effect, are important phenomena that can be probed by "chiral" electrochemistry. Here, we prepared chiralized surfaces of gold and nickel, to serve as working electrodes, through effective chemisorption of enantiopure dimethyl-bis(ethylenedithio)-tetrathiafulvalene (DM-BEDT-TTF) 1, tetramethyl-bis(ethylenedithio)-tetrathiafulvalene (TM-BEDT-TTF) 2, and their capped silver nanoparticle (AgNPs) aggregate by simple incubation of the metallic substrates. The effective chemisorption was checked by means of ultrahigh vacuum x-ray photoelectron spectroscopy (XPS) and by electro-desorption experiments, i.e., cyclic voltammetry (CV) scans showing a first electro-desorption peak at about -1.0 V. The Au|1 and Au|2 chiral electrodes were successfully used in CV experiments exploiting chiral redox probes. Finally, the hybrid interfaces Ni|enantiopure 1 or 2|AgNPs served as working electrodes in SDE experiments. In particular, the hybrid chiral interfaces Ni|(R)-2|AgNPs and Ni|(S)-2|AgNPs exhibited a significant spin-filtering ability, as a manifestation of the CISS effect, with average spin polarization values of 15%.
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0171831
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  9. Article ; Online: Mechanisms of mitochondrial translational regulation.

    Fontanesi, Flavia

    IUBMB life

    2013  Volume 65, Issue 5, Page(s) 397–408

    Abstract: The mitochondrial oxidative phosphorylation system is formed by multimeric enzymes. In the yeast Saccharomyces cerevisiae, the bc1 complex, cytochrome c oxidase and the F1 FO ATP synthase contain subunits of dual genetic origin. It has been recently ... ...

    Abstract The mitochondrial oxidative phosphorylation system is formed by multimeric enzymes. In the yeast Saccharomyces cerevisiae, the bc1 complex, cytochrome c oxidase and the F1 FO ATP synthase contain subunits of dual genetic origin. It has been recently established that key subunits of these enzymes, translated on mitochondrial ribosomes, are the subjects of assembly-dependent translational regulation. This type of control of gene expression plays a pivotal role in optimizing the biogenesis of mitochondrial respiratory membranes by coordinating protein synthesis and complex assembly and by limiting the accumulation of potentially harmful assembly intermediates. Here, the author will discuss the mechanisms governing translational regulation in yeast mitochondria in the light of the most recent discoveries in the field.
    MeSH term(s) Electron Transport Complex IV/genetics ; Electron Transport Complex IV/metabolism ; Gene Expression Regulation, Fungal ; Gene Regulatory Networks ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Proton-Translocating ATPases/genetics ; Mitochondrial Proton-Translocating ATPases/metabolism ; Saccharomyces cerevisiae/enzymology ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism
    Chemical Substances Electron Transport Complex IV (EC 1.9.3.1) ; Mitochondrial Proton-Translocating ATPases (EC 3.6.3.-)
    Language English
    Publishing date 2013-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1492141-8
    ISSN 1521-6551 ; 1521-6543
    ISSN (online) 1521-6551
    ISSN 1521-6543
    DOI 10.1002/iub.1156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Vicious Cycle of Renal Lipotoxicity and Mitochondrial Dysfunction.

    Ge, Mengyuan / Fontanesi, Flavia / Merscher, Sandra / Fornoni, Alessia

    Frontiers in physiology

    2020  Volume 11, Page(s) 732

    Abstract: The kidney is one of the most energy-demanding organs that require abundant and healthy mitochondria to maintain proper function. Increasing evidence suggests a strong association between mitochondrial dysfunction and chronic kidney diseases (CKDs). ... ...

    Abstract The kidney is one of the most energy-demanding organs that require abundant and healthy mitochondria to maintain proper function. Increasing evidence suggests a strong association between mitochondrial dysfunction and chronic kidney diseases (CKDs). Lipids are not only important sources of energy but also essential components of mitochondrial membrane structures. Dysregulation of mitochondrial oxidative metabolism and increased reactive oxygen species (ROS) production lead to compromised mitochondrial lipid utilization, resulting in lipid accumulation and renal lipotoxicity. However, lipotoxicity can be either the cause or the consequence of mitochondrial dysfunction. Imbalanced lipid metabolism, in turn, can hamper mitochondrial dynamics, contributing to the alteration of mitochondrial lipids and reduction in mitochondrial function. In this review, we summarize the interplay between renal lipotoxicity and mitochondrial dysfunction, with a focus on glomerular diseases.
    Language English
    Publishing date 2020-07-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2020.00732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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