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Book: Chromosomenanalysen bei exponierten und vermutlich exponierten Personen

Romm, Horst / Stephan, Günther

1985 - 1987

(ISH-Heft ; 126)

1988

Author's details	von Horst Romm ; Günther Stephan. [Inst. für Strahlenhygiene, Bundesgesundheitsamt]
Series title	ISH-Heft ; 126
Collection
Keywords	Chromosome Aberrations ; Radiation Effects ; Chromosome Mapping ; Chromosomenanalyse ; Strahlenschaden
Subject	Bestrahlungsschaden ; Strahlungsschaden ; Spätschaden ; Strahlungsschädigung ; Strahlendefekt ; Strahlenfolge ; Chromosom
Size	37, 9 S. : graph. Darst.
Publishing place	Neuherberg/München
Document type	Book
HBZ-ID	HT003304210
ISBN	3-89254-055-1 ; 978-3-89254-055-7
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
Se 967 -126-	verfügbar in Königswinter	Königswinter

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Article ; Online: Biological dosimetry for triage of casualties in a large-scale radiological emergency:capacity of the EU member states.

Wojcik, Andrzej / Lloyd, David / Romm, Horst / Roy, Laurence

Radiation protection dosimetry

2010 Volume 138, Issue 4, Page(s) 397–401

Abstract: In recent years, a number of events have occurred that highlight the necessity of being prepared for a possible large-scale radiological event. An important question is how well are European Union (EU) Member States prepared to cope with mass ... ...

Abstract	In recent years, a number of events have occurred that highlight the necessity of being prepared for a possible large-scale radiological event. An important question is how well are European Union (EU) Member States prepared to cope with mass radiological casualties. A survey to establish the current status of biological dosimetry across the EU was carried out with the aim of assessing capacity to perform biodosimetric triage of accident victims. Information was sought from the radiation protection authorities of the 27 Member States plus Switzerland and Norway. Biology dosimetry is established in 15 EU countries. Their total capacity for dosimetric triage is about 1500 cases per week analysed with a dicentric assay or about 800 cases analysed with a micronucleus assay. Although these numbers appear encouraging, there is not much collaboration between the laboratories and what is required is a network at the EU level.
MeSH term(s)	Biological Assay ; Cytogenetic Analysis ; Disaster Planning/organization & administration ; European Union ; Humans ; Mass Casualty Incidents ; Micronucleus Tests ; Radiation Injuries ; Radiation Monitoring ; Radioactive Hazard Release ; Triage/methods
Language	English
Publishing date	2010-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	225912-6
ISSN	1742-3406 ; 0144-8420
ISSN (online)	1742-3406
ISSN	0144-8420
DOI	10.1093/rpd/ncp279
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Article: Cytogenetic damage analysed by the dicentric assay.

Romm, Horst / Oestreicher, Ursula / Kulka, Ulrike

Annali dell'Istituto superiore di sanita

2009 Volume 45, Issue 3, Page(s) 251–259

Abstract: Biological dosimetry, based on the analysis of dicentric chromosomes, is an internationally established, independent method applied in the area of radiation protection. The biodosimetry is mainly performed, in addition to physical dosimetry, with the aim ...

Abstract	Biological dosimetry, based on the analysis of dicentric chromosomes, is an internationally established, independent method applied in the area of radiation protection. The biodosimetry is mainly performed, in addition to physical dosimetry, with the aim of individual dose assessment, especially after unclear or suspected radiation dose exposures. However, a new biodosimetrical challenge has emerged in recent years in the form of a possible large scale radiation accident potentially involving large numbers of exposed persons. In order to be prepared to act in an efficient manner in such an accident, the established cytogenetic laboratories have increased their cooperation at the national and international level. General experience and results of intercomparisons are reported and future options to increase sample throughput are outlined.
MeSH term(s)	Blood Cells/radiation effects ; Blood Cells/ultrastructure ; Chromosome Aberrations/radiation effects ; Chromosomes/radiation effects ; Dose-Response Relationship, Radiation ; Humans ; Radioactive Hazard Release ; Radiometry/methods
Language	English
Publishing date	2009
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	950344-4
ISSN	0021-2571
ISSN	0021-2571
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Article ; Online: 30-y follow-up of a Pu/Am inhalation case.

Wernli, Christian / Eikenberg, Jost / Marzocchi, Olaf / Breustedt, Bastian / Oestreicher, Ursula / Romm, Horst / Gregoratto, Demetrio / Marsh, James

Radiation protection dosimetry

2015 Volume 164, Issue 1-2, Page(s) 57–64

Abstract: In 1983, a young man inhaled accidentally a large amount of plutonium and americium. This case was carefully followed until 2013. Since no decorporation measures had been taken, the undisturbed metabolism of Pu and Am can be derived from the data. First ... ...

Abstract	In 1983, a young man inhaled accidentally a large amount of plutonium and americium. This case was carefully followed until 2013. Since no decorporation measures had been taken, the undisturbed metabolism of Pu and Am can be derived from the data. First objective was to determine the amount of inhaled radionuclides and to estimate committed effective dose. In vivo and excretion measurements started immediately after the inhalation, and for quality assurance, all types of measurements were performed by different labs in Europe and the USA. After dose assessment by various international groups were completed, the measurements were continued to produce scientific data for model validation. The data have been analysed here to estimate lung absorption parameter values for the inhaled plutonium and americium oxide using the proposed new ICRP Human Respiratory Tract Model. As supplement to the biokinetic modelling, biological data from three different cytogenetic markers have been added. The estimated committed effective dose is in the order of 1 Sv. The subject is 30 y after the inhalation, of good health, according to a recent medical check-up.
MeSH term(s)	Administration, Inhalation ; Adult ; Air Pollutants, Radioactive/pharmacokinetics ; Americium/pharmacokinetics ; Body Burden ; Computer Simulation ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Models, Biological ; Plutonium/pharmacokinetics ; Radiation Dosage ; Whole-Body Counting/methods
Chemical Substances	Air Pollutants, Radioactive ; Plutonium (53023GN24M) ; Americium (VW92PHU2UY)
Language	English
Publishing date	2015-04
Publishing country	England
Document type	Journal Article
ZDB-ID	225912-6
ISSN	1742-3406 ; 0144-8420
ISSN (online)	1742-3406
ISSN	0144-8420
DOI	10.1093/rpd/ncu342
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Article: Dosisabschätzung nach Überexposition mit ionisierender Strahlung Teil 1: Biologische Dosimetrie. Dose estimation following an overexposure with ionising radiation Part 1: Biological dosimetry

Kulka, Ulrike / Oestreicher, Ursula / Romm, Horst

Umwelt und Mensch, Informationsdienst

2010 Volume -, Issue 4, Page(s) 11

Language	German
Document type	Article
ZDB-ID	2548774-7
ISSN	2190-1120
Database	Current Contents Medicine

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Zs.A 4784: Show issues

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Article ; Online: A New Cytogenetic Biodosimetry Image Repository for the Dicentric Assay.

Romm, Horst / Beinke, Christina / Garcia, Omar / Di Giorgio, Marina / Gregoire, Eric / Livingston, Gordon / Lloyd, David C / Martìnez-Lopez, Wilner / Moquet, Jayne E / Sugarman, Stephen L / Wilkins, Ruth C / Ainsbury, Elizabeth A

Radiation protection dosimetry

2016 Volume 172, Issue 1-3, Page(s) 192–200

Abstract: The BioDoseNet was founded by the World Health Organization as a global network of biodosimetry laboratories for building biodosimetry laboratory capacities in countries. The newly established BioDoseNet image repository is a databank of ~25 000 ... ...

Abstract	The BioDoseNet was founded by the World Health Organization as a global network of biodosimetry laboratories for building biodosimetry laboratory capacities in countries. The newly established BioDoseNet image repository is a databank of ~25 000 electronically captured images of metaphases from the dicentric assay, which have been previously analysed by international experts. The detailed scoring results and dose estimations have, in most cases, already been published. The compilation of these images into one image repository provides a valuable tool for training and research purposes in biological dosimetry. No special software is needed to view and score the image galleries. For those new to the dicentric assay, the BioDoseNet Image Repository provides an introduction to and training for the dicentric assay. It is an excellent instrument for intra-laboratory training purposes or inter-comparisons between laboratories, as recommended by the International Organization for Standardisation standards. In the event of a radiation accident, the repository can also increase the surge capacity and reduce the turnaround time for dose estimations. Finally, it provides a mechanism for the discussion of scoring discrepancies in difficult cases.
Language	English
Publishing date	2016-12
Publishing country	England
Document type	Journal Article
ZDB-ID	225912-6
ISSN	1742-3406 ; 0144-8420
ISSN (online)	1742-3406
ISSN	0144-8420
DOI	10.1093/rpd/ncw158
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Article ; Online: Automated micronucleus (MN) scoring for population triage in case of large scale radiation events.

Willems, Petra / August, Liezel / Slabbert, Jacobus / Romm, Horst / Oestreicher, Ursula / Thierens, Hubert / Vral, Anne

International journal of radiation biology

2010 Volume 86, Issue 1, Page(s) 2–11

Abstract: Purpose: In case of a large-scale radiation accident when hundreds of people may be exposed, it is important to distinguish the severely exposed individuals (> or =1 gray), who require early medical treatment, from those less exposed. The aim of our ... ...

Abstract	Purpose: In case of a large-scale radiation accident when hundreds of people may be exposed, it is important to distinguish the severely exposed individuals (> or =1 gray), who require early medical treatment, from those less exposed. The aim of our study was to develop a quick population triage method based on automated micronucleus (MN) scoring. Materials and methods: Using the MN software module developed by MetaSystems specifically for the Metafer4 platform, about 60 blood samples can be scored in one day. Standard dose response curves were determined for manual and automated MN scoring. Results: The automated MN assay results were closely correlated with MN yields obtained with the manual procedure. A dose of 1 Gy can be estimated with an uncertainty of 0.2 Gy. Corrections for false positives and false negatives by visual inspection of the image gallery did not result in an improved accuracy or reproducibility. To test the automated MN assay in a multicenter setting, an inter-laboratory comparison was performed whereby irradiated blood samples were processed in Ghent University (Belgium) and BfS (Bundesamt fuer Strahlenschutz; Germany). Both laboratories obtained comparable results. Conclusions: These results confirm the efficacy of the automated MN assay for fast population triage in a multicenter setting, in the case of large radiation accidents.
MeSH term(s)	Adult ; Dose-Response Relationship, Radiation ; Female ; Humans ; Indoles ; Male ; Micronucleus Tests ; Middle Aged ; Radioactive Hazard Release ; Triage
Chemical Substances	Indoles ; DAPI (47165-04-8)
Language	English
Publishing date	2010-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3065-x
ISSN	1362-3095 ; 0020-7616 ; 0955-3002
ISSN (online)	1362-3095
ISSN	0020-7616 ; 0955-3002
DOI	10.3109/09553000903264481
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Article ; Online: Operational guidance for radiation emergency response organisations in Europe for using biodosimetric tools developed in EU MULTIBIODOSE project.

Jaworska, Alicja / Ainsbury, Elizabeth A / Fattibene, Paola / Lindholm, Carita / Oestreicher, Ursula / Rothkamm, Kai / Romm, Horst / Thierens, Hubert / Trompier, Francois / Voisin, Philippe / Vral, Anne / Woda, Clemens / Wojcik, Andrzej

Radiation protection dosimetry

2015 Volume 164, Issue 1-2, Page(s) 165–169

Abstract: In the event of a large-scale radiological emergency, the triage of individuals according to their degree of exposure forms an important initial step of the accident management. Although clinical signs and symptoms of a serious exposure may be used for ... ...

Abstract	In the event of a large-scale radiological emergency, the triage of individuals according to their degree of exposure forms an important initial step of the accident management. Although clinical signs and symptoms of a serious exposure may be used for radiological triage, they are not necessarily radiation specific and can lead to a false diagnosis. Biodosimetry is a method based on the analysis of radiation-induced changes in cells of the human body or in portable electronic devices and enables the unequivocal identification of exposed people who should receive medical treatment. The MULTIBIODOSE (MBD) consortium developed and validated several biodosimetric assays and adapted and tested them as tools for biological dose assessment in a mass-casualty event. Different biodosimetric assays were validated against the 'gold standard' of biological dosimetry-the dicentric assay. The assays were harmonised in such a way that, in an emergency situation, they can be run in parallel in a network of European laboratories. The aim of this guidance is to give a concise overview of the developed biodosimetric tools as well as how and when they can be used in an emergency situation.
MeSH term(s)	Biological Assay/standards ; Emergencies ; Europe ; Guidelines as Topic ; Humans ; Radiation Dosage ; Radiation Exposure/analysis ; Radiation Injuries/diagnosis ; Radiation Injuries/prevention & control ; Radiation Monitoring/standards ; Radioactive Hazard Release ; Triage/methods
Language	English
Publishing date	2015-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	225912-6
ISSN	1742-3406 ; 0144-8420
ISSN (online)	1742-3406
ISSN	0144-8420
DOI	10.1093/rpd/ncu294
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Article: Biological Dosimetry by the Triage Dicentric Chromosome Assay - Further validation of International Networking.

Wilkins, Ruth C / Romm, Horst / Oestreicher, Ursula / Marro, Leonora / Yoshida, Mitsuaki A / Suto, Y / Prasanna, Pataje G S

Radiation measurements

2011 Volume 46, Issue 9, Page(s) 923–928

Abstract: Biological dosimetry is an essential tool for estimating radiation doses received to personnel when physical dosimetry is not available or inadequate. The current preferred biodosimetry method is based on the measurement of radiation-specific dicentric ... ...

Abstract	Biological dosimetry is an essential tool for estimating radiation doses received to personnel when physical dosimetry is not available or inadequate. The current preferred biodosimetry method is based on the measurement of radiation-specific dicentric chromosomes in exposed individuals' peripheral blood lymphocytes. However, this method is labour-, time- and expertise-demanding. Consequently, for mass casualty applications, strategies have been developed to increase its throughput. One such strategy is to develop validated cytogenetic biodosimetry laboratory networks, both national and international. In a previous study, the dicentric chromosome assay (DCA) was validated in our cytogenetic biodosimetry network involving five geographically dispersed laboratories. A complementary strategy to further enhance the throughput of the DCA among inter-laboratory networks is to use a triage DCA where dose assessments are made by truncating the labour-demanding and time-consuming metaphase-spread analysis to 20 to 50 metaphase spreads instead of routine 500 to 1000 metaphase spread analysis. Our laboratory network also validated this triage DCA, however, these dose estimates were made using calibration curves generated in each laboratory from the blood samples irradiated in a single laboratory. In an emergency situation, dose estimates made using pre-existing calibration curves which may vary according to radiation type and dose rate and therefore influence the assessed dose. Here, we analyze the effect of using a pre-existing calibration curve on assessed dose among our network laboratories. The dose estimates were made by analyzing 1000 metaphase spreads as well as triage quality scoring and compared to actual physical doses applied to the samples for validation. The dose estimates in the laboratory partners were in good agreement with the applied physical doses and determined to be adequate for guidance in the treatment of acute radiation syndrome.
Language	English
Publishing date	2011-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1204268-7
ISSN	1350-4487
ISSN	1350-4487
DOI	10.1016/j.radmeas.2011.03.012
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Article ; Online: Uncertainty of fast biological radiation dose assessment for emergency response scenarios.

International journal of radiation biology

2017 Volume 93, Issue 1, Page(s) 127–135

Abstract: Purpose: Reliable dose estimation is an important factor in appropriate dosimetric triage categorization of exposed individuals to support radiation emergency response.: Materials and methods: Following work done under the EU FP7 MULTIBIODOSE and ... ...

Abstract	Purpose: Reliable dose estimation is an important factor in appropriate dosimetric triage categorization of exposed individuals to support radiation emergency response. Materials and methods: Following work done under the EU FP7 MULTIBIODOSE and RENEB projects, formal methods for defining uncertainties on biological dose estimates are compared using simulated and real data from recent exercises. Results: The results demonstrate that a Bayesian method of uncertainty assessment is the most appropriate, even in the absence of detailed prior information. The relative accuracy and relevance of techniques for calculating uncertainty and combining assay results to produce single dose and uncertainty estimates is further discussed. Conclusions: Finally, it is demonstrated that whatever uncertainty estimation method is employed, ignoring the uncertainty on fast dose assessments can have an important impact on rapid biodosimetric categorization.
MeSH term(s)	Algorithms ; Bayes Theorem ; Biological Assay/methods ; Europe ; Humans ; Practice Guidelines as Topic ; Radiation Dosage ; Radiation Exposure/analysis ; Radiation Monitoring/methods ; Reproducibility of Results ; Sensitivity and Specificity ; Triage/methods
Language	English
Publishing date	2017-01
Publishing country	England
Document type	Comparative Study ; Evaluation Studies ; Journal Article ; Validation Studies
ZDB-ID	3065-x
ISSN	1362-3095 ; 0020-7616 ; 0955-3002
ISSN (online)	1362-3095
ISSN	0020-7616 ; 0955-3002
DOI	10.1080/09553002.2016.1227106
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