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Article: A modified perineal approach for the management of strangulated rectal prolapse: A case report.

Biegel, C / Brock, S / Porter, J / Kim, D

International journal of surgery case reports

2023 Volume 109, Page(s) 108504

Abstract: Introduction: Conditions associated with increased intraabdominal pressure may lead to rectal prolapse. Like any pathological herniation, rectal prolapse can strangulate if incarcerated. When a patient presents with signs and symptoms of strangulation, ... ...

Abstract	Introduction: Conditions associated with increased intraabdominal pressure may lead to rectal prolapse. Like any pathological herniation, rectal prolapse can strangulate if incarcerated. When a patient presents with signs and symptoms of strangulation, emergent surgical intervention is warranted. This report strives to strengthen existing evidence for the use of an Altemeier-type perineal approach as a viable choice for the management of strangulated rectal prolapse in healthy individuals. Presentation of case: A healthy 70-year-old female presents with worsening rectal pain and an irreducible strangulated rectal prolapse. She is brought to the operating suite for an emergent exploration under anesthesia followed by an Altemeier-type procedure without diverting colostomy. The postoperative course is uneventful, and the patient is discharged on postoperative day three. Upon follow up, the patient reports having normal bowel function, and there is no evidence of recurrence. Discussion: Rectal prolapse is traditionally managed through either a perineal or transabdominal approach depending on the patient's clinical disposition. Incarcerated prolapse is a precursor to strangulation, and recent case reports have demonstrated the efficacy of the Altemeier procedure (perineal rectosigmoidectomy) to treat strangulated prolapse. Our initial exploration under anesthesia revealed a small section of ischemic rectal mucosa that was proximal to the rectosigmoid junction. As a result, we decided to remain within perineal parameters and perform the resection in an Altemeier-type fashion based on the boundary of ischemia. Conclusion: An Altemeier approach was a reasonable option for emergent surgical management of strangulated rectal prolapse in an otherwise relatively healthy individual. This case has been reported in line with the SCARE criteria (Agha et al. [1]).
Language	English
Publishing date	2023-07-13
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2023.108504
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Article ; Online: Barriers to service and unmet need among autistic adolescents and young adults.

Ishler, Karen J / Berg, Kristen A / Olgac, Tugba / Obeid, Rita / Biegel, David E

Autism : the international journal of research and practice

2023 Volume 27, Issue 7, Page(s) 1997–2010

Abstract: Lay abstract: Prior studies have described the roadblocks, or barriers, to needed services experienced by families with young autistic children, but less research has focused on those faced by autistic adolescents and young adults. In this study, we ... ...

Abstract	Lay abstract: Prior studies have described the roadblocks, or barriers, to needed services experienced by families with young autistic children, but less research has focused on those faced by autistic adolescents and young adults. In this study, we wished to understand the barriers to service experienced by autistic adolescents and young adults and their families. We surveyed 174 caregivers of autistic youth between 16 to 30 years old. We found that caregivers who felt more caregiving burden had more difficulty accessing services for their youth. Specifically, caregivers who felt more strongly that their daily lives had been disrupted, felt more financial strain, and worried more about their youth well-being experienced more roadblocks to getting services for the youth. Male caregivers also reported fewer difficulties related to service access. Importantly, the older the youth was when they had been diagnosed with autism, the more service barriers their caregivers reported. We did not see any differences in the level of barriers experienced by youth who lived in urban versus suburban settings, or between white and non-white families. However, when youth lived with their caregivers (rather than, for example, in a group home), fewer quality-related barriers to services were reported. Finally, greater access (but not quality) barriers were linked to youth having more unmet service needs. These findings can help to reduce the barriers to service experienced by autistic adolescents and young adults and their families.
MeSH term(s)	Child ; Humans ; Male ; Adolescent ; Young Adult ; Adult ; Autistic Disorder ; Autism Spectrum Disorder ; Surveys and Questionnaires
Language	English
Publishing date	2023-02-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1338513-6
ISSN	1461-7005 ; 1362-3613
ISSN (online)	1461-7005
ISSN	1362-3613
DOI	10.1177/13623613221150569
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Zs.A 5838: Show issues

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Article: A model to study drug effects on lymphoma and normal cell populations using the AKR/J mouse.

Schwartz, G N / Biegel, J A / Boggs, S S

Leukemia research

1982 Volume 6, Issue 2, Page(s) 269–279

Abstract: ... 1A1d lymphoma cell line has been maintained for 6 yr by serial passage in AKR/J recipients. The mice ...

Abstract	The existence of an AKR subline, AKR(Rb6.15)1A1d, with a chromosome marker provided a means to differentiate between proliferating lymphoma and normal cell populations within a single animal. An AKR(Rb6.15)1A1d lymphoma cell line has been maintained for 6 yr by serial passage in AKR/J recipients. The mice die in 7 +/- 2.0 days with evidence of extensive infiltration of the tissues by lymphoma cells. Cytogenetic analysis showed that approx. 1% of the metaphase cells in the bone marrow of mice at day 1 of the lymphoma passage were of the AKR(Rb6.15)1A1d donor-type. This increased to 54% by day 4 and 96% by day 6. The number of donor-type metaphase cells per humerus increased from 3.4 +/- 0.29 (X 10(3] at day 1 to 2.0 +/- 0.49 (X 10(5] at day 4 with a concomitant decrease in the number of non-lymphoma host-type metaphase cells. The population doubling time of donor-type metaphase cells per humerus was 12 +/- 1.4 h. At day 4, there was a significant decrease in the percentage of donor-type metaphase cells in mice that had been treated with BCNU (19.0 +/- 5.85%) or spirogermanium (38.6 +/- 5.85%) 24 h earlier. For BCNU treated animals, this also represented a decrease to 4.4 +/- 1.1 (X 10(4] donor-type metaphase cells per humerus.
MeSH term(s)	Animals ; Carmustine/therapeutic use ; Cell Line ; Disease Models, Animal ; Germanium/therapeutic use ; Karyotyping ; Leukemia, Experimental/drug therapy ; Lymphoma/drug therapy ; Lymphoma/genetics ; Mice ; Mice, Inbred AKR/physiology ; Neoplasm Transplantation ; Organometallic Compounds ; Spiro Compounds/therapeutic use
Chemical Substances	Organometallic Compounds ; Spiro Compounds ; Germanium (00072J7XWS) ; spirogermanium (1F01P3Y61E) ; Carmustine (U68WG3173Y)
Language	English
Publishing date	1982
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/0145-2126(82)90033-9
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Zs.A 1321: Show issues

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Article: Comparison of BCNU-induced SCE in bone-marrow cells of AKR/J and BDF1 mice.

Biegel, J A / Boggs, S S / Conner, M K

Mutation research

1980 Volume 79, Issue 1, Page(s) 87–90

MeSH term(s)	Animals ; Bone Marrow/ultrastructure ; Carmustine/pharmacology ; Chromatids/drug effects ; Crosses, Genetic ; Crossing Over, Genetic ; Dose-Response Relationship, Drug ; Female ; Mice ; Mice, Inbred AKR/genetics ; Mice, Inbred Strains/genetics ; Sister Chromatid Exchange ; Species Specificity
Chemical Substances	Carmustine (U68WG3173Y)
Language	English
Publishing date	1980-09
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	206607-5
ISSN	1873-135X ; 0027-5107 ; 1383-5718 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
ISSN (online)	1873-135X
ISSN	0027-5107 ; 1383-5718 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
DOI	10.1016/0165-1218(80)90152-4
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Article ; Conference proceedings: Stand der Wissenschaft in der Misteltherapie von Hund, Katze und Pferd

Biegel, U

Zeitschrift für Phytotherapie

2016

Abstract: ... unserer Arbeit. [1] Christen-Clottu et al. J Vet Intern Med 2010; 24: 1483 – 1489 [2] Biegel et al. Die Mistel ...

Event/congress	Phytotherapie 2016 „Extraktentwicklung - Klinik - Versorgungsforschung“, Bonn, 2016
Abstract	Die komplementäre Misteltherapie wird bei Krebserkrankungen nicht nur in der Human-, sondern auch in der Veterinärmedizin vielfach angewendet. Seit 1999 ist die Forschung zur Wirkung und Wirksamkeit der Misteltherapie bei Tieren am FiBL (Frick, Schweiz) implementiert. Innerhalb klinischer Studien konnten Fragen nach geeigneten Therapieprotokollen, der Verträglichkeit und Wirksamkeit bei verschiedenen Tumorerkrankungen für unterschiedliche Tierarten beantwortet werden. In einer RCT-Studie bei Equinem Sarkoid zeigten sich neben der guten Verträglichkeit der Injektionstherapie auch signifikant höhere Heilungs- und Besserungsraten in der Viscum- gegenüber der Placebogruppe [1]. Bei einer Anwendungsbeobachtung von Katzen mit Fibrosarkom (Impfsarkom oder „injectionside-sarcoma“), welches extrem hohe Rezidivraten aufweist, wurde ein orales Eichenmistelpräparat (viscum quercus praeparatum 0,1% Dilutio aquosa) postoperativ eingesetzt. Es zeigte sich, dass im Literaturvergleich die ausschließlich operierten Tiere innert deutlich kürzerer Zeit wieder Rezidive zeigten. Die rezidivfreien Zeiten mit postoperativer Misteltherapie sind in etwa im Bereich der adjuvanten Chemotherapie zu sehen [2]. An der Universität Bern (Vetsuisse Fakultät) wurde eine Studie zur Mistelinjektionstherapie bei der Katze durchgeführt. Hier konnte zum einen die nebenwirkungsfreie, gute Verträglichkeit der Therapie gezeigt und Indikationsgebiete für die antitumorale und immunmodulierende Wirkung genannt werden [3]. In der Universität Paulista in Sao Paulo wurde 2007 eine Studie zur komplementären Behandlung des Stickersarkoms beim Hund durchgeführt und zeigte eine Verkürzung der notwendigen Chemotherapiedauer mit vermindertem Auftreten von Leukopenien sowie innerhalb der beobachteten Patienten keine Rezidive [4]. Ich danke dem Verein für Krebsforschung in Arlesheim, Schweiz, sehr herzlich für das Vertrauen und die Unterstützung unserer Arbeit. [1] Christen-Clottu et al. J Vet Intern Med 2010; 24: 1483 – 1489 [2] Biegel et al. Die Mistel in der Tumortherapie 3, KVC Verlag, Essen, 2013 [3] Glardon et al. Schweiz Arch Tierheilkd 2014; 156: 381 – 388 [4] Lefebvre et al. Clin Vet 2007, XII (70): 78 – 86
Language	German
Publishing date	2016-06-01
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	604850-x
ISSN	1438-9584 ; 0722-348X ; 0720-227X
ISSN (online)	1438-9584
ISSN	0722-348X ; 0720-227X
DOI	10.1055/s-0036-1584419
Database	Thieme publisher's database

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Zs.B 2525: Show issues

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Article: "Don't Promise Something You can't Deliver:" Caregivers' Advice for Improving Services to Adolescents and Young Adults with Autism.

Berg, Kristen A / Ishler, Karen J / Lytle, Sarah / Kaplan, Ronna / Wang, Fei / Olgac, Tugba / Miner, Stacy / Edguer, Marjorie N / Biegel, David E

Autism research and treatment

2023 Volume 2023, Page(s) 6597554

Abstract: Approximately 50,000 youths with autism spectrum disorders (ASD) exit U.S. high schools yearly to enter adult systems of care, many of whom remain dependent on family for day-to-day care and service system navigation. As part of a larger study, 174 ... ...

Abstract	Approximately 50,000 youths with autism spectrum disorders (ASD) exit U.S. high schools yearly to enter adult systems of care, many of whom remain dependent on family for day-to-day care and service system navigation. As part of a larger study, 174 family caregivers for adolescents or young adults with ASD were asked what advice they would give service providers about how to improve services for youth with ASD. Reflexive thematic analysis identified a framework of five directives: (1) provide a roadmap to services; (2) improve service access; (3) fill gaps to address unmet needs; (4) educate themselves, their families, and society about autism; and (5) operate from a relationship-building paradigm with families. Education, health, and social service providers, as well as policymakers, can use these directives to better assist youth with ASD and their families in the transition to adulthood.
Language	English
Publishing date	2023-03-21
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2626622-2
ISSN	2090-1933 ; 2090-1925
ISSN (online)	2090-1933
ISSN	2090-1925
DOI	10.1155/2023/6597554
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Article: Inactivation times from 290 to 315 nm UVB in sunlight for SARS coronaviruses CoV and CoV-2 using OMI satellite data for the sunlit Earth.

Herman, Jay / Biegel, Bryan / Huang, Liang

Air quality, atmosphere, & health

2020 Volume 14, Issue 2, Page(s) 217–233

Abstract: ... many viruses and bacteria in times less than 30 min. Estimated UVB inactivation doses from sunlight in J/m ...

Abstract	UVB in sunlight, 290-315 nm, can inactivate SARS CoV and SARS CoV-2 viruses on surfaces and in the air. Laboratory exposure to ultraviolet irradiance in the UVC range inactivates many viruses and bacteria in times less than 30 min. Estimated UVB inactivation doses from sunlight in J/m
Keywords	covid19
Language	English
Publishing date	2020-09-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2424084-9
ISSN	1873-9326 ; 1873-9318
ISSN (online)	1873-9326
ISSN	1873-9318
DOI	10.1007/s11869-020-00927-2
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Article ; Online: Efficient quenching sheds light on early stages of gold nanoparticle formation.

Biegel, Markus / Schikarski, Tobias / Cardenas Lopez, Paola / Gromotka, Lukas / Lübbert, Christian / Völkl, Andreas / Damm, Cornelia / Walter, Johannes / Peukert, Wolfgang

RSC advances

2023 Volume 13, Issue 26, Page(s) 18001–18013

Abstract: The formation mechanism of plasmonic gold nanoparticles (Au NPs) by fast ... ...

Abstract	The formation mechanism of plasmonic gold nanoparticles (Au NPs) by fast NaBH
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra02195e
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Article ; Online: Characterization of PAX5 intragenic tandem multiplication in pediatric B-lymphoblastic leukemia by optical genome mapping.

Jean, Jeffrey / Kovach, Alexandra E / Doan, Andrew / Oberley, Matthew / Ji, Jianling / Schmidt, Ryan J / Biegel, Jaclyn A / Bhojwani, Deepa / Raca, Gordana

Blood advances

2022 Volume 6, Issue 11, Page(s) 3343–3346

MeSH term(s)	Child ; Chromosome Mapping ; Humans ; Lymphoma, Non-Hodgkin ; PAX5 Transcription Factor/genetics ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics
Chemical Substances	PAX5 Transcription Factor ; PAX5 protein, human
Language	English
Publishing date	2022-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2021006328
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Zs.A 7153: Show issues

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Article ; Online: Rapidly emerging SARS-CoV-2 B.1.1.7 sub-lineage in the United States of America with spike protein D178H and membrane protein V70L mutations.

Shen, Lishuang / Bard, Jennifer Dien / Triche, Timothy J / Judkins, Alexander R / Biegel, Jaclyn A / Gai, Xiaowu

Emerging microbes & infections

2021 Volume 10, Issue 1, Page(s) 1293–1299

Abstract: The SARS-CoV-2 B.1.1.7 lineage is highly infectious and as of April 2021 accounted for 92% of COVID-19 cases in Europe and 59% of COVID-19 cases in the U.S. It is defined by the N501Y mutation in the receptor-binding domain (RBD) of the Spike (S) protein, ...

Abstract	The SARS-CoV-2 B.1.1.7 lineage is highly infectious and as of April 2021 accounted for 92% of COVID-19 cases in Europe and 59% of COVID-19 cases in the U.S. It is defined by the N501Y mutation in the receptor-binding domain (RBD) of the Spike (S) protein, and a few other mutations. These include two mutations in the N terminal domain (NTD) of the S protein, HV69-70del and Y144del (also known as Y145del due to the presence of tyrosine at both positions). We recently identified several emerging SARS-CoV-2 variants of concerns, characterized by Membrane (M) protein mutations, including I82T and V70L. We now identify a sub-lineage of B.1.1.7 that emerged through sequential acquisitions of M:V70L in November 2020 followed by a novel S:D178H mutation first observed in early February 2021. The percentage of B.1.1.7 isolates in the US that belong to this sub-lineage increased from 0.15% in February 2021 to 1.8% in April 2021. To date, this sub-lineage appears to be U.S.-specific with reported cases in 31 states, including Hawaii. As of April 2021, it constituted 36.8% of all B.1.1.7 isolates in Washington. Phylogenetic analysis and transmission inference with Nextstrain suggest this sub-lineage likely originated in either California or Washington. Structural analysis revealed that the S:D178H mutation is in the NTD of the S protein and close to two other signature mutations of B.1.1.7, HV69-70del and Y144del. It is surface exposed and may alter NTD tertiary configuration or accessibility, and thus has the potential to affect neutralization by NTD directed antibodies.
MeSH term(s)	Binding Sites ; Humans ; Models, Molecular ; Mutation ; Phylogeny ; Protein Domains ; Protein Structure, Tertiary ; SARS-CoV-2/classification ; SARS-CoV-2/genetics ; Sequence Analysis, RNA ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; United States ; Viral Matrix Proteins/genetics ; Whole Genome Sequencing/methods
Chemical Substances	Spike Glycoprotein, Coronavirus ; Viral Matrix Proteins ; membrane protein, SARS-CoV-2 ; spike protein, SARS-CoV-2
Language	English
Publishing date	2021-06-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2021.1943540
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