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Article ; Online: Paeoniflorin mitigates MMP-12 inflammation in silicosis via Yang-Yin-Qing-Fei Decoction in murine models.

Li, Tian / Mao, Na / Xie, Zihao / Wang, Jianing / Jin, Fuyu / Li, Yaqian / Liu, Shupeng / Cai, Wenchen / Gao, Xuemin / Wei, Zhongqiu / Yang, Fang / Xu, Hong / Liu, Heliang / Zhang, Haibo / Xu, Dingjie

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 129, Page(s) 155616

Abstract: ... to elucidate the therapeutic role and mechanisms of the Yang-Yin-Qing-Fei Decoction (YYQFD) and its key ...

Abstract	Background: Silicosis presents a significant clinical challenges and economic burdens, with Traditional Chinese Medicine (TCM) emerging as a potential therapeutic avenue. However, the precise effects and mechanisms of TCM in treating silicosis remain uncertain and subject to debate. Objective: The study aims to elucidate the therapeutic role and mechanisms of the Yang-Yin-Qing-Fei Decoction (YYQFD) and its key component, paeoniflorin, in silicosis using a murine model. Methods: Silicotic mice were treated with YYQFD, pirfenidone (PFD), or paeoniflorin. RAW264.7 cells and mouse lung fibroblasts (MLF) were stimulated with silica, matrix metalloproteinase-12 (MMP-12), or TGF-β1, followed by treatment with paeoniflorin, PFD, or relevant inhibitors. YYQFD constituents were characterized using High-Performance Liquid Chromatography (HPLC). Lung fibrosis severity was assessed via histopathological examination, micro-CT imaging, lung functions, and Western blot analysis. Transcriptome sequencing and bioinformatics analysis were employed to delineate the gene expression profile and target genes modulated by YYQFD in silicosis. Results: Treatment with YYQFD ameliorated silica-induced lung fibrosis. Transcriptome sequencing identified MMP-12 as a potential common target of YYQFD and PFD. Additionally, a potential pro-inflammatory role of MMP-12, regulated by silica-induced TLR4 signaling pathways, was revealed. Paeoniflorin, one of the most distinctive compounds in YYQFD, attenuated silica-induced MMP-12 increase and its derived inflammatory factors in macrophages through a direct binding effect. Notably, paeoniflorin treatment exerted anti-fibrotic effects by inhibiting MMP-12-derived inflammatory factors and TGF-β1-induced myofibroblast differentiation in silica-exposed mice. Conclusions: This study underscores paeoniflorin as one of the most principal bioactive compounds in YYQFD, highlighting its capacity to attenuate lung inflammation driven by macrophage-derived MMP-12 and reduce lung fibrosis both in vivo and in vitro.
Language	English
Publishing date	2024-04-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2024.155616
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Article ; Online: Two new species of genus Spilolonchoptera Yang, 1998 from China (Diptera, Lonchopteridae).

Gao, Shang / Zhang, Bing / Yang, Ding

Zootaxa

2021 Volume 4980, Issue 2, Page(s) 389394

Abstract: Only five species of the genus Spilolonchoptera Yang, 1998 were previously known from China. Here ...

Abstract	Only five species of the genus Spilolonchoptera Yang, 1998 were previously known from China. Here two new species, Spilolonchoptera hainanensis sp. nov. and Spilolonchoptera zhejiangensis sp. nov. are reported from China. A key to species of the genus Spilolonchoptera from China is presented.
Language	English
Publishing date	2021-06-01
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.4980.2.10
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Article: Yang-xin-xue keli exerts therapeutic effects

Long, Kunlan / Zhao, Ziyi / Chen, Jun / Zhi, Lijia / Wang, Chunxia / Liao, Dan / Wang, Meng / Gao, Peiyang

Frontiers in pharmacology

2022 Volume 13, Page(s) 931453

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-08-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.931453
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Article ; Online: Letter to the Editor From Yang et al: "Prevalence of Postoperatively Detected High-Risk Features in 2- to 4-cm Papillary Thyroid Cancers".

Yang, Shijie / Tan, Meijuan / Gao, Feng / Xu, Xiequn

The Journal of clinical endocrinology and metabolism

2022 Volume 108, Issue 5, Page(s) e197

MeSH term(s)	Humans ; Thyroid Cancer, Papillary/epidemiology ; Thyroid Cancer, Papillary/surgery ; Prevalence ; Thyroid Neoplasms/epidemiology ; Thyroid Neoplasms/surgery
Language	English
Publishing date	2022-12-28
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgac753
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Article: CCDC43 as a potential therapeutic target of Tian Yang Wan for the treatment of hepatocellular carcinoma by activating the hippo pathway.

Tao, Mingyuan / Han, Dongwei / Wei, Siyu / Gao, Changyu

Frontiers in oncology

2023 Volume 13, Page(s) 1232190

Abstract: ... Here, we investigate the potential anti-cancer mechanism of an herbal medicine called Tian Yang Wan ...

Abstract	Introduction: Hepatocellular carcinoma (HCC) prevalence is rising annually, but the existing treatment strategies are limited; therefore, it is crucial to explore new therapeutic approaches. Methods: Here, we investigate the potential anti-cancer mechanism of an herbal medicine called Tian Yang Wan (TYW) in the treatment of HCC. The relationship of CCDC43 with immunity and cell death was analyzed by bioinformatics. Confirming the tumor suppressor effect of TYW on HCC cells by proliferation, invasion, migration and apoptosis assays. Results: First, we analyzed by proteomics that CCDC43 expression was downregulated after TYW administration and promoted the hippo pathway. Then, a large sample's transcriptome study demonstrated that elevated CCDC43 expression was strongly correlated with clinical traits and a bad prognosis in HCC patients. Next, we observed through multiple advanced algorithms that CCDC43 is involved in a variety of oncology and immunology related pathways. Notably, we found higher tumor immune microenvironment with high CCDC43 expression. Furthermore, we demonstrated that CCDC43 is associated with immune checkpoints and found that it is a sensitive indicator of a large number of chemotherapeutic agents. Subsequently, we conducted experimental investigations to demonstrate the capacity of TYW to impede proliferation and migration, while inducing apoptosis in human HCC cell lines. Finally, we performed analysis of two cell death patterns which showed CCDC43 to be strongly correlated with multiple ferroptosis factors and cuproptosis factors. Discusion: In conclusion, our study comprehensively examined the prognostic, immunological, and therapeutic implications of CCDC43 in HCC, thereby elucidating the therapeutic mechanism of action in TYW.
Language	English
Publishing date	2023-08-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1232190
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Article: Yin/Yang associated differential responses to Psoralea corylifolia Linn. In rat models: an integrated metabolomics and transcriptomics study.

Zhang, Ming-Liang / Zhao, Xu / Li, Wei-Xia / Wang, Xiao-Yan / Niu, Ming / Zhang, Hui / Chen, Yu-Long / Kong, De-Xin / Gao, Yuan / Guo, Yu-Ming / Bai, Zhao-Fang / Zhao, Yan-Ling / Tang, Jin-Fa / Xiao, Xiao-He

Chinese medicine

2023 Volume 18, Issue 1, Page(s) 102

Abstract: ... traditional Chinese medicine (TCM) for the treatment of kidney-yang deficiency syndrome (Yang: Aim of the study: Liver ... to investigate the differential responses to BGZ in Yang: Materials and methods: The corresponding ... animal models of Yang: Results: The level changes of liver organ index, alanine aminotransferase (ALT), and ...

Abstract	Ethnopharmacological relevance: Psoralea corylifolia Linn. (BGZ) is a commonly used traditional Chinese medicine (TCM) for the treatment of kidney-yang deficiency syndrome (Yang Aim of the study: Liver injury caused by TCM is a rare but potentially serious adverse drug reaction, and the identification of predisposed individuals for drug-induced liver injury (DILI) remains challenging. The study aimed to investigate the differential responses to BGZ in Yang Materials and methods: The corresponding animal models of Yang Results: The level changes of liver organ index, alanine aminotransferase (ALT), and aspartate aminotransferase (AST), suggested that BGZ has liver-protective and liver-damaging effects on Yang Conclusions: Yin
Language	English
Publishing date	2023-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-023-00793-x
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Article: Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity.

Guo, Qianqian / Wang, Ting / Yang, Yue / Gao, Lanlan / Zhao, Qiong / Zhang, Wenzhou / Xi, Tao / Zheng, Lufeng

Molecular therapy. Nucleic acids

2020 Volume 21, Page(s) 527–541

Abstract: Transcription factor Yin Yang 1 (YY1) is upregulated in multiple tumors and plays essential roles ...

Abstract	Transcription factor Yin Yang 1 (YY1) is upregulated in multiple tumors and plays essential roles in tumor proliferation and metastasis. However, the function of YY1 in breast cancer stemness remains unclear. Herein, we found that YY1 expression was negatively correlated with the overall survival and relapse-free survival of breast cancer patients and positively correlated with the expression of stemness markers in breast cancer. Overexpression of YY1 increased the expression of stemness markers, elevated CD44
Language	English
Publishing date	2020-06-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2662631-7
ISSN	2162-2531
ISSN	2162-2531
DOI	10.1016/j.omtn.2020.06.018
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Article ; Online: Effects of Fusu mixture (Wen-Shen-Qian-Yang Method) on sepsis-induced acute respiratory distress syndrome.

Zhang, Li / Long, Kunlan / Wang, Chunxia / Zhang, Xuemei / Yang, Hongjing / Chen, Jun / Li, Xue / Gao, Peiyang / Zhang, Song

Medicine

2020 Volume 99, Issue 29, Page(s) e21066

Abstract: Introduction: Sepsis is the most common etiology of acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Capillary leakage caused by lung endothelial injury is the central cause of ARDS. The results of research in modern medicine in ... ...

Abstract	Introduction: Sepsis is the most common etiology of acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Capillary leakage caused by lung endothelial injury is the central cause of ARDS. The results of research in modern medicine in reducing endothelial damage and restoring endothelial functions are limited. In the previous clinical observations, we found that the Fusu mixture not only improves the clinical symptoms but also reduces the leakage of pulmonary capillaries. Therefore, the purpose of this study is to determine the clinical efficacy of the Fusu mixture combined with Western medicine in the treatment of ARDS caused by sepsis and to explore the mechanism of traditional Chinese medicine. Methods: This is a prospective, single-center, randomized, single-blind, and controlled clinical study involving 620 eligible patients. The patients will be randomly divided into 2 groups: the Western medicine treatment group and the combination of Chinese and Western medicine treatment group. After 14 days of intervention, the clinical efficacy and safety of the Fusu mixture on sepsis-induced ARDS patients will be observed. The primary outcome will be measured as 28-day mortality. The secondary outcome indices include inflammatory markers (CRP, PCT, IL-6, TNF - α), APACHE II score, SOFA score, days without a ventilator, blood gas analysis (Lac, PaO2 / FiO2), intensive care unit hospital stay time, intensive care unit mortality. Simultaneously, the analysis of the exploratory results will be carried out to analyze the possible mechanism of Fusu mixture in the treatment of sepsis-induced ARDS by the high-throughput sequencing and bioinformatics. Discussion: The purpose of this study is to evaluate the clinical efficacy of Fusu mixture in the treatment of sepsis-induced ARDS and explore its possible mechanism of action. If successful, it will provide evidence-based adjuvant therapy for the clinical treatment of ARDS.
MeSH term(s)	Adult ; Blood Gas Analysis ; Capillary Leak Syndrome/complications ; Capillary Leak Syndrome/etiology ; Female ; Humans ; Male ; Medicine, Chinese Traditional/methods ; Medicine, Chinese Traditional/standards ; Middle Aged ; Prospective Studies ; Respiratory Distress Syndrome/drug therapy ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/physiopathology ; Sepsis/complications ; Sepsis/drug therapy ; Sepsis/physiopathology ; Single-Blind Method ; Treatment Outcome
Language	English
Publishing date	2020-04-16
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000021066
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Article ; Online: A dual-responsive "Yin-Yang" photothermal delivery system to accelerate Parthenolide anti-tumor efficacy.

Li, Anshuo / Gao, Wenbin / Zhang, Xuwu / Deng, Yuwei / Zhu, Yuhui / Gu, Hao / Wen, Jin / Jiang, Xinquan

Biomaterials advances

2022 Volume 138, Page(s) 212935

Abstract: Parthenolide (PTL), a germacrane sesquiterpene lactone extracted from the "Yin" Chinese traditional herb feverfew, has gained interest due to its lethal effects on tumor cells and its pharmacological effects within traditional Chinese medicine theory. To ...

Abstract	Parthenolide (PTL), a germacrane sesquiterpene lactone extracted from the "Yin" Chinese traditional herb feverfew, has gained interest due to its lethal effects on tumor cells and its pharmacological effects within traditional Chinese medicine theory. To overcome low, non-targeted accumulation and uncontrolled release of PTL administration, a dual-responsive PTL-liposomes@chitosan@gold nanoshells (PTL-Lips@CS@GNS) system was fabricated. Hyperthermia generated under light irradiation in the near-infrared region via local surface plasmon resonance of gold nanoshells induced photothermal therapy, which also stimulated PTL release due to the liposomes gel-to-liquid crystalline phase transition. Additionally, PTL-Lips@CS@GNS exhibited a pH-responsive release in the acidic tumor microenvironment. Collectively, this study provides a realistic strategy for an effective combination of traditional Chinese medicine and current nanotechnology for tumor therapy.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Gold/chemistry ; Humans ; Hyperthermia, Induced ; Liposomes/chemistry ; Neoplasms ; Phototherapy ; Sesquiterpenes ; Tumor Microenvironment
Chemical Substances	Antineoplastic Agents ; Liposomes ; Sesquiterpenes ; parthenolide (2RDB26I5ZB) ; Gold (7440-57-5)
Language	English
Publishing date	2022-05-25
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-9508
ISSN (online)	2772-9508
DOI	10.1016/j.bioadv.2022.212935
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Article ; Online: Yin Yang 1 promotes aggressive cell growth in high-grade breast cancer by directly transactivating kinectin 1.

Gao, Lin / Zhou, Wenbin / Xie, Ni / Qiu, Junying / Huang, Jingyi / Zhang, Zhe / Hong, Malin / Xia, Jinquan / Xu, Jing / Zhao, Pan / Fu, Li / Luo, Yuwei / Jiang, Jing / Gong, Hui / Wang, Jigang / Dai, Yong / Luo, Dixian / Zou, Chang

MedComm

2022 Volume 3, Issue 3, Page(s) e133

Abstract: ... indicated that transcription factor Yin Yang 1 (YY1) was a potential transactivator of KTN1. High YY1 ...

Abstract	Invasive cancer growth and metastasis account for the poor prognosis of high-grade breast cancer. Recently, we reported that kinectin 1 (KTN1), a member of the kinesin-binding protein family, promotes cell invasion of triple-negative breast cancer and high-grade breast cancer cells by augmenting the NF-κB signaling pathway. However, the upstream mechanism regulating KTN1 is unknown. Therefore, this functional study was performed to decipher the regulatory cohort of KTN1 in high-grade breast cancer. Bioinformatic analysis indicated that transcription factor Yin Yang 1 (YY1) was a potential transactivator of KTN1. High YY1 expression correlated positively with pathological progression and poor prognosis of high-grade breast cancer. Additionally, YY1 promoted cell invasive growth both in vitro and in vivo, in a KTN1-dependent manner. Mechanistically, YY1 could transactivate the KTN1 gene promoter. Alternatively, YY1 could directly interact with a co-factor, DEAD-box helicase 3 X-linked (DDX3X), which significantly co-activated YY1-mediated transcriptional expression of KTN1. Moreover, DDX3X augmented YY1-KTN1 signaling-promoted invasive cell growth of breast cancer. Importantly, overexpression of YY1 enhanced tumor aggressive growth in a mouse breast cancer model. Our findings established a novel DDX3X-assisted YY1-KTN1 regulatory axis in breast cancer progression, which could lead to the development novel therapeutic targets for breast cancer.
Language	English
Publishing date	2022-07-05
Publishing country	China
Document type	Journal Article
ISSN	2688-2663
ISSN (online)	2688-2663
DOI	10.1002/mco2.133
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