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  1. Article: In silico

    Khaleghian, Mohammad / Sahrayi, Hamidreza / Hafezi, Yousef / Mirshafeeyan, Mahshad / Moghaddam, Zahra Salehi / Farasati Far, Bahareh / Noorbazargan, Hassan / Mirzaie, Amir / Ren, Qun

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1277533

    Abstract: Curcumin, an important natural component of turmeric, has been known for a long time for its antimicrobial properties. This study aimed to investigate the anti-biofilm action of the niosome-encapsulated curcumin and explore the involved anti-biofilm ... ...

    Abstract Curcumin, an important natural component of turmeric, has been known for a long time for its antimicrobial properties. This study aimed to investigate the anti-biofilm action of the niosome-encapsulated curcumin and explore the involved anti-biofilm mechanism.
    Language English
    Publishing date 2023-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1277533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cytokine Storm Syndrome in SARS-CoV-2 Infections: A Functional Role of Mast Cells.

    Hafezi, Bahareh / Chan, Lily / Knapp, Jason P / Karimi, Negar / Alizadeh, Kimia / Mehrani, Yeganeh / Bridle, Byram W / Karimi, Khalil

    Cells

    2021  Volume 10, Issue 7

    Abstract: Cytokine storm syndrome is a cascade of escalated immune responses disposing the immune system to exhaustion, which might ultimately result in organ failure and fatal respiratory distress. Infection with severe acute respiratory syndrome-coronavirus-2 ... ...

    Abstract Cytokine storm syndrome is a cascade of escalated immune responses disposing the immune system to exhaustion, which might ultimately result in organ failure and fatal respiratory distress. Infection with severe acute respiratory syndrome-coronavirus-2 can result in uncontrolled production of cytokines and eventually the development of cytokine storm syndrome. Mast cells may react to viruses in collaboration with other cells and lung autopsy findings from patients that died from the coronavirus disease that emerged in 2019 (COVID-19) showed accumulation of mast cells in the lungs that was thought to be the cause of pulmonary edema, inflammation, and thrombosis. In this review, we present evidence that a cytokine response by mast cells may initiate inappropriate antiviral immune responses and cause the development of cytokine storm syndrome. We also explore the potential of mast cell activators as adjuvants for COVID-19 vaccines and discuss the medications that target the functions of mast cells and could be of value in the treatment of COVID-19. Recognition of the cytokine storm is crucial for proper treatment of patients and preventing the release of mast cell mediators, as impeding the impacts imposed by these mediators could reduce the severity of COVID-19.
    MeSH term(s) Animals ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/prevention & control ; Cytokines/immunology ; Humans ; Mast Cells/drug effects ; Mast Cells/immunology ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology ; COVID-19 Drug Treatment
    Chemical Substances COVID-19 Vaccines ; Cytokines
    Language English
    Publishing date 2021-07-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10071761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cytokine Storm Syndrome in SARS-CoV-2 Infections

    Bahareh Hafezi / Lily Chan / Jason P. Knapp / Negar Karimi / Kimia Alizadeh / Yeganeh Mehrani / Byram W. Bridle / Khalil Karimi

    Cells, Vol 10, Iss 1761, p

    A Functional Role of Mast Cells

    2021  Volume 1761

    Abstract: Cytokine storm syndrome is a cascade of escalated immune responses disposing the immune system to exhaustion, which might ultimately result in organ failure and fatal respiratory distress. Infection with severe acute respiratory syndrome-coronavirus-2 ... ...

    Abstract Cytokine storm syndrome is a cascade of escalated immune responses disposing the immune system to exhaustion, which might ultimately result in organ failure and fatal respiratory distress. Infection with severe acute respiratory syndrome-coronavirus-2 can result in uncontrolled production of cytokines and eventually the development of cytokine storm syndrome. Mast cells may react to viruses in collaboration with other cells and lung autopsy findings from patients that died from the coronavirus disease that emerged in 2019 (COVID-19) showed accumulation of mast cells in the lungs that was thought to be the cause of pulmonary edema, inflammation, and thrombosis. In this review, we present evidence that a cytokine response by mast cells may initiate inappropriate antiviral immune responses and cause the development of cytokine storm syndrome. We also explore the potential of mast cell activators as adjuvants for COVID-19 vaccines and discuss the medications that target the functions of mast cells and could be of value in the treatment of COVID-19. Recognition of the cytokine storm is crucial for proper treatment of patients and preventing the release of mast cell mediators, as impeding the impacts imposed by these mediators could reduce the severity of COVID-19.
    Keywords COVID-19 ; SARS-CoV-2 ; mast cells ; cytokine storm ; vaccine ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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