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  1. Article ; Online: Cytokine Storm in COVID19: A Neural Hypothesis.

    Ur, Anoop / Verma, Kavita

    ACS chemical neuroscience

    2020  Volume 11, Issue 13, Page(s) 1868–1870

    Abstract: Cytokine storm in COVID-19 is characterized by an excessive inflammatory response to SARS-CoV-2 that is caused by a dysregulated immune system of the host. We are proposing a new hypothesis that SARS-CoV-2 mediated inflammation of nucleus tractus ... ...

    Abstract Cytokine storm in COVID-19 is characterized by an excessive inflammatory response to SARS-CoV-2 that is caused by a dysregulated immune system of the host. We are proposing a new hypothesis that SARS-CoV-2 mediated inflammation of nucleus tractus solitarius (NTS) may be responsible for the cytokine storm in COVID 19. The inflamed NTS may result in a dysregulated cholinergic anti-inflammatory pathway and hypothalamic-pituitary-adrenal axis.
    MeSH term(s) Axons/immunology ; Axons/metabolism ; Axons/virology ; Betacoronavirus/immunology ; Betacoronavirus/metabolism ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/metabolism ; Cranial Nerves/immunology ; Cranial Nerves/metabolism ; Cranial Nerves/virology ; Cytokines/immunology ; Cytokines/metabolism ; Humans ; Hypothalamo-Hypophyseal System/immunology ; Hypothalamo-Hypophyseal System/metabolism ; Hypothalamo-Hypophyseal System/virology ; Inflammation Mediators/immunology ; Inflammation Mediators/metabolism ; Pandemics ; Pituitary-Adrenal System/immunology ; Pituitary-Adrenal System/metabolism ; Pituitary-Adrenal System/virology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/metabolism ; SARS-CoV-2 ; Solitary Nucleus/immunology ; Solitary Nucleus/metabolism ; Solitary Nucleus/virology
    Chemical Substances Cytokines ; Inflammation Mediators
    Keywords covid19
    Language English
    Publishing date 2020-06-17
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.0c00346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pulmonary Edema in COVID19—A Neural Hypothesis

    U.R., Anoop / Verma, Kavita

    ACS Chemical Neuroscience

    2020  Volume 11, Issue 14, Page(s) 2048–2050

    Keywords Cell Biology ; Biochemistry ; Physiology ; Cognitive Neuroscience ; General Medicine ; covid19
    Language English
    Publisher American Chemical Society (ACS)
    Publishing country us
    Document type Article ; Online
    ISSN 1948-7193
    DOI 10.1021/acschemneuro.0c00370
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Cytokine Storm in COVID19

    UR, Anoop / Verma, Kavita

    ACS Chemical Neuroscience

    A Neural Hypothesis

    2020  Volume 11, Issue 13, Page(s) 1868–1870

    Keywords Cell Biology ; Biochemistry ; Physiology ; Cognitive Neuroscience ; General Medicine ; covid19
    Language English
    Publisher American Chemical Society (ACS)
    Publishing country us
    Document type Article ; Online
    ISSN 1948-7193
    DOI 10.1021/acschemneuro.0c00346
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Happy Hypoxemia in COVID-19—A Neural Hypothesis

    U.R., Anoop / Verma, Kavita

    ACS Chemical Neuroscience

    2020  Volume 11, Issue 13, Page(s) 1865–1867

    Keywords Cell Biology ; Biochemistry ; Physiology ; Cognitive Neuroscience ; General Medicine ; covid19
    Language English
    Publisher American Chemical Society (ACS)
    Publishing country us
    Document type Article ; Online
    ISSN 1948-7193
    DOI 10.1021/acschemneuro.0c00318
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Cytokine Storm in COVID19: A Neural Hypothesis

    Ur, Anoop / Verma, Kavita

    ACS Chem Neurosci

    Abstract: Cytokine storm in COVID-19 is characterized by an excessive inflammatory response to SARS-CoV-2 that is caused by a dysregulated immune system of the host. We are proposing a new hypothesis that SARS-CoV-2 mediated inflammation of nucleus tractus ... ...

    Abstract Cytokine storm in COVID-19 is characterized by an excessive inflammatory response to SARS-CoV-2 that is caused by a dysregulated immune system of the host. We are proposing a new hypothesis that SARS-CoV-2 mediated inflammation of nucleus tractus solitarius (NTS) may be responsible for the cytokine storm in COVID 19. The inflamed NTS may result in a dysregulated cholinergic anti-inflammatory pathway and hypothalamic-pituitary-adrenal axis.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #606648
    Database COVID19

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  6. Article ; Online: Pulmonary hypertension, pulmonary embolism and COVID-19: A district general hospital experience from the UK.

    Mahdi, Noor / Nadeem, Iftikhar / Ur Rasool, Masood / Ul Munamm, Syed Ata / Khatana, Usman Feroze / Rashad, Faisal / Babu, Anoop

    The journal of the Royal College of Physicians of Edinburgh

    2023  Volume 53, Issue 1, Page(s) 9–12

    Abstract: Background: Preliminary data suggest that the prevalence of pulmonary hypertension (PH) in patients with COVID-19 is around 13%, but its prognostic role remains unclear. Approximately 3% of patients develop chronic thrombo-embolic pulmonary hypertension ...

    Abstract Background: Preliminary data suggest that the prevalence of pulmonary hypertension (PH) in patients with COVID-19 is around 13%, but its prognostic role remains unclear. Approximately 3% of patients develop chronic thrombo-embolic pulmonary hypertension (CTEPH) following diagnosis of acute pulmonary embolism (PE). It is recommended that patients are screened for CTEPH if they remain symptomatic 3 months following diagnosis of PE. The primary aim of the study was to assess the chances of persistent PH following PE secondary to COVID-19.
    Methods: We conducted a retrospective cohort study at a District General Hospital (DGH) in the United Kingdom. All patients diagnosed with COVID-19 and PE between April 2020 and October 2021 were examined. Patients were divided into two groups:·COVID-19 and PE with comorbidities (excluding pre-existing PH) and·COVID-19 and PE without comorbidities. We compared the ECHO features suggestive of PH between the two groups at the time of diagnosis of PE and at 3 months following treatment.
    Results: 80 patients were included in the study (49 with comorbidities and 31 with no comorbidities). Average age of comorbidities and no comorbidities groups were 73 years and 70 years, respectively. Average PaO
    Conclusion: Patients with comorbidities are at high risk of persistent PH and mortality due to PE secondary to COVID-19.
    MeSH term(s) Humans ; Aged ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/complications ; Risk Factors ; Retrospective Studies ; Hospitals, General ; COVID-19/complications ; COVID-19/epidemiology ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/complications ; Pulmonary Embolism/diagnosis ; Chronic Disease
    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2866363-9
    ISSN 2042-8189 ; 0953-0932
    ISSN (online) 2042-8189
    ISSN 0953-0932
    DOI 10.1177/14782715231152677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3088 -Suppl.-: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: SARS-CoV-2

    Jayamuruga Pandian Arunachalam / Anoop U.R. / Kavita Verma / Rahini Rajendran / Subbulakshmi Chidambaram

    ACS Omega, Vol 6, Iss 10, Pp 7068-

    The Road Less TraveledFrom the Respiratory Mucosa to the Brain

    2021  Volume 7072

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Immediate Versus Staged Complete Revascularization in Patients With Acute Coronary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    Cheema, Huzaifa Ahmad / Bhanushali, Karan / Sohail, Aruba / Fatima, Areej / Hermis, Alaa Hamza / Titus, Anoop / Ahmad, Adeel / Majmundar, Vidit / Rehman, Wajeeh Ur / Sulaiman, Samian / Lakhter, Vladimir / Baron, Suzanne J / Dani, Sourbha S

    The American journal of cardiology

    2024  Volume 220, Page(s) 77–83

    Abstract: A strategy of complete revascularization (CR) is recommended in patients with acute coronary syndrome (ACS) and multivessel disease (MVD). However, the optimal timing of CR remains equivocal. We searched MEDLINE, Embase, the Cochrane Library, and ... ...

    Abstract A strategy of complete revascularization (CR) is recommended in patients with acute coronary syndrome (ACS) and multivessel disease (MVD). However, the optimal timing of CR remains equivocal. We searched MEDLINE, Embase, the Cochrane Library, and ClinicalTrials.gov for randomized controlled trials (RCTs) comparing immediate CR (ICR) with staged CR in patients with ACS and MVD. Our primary outcomes were all-cause and cardiovascular mortality. All outcomes were assessed at 3 time points: in-hospital or at 30 days, at 6 months to 1 year, and at >1 year. Data were pooled in RevMan 5.4 using risk ratios as the effect measure. A total of 9 RCTs (7,506 patients) were included in our review. A total of 7 trials enrolled patients with ST-segment elevation myocardial infarction (STEMI), 1 enrolled patients with non-STEMI only, and 1 enrolled patients with all types of ACS. There was no difference between ICR and staged CR regarding all-cause and cardiovascular mortality at any time window. ICR reduced the rate of myocardial infarction and decreased the rate of repeat revascularization at 6 months and beyond. The rates of cerebrovascular events and stent thrombosis were similar between the 2 groups. In conclusion, the present meta-analysis demonstrated a lower rate of myocardial infarction and a reduction in repeat revascularization at and after 6 months with ICR strategy in patients with mainly STEMI and MVD. The 2 groups had no difference in the risk of all-cause and cardiovascular mortality. Further RCTs are needed to provide more definitive conclusions and investigate CR strategies in other ACS.
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2024.03.037
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    Ui IV Zs.73: Show issues Location:
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  9. Article ; Online: The ECG made easy for the dental practitioner.

    Anoop, U R / Verma, Kavita

    Indian journal of dental research : official publication of Indian Society for Dental Research

    2014  Volume 25, Issue 3, Page(s) 386–389

    Abstract: ECG is not taught to dental students formally in the dental curriculum. The general assumption is that dental surgeons do not handle any ECG related cases in clinical practice. But with an increase in medically compromised patients, the need for an ... ...

    Abstract ECG is not taught to dental students formally in the dental curriculum. The general assumption is that dental surgeons do not handle any ECG related cases in clinical practice. But with an increase in medically compromised patients, the need for an interdisciplinary approach among dental and medical practitioners in the treatment of critically ill patients is becoming more relevant. Hence, we have to be aware of the basics of common medical investigations to be competent to assess and comprehend the medical conditions. So, this paper focuses on orienting the beginner to the basic concepts of ECG from the clinical perspective. The paper also discusses the ECG changes of myocardial infarction to familiarize the dental surgeon to read the ECG.
    MeSH term(s) Dentists ; Electrocardiography/instrumentation ; Electrocardiography/methods ; Humans
    Language English
    Publishing date 2014-05
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 1354886-4
    ISSN 1998-3603 ; 0970-9290
    ISSN (online) 1998-3603
    ISSN 0970-9290
    DOI 10.4103/0970-9290.138349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4581: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article: The Administration of Levodopa in a Patient With Parkinson's Disease Using a Novel Maxillofacial Route: A First-in-Human Report.

    Thirunavukarasu, Suresh / Ramanan, Balasubramanian Bala Venkata / Suresh, Sathya Krishnan / Antonisamy, Vincent Jayakumar / Varadharaj, Devi / Shanmugam, Paranjothi / Verma, Kavita / Elumalai, Canmany / Selvakumar, Gladson / Elumalai, Ahila / Prabahar, Lydia / Janardhanan, Hridwik Adiyeri / Ur, Anoop

    Cureus

    2023  Volume 15, Issue 10, Page(s) e48011

    Abstract: Parkinson's disease is characterized by the loss of nigrostriatal dopaminergic neurons in the brain. Dopamine cannot be administered systemically because it does not cross the blood-brain barrier. Oral levodopa remains the gold standard to date. ... ...

    Abstract Parkinson's disease is characterized by the loss of nigrostriatal dopaminergic neurons in the brain. Dopamine cannot be administered systemically because it does not cross the blood-brain barrier. Oral levodopa remains the gold standard to date. Currently, for patients who show a poor response to oral levodopa and for those who cannot take it orally, the alternate routes available are inhalation and continuous administration via intestinal and subcutaneous routes. In this report, a novel maxillofacial route was used for the first time in the world to administer levodopa to a Parkinson's patient. Furthermore, the efficacy of maxillofacial administration was compared with the oral route of administration.
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.48011
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