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  1. Article ; Online: The authors reply.

    Belletti, Alessandro / Nardelli, Pasquale / Fominskiy, Evgeny V / Landoni, Giovanni / Scandroglio, Anna Mara

    Critical care medicine

    2024  Volume 52, Issue 5, Page(s) e252

    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000006220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Enhance the science of uncertainty with the art of probability.

    Landoni, Giovanni / Nardelli, Pasquale

    Medical hypotheses

    2021  Volume 150, Page(s) 110562

    MeSH term(s) Choice Behavior ; Humans ; Probability ; Uncertainty
    Language English
    Publishing date 2021-03-23
    Publishing country United States
    Document type Editorial
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2021.110562
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
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  3. Article ; Online: Autonomic Regulation of Facial Temperature during Stress: A Cross-Mapping Analysis.

    Gioia, Federica / Nardelli, Mimma / Scilingo, Enzo Pasquale / Greco, Alberto

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 14

    Abstract: Skin temperature reflects the Autonomic Nervous System (ANS)'s response to emotions and mental states and can be remotely measured using InfraRed Thermography. Understanding the physiological mechanisms that affect facial temperature is essential to ... ...

    Abstract Skin temperature reflects the Autonomic Nervous System (ANS)'s response to emotions and mental states and can be remotely measured using InfraRed Thermography. Understanding the physiological mechanisms that affect facial temperature is essential to improve the precision of emotional inference from thermal imaging. To achieve this aim, we recorded thermal images from 30 volunteers, at rest and under acute stress induced by the Stroop test, together with two autonomic correlates, i.e., heart rate variability and electrodermal activity, the former serving as a measure of cardiovascular dynamics, and the latter of the activity of the sweat glands. We used a Cross Mapping (CM) approach to quantify the nonlinear coupling of the temperature from four facial regions with the ANS correlates. CM reveals that facial temperature has a statistically significant correlation with the two autonomic time series, under both conditions, which was not evident in the linear domain. In particular, compared to the other regions, the nose shows a significantly higher link to the electrodermal activity in both conditions, and to the heart rate variability under stress. Moreover, the cardiovascular activity seems to be primarily responsible for the well-known decrease in nose temperature, and its coupling with the thermal signals significantly varies with gender.
    MeSH term(s) Humans ; Temperature ; Body Temperature/physiology ; Skin Temperature ; Emotions/physiology ; Autonomic Nervous System/physiology ; Heart Rate/physiology
    Language English
    Publishing date 2023-07-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23146403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19-Related Thromboinflammatory Status

    Pasquale Nardelli / Giovanni Landoni

    Obŝaâ Reanimatologiâ, Vol 0, Iss

    MicroCLOTS and Beyond

    2020  

    Abstract: The COVID-19 global pandemic, infecting over 3.5 million people and killing over a quarter of a million in the first 4 months of 2020 [1], required physicians all over the world to suddenly face a completely new nosological identity, with unknown ... ...

    Abstract The COVID-19 global pandemic, infecting over 3.5 million people and killing over a quarter of a million in the first 4 months of 2020 [1], required physicians all over the world to suddenly face a completely new nosological identity, with unknown characteristics and clinical challenges.
    Keywords Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Language Russian
    Publishing date 2020-05-01T00:00:00Z
    Publisher Russian Academy of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Impella as Bridge to Durable Left Ventricular Assist Device in Acute Myocardial Infarction Cardiogenic Shock Patients.

    Ajello, Silvia / Pieri, Marina / Dormio, Sara / Baldetti, Luca / Altizio, Savino / Consolo, Filippo / Nardelli, Pasquale / Ortalda, Alessandro / Scandroglio, Anna Mara

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2024  

    Abstract: Implantation of durable left ventricular assist device (LVAD) in cardiogenic shock (CS) patients after acute myocardial infarction (AMI) poses specific challenges (small left ventricular size, acute infarct area, need for antithrombotic therapy, status ... ...

    Abstract Implantation of durable left ventricular assist device (LVAD) in cardiogenic shock (CS) patients after acute myocardial infarction (AMI) poses specific challenges (small left ventricular size, acute infarct area, need for antithrombotic therapy, status Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) 1 with impaired organ function and derangements in coagulation and inflammatory parameters) which may affect outcomes. We reviewed data of all AMI-CS patients who were implanted LVAD after Impella support at a referral center with the aim to analyze feasibility, timing, and outcomes of durable LVAD implantation after tMCS with Impella due to AMI-CS. Twenty-one patients were treated between 2013 and 2023: all were in Society for Cardiovascular Angiography & Interventions (SCAI) class D-E and INTERMACS 1-2 at presentation, median LV ejection fraction (EF) and LV end-diastolic diameter (EDD) were 15 (10-20)% and 57 (54-60) mm, respectively. Eleven patients (52%) were supported with Impella CP, seven with Impella 5.0 (33%), and three (14%) with Impella 2.5. Axillary cannulation was performed in nine patients (43%). Five patients (24%) had concomitant venoarterial extracorporeal membrane oxygenation (VA-ECMO) support. Median duration of Impella support was 12 (8-14) days. Overall, the use of Impella was characterized by low rate of complications and allowed successful bridge to durable LVAD in all patients, with 100% 30 day survival rate.
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000002201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.199: Show issues Location:
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    Zs.B 2435: Show issues Location:
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  7. Article ; Online: ComEDA: A new tool for stress assessment based on electrodermal activity.

    Nardelli, Mimma / Greco, Alberto / Sebastiani, Laura / Scilingo, Enzo Pasquale

    Computers in biology and medicine

    2022  Volume 150, Page(s) 106144

    Abstract: Non-specific sympathetic arousal responses to different stressful elicitations can be easily recognized from the analysis of physiological signals. However, neural patterns of sympathetic arousal during physical and mental fatigue are clearly not unitary. ...

    Abstract Non-specific sympathetic arousal responses to different stressful elicitations can be easily recognized from the analysis of physiological signals. However, neural patterns of sympathetic arousal during physical and mental fatigue are clearly not unitary. In the context of physiological monitoring through wearable and non-invasive devices, electrodermal activity (EDA) is the most effective and widely used marker of sympathetic activation. This study presents ComEDA, a novel approach for the characterization of complex dynamics of EDA. ComEDA overcomes the methodological limitations related to the application of nonlinear analysis to EDA dynamics, is not parameter-sensitive and is suitable for the analysis of ultra-short time series. We validated the proposed algorithm using synthetic series of white noise and 1/f noise, varying the number of samples from 50 to 5000. By applying our approach, we were able to discriminate a statistically significant increase of complexity in the 1/f noise with respect to white noise, obtaining p-values in the range [4.35 × 10
    MeSH term(s) Humans ; Galvanic Skin Response ; Algorithms ; Physical Examination
    Language English
    Publishing date 2022-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2022.106144
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 653: Show issues Location:
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  8. Article ; Online: Organ donation after extracorporeal cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest in a metropolitan cardiac arrest centre in Milan, Italy.

    Bonizzoni, Matteo Aldo / Scquizzato, Tommaso / Pieri, Marina / Delrio, Silvia / Nardelli, Pasquale / Ortalda, Alessandro / Dell'Acqua, Antonio / Scandroglio, Anna Mara

    Resuscitation

    2024  , Page(s) 110214

    Abstract: Introduction: Extracorporeal cardiopulmonary resuscitation (ECPR) may improve survival in refractory out-of-hospital cardiac arrest (OHCA) but also expand the donor pool as these patients often become eligible for organ donation. Our aim is to describe ... ...

    Abstract Introduction: Extracorporeal cardiopulmonary resuscitation (ECPR) may improve survival in refractory out-of-hospital cardiac arrest (OHCA) but also expand the donor pool as these patients often become eligible for organ donation. Our aim is to describe the impact of organ donation in OHCA patients treated with ECPR in a high-volume cardiac arrest centre.
    Methods: Rate of organ donation (primary outcome), organs harvested, a composite of patient survival with favourable neurological outcome or donation of ≥1 solid organ (ECPR benefit), and the potential total number of individuals benefiting from ECPR (survivors with favourable neurological outcome and potential recipients of one solid organ) were analysed among all-rhythms refractory OHCA patients treated with ECPR between January 2013-November 2022 at San Raffaele Hospital in Milan, Italy.
    Results: Among 307 adults with refractory OHCA treated with ECPR (95% witnessed, 66% shockable, low-flow 70 [IQR 58-81] minutes), 256 (83%) died during hospital stay, 33% from brain death. Donation of at least one solid organ occurred in 58 (19%) patients, 53 (17%) after determination of brain death and 5 (1.6%) after determination of circulatory death, contributing a total of 167 solid organs (3.0 [IQR 2.5-4.0] organs/donor). Overall, 196 individuals (29 survivors with favourable neurological outcome and 167 potential recipients of 1 solid organ) possibly benefited from ECPR. ECPR benefit composite outcome was achieved in 87 (28%) patients. Solid organ donation decreased from 19% to 16% in patients with low-flow <60 min and to 11% with low-flow <60 min and initial shockable rhythm.
    Conclusions: When ECPR fails in patients with refractory OHCA, organ donation after brain or circulatory death can help a significant number of patients awaiting transplantation, enhancing the overall benefit of ECPR. ECPR selection criteria may affect the number of potential organ donors.
    Language English
    Publishing date 2024-04-10
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2024.110214
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    Zs.A 1048: Show issues Location:
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  9. Article ; Online: Contactless Cardiovascular Assessment by Imaging Photoplethysmography: A Comparison with Wearable Monitoring.

    van Es, Valerie A A / Lopata, Richard G P / Scilingo, Enzo Pasquale / Nardelli, Mimma

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 3

    Abstract: Despite the notable recent developments in the field of remote photoplethysmography (rPPG), extracting a reliable pulse rate variability (PRV) signal still remains a challenge. In this study, eight image-based photoplethysmography (iPPG) extraction ... ...

    Abstract Despite the notable recent developments in the field of remote photoplethysmography (rPPG), extracting a reliable pulse rate variability (PRV) signal still remains a challenge. In this study, eight image-based photoplethysmography (iPPG) extraction methods (GRD, AGRD, PCA, ICA, LE, SPE, CHROM, and POS) were compared in terms of pulse rate (PR) and PRV features. The algorithms were made robust for motion and illumination artifacts by using ad hoc pre- and postprocessing steps. Then, they were systematically tested on the public dataset UBFC-RPPG, containing data from 42 subjects sitting in front of a webcam (30 fps) while playing a time-sensitive mathematical game. The performances of the algorithms were evaluated by statistically comparing iPPG-based and finger-PPG-based PR and PRV features in terms of Spearman's correlation coefficient, normalized root mean square error (NRMSE), and Bland-Altman analysis. The study revealed POS and CHROM techniques to be the most robust for PR estimation and the assessment of overall autonomic nervous system (ANS) dynamics by using PRV features in time and frequency domains. Furthermore, we demonstrated that a reliable characterization of the vagal tone is made possible by computing the Poincaré map of PRV series derived from the POS and CHROM methods. This study supports the use of iPPG systems as promising tools to obtain clinically useful and specific information about ANS dynamics.
    MeSH term(s) Humans ; Photoplethysmography/methods ; Signal Processing, Computer-Assisted ; Heart Rate/physiology ; Diagnostic Imaging ; Algorithms ; Wearable Electronic Devices
    Language English
    Publishing date 2023-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23031505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cytokine adsorption and ECMO in patients with COVID-19.

    Nardelli, Pasquale / Pieri, Marina / Fominskiy, Evgeny / Scandroglio, Anna Mara

    The Lancet. Respiratory medicine

    2021  Volume 9, Issue 8, Page(s) e71

    MeSH term(s) Adsorption ; COVID-19 ; Cytokines ; Extracorporeal Membrane Oxygenation ; Humans ; SARS-CoV-2
    Chemical Substances Cytokines
    Language English
    Publishing date 2021-07-06
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00285-X
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