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  1. Article ; Online: Gene Therapy for Occupational Lung Disease: Steering Macrophages in the Right Direction?

    Remcho, T Parks / Kolls, Jay K

    American journal of respiratory cell and molecular biology

    2022  Volume 68, Issue 2, Page(s) 129–130

    MeSH term(s) Humans ; Adenoviridae ; Lung Diseases/genetics ; Lung Diseases/therapy ; Pneumonia ; Fibrosis ; Genetic Therapy
    Language English
    Publishing date 2022-10-26
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2022-0408ED
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    Zs.A 2851: Show issues Location:
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  2. Article ; Online: An ALARMINg Type 2 Response in Cystic Fibrosis-The Key to Understanding ABPA?

    Bojanowski, Christine M / Bitoun, Jacob P / Kolls, Jay K

    American journal of respiratory and critical care medicine

    2023  Volume 207, Issue 11, Page(s) 1418–1419

    MeSH term(s) Humans ; Cystic Fibrosis/genetics ; Interleukin-33 ; Respiratory System ; Inflammation
    Chemical Substances Interleukin-33
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202303-0580ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Multi-omic comparisons between CFBE41o- cells stably expressing wild-type CFTR and F508del-mutant CFTR.

    Lu, Shiping / Kolls, Jay K

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2022  Volume 22, Issue 1, Page(s) 146–155

    Abstract: Background: Cystic fibrosis (CF) is characterized by chronic inflammation and excessive cytokines secretion in the lung. Isogenic human CF bronchial epithelial (CFBE41o-) cell lines stably expressing wt-CFTR (WTBE) or F508del mutant (CFBE) are widely ... ...

    Abstract Background: Cystic fibrosis (CF) is characterized by chronic inflammation and excessive cytokines secretion in the lung. Isogenic human CF bronchial epithelial (CFBE41o-) cell lines stably expressing wt-CFTR (WTBE) or F508del mutant (CFBE) are widely used tools in understanding responses to stimuli or drugs and CF pathogenesis in vitro. However, the intrinsic cellular differences in culture are unknown.
    Methods: We performed integrative analyses of these isogenic cells at the protein, mRNA, and chromatin levels in the submerged and air-liquid interface (ALI) conditions to determine cell intrinsic effects of mutant versus complemented CFTR expression.
    Results: CFBE and WTBE cells displayed different cytokine secretion patterns, including IL-6, IL-8, CXCL1, CXCL10, and CCL5. The ALI culture dramatically increased cytokine secretion in both cells. Assay for transposase-accessible chromatin using sequencing (ATAC-seq) result showed different chromatin landscapes upon polarization and CFBE cells, compared to WTBE cells, exhibited higher genome-wide chromatin accessibility under both culture methods. At the transcriptome level, differentially expressed genes identified by mRNA sequencing between two cell lines were highly concentrated in immunity-related pathways.
    Conclusions: This multilayered study shows that expression of wild-type CFTR has an epithelial cell intrinsic effect on the cell's epigenome and transcriptome particularly in immunity relevant activities. These data will serve as a resource for the CF community and may serve as epithelial biomarkers for CFTR mRNA therapy.
    MeSH term(s) Humans ; Chromatin/metabolism ; Cystic Fibrosis/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cytokines/metabolism ; Epithelial Cells/metabolism ; Multiomics ; RNA, Messenger/metabolism
    Chemical Substances CFTR protein, human ; Chromatin ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Cytokines ; RNA, Messenger
    Language English
    Publishing date 2022-07-06
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2022.06.010
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    Zs.MO 459: Show issues

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  4. Article ; Online: Genetic Mouse Models of Pneumocystis Pneumonia.

    Hoving, J Claire / Munyonho, Ferris T / Kolls, Jay K

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2667, Page(s) 169–179

    Abstract: Pneumocystis jirovecii causes pneumonia in immunocompromised patients. A major challenge in drug susceptibility testing and in understanding host/pathogen interactions is that Pneumocystis spp. are not viable in vitro. Continuous culture of the organism ... ...

    Abstract Pneumocystis jirovecii causes pneumonia in immunocompromised patients. A major challenge in drug susceptibility testing and in understanding host/pathogen interactions is that Pneumocystis spp. are not viable in vitro. Continuous culture of the organism is not currently available, and therefore, developing new drug targets is very limited. Due to this limitation, mouse models of Pneumocystis pneumonia have proven to be an invaluable resource to researchers. In this chapter, we provide an overview of selected methods used in mouse models of infection including, in vivo Pneumocystis murina propagation, routes of transmission, genetic mouse models available, a P. murina life form-specific model, a mouse model of PCP immune reconstitution inflammatory syndrome (IRIS), and the experimental parameters associated with these models.
    MeSH term(s) Animals ; Mice ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis ; Pneumocystis carinii/genetics ; Pneumonia, Pneumocystis/genetics
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3199-7_13
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  5. Article ; Online: Early Antibiotics in Cystic Fibrosis: Lessons from the Cystic Fibrosis Pig Model.

    Lu, Shiping / Kolls, Jay K

    American journal of respiratory and critical care medicine

    2021  Volume 204, Issue 6, Page(s) 626–627

    MeSH term(s) Animals ; Anti-Bacterial Agents/therapeutic use ; Cystic Fibrosis/drug therapy ; Pseudomonas Infections/drug therapy ; Swine ; Tobramycin
    Chemical Substances Anti-Bacterial Agents ; Tobramycin (VZ8RRZ51VK)
    Language English
    Publishing date 2021-08-03
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202106-1383ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Role of the T cell vitamin D receptor in severe COVID-19.

    Kolls, Jay K / Garry, Robert F

    Nature immunology

    2021  Volume 23, Issue 1, Page(s) 5–6

    MeSH term(s) Basic-Leucine Zipper Transcription Factors/metabolism ; COVID-19/pathology ; Humans ; Interferon-gamma/immunology ; Interleukin-10/immunology ; Membrane Cofactor Protein/immunology ; Proto-Oncogene Proteins c-jun/metabolism ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; SARS-CoV-2/immunology ; STAT3 Transcription Factor/metabolism ; Signal Transduction/immunology ; Th1 Cells/immunology ; Vitamin D/metabolism
    Chemical Substances BACH2 protein, human ; Basic-Leucine Zipper Transcription Factors ; CD46 protein, human ; IFNG protein, human ; IL10 protein, human ; JUN protein, human ; Membrane Cofactor Protein ; Proto-Oncogene Proteins c-jun ; Receptors, Calcitriol ; STAT3 Transcription Factor ; STAT3 protein, human ; VDR protein, human ; Interleukin-10 (130068-27-8) ; Vitamin D (1406-16-2) ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2021-12-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-021-01098-7
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    Zs.MG 42: Show issues

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  7. Article ; Online: An Emerging Role of B Cell Immunity in Susceptibility to Pneumocystis Pneumonia.

    Kolls, Jay K

    American journal of respiratory cell and molecular biology

    2017  Volume 56, Issue 3, Page(s) 279–280

    Language English
    Publishing date 2017-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2016-0360ED
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  8. Article: Commentary: Understanding the Impact of Infection, Inflammation and Their Persistence in the Pathogenesis of Bronchopulmonary Dysplasia.

    Kolls, Jay K

    Frontiers in medicine

    2017  Volume 4, Page(s) 24

    Language English
    Publishing date 2017-03-02
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2017.00024
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  9. Article ; Online: Mucosal Immunity in Cystic Fibrosis.

    Bojanowski, Christine M / Lu, Shiping / Kolls, Jay K

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Volume 207, Issue 12, Page(s) 2901–2912

    Abstract: The highly complex and variable genotype-phenotype relationships observed in cystic fibrosis (CF) have been an area of growing interest since the discovery of the CF transmembrane conductance regulator ( ...

    Abstract The highly complex and variable genotype-phenotype relationships observed in cystic fibrosis (CF) have been an area of growing interest since the discovery of the CF transmembrane conductance regulator (
    MeSH term(s) Cystic Fibrosis/microbiology ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Humans ; Immunity, Mucosal ; Inflammation ; Lung/pathology ; Phenotype
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2100424
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  10. Article ; Online: Cell-intrinsic and -extrinsic effects of SARS-CoV-2 RNA on pathogenesis: single-cell meta-analysis.

    Khatun, Mst Shamima / Remcho, T Parks / Qin, Xuebin / Kolls, Jay K

    mSphere

    2023  Volume 8, Issue 5, Page(s) e0037523

    Abstract: Single-cell RNA-seq has been used to characterize human COVID-19. To determine if preclinical models successfully mimic the cell-intrinsic and -extrinsic effects of severe disease, we conducted a meta-analysis of single-cell data across five model ... ...

    Abstract Single-cell RNA-seq has been used to characterize human COVID-19. To determine if preclinical models successfully mimic the cell-intrinsic and -extrinsic effects of severe disease, we conducted a meta-analysis of single-cell data across five model species. To assess whether dissemination of viral RNA in lung cells tracks pathology and results in cell-intrinsic and -extrinsic transcriptomic changes in COVID-19. We conducted a meta-analysis by analyzing six publicly available, scRNA-seq data sets. We used dual mapping (host and virus) and differential gene expression analyses to compare viral
    MeSH term(s) Cricetinae ; Humans ; Animals ; Mice ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; Endothelial Cells ; Ferrets ; Interleukin-18 ; Macaca mulatta ; COVID-19
    Chemical Substances RNA, Viral ; K-18 conjugate ; Interleukin-18
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Meta-Analysis ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00375-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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