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Article ; Online: Editorial: STATus of STAT3 in Psoriatic Arthritis.

Mountz, John D

Arthritis & rheumatology (Hoboken, N.J.)

2018 Volume 70, Issue 6, Page(s) 801–804

MeSH term(s)	Arthritis, Psoriatic ; Humans ; Inflammation ; STAT3 Transcription Factor ; Th17 Cells
Chemical Substances	STAT3 Transcription Factor ; STAT3 protein, human
Language	English
Publishing date	2018-05-02
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.40445
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Impact of immune senescence on human aging

Mountz, John D.

(Immunology and allergy clinics of North America ; 23,1)

2003

Author's details	John D. Mountz ... guest ed
Series title	Immunology and allergy clinics of North America ; 23,1
Collection
Language	English
Size	XV, 153 S. : Ill., graph. Darst.
Publisher	Saunders
Publishing place	Philadelphia u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT013613033
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Interrelation of T cell cytokines and autoantibodies in systemic lupus erythematosus: A cross-sectional study.

Alduraibi, Fatima K / Sullivan, Kathryn A / Chatham, W Winn / Hsu, Hui-Chen / Mountz, John D

Clinical immunology (Orlando, Fla.)

2023 Volume 247, Page(s) 109239

Abstract: T-helper cytokines interferon gamma (IFNɣ), interleukin 17 (IL-17) and IL-10 impact systemic lupus erythematosus (SLE) directly and indirectly via modulation of autoAb production. We determined the separate and combined effects on clinical manifestations ...

Abstract	T-helper cytokines interferon gamma (IFNɣ), interleukin 17 (IL-17) and IL-10 impact systemic lupus erythematosus (SLE) directly and indirectly via modulation of autoAb production. We determined the separate and combined effects on clinical manifestations of SLE (N = 62). IFNɣ, IL-17 but not IL-10 were significantly elevated in patients with SLE. IFNɣ positively correlated with anti-DNA and anti-SSA. IL-17 positively correlated with anti-SSA and was significantly higher in patients with discoid rash and class V LN. IL-10 did not correlate with circulating autoantibodies but was significantly elevated in patients with LN. Patients with LN had elevated plasma levels of anti-DNA and anti-Sm/ribonuclear protein (RNP). Anti-Sm/RNP levels were decreased in patients with acute mucocutaneous manifestations, including photosensitivity and/or malar rash. The study provides critical insights into pathological mechanisms of LN, which could help guide future diagnoses and therapies.
MeSH term(s)	Humans ; Cytokines ; Interleukin-17 ; Cross-Sectional Studies ; Autoantibodies ; T-Lymphocytes ; Lupus Erythematosus, Systemic ; Interferon-gamma ; Antibodies, Antinuclear ; Lupus Nephritis
Chemical Substances	Cytokines ; Interleukin-17 ; Autoantibodies ; Interferon-gamma (82115-62-6) ; Antibodies, Antinuclear
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2023.109239
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Article ; Online: IL-4-Induced Quiescence of Resting Naive B Cells Is Disrupted in Systemic Lupus Erythematosus.

Gao, Min / Liu, Shanrun / Chatham, W Winn / Mountz, John D / Hsu, Hui-Chen

Journal of immunology (Baltimore, Md. : 1950)

2022 Volume 209, Issue 8, Page(s) 1513–1522

Abstract: Activated naive (aNAV) B cells have been shown to be the precursor of the ... ...

Abstract	Activated naive (aNAV) B cells have been shown to be the precursor of the CD11c
MeSH term(s)	Autoantibodies/metabolism ; B-Lymphocyte Subsets ; Humans ; Immunoglobulin D/metabolism ; Interleukin-4/metabolism ; Lupus Erythematosus, Systemic ; RNA/metabolism
Chemical Substances	Autoantibodies ; Immunoglobulin D ; Interleukin-4 (207137-56-2) ; RNA (63231-63-0)
Language	English
Publishing date	2022-09-07
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2200409
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Article ; Online: Lupus nephritis correlates with B cell interferon-β, anti-Smith, and anti-DNA: a retrospective study.

Alduraibi, Fatima / Fatima, Huma / Hamilton, Jennie A / Chatham, W Winn / Hsu, Hui-Chen / Mountz, John D

Arthritis research & therapy

2022 Volume 24, Issue 1, Page(s) 87

Abstract: Background: In systemic lupus erythematosus (SLE), detection of interferon-β (IFNβ) in B cells was found to be most prominent in patients with high anti-Smith (Sm) and renal disease, but a mechanistic connection was not clear. The objective of the ... ...

Abstract	Background: In systemic lupus erythematosus (SLE), detection of interferon-β (IFNβ) in B cells was found to be most prominent in patients with high anti-Smith (Sm) and renal disease, but a mechanistic connection was not clear. The objective of the present study is to determine the association of IFNβ in peripheral blood naïve B cells with the histopathological features of lupus nephritis (LN). Methods: The percentage of IFNβ Results: B cell IFNβ is positively associated with anti-Sm (p = 0.001), anti-DNA (p = 0.013), and LN (p < 0.001) but was negatively associated with oral/nasal ulcer (p = 0.003) and photosensitivity (p = 0.045). B cell IFNβ positively correlated with immune complex (IC) deposit in the glomerular basement membrane (GBM) (p = 0.002) but not in the mesangial (p = 0.107) or tubular region (p = 0.313). Patients with high B cell IFNβ had statistically increased development of the proliferative LN (Classes III, IV and/or V), compared to patients with low B cell IFNβ (p < 0.0001). Histopathological features positively associated with increased B cell IFNβ included active glomerular lesions as determined by fibrocellular crescents (p = 0.023), chronic glomerular lesions indicated by segmental sclerosis (p = 0.033), and a membranous pattern of renal damage indicated by spike/holes (p = 0.015). Conclusion: B cell IFNβ correlates with history of severe LN, glomerular basement membrane (GBM) IC deposition, and anatomical features of both active and chronic glomerular lesions.
MeSH term(s)	Antibodies, Antinuclear ; Female ; Humans ; Interferon-beta ; Kidney Diseases ; Leukocytes, Mononuclear/metabolism ; Lupus Erythematosus, Systemic ; Lupus Nephritis/pathology ; Male ; Retrospective Studies
Chemical Substances	Antibodies, Antinuclear ; Interferon-beta (77238-31-4)
Language	English
Publishing date	2022-04-18
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-022-02766-1
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Article ; Online: Dysregulation of T Follicular Helper Cells in Lupus.

Mountz, John D / Hsu, Hui-Chen / Ballesteros-Tato, Andre

Journal of immunology (Baltimore, Md. : 1950)

2019 Volume 202, Issue 6, Page(s) 1649–1658

Abstract: Although multiple and overlapping mechanisms are ultimately responsible for the immunopathology observed in patients with systemic lupus erythematosus, autoreactive Abs secreted by autoreactive plasma cells (PCs) are considered to play a critical role in ...

Abstract	Although multiple and overlapping mechanisms are ultimately responsible for the immunopathology observed in patients with systemic lupus erythematosus, autoreactive Abs secreted by autoreactive plasma cells (PCs) are considered to play a critical role in disease progression and immunopathology. Given that PCs derive from the germinal centers (GC), long-term dysregulated GC reactions are often associated with the development of spontaneous autoantibody responses and immunopathology in systemic lupus erythematosus patients. In this review, we summarize the emerging evidence concerning the roles of T follicular helper cells in regulating pathogenic GC and autoreactive PC responses in lupus.
MeSH term(s)	Animals ; Autoantibodies/immunology ; Germinal Center/immunology ; Humans ; Lupus Erythematosus, Systemic/immunology ; Plasma Cells/immunology ; T-Lymphocytes, Helper-Inducer/immunology
Chemical Substances	Autoantibodies
Language	English
Publishing date	2019-03-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1801150
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Article ; Online: Autoreactive B cells in SLE, villains or innocent bystanders?

Hamilton, Jennie A / Hsu, Hui-Chen / Mountz, John D

Immunological reviews

2019 Volume 292, Issue 1, Page(s) 120–138

Abstract: The current concepts for development of autoreactive B cells in SLE (systemic lupus erythematosus) focus on extrinsic stimuli and factors that provoke B cells into tolerance loss. Traditionally, major tolerance loss pathways are thought to be regulated ... ...

Abstract	The current concepts for development of autoreactive B cells in SLE (systemic lupus erythematosus) focus on extrinsic stimuli and factors that provoke B cells into tolerance loss. Traditionally, major tolerance loss pathways are thought to be regulated by factors outside the B cell including autoantigen engagement of the B-cell receptor (BCR) with simultaneous type I interferon (IFN) produced by dendritic cells, especially plasmacytoid dendritic cells (pDCs). Later, in autoreactive follicles, B-cells encounter T-follicular helper cells (Tfh) that produce interleukin (IL)-21, IL-4 and pathogenic cytokines, IL-17 and IFN gamma (IFNɣ). This review discusses these mechanisms and also highlights recent advances pointing to the peripheral transitional B-cell stage as a major juncture where transient autocrine IFNβ expression by developing B-cells imprints a heightened susceptibility to external factors favoring differentiation into autoantibody-producing plasmablasts. Recent studies highlight transitional B-cell heterogeneity as a determinant of intrinsic resistance or susceptibility to tolerance loss through the shaping of B-cell responsiveness to cytokines and other environment factors.
MeSH term(s)	Animals ; Autoantibodies/immunology ; Autoimmunity/immunology ; B-Lymphocytes/immunology ; Cytokines/immunology ; Cytokines/metabolism ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Humans ; Immune Tolerance/immunology ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/metabolism ; T-Lymphocytes, Helper-Inducer/immunology
Chemical Substances	Autoantibodies ; Cytokines
Language	English
Publishing date	2019-10-21
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	391796-4
ISSN	1600-065X ; 0105-2896
ISSN (online)	1600-065X
ISSN	0105-2896
DOI	10.1111/imr.12815
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Article ; Online: mRNA editing, FAS, and systemic lupus erythematosus.

Mountz, John D

Human mutation

2011 Volume 32, Issue 11, Page(s) v–vi

MeSH term(s)	Animals ; Humans ; Lupus Erythematosus, Systemic/genetics ; RNA, Messenger/genetics ; fas Receptor/genetics
Chemical Substances	FAS protein, human ; RNA, Messenger ; fas Receptor
Language	English
Publishing date	2011-11
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1126646-6
ISSN	1098-1004 ; 1059-7794
ISSN (online)	1098-1004
ISSN	1059-7794
DOI	10.1002/humu.21620
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Article ; Online: Role of production of type I interferons by B cells in the mechanisms and pathogenesis of systemic lupus erythematosus.

Hamilton, Jennie A / Hsu, Hui-Chen / Mountz, John D

Discovery medicine

2018 Volume 25, Issue 135, Page(s) 21–29

Abstract: Type I interferons (IFNs) have a prominent role in many aspects of normal innate and adaptive immunity and autoimmunity. However, cell-type specific information about type I IFN expression and autocrine/paracrine signaling is sparse and mostly focused on ...

Abstract	Type I interferons (IFNs) have a prominent role in many aspects of normal innate and adaptive immunity and autoimmunity. However, cell-type specific information about type I IFN expression and autocrine/paracrine signaling is sparse and mostly focused on non-lymphocyte and non-immune cell populations. A major function of B cells is cytokine production, but surprisingly, type I IFN production by B cells in systemic lupus erythematosus (SLE) has not been thoroughly investigated. This is due, in part, to the established view that plasmacytoid dendritic cells (pDCs) are the primary source of pathogenic type I IFN in lupus. Recent studies, however, have provided evidence to challenge this paradigm. Here, we discuss data supporting a new concept that the production of type I IFN, especially IFNβ, by early stage transitional B cells may be an important source of type I IFN to support autoreactive B cell development in lupus. These findings, if confirmed, may provide a new paradigm in designing and developing more effective therapies for preventing the formation of autoreactive B cells.
MeSH term(s)	Animals ; Autocrine Communication/immunology ; Dendritic Cells/immunology ; Dendritic Cells/pathology ; Humans ; Interferon Type I/immunology ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/pathology ; Paracrine Communication/immunology ; Plasma Cells/immunology ; Plasma Cells/pathology ; Signal Transduction/immunology
Chemical Substances	Interferon Type I
Language	English
Publishing date	2018-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	1944-7930
ISSN (online)	1944-7930
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Increased development of T-bet

Sullivan, Kathryn A / Chapman, Casey / Lu, Lu / Ashbrook, David G / Wang, Yong / Alduraibi, Fatima K / Lu, Changming / Sun, Chao-Wang / Liu, Shanrun / Williams, Robert W / Mountz, John D / Hsu, Hui-Chen

Clinical immunology (Orlando, Fla.)

2023 Volume 257, Page(s) 109842

Abstract: Cardinal features of lupus include elevated B cell activation and autoantibody production with a female sex preponderance. We quantified interactions of sex and genetic variation on the development of autoimmune B-cell phenotypes and autoantibodies in ... ...

Abstract	Cardinal features of lupus include elevated B cell activation and autoantibody production with a female sex preponderance. We quantified interactions of sex and genetic variation on the development of autoimmune B-cell phenotypes and autoantibodies in the BXD2 murine model of lupus using a cohort of backcrossed progeny (BXD2 x C57BL/6J) x BXD2. Sex was the key factor leading to increased total IgG, IgG2b, and autoantibodies. The percentage of T-bet
MeSH term(s)	Animals ; Female ; Humans ; Male ; Mice ; Autoantibodies ; B-Lymphocytes ; Crosses, Genetic ; Germinal Center ; Lupus Erythematosus, Systemic/genetics ; Mice, Inbred C57BL ; T-Lymphocytes, Helper-Inducer ; Sex Characteristics
Chemical Substances	Autoantibodies
Language	English
Publishing date	2023-11-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2023.109842
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