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  1. Article ; Online: LIC_12757 from the pathogenic spirochaete Leptospira interrogans encodes an autoregulated ECF σ

    Kędzierska-Mieszkowska, Sabina / Kędzierska, Barbara / Potrykus, Katarzyna

    Veterinary microbiology

    2024  Volume 293, Page(s) 110092

    Abstract: ECF (extracytoplasmic function) σ factors, members of the ... ...

    Abstract ECF (extracytoplasmic function) σ factors, members of the σ
    Language English
    Publishing date 2024-04-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 753154-0
    ISSN 1873-2542 ; 0378-1135
    ISSN (online) 1873-2542
    ISSN 0378-1135
    DOI 10.1016/j.vetmic.2024.110092
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  2. Article ; Online: The power of memory T cells minus antibodies.

    Nguyen, Thi H O / Kedzierska, Katherine

    Nature immunology

    2024  Volume 25, Issue 4, Page(s) 594–595

    MeSH term(s) Memory T Cells
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-024-01796-y
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  3. Article ; Online: Nutritional Risk of Candidates for Simultaneous Pancreatic-Kidney Transplantation-A Narrative Review.

    Mizerska, Agnieszka / Durlik, Marek / Kędzierska-Kapuza, Karolina

    Nutrients

    2023  Volume 15, Issue 19

    Abstract: Introduction: Not much is known about the significance of nutritional status and support in transplant surgery, least of all in simultaneous pancreatic and kidney transplantation. Malnutrition in the context of simultaneous pancreatic-kidney ... ...

    Abstract Introduction: Not much is known about the significance of nutritional status and support in transplant surgery, least of all in simultaneous pancreatic and kidney transplantation. Malnutrition in the context of simultaneous pancreatic-kidney transplantation seems to be complex and a still poorly investigated problem. Since SPKTX is highly qualified and also has a small volume procedure, it is difficult to obtain data from large cohorts of patients. The aim of this article is to gather existing evidence and information about the subject, as well as to elicit some questions and goals for the future.
    Methods: We searched through the Pub-Med database using the keywords "pancreas and kidney transplantation" combined with "nutritional risk", "nutritional status", "malnutrition", "nutritional intervention", and "frailty", finding a total of 4103 matching results. We then narrowed it down to articles written in English with the full text available. We also researched through the references of articles most accurately matching our researched terms.
    Results: There are numerous tools that have been investigated for the screening of malnutrition, such as the NRI index, PNI index, NLR, SGA scale, and NRS-2002 scale, each of which proved to be of some use in predicting patient outcomes in different surgical settings. Since all of them differed in components and assessed parameters and, in the absence of more sensitive or infallible indicators, the most reasonable approach seems to evaluate them jointly.
    Conclusion: It is important to underline the necessity of nutritional screening and the subsequent introduction of adequate therapy while awaiting transplantation in an attempt to improve results. Considering the complexity of surgical procedures and the severity of underlying diseases with their intense metabolic components, the patient's nutritional status seems to significantly influence results. Consequently, nutritional risk assessments should be a part of the routine care of patients qualified for transplantation.
    MeSH term(s) Humans ; Nutritional Status ; Nutrition Assessment ; Kidney Transplantation/adverse effects ; Malnutrition/diagnosis ; Risk Assessment
    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15194179
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  4. Article ; Online: Minigene as a Novel Regulatory Element in Toxin-Antitoxin Systems.

    Kędzierska, Barbara / Potrykus, Katarzyna

    International journal of molecular sciences

    2021  Volume 22, Issue 24

    Abstract: ... ...

    Abstract The
    MeSH term(s) Antitoxins/metabolism ; Bacterial Proteins/metabolism ; Bacterial Toxins/metabolism ; Enterococcus faecium/genetics ; Enterococcus faecium/metabolism ; Gene Expression/genetics ; Gene Expression Regulation, Bacterial/genetics ; Open Reading Frames/genetics ; Operon/genetics ; Promoter Regions, Genetic/genetics ; Regulatory Sequences, Nucleic Acid/genetics ; Toxin-Antitoxin Systems/genetics
    Chemical Substances Antitoxins ; Bacterial Proteins ; Bacterial Toxins
    Language English
    Publishing date 2021-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222413389
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  5. Article ; Online: Indices of Nutrition Status of Kidney and Pancreas Transplant Candidates.

    Kędzierska-Kapuza, Karolina / Safranow, Krzysztof / Niewiński, Kacper / Niewiński, Grzegorz / Durlik, Marek / Szczuko, Małgorzata

    Transplantation proceedings

    2024  

    Abstract: Nutritional assessment is used to implement early nutritional interventions and reduce complications associated with malnutrition, which plays a crucial role in improving postoperative outcomes for patients undergoing pancreas and/or kidney ... ...

    Abstract Nutritional assessment is used to implement early nutritional interventions and reduce complications associated with malnutrition, which plays a crucial role in improving postoperative outcomes for patients undergoing pancreas and/or kidney transplantation.
    Objective: The aim of this study was to analyze the nutritional status (NS) in patients eligible for kidney transplantation (KTx) and simultaneous kidney-pancreas transplantation (SPKTx).
    Methods: We analyzed the database of hospitalized patients from 2020 to 2023 to identify preoperative parameters of NS in patients eligible for KTx and SPKTx. A total of 59 patients participated in the study, all of whom were candidates for KTx-23 or SPKTx-36. The study population consisted of 35 women (W) and 24 men (M), with an overall mean age of 44.8 ± 10.2 years (43.5 ± 10.2 years for W and 46.2 ± 10.9 years for M). Both groups included patients on hemodialysis (n = 34) and peritoneal dialysis (n = 12), and patients in the predialysis period (pre-emptive, n = 13). The examined parameters included Onodera's prognostic nutritional index (PNIO), the nutritional risk index (NRI), proper body mass calculated using the Lorenz formula, and the neutrophil-to-lymphocyte ratio (NLR). All patients were assessed according to the NRS 2002 scale.
    Results: Analysis of the obtained results revealed that the NLR was only one differentiating parameter between Ktx and SPKtx group. Multivariate analysis adjusted for patients' age and gender, comparing quantitative NS indicators was performed. Albumin serum concentration was not dependent on patients' group (KTx/SPKTx) neither age nor gender P = .382. BMI was dependent on patients' age and gender, but not a group (KTx/SPKTx) P = .008. PNIO, NRI, and NRL were not dependent on patients' group (KTx/SPKTx) neither age nor gender.
    Conclusions: Additional effort should be devoted to the development of a proper nutrition plan for SPKTx a especially in peritoneal dialysis patients. Toward patients on the waiting list, the regular assessment of nutritional status should be performed which is not a rule in dialysis centers. SPKTx candidates in the perioperative period should receive proper nutrition taking into account their caloric and protein needs.
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2024.03.012
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  6. Article ; Online: Age-Related Changes in Female Murine Reproductive Mucosa with respect to

    Skulska, Katarzyna / Kędzierska, Anna Ewa / Krzyżowska, Małgorzata / Chodaczek, Grzegorz

    Journal of immunology research

    2023  Volume 2023, Page(s) 3072573

    Abstract: Many studies have demonstrated a general decline and dysregulation in immune functions with age. It is not clear, however, how the aging affects the immune surveillance of the female reproductive tract (FRT) ... ...

    Abstract Many studies have demonstrated a general decline and dysregulation in immune functions with age. It is not clear, however, how the aging affects the immune surveillance of the female reproductive tract (FRT) by
    MeSH term(s) Mice ; Female ; Animals ; Mice, Inbred C57BL ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Mucous Membrane/metabolism ; Vagina ; Intraepithelial Lymphocytes/metabolism
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2023-01-23
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-7156
    ISSN (online) 2314-7156
    ISSN 2314-7156
    DOI 10.1155/2023/3072573
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  7. Article ; Online: Phospholipid:diacylglycerol acyltransferase1-overexpression stimulates lipid turnover, oil production and fitness in cold-grown plants.

    Klińska-Bąchor, Sylwia / Kędzierska, Sara / Demski, Kamil / Banaś, Antoni

    BMC plant biology

    2023  Volume 23, Issue 1, Page(s) 370

    Abstract: Background: Extensive population growth and climate change accelerate the search for alternative ways of plant-based biomass, biofuel and feed production. Here, we focus on hitherto unknow, new promising cold-stimulated function of phospholipid: ... ...

    Abstract Background: Extensive population growth and climate change accelerate the search for alternative ways of plant-based biomass, biofuel and feed production. Here, we focus on hitherto unknow, new promising cold-stimulated function of phospholipid:diacylglycerol acyltransferase1 (PDAT1) - an enzyme catalyzing the last step of triacylglycerol (TAG) biosynthesis.
    Result: Overexpression of AtPDAT1 boosted seed yield by 160% in Arabidopsis plants exposed to long-term cold compared to standard conditions. Such seeds increased both their weight and acyl-lipids content. This work also elucidates PDAT1's role in leaves, which was previously unclear. Aerial parts of AtPDAT1-overexpressing plants were characterized by accelerated growth at early and vegetative stages of development and by biomass weighing three times more than control. Overexpression of PDAT1 increased the expression of SUGAR-DEPENDENT1 (SDP1) TAG lipase and enhanced lipid remodeling, driving lipid turnover and influencing biomass increment. This effect was especially pronounced in cold conditions, where the elevated synergistic expression of PDAT1 and SDP1 resulted in double biomass increase compared to standard conditions. Elevated phospholipid remodeling also enhanced autophagy flux in AtPDAT1-overexpresing lines subjected to cold, despite the overall diminished autophagy intensity in cold conditions.
    Conclusions: Our data suggest that PDAT1 promotes greater vitality in cold-exposed plants, stimulates their longevity and boosts oilseed oil production at low temperature.
    MeSH term(s) Phospholipids/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Diacylglycerol O-Acyltransferase/genetics ; Diacylglycerol O-Acyltransferase/metabolism ; Diglycerides/metabolism ; Triglycerides ; Arabidopsis/metabolism ; Plants/metabolism ; Seeds ; Plants, Genetically Modified/metabolism ; Plant Oils/metabolism ; Carboxylic Ester Hydrolases/metabolism
    Chemical Substances Phospholipids ; Arabidopsis Proteins ; Diacylglycerol O-Acyltransferase (EC 2.3.1.20) ; Diglycerides ; Triglycerides ; Plant Oils ; SDP1 protein, Arabidopsis (EC 3.1.1.3) ; Carboxylic Ester Hydrolases (EC 3.1.1.-)
    Language English
    Publishing date 2023-07-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059868-3
    ISSN 1471-2229 ; 1471-2229
    ISSN (online) 1471-2229
    ISSN 1471-2229
    DOI 10.1186/s12870-023-04379-5
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  8. Article: Immunolocalization of Matrix Metalloproteinases 2 and 9 and Their Inhibitors in the Hearts of Rats Treated with Immunosuppressive Drugs-An Artificial Intelligence-Based Digital Analysis.

    Wilk, Aleksandra / Król, Małgorzata / Kiełbowski, Kajetan / Bakinowska, Estera / Szumilas, Kamila / Surówka, Anna / Kędzierska-Kapuza, Karolina

    Biomedicines

    2024  Volume 12, Issue 4

    Abstract: Background: Immunosuppressive agents represent a broad group of drugs, such as calcineurin inhibitors, mTOR inhibitors, and glucocorticosteroids, among others. These drugs are widely used in a number of conditions, but lifelong therapy is crucial in the ...

    Abstract Background: Immunosuppressive agents represent a broad group of drugs, such as calcineurin inhibitors, mTOR inhibitors, and glucocorticosteroids, among others. These drugs are widely used in a number of conditions, but lifelong therapy is crucial in the case of organ recipients to prevent rejection. To further increase the safety and efficacy of these agents, their off-target mechanisms of action, as well as processes underlying the pathogenesis of adverse effects, need to be thoroughly investigated. The aim of this study was to examine the impact of various combinations of cyclosporine/tacrolimus/mycophenolate with rapamycin and steroids (CRG, TRG, MRG), on the morphology and morphometry of rats' cardiomyocytes, together with the presence of cardiac collagen and the immunoexpression of MMPs and TIMPs.
    Methods: Twenty-four rats were divided into four groups receiving different immunosuppressive regiments. After six months of treatment, the hearts were collected and analyzed.
    Results: Cardiomyocytes from the CRG cohorts demonstrated the most pronounced morphological alterations. In addition, chronic immunosuppression reduced the width and length of cardiac cells. However, immunosuppressive therapy did not alter the presence of cardiac collagen fibers. Nevertheless, we observed significant alterations regarding MMP/TIMP homeostasis.
    Conclusions: Chronic immunosuppression seems to disturb the MMP/TIMP balance in aspects of immunolocalization in the hearts of rats. Further studies are required to analyze other mechanisms and pathways affected by the use of immunosuppressants.
    Language English
    Publishing date 2024-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12040769
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  9. Article ; Online: Count on us: T cells in SARS-CoV-2 infection and vaccination.

    Kedzierska, Katherine / Thomas, Paul G

    Cell reports. Medicine

    2022  Volume 3, Issue 3, Page(s) 100562

    Abstract: Robust T cell responses have been associated with milder outcomes in many infections. T cells also establish long-term memory pools and, as they are predominantly directed toward epitopes encompassing conserved peptides, can respond to SARS-CoV-2 ... ...

    Abstract Robust T cell responses have been associated with milder outcomes in many infections. T cells also establish long-term memory pools and, as they are predominantly directed toward epitopes encompassing conserved peptides, can respond to SARS-CoV-2 variants, including Omicron. Here, we discuss epitope-specific CD8
    MeSH term(s) CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; COVID-19/prevention & control ; Epitopes ; Humans ; Immunologic Memory ; SARS-CoV-2 ; Vaccination
    Chemical Substances Epitopes
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2022.100562
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  10. Article ; Online: PD-1 blockade unblocks immune responses to vaccination.

    Kedzierska, Katherine / Nguyen, Thi H O

    Nature immunology

    2022  Volume 23, Issue 8, Page(s) 1135–1137

    MeSH term(s) B7-H1 Antigen ; Immunity ; Immunotherapy ; Programmed Cell Death 1 Receptor ; Vaccination
    Chemical Substances B7-H1 Antigen ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2022-07-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-022-01254-7
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