Article: Echinoderm eggs as a model for discoveries in cell biology.
2019 Volume 151, Page(s) 29–36
Abstract: I happen to have been trained in cell and developmental biology in the early 1970s, which was near the beginning of the explosive growth of the field of cell biology. The American Society for Cell Biology had been founded in 1960 and so the field was in ... ...
| Abstract | I happen to have been trained in cell and developmental biology in the early 1970s, which was near the beginning of the explosive growth of the field of cell biology. The American Society for Cell Biology had been founded in 1960 and so the field was in its early days. Cell biology research was dominated by the use of the electron microscope and by protein biochemistry. Molecular biology and the use of genetics were in their infancy. When we track the path of discoveries in cell biology contributed by research using echinoderm eggs, we follow the development of new technologies in genetics, molecular biology, biochemistry and biophysics, bioengineering, and imaging. The changes in approaches and methods have led to many key discoveries in cell biology through the use of sea urchin, sand dollar and sea star eggs. These include the discovery of cyclin, cytoplasmic dynein, rho activation for cytokinesis, new membrane addition as a late event in cytokinesis, multiple kinesins playing multiple roles, how flagella beat, the dynamics of microtubules in the mitotic apparatus, control over centrosomes and cell cycle checkpoints, the process of nuclear envelope breakdown for cell division, the discovery of 1-methyl adenine (hormones) as the trigger for meiotic maturation, Ca |
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| MeSH term(s) | Animals ; Cell Biology/history ; Centrosome/metabolism ; Cytokinesis/genetics ; Echinodermata/genetics ; Echinodermata/growth & development ; Embryonic Development/genetics ; Fertilization/genetics ; History, 20th Century ; History, 21st Century ; Mitosis/genetics ; Ovum/growth & development |
| Language | English |
| Publishing date | 2019-03-09 |
| Publishing country | United States |
| Document type | Autobiography ; Historical Article ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. |
| ISSN | 0091-679X |
| ISSN | 0091-679X |
| DOI | 10.1016/bs.mcb.2019.03.004 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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