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Book: Genetically engineered viruses

Ring, Christopher J. A.

development and applications

2001

Author's details	ed. by Christopher J. A. Ring
Language	English
Publisher	BIOS
Publishing place	Oxford u.a.
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT012902027
ISBN	1-85996-103-7 ; 978-1-85996-103-2
Database	Catalogue ZB MED Medicine, Health

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2001 A 510	order for loan	Magazin

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Article ; Online: Some pressures are more equal than others: Effects of isolated pressure on performance.

Henderson, Jennifer / Kavussanu, Maria / Cooke, Andrew / Ring, Christopher

Psychology of sport and exercise

2024 Volume 72, Page(s) 102592

Abstract: It is commonly assumed that performance is impaired by pressure and that different types of individual situational factors can produce equivalent pressure. Our aim was to explore the psychophysiological effects of pressure to test this assumption. Eighty- ...

Abstract	It is commonly assumed that performance is impaired by pressure and that different types of individual situational factors can produce equivalent pressure. Our aim was to explore the psychophysiological effects of pressure to test this assumption. Eighty-one novices completed a golf putting task under control and eight individual pressure conditions: time, difficulty, video, team, goal, fame, shame, and distraction. Performance was measured by the number of holed putts and ball-hole distance. Psychological, physiological and kinematic measures were collected. Performance was impaired by time and difficulty conditions but improved by team, goal and shame conditions compared to control. Perceived pressure and effort were higher than control in all conditions except distraction. Conscious processing was greater than control in all conditions except distraction and time constraint. Heart rate was faster with time, team, fame and shame. Heart rate variability and muscle activity were largely unaffected. Putter kinematics provided evidence of swing profiles slowing and/or becoming constrained in conditions where conscious processing increased, while the swing became faster in the time-pressure condition where conscious processing was decreased. Taken together, these results reveal heterogenous effects of pressure on performance, with performance impaired, unaffected, and improved by individual pressure situations. Similarly, heterogeneity characterized the effects of pressure on psychological, physiological and kinematic responses associated with task performance. In sum, the evidence challenges the standard tacit assumptions about the pressure-performance relationship in sport.
MeSH term(s)	Psychomotor Performance/physiology ; Task Performance and Analysis ; Sports ; Golf/physiology ; Biomechanical Phenomena
Language	English
Publishing date	2024-01-17
Publishing country	Netherlands
Document type	Journal Article
ISSN	1878-5476
ISSN (online)	1878-5476
DOI	10.1016/j.psychsport.2024.102592
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Article ; Online: Effects of Stroop task duration on subsequent cognitive and physical performance.

Dallaway, Neil / Lucas, Samuel J E / Ring, Christopher

Psychology of sport and exercise

2023 Volume 68, Page(s) 102459

Abstract: The strength model of self-control purports to explain why brief cognitive response inhibition tasks impair subsequent isometric handgrip endurance. According to the model, ego depleting tasks requiring self-control resources impair performance on ... ...

Abstract	The strength model of self-control purports to explain why brief cognitive response inhibition tasks impair subsequent isometric handgrip endurance. According to the model, ego depleting tasks requiring self-control resources impair performance on subsequent tasks that also require self-control resources. However, several lines of evidence challenge this model, including evidence of improved exercise performance following longer cognitive tasks. Our study investigated the effects of cognitive task duration on (1) subsequent physical endurance performance, (2) concurrent cognitive task performance, and (3) subsequent novel cognitive task performance. Adopting an experimental design, with Stroop task type (incongruent, congruent) and duration (5, 10, 20 min) as between-participant factors, participants (N = 180) completed a color word Stroop task, an isometric handgrip to exhaustion task, and a novel 5-min incongruent number word Stroop task. In the handgrip task, endurance performance was worse following incongruent word Stroop than congruent word Stroop for 10-min tasks but not 5-min and 20-min tasks. In the word Stroop task, accuracy was lower and speed was slower following incongruent word Stroop than congruent word Stroop. Importantly, reaction times improved with longer task durations. In the novel number Stroop task, accuracy was higher following incongruent word Stroop than congruent word Stroop. In conclusion, the finding that the ego depletion effect was moderated by cognitive task duration is better explained by the expected value of control model than the strength model.
MeSH term(s)	Humans ; Cognition ; Hand Strength ; Physical Functional Performance ; Stroop Test
Language	English
Publishing date	2023-05-22
Publishing country	Netherlands
Document type	Journal Article
ISSN	1878-5476
ISSN (online)	1878-5476
DOI	10.1016/j.psychsport.2023.102459
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Article ; Online: Responsiveness of the Patient-Reported Outcome Measure for Vascular Malformation Questionnaire in Patients with Low-Flow Vascular Malformations.

Ring, Natalie Y / England, Ryan W / Motaghi, Mina / Garg, Tushar / Gong, Anna J / Gullotti, David M / Khalil, Adham / Bailey, Christopher R / Grossberg, Anna L / Wu, Albert W / Weiss, Clifford R

Journal of vascular and interventional radiology : JVIR

2023 Volume 34, Issue 5, Page(s) 840–848.e5

Abstract: Purpose: To assess the responsiveness, defined as the ability to detect change in a patient's health or function, of the Patient-Reported Outcome Measure for Vascular Malformation (PROVAM) questionnaire in a cohort of patients with low-flow vascular ... ...

Abstract	Purpose: To assess the responsiveness, defined as the ability to detect change in a patient's health or function, of the Patient-Reported Outcome Measure for Vascular Malformation (PROVAM) questionnaire in a cohort of patients with low-flow vascular malformations (VMs). Materials and methods: PROVAM was previously developed to assess symptoms, functional limitations, and social/emotional effects experienced by patients with VMs. This is a prospective cohort study of 56 patients with venous and lymphatic VMs who completed at least 2 PROVAM questionnaires, of whom 43 had undergone treatment with sclerotherapy in the interim between questionnaires. External responsiveness was assessed using a receiver operating characteristic (ROC) curve to ascertain whether a change in the total PROVAM score predicts whether patients reported symptom improvement and by correlating the change in the total PROVAM score and change in symptoms reported during clinic visit. Internal responsiveness was evaluated using Wilcoxon signed rank test, Cohen d effect size (ESp), and standard response mean difference (SRM). Results: The total PROVAM score demonstrated excellent discrimination for symptom improvement with an area under the ROC curve of 0.856. There was a statistically significant, moderate positive correlation between the change in the total PROVAM score and the change in patient symptoms as determined from clinical visits (Spearman correlation coefficient [r Conclusions: PROVAM is responsive to improvement after treatment and may be useful to assess health-related quality of life in patients treated for VMs.
MeSH term(s)	Humans ; Quality of Life/psychology ; Prospective Studies ; Surveys and Questionnaires ; Patient Reported Outcome Measures ; Vascular Malformations/diagnostic imaging ; Vascular Malformations/therapy ; Treatment Outcome
Language	English
Publishing date	2023-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2023.01.036
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Article ; Online: Cognitive tasks elicit mental fatigue and impair subsequent physical task endurance: Effects of task duration and type.

Dallaway, Neil / Lucas, Samuel J E / Ring, Christopher

Psychophysiology

2022 Volume 59, Issue 12, Page(s) e14126

Abstract: Although mentally fatiguing cognitive tasks can impair subsequent physical endurance, the importance of cognitive task duration and the role of response inhibition remain unclear. This study compared the effects of a serial incongruent Stroop color- ... ...

Abstract	Although mentally fatiguing cognitive tasks can impair subsequent physical endurance, the importance of cognitive task duration and the role of response inhibition remain unclear. This study compared the effects of a serial incongruent Stroop color-classification task (i.e., with response inhibition) and N-back memory updating task (i.e., without response inhibition) on mental fatigue and subsequent rhythmic handgrip exercise. Participants (N = 90) were randomly assigned to one of three cognitive task groups (Stroop, 2-back, control) and completed four 10-min blocks of one cognitive task followed by a 5-min physical endurance task (self-paced rhythmic handgrip exercise). Heart rate, heart rate variability, electromyographic forearm activity, and force were recorded throughout along with self-reported measures of fatigue, exertion, and motivation. From the start, the Stroop and 2-back tasks elicited higher heart rate and lower heart rate variability as well as greater fatigue, effort, and interest/enjoyment than the control task. From the second block onwards, the Stroop and 2-back groups produced less force than the control group. There were no group differences in forearm muscle activity. In sum, mental fatigue was induced after performing a cognitive task for 10 mins, whereas muscular endurance was impaired after performing a cognitive task for 20 mins. That these effects were observed for both types of cognitive task indicates that response inhibition is not a necessary condition. The cognitive task duration required to induce mental fatigue and impair rhythmic handgrip endurance performance lay between the durations reported previously for isometric (a few minutes) and whole-body (half an hour) endurance exercise.
MeSH term(s)	Humans ; Physical Endurance/physiology ; Hand Strength/physiology ; Mental Fatigue ; Stroop Test ; Cognition/physiology ; Physical Exertion
Language	English
Publishing date	2022-06-21
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209486-1
ISSN	1540-5958 ; 0048-5772
ISSN (online)	1540-5958
ISSN	0048-5772
DOI	10.1111/psyp.14126
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Article ; Online: Multiple gunshot wounds with bullet embolus to the right iliac artery.

Devlin, Bridget A / Lee, Jake J / Hutchinson, Chelsea M / Ring, Adam C / Kainth, Amit S / Horn, Christopher B

The journal of trauma and acute care surgery

2020 Volume 90, Issue 5, Page(s) e113–e115

MeSH term(s)	Adult ; Computed Tomography Angiography ; Embolism/etiology ; Foreign-Body Migration/complications ; Foreign-Body Migration/diagnostic imaging ; Foreign-Body Migration/surgery ; Humans ; Iliac Artery/surgery ; Laparotomy ; Male ; Multiple Trauma/complications ; Wounds, Gunshot/complications ; Wounds, Gunshot/diagnostic imaging ; Wounds, Gunshot/surgery
Language	English
Publishing date	2020-10-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2651070-4
ISSN	2163-0763 ; 2163-0755
ISSN (online)	2163-0763
ISSN	2163-0755
DOI	10.1097/TA.0000000000002960
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Article ; Online: Mind and body: Psychophysiological profiles of instructional and motivational self-talk.

Bellomo, Eduardo / Cooke, Andrew / Gallicchio, Germano / Ring, Christopher / Hardy, James

Psychophysiology

2020 Volume 57, Issue 9, Page(s) e13586

Abstract: Self-talk is a psychological skill that benefits motor performance by controlling and organizing performers' thoughts. While the behavioral effects of self-talk are clear, research on the mechanisms underpinning the effects of different modes of self- ... ...

Abstract	Self-talk is a psychological skill that benefits motor performance by controlling and organizing performers' thoughts. While the behavioral effects of self-talk are clear, research on the mechanisms underpinning the effects of different modes of self-talk is sparse. To address this issue, we propose and test a psychophysiological model of the effects of self-talk on motor performance. Forty golf novices practiced a golf putting task while using either instructional or motivational self-talk preceding each putt. We measured performance (radial error), technique (club kinematics and muscle activity), cardiac activity (heart-rate and event-related heart-rate change), as well as electroencephalographic alpha power and connectivity in a randomized (group: instructional self-talk, motivational self-talk) experimental design. Instructional self-talk promoted superior technique and was associated with greater parietal alpha power and weaker connectivity between frontal and parietal electrodes and all other scalp sites, possibly indicative of increased top-down control of action. These findings provide initial evidence for an information-processing mechanism underlying the benefits of instructional self-talk. They also cast doubt on the validity of left-frontotemporal connectivity as a measure of verbal-analytic processing during motor tasks. Motivational self-talk led to increased heart-rate and reduced event-related heart rate variability, suggesting an effort-based mechanism to explain the benefits of motivational self-talk. Our study represents the most complete multi-measure investigation of self-talk to date. We hope that our psychophysiological model of self-talk will encourage researchers to move beyond the exclusive reliance on behavioral and self-report measures to discover the mechanisms underlying the benefits of self-talk for performance.
MeSH term(s)	Adult ; Alpha Rhythm ; Biomechanical Phenomena ; Brain/physiology ; Electrocardiography ; Electroencephalography ; Female ; Frontal Lobe ; Golf ; Heart Rate ; Humans ; Male ; Motivation ; Motor Skills ; Neural Pathways ; Parietal Lobe ; Psychomotor Performance ; Psychophysiology ; Random Allocation ; Young Adult
Language	English
Publishing date	2020-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	209486-1
ISSN	1540-5958 ; 0048-5772
ISSN (online)	1540-5958
ISSN	0048-5772
DOI	10.1111/psyp.13586
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Article ; Online: Divergent responses of pelagic and benthic fish body-size structure to remoteness and protection from humans.

Letessier, Tom B / Mouillot, David / Mannocci, Laura / Jabour Christ, Hanna / Elamin, Elamin Mohammed / Elamin, Sheikheldin Mohamed / Friedlander, Alan M / Hearn, Alex / Juhel, Jean-Baptiste / Kleiven, Alf Ring / Moland, Even / Mouquet, Nicolas / Nillos-Kleiven, Portia Joy / Sala, Enric / Thompson, Christopher D H / Velez, Laure / Vigliola, Laurent / Meeuwig, Jessica J

Science (New York, N.Y.)

2024 Volume 383, Issue 6686, Page(s) 976–982

Abstract: Animal body-size variation influences multiple processes in marine ecosystems, but habitat heterogeneity has prevented a comprehensive assessment of size across pelagic (midwater) and benthic (seabed) systems along anthropic gradients. In this work, we ... ...

Abstract	Animal body-size variation influences multiple processes in marine ecosystems, but habitat heterogeneity has prevented a comprehensive assessment of size across pelagic (midwater) and benthic (seabed) systems along anthropic gradients. In this work, we derive fish size indicators from 17,411 stereo baited-video deployments to test for differences between pelagic and benthic responses to remoteness from human pressures and effectiveness of marine protected areas (MPAs). From records of 823,849 individual fish, we report divergent responses between systems, with pelagic size structure more profoundly eroded near human markets than benthic size structure, signifying greater vulnerability of pelagic systems to human pressure. Effective protection of benthic size structure can be achieved through MPAs placed near markets, thereby contributing to benthic habitat restoration and the recovery of associated fishes. By contrast, recovery of the world's largest and most endangered fishes in pelagic systems requires the creation of highly protected areas in remote locations, including on the High Seas, where protection efforts lag.
MeSH term(s)	Animals ; Body Size ; Fishes ; Oceans and Seas ; Endangered Species ; Conservation of Natural Resources
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.adi7562
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Article: Recent advances in the manipulation of murine gene expression and its utility for the study of human neurological disease.

Cazzin, Chiara / Ring, Christopher J A

Biochimica et biophysica acta

2010 Volume 1802, Issue 10, Page(s) 796–807

Abstract: Transgenic mouse models have vastly contributed to our knowledge of the genetic and molecular pathways underlying the pathogenesis of neurological disorders that affect millions of people worldwide. Not only have they allowed the generation of disease ... ...

Abstract	Transgenic mouse models have vastly contributed to our knowledge of the genetic and molecular pathways underlying the pathogenesis of neurological disorders that affect millions of people worldwide. Not only have they allowed the generation of disease models mimicking the human pathological state but they have also permitted the exploration of the pathological role of specific genes through the generation of knock-out and knock-in models. Classical constitutive transgenic mice have several limitations however, due to behavioral adaptation process occurring and conditional mouse models are time-consuming and often lack extensive spatial or temporal control of gene manipulation. These limitations could be overcome by means of innovative methods that are now available such as RNAi, viral vectors and large cloning DNA vectors. These tools have been extensively used for the generation of mouse models and are characterized by the superior control of transgene expression that has been proven invaluable in the assessment of novel treatments for neurological diseases and to further investigate the molecular processes underlying the etiopathology of neurological disorders. Furthermore, in association with classical transgenic mouse models, they have allowed the validation of innovative therapeutic strategies for the treatment of human neurological disorders. This review describes how these tools have overcome the limitations of classical transgenic mouse models and how they have been of value for the study of human neurological diseases.
MeSH term(s)	Animals ; Disease Models, Animal ; Gene Expression ; Genetic Vectors ; Humans ; Mice ; Nervous System Diseases/genetics
Language	English
Publishing date	2010-10
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbadis.2009.11.005
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Article ; Online: Storylines of family medicine IV: perspectives on practice-lenses of appreciation.

Ventres, William B / Stone, Leslie A / Akhtar, Radeeb / Ring, Jeffrey M / Candib, Lucy M / Messias, Erick / Epstein, Ronald M / Tunzi, Marc / Lee, Amy L / Morley, Christopher P / Brown, Carina M / Slawson, David / Konkin, Jill / Campbell, David G / Couper, Ian / Williams, Susan / Brooks, Robert / Walters, Lucie

Family medicine and community health

2024 Volume 12, Issue Suppl 3

Abstract: Storylines of Family ... ...

Abstract	Storylines of Family Medicine
MeSH term(s)	Humans ; Animals ; Family Practice ; Lens, Crystalline ; Lenses ; Physicians, Family ; Courage ; Fabaceae ; Unionidae
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2986753-8
ISSN	2009-8774 ; 2305-6983
ISSN (online)	2009-8774
ISSN	2305-6983
DOI	10.1136/fmch-2024-002791
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