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  1. Article ; Online: Research progress of soluble CD83 in organ transplantation

    Liang-Xing Xiong / Liang-Hui Gao

    Journal of Hainan Medical University, Vol 27, Iss 7, Pp 57-

    2021  Volume 60

    Abstract: Organ transplantation is considered to be an effective method for the treatment of end-stage organ failure, early malignant tumors and tissue damage. In order to reduce the rejection of the transplanted organ by the host, immunosuppressive drugs should ... ...

    Abstract Organ transplantation is considered to be an effective method for the treatment of end-stage organ failure, early malignant tumors and tissue damage. In order to reduce the rejection of the transplanted organ by the host, immunosuppressive drugs should be used for a long time, but the suppression of the host immune system by immunosuppressive drugs can cause serious side effects. Therefore, how to induce the recipient's immune system to have no response to the transplanted organ after transplantation, while still showing a normal immune response to the alien antigen. Induction of immune tolerance to donor organs has long been a focus of research by transplant scientists. Soluble CD83 (sCD83) is a glycoprotein with specific immunosuppressive effects. In recent years, there have been more and more reports on the immune tolerance induced by sCD83 in animal experiments, which has shown a broad prospect in the treatment of host immune rejection after organ transplantation and provided an experimental basis for its clinical transformation.
    Keywords soluble cd83 ; organ transplantation ; immune tolerance ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Editorial Board of Journal of Hainan Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Development research of latent fingermarks based on aggregation-induced emission technique.

    Liang, Shuai / Gao, Shu-Hui

    Journal of forensic sciences

    2024  Volume 69, Issue 3, Page(s) 856–868

    Abstract: Fingerprints hold evidential value for individual identification; a sensitive, efficient, and convenient method for visualizing latent fingermarks (LFMs) is of great importance in the field of crime scene investigation. In this study, we proposed an ... ...

    Abstract Fingerprints hold evidential value for individual identification; a sensitive, efficient, and convenient method for visualizing latent fingermarks (LFMs) is of great importance in the field of crime scene investigation. In this study, we proposed an aggregation-induced emission atomization technique (AIE-AT) to obtain high-quality fingermark images. Six volunteers made over 1566 fingerprint samples on 17 different objects. The quality of fingermark development was evaluated using grayscale analysis for quantitative assessment, combining the fluency of fingermark ridges and the degree of level 2 and level 3 features. Both qualitative and quantitative methods were employed to explore the effectiveness of AIE molecule C
    MeSH term(s) Humans ; Dermatoglyphics ; Surface Properties ; Image Processing, Computer-Assisted
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219216-0
    ISSN 1556-4029 ; 0022-1198
    ISSN (online) 1556-4029
    ISSN 0022-1198
    DOI 10.1111/1556-4029.15506
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  3. Article ; Online: Patient-specific temperature distribution prediction in laser interstitial thermal therapy: single-irradiation data-driven method.

    Gao, Tingting / Liang, Libin / Ding, Hui / Wang, Guangzhi

    Physics in medicine and biology

    2024  

    Abstract: Laser interstitial thermal therapy (LITT) has been popular for treating brain tumours and epilepsy. The strict control of tissue thermal damage extent is crucial for LITT. Temperature prediction is useful for predicting thermal damage extent. Accurately ... ...

    Abstract Laser interstitial thermal therapy (LITT) has been popular for treating brain tumours and epilepsy. The strict control of tissue thermal damage extent is crucial for LITT. Temperature prediction is useful for predicting thermal damage extent. Accurately predicting in vivo brain tissue temperature is challenging due to the temperature dependence and the individual variations in tissue properties. Considering these factors is essential for improving the temperature prediction accuracy.
    Objective: To present a method for predicting patient-specific tissue temperature distribution within a target lesion area in the brain during LITT.
    Approach: A magnetic resonance temperature imaging (MRTI) data-driven estimation model was constructed and combined with a modified Pennes bioheat transfer equation (PBHE) to predict patient-specific temperature distribution. In the PBHE for temperature prediction, the individual specificity and temperature dependence of thermal tissue properties and blood perfusion, as well as the individual specificity of optical tissue properties were considered. Only MRTI data during one laser irradiation were required in the method. This enables the prediction of patient-specific temperature distribution and the resulting thermal damage region for subsequent ablations.
    Main results: Patient-specific temperature prediction was evaluated based on patients' data acquired during LITT in the brain, using intraoperative MRTI data as the reference standard. Our method significantly improved the prediction performance of temperature distribution and thermal damage region. The average root mean square error was decreased by 69.54%, the average intraclass correlation coefficients was increased by 37.5%, the average Dice similarity coefficient was increased by 43.14% for thermal damage region prediction.
    Significance: The proposed method can predict temperature distribution and thermal damage region at an individual patient level during LITT, providing a promising approach to assist in patient-specific treatment planning for LITT in the brain.
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ad4194
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  4. Article: Isolation of triazole-resistant

    Xu, Hui / Gao, Yuhong / Liang, Tianyu / Wang, Qiqi / Wan, Zhe / Li, Ruoyu / Liu, Wei

    Mycology

    2024  Volume 15, Issue 1, Page(s) 85–90

    Abstract: Invasive aspergillosis (IA) is the most severe type ... ...

    Abstract Invasive aspergillosis (IA) is the most severe type of
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553667-9
    ISSN 2150-1211 ; 2150-1203
    ISSN (online) 2150-1211
    ISSN 2150-1203
    DOI 10.1080/21501203.2023.2299472
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  5. Article ; Online: Laryngeal paraganglioma: The analysis of misdiagnosed cases and literature review.

    Dong, Yi-Jun / Zhang, Hong-Hui / Liang, Jia-Qiao / Gao, Ya-Ya / Xiong, Ming / Yang, Hui

    Head & neck

    2024  Volume 46, Issue 5, Page(s) 1234–1247

    Abstract: Laryngeal paraganglioma (LP) is an exceptionally rare neuroendocrine tumor, underscoring importance of accurate identification to preclude misdiagnoses. In this review, we presented two typical misdiagnosed LPs, and offered reviews of LP cases reported ... ...

    Abstract Laryngeal paraganglioma (LP) is an exceptionally rare neuroendocrine tumor, underscoring importance of accurate identification to preclude misdiagnoses. In this review, we presented two typical misdiagnosed LPs, and offered reviews of LP cases reported over the preceding decade and all documented misdiagnosed LP cases. Furthermore, we systematically investigated the underlying causes of misdiagnosis and elucidated key points for effective differentiation. A retrospective analysis of 28 LP cases revealed a predominant occurrence in middle-aged women, with an average history of 25.1 months. Through an analysis of all misdiagnosed cases (n = 37), supraglottic LPs were frequently misidentified as laryngeal carcinomas and vascular tumors, while subglottic LPs were often misdiagnosed as thyroid cancers. And the occurrence of misdiagnosis resulted in delayed and inappropriate treatments, contributing to the deterioration of LP patients (14 cases, 37.8%). In conclusion, this review endeavored to heighten awareness of LPs, with the ultimate goal of advancing diagnostic precision and enhancing patient outcomes.
    MeSH term(s) Middle Aged ; Humans ; Female ; Paraganglioma/diagnosis ; Paraganglioma/pathology ; Retrospective Studies ; Lipopolysaccharides ; Laryngeal Neoplasms/diagnosis ; Laryngeal Neoplasms/therapy ; Laryngeal Neoplasms/pathology ; Paraganglioma, Extra-Adrenal
    Chemical Substances Lipopolysaccharides
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Case report: A novel variant (H49N) in

    Cao, Gao-Hui / Zhao, Mei-Fang / Dong, Yi / Fan, Liang-Liang / Liu, Yi-Hui / Deng, Yao / Tang, Lu-Lu

    Frontiers in neurology

    2024  Volume 15, Page(s) 1319962

    Abstract: This report presents a case of Charcot-Marie-Tooth dominant intermediate D (CMTDID), a rare subtype of Charcot-Marie-Tooth disease, in a 52 years-old male patient. The patient exhibited mobility impairment, foot abnormalities (pes cavus), and calf muscle ...

    Abstract This report presents a case of Charcot-Marie-Tooth dominant intermediate D (CMTDID), a rare subtype of Charcot-Marie-Tooth disease, in a 52 years-old male patient. The patient exhibited mobility impairment, foot abnormalities (pes cavus), and calf muscle atrophy. Whole exome sequencing and Sanger sequencing suggested that a novel variant (NM_000530.8, c.145C>A/p.His49Asn) of
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1319962
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  7. Article ; Online: Facile synthesis of sulfide Bi

    Yang, Cheng-Lu / Liang, Chen / Gao, Chao / Guo, Jun / Chen, Bu-Ming / Huang, Hui

    RSC advances

    2023  Volume 13, Issue 41, Page(s) 28389–28394

    Abstract: ... A novel ... ...

    Abstract A novel Bi
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra04845d
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  8. Article ; Online: Green manuring reduces cadmium accumulation in rice: Roles of iron plaque and dissolved organic matter.

    Xie, Jiancheng / Fan, Qianyu / Liang, Ting / Liang, Hai / Wang, Hui / Gui, Zhaogui / Wu, Ji / Gao, Songjuan / Cao, Weidong

    Environmental research

    2024  Volume 251, Issue Pt 2, Page(s) 118719

    Abstract: In southern China, winter green manure is widely used in rice cropping systems for improving grain yields and soil fertility. Cd pollution has recently been reported in some of these paddy fields. Research on the in-depth understanding of how green ... ...

    Abstract In southern China, winter green manure is widely used in rice cropping systems for improving grain yields and soil fertility. Cd pollution has recently been reported in some of these paddy fields. Research on the in-depth understanding of how green manuring affects Cd absorption in rice is limited. This study aimed to investigate the impacts of different green manures, including single plantation and mixed plantation on the absorption of Cd by rice and explore the underlying mechanisms. Pot experiments demonstrated that compared with winter fallow-rice, green manuring treatments considerably decreased rice Cd content, promoted the conversion of bioavailable Cd fraction into a more stable form, induced the formation of iron plaque, and increased the content of humic-like fraction (HF) in soil dissolved organic matter (DOM). Treatment with mixed plantation resulted in a greater decrease in rice Cd content and an increase in HF and iron plaque contents than single plantation. Hydroponic experiments confirmed that both iron plaque and green manure-derived DOM significantly reduced the Cd content in rice seedlings. In conclusion, green manure incorporation is an efficient measure for the safe utilization of Cd-contaminated soil, and mixed plantation of different green manures exerts stronger effects.
    Language English
    Publishing date 2024-03-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118719
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    Zs.A 726: Show issues Location:
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  9. Article ; Online: Developing an efficient MGCR microneedle nanovaccine patch for eliciting Th 1 cellular response against the SARS-CoV-2 infection.

    Gao, Ang / Chen, Yunsheng / Liang, Hui / Cui, Xinyuan / Zhang, Amin / Cui, Daxiang

    Theranostics

    2023  Volume 13, Issue 14, Page(s) 4821–4835

    Abstract: ... ...

    Abstract Rational
    Language English
    Publishing date 2023-09-04
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.83390
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  10. Article: Proteomic study of vitreous in proliferative diabetic retinopathy patients after treatment with aflibercept: a quantitative analysis based on 4D label-free technique.

    Feng, Ting-Ting / Gao, Xiang / Liang, An-Ran / Zhao, Bo-Wen / He, Guang-Hui / Chen, Song

    International journal of ophthalmology

    2024  Volume 17, Issue 4, Page(s) 676–685

    Abstract: Aim: To identify different metabolites, proteins and related pathways to elucidate the causes of proliferative diabetic retinopathy (PDR) and resistance to anti-vascular endothelial growth factor (VEGF) drugs, and to provide biomarkers for the diagnosis ...

    Abstract Aim: To identify different metabolites, proteins and related pathways to elucidate the causes of proliferative diabetic retinopathy (PDR) and resistance to anti-vascular endothelial growth factor (VEGF) drugs, and to provide biomarkers for the diagnosis and treatment of PDR.
    Methods: Vitreous specimens from patients with diabetic retinopathy were collected and analyzed by Liquid Chromatography-Mass Spectrometry (LC-MS/MS) analyses based on 4D label-free technology. Statistically differentially expressed proteins (DEPs), Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway representation and protein interactions were analyzed.
    Results: A total of 12 samples were analyzed. The proteomics results showed that a total of 58 proteins were identified as DEPs, of which 47 proteins were up-regulated and 11 proteins were down-regulated. We found that C1q and tumor necrosis factor related protein 5 (C1QTNF5), Clusterin (CLU), tissue inhibitor of metal protease 1 (TIMP1) and signal regulatory protein alpha (SIRPα) can all be specifically regulated after aflibercept treatment. GO functional analysis showed that some DEPs are related to changes in inflammatory regulatory pathways caused by PDR. In addition, protein-protein interaction (PPI) network evaluation revealed that TIMP1 plays a central role in neural regulation. In addition, CD47/SIRPα may become a key target to resolve anti-VEGF drug resistance in PDR.
    Conclusion: Proteomic analysis is an approach of choice to explore the molecular mechanisms of PDR. Our data show that multiple proteins are differentially changed in PDR patients after intravitreal injection of aflibercept, among which C1QTNF5, CLU, TIMP1 and SIRPα may become targets for future treatment of PDR and resolution of anti-VEGF resistance.
    Language English
    Publishing date 2024-04-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2024.04.11
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