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Article: Noncovalent functionalization of boron nitride nanotubes with poly(p-phenylene-ethynylene)s and polythiophene.

Velayudham, Singaravelu / Lee, Chee Huei / Xie, Ming / Blair, Dominique / Bauman, Nicholas / Yap, Yoke Khin / Green, Sarah A / Liu, Haiying

ACS applied materials & interfaces

2010 Volume 2, Issue 1, Page(s) 104–110

Abstract: ... such as chloroform, methylene chloride, and tetrahydrofuran by using conjugated poly(p-phenylene ethynylene)s (PPEs ...

Abstract	Boron nitride nanotubes (BNNTs) are functionalized and solubilized in organic solvents such as chloroform, methylene chloride, and tetrahydrofuran by using conjugated poly(p-phenylene ethynylene)s (PPEs) (polymers A and B) and polythiophene (polymer C) via a noncovalent functionalization approach through strong pi-pi stacking interactions between the conjugated polymers and BNNTs. The functionalization of BNNTs with PPEs enhanced planarization of PPEs with red shifts in both absorbance and emission of the composite materials with reference to free PPEs, whereas the functionalization of BNNTs with polythiophene disrupts the pi-conjugation, resulting in blue shifts in both the absorption and emission of the composite material.
MeSH term(s)	Boron Compounds/chemistry ; Nanotubes/chemistry ; Nanotubes/ultrastructure ; Particle Size ; Polymers/chemistry ; Thiophenes/chemistry
Chemical Substances	Boron Compounds ; Polymers ; Thiophenes ; poly(phenylene ethynylene) ; polythiophene (25233-34-5) ; boron nitride (2U4T60A6YD)
Language	English
Publishing date	2010-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1944-8244
ISSN	1944-8244
DOI	10.1021/am900613j
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Article ; Online: Demyelinating plaque-associated uveitis.

Hedayatfar, Alireza / Anvari, Pasha / Herbort, C P / Chee, Soon-Phaik

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2023 Volume 262, Issue 2, Page(s) 575–582

Abstract: Purpose: To report the clinical and fluorescein angiographic (FA) features of demyelinating plaque-associated uveitis (DPU), a subset of uveitis in which patients have demyelinating plaques on the brain/cervical magnetic resonance image (MRI) but do not ...

Abstract	Purpose: To report the clinical and fluorescein angiographic (FA) features of demyelinating plaque-associated uveitis (DPU), a subset of uveitis in which patients have demyelinating plaques on the brain/cervical magnetic resonance image (MRI) but do not meet the criteria for multiple sclerosis (MS). Methods: In this retrospective observational study, Persian Patients were diagnosed with DPU and included if (1) they never satisfied the MS criteria, (2) all other possible etiologies were excluded, and (3) they were followed for at least 2 years. Results: After a median follow-up of 3 years (interquartile range, 2.0-5.3), 8 out of 40 (20%) patients diagnosed with DPU were excluded as they subsequently met the MS criteria. Of remaining 32 patients studied, the mean age was 36.3±9.9 (range 20-56 years), and 30 (93.8%) were female. Twenty-four (75.0%) showed bilateral involvement and 27 (84.4%) had insidious-chronic course. Uveitis was classified as intermediate (with or without anterior uveitis) in 29 (90.6%) and isolated anterior in 3 (9.4%) patients. Nine (28.1%) patients had at least one systemic neurological complaint. Ocular findings were: granulomatous keratic precipitates in 43/44 (97.7%) eyes; snowballs in 25/52 (48.1%) eyes; snowbanks in 4/52 (7.7%) eyes; cystoid macular edema in 20/56 (35.7%) eyes; and optic neuritis in 5/56 (8.9%) eyes. Visual acuity was ≥ 20/40 in 39 eyes (69.6%) at presentation which improved to 46 eyes (81.2%) at 2-year follow up. The two most frequent findings in FA were optic disc leakage/staining in 44/52 (81.5%) eyes, and peripheral retinal perivascular leakage in 39/52 (76.9%) eyes, which in 14/52 (26.9%) eyes extended beyond the equator. Conclusion: DPU usually presents as a bilateral chronic granulomatous intermediate and, less often, isolated anterior uveitis, especially in females. Most are neurologically asymptomatic. Visual outcome is generally favorable. In FA, peripheral retinal perivascular leakage is common. DPU patients have an increased tendency to develop MS and should be prohibited from anti-TNF treatment.
MeSH term(s)	Humans ; Female ; Young Adult ; Adult ; Middle Aged ; Male ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Uveitis/diagnosis ; Uveitis, Anterior/diagnosis ; Uveitis, Anterior/drug therapy ; Uveitis, Anterior/etiology ; Retina ; Fluorescein Angiography ; Retrospective Studies ; Plaque, Atherosclerotic ; Uveitis, Intermediate/diagnosis ; Uveitis, Intermediate/drug therapy
Chemical Substances	Tumor Necrosis Factor Inhibitors
Language	English
Publishing date	2023-10-19
Publishing country	Germany
Document type	Observational Study ; Journal Article
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-023-06270-3
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Article ; Online: Surgical site infection and development of antimicrobial sutures: a review.

Chua, R A H W / Lim, S K / Chee, C F / Chin, S P / Kiew, L V / Sim, K S / Tay, S T

European review for medical and pharmacological sciences

2022 Volume 26, Issue 3, Page(s) 828–845

Abstract: Sutures are used to facilitate wound healing and play an important role in ensuring the success of surgical interventions in healthcare facilities. Suture-associated surgical site infection (SSI) may develop when bacterial contaminants colonize the ... ...

Abstract	Sutures are used to facilitate wound healing and play an important role in ensuring the success of surgical interventions in healthcare facilities. Suture-associated surgical site infection (SSI) may develop when bacterial contaminants colonize the suture surface and establish biofilms that are highly resistant to antibiotic treatment. The outcome of SSI affects postoperative care, leading to high rates of morbidity and mortality, prolonged hospitalization, and increased financial burden. Antimicrobial sutures coated with antiseptics such as triclosan and chlorhexidine have been used to minimize the occurrence of SSI. However, as the efficacy of antiseptic-based sutures may be affected due to the emergence of resistant strains, new approaches for the development of alternative antimicrobial sutures are necessary. This review provides an update and outlook of various approaches in the design and development of antimicrobial sutures. Attaining a zero SSI rate will be possible with the advancement in suturing technology and implementation of good infection control practice in clinical settings.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents ; Anti-Infective Agents, Local/therapeutic use ; Humans ; Surgical Wound Infection/drug therapy ; Sutures ; Triclosan/pharmacology ; Triclosan/therapeutic use
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Anti-Infective Agents, Local ; Triclosan (4NM5039Y5X)
Language	English
Publishing date	2022-02-18
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202202_27991
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Article ; Online: Acute unilateral red eye in a patient with psoriasis.

Oon, H H / Ho, G / Sandar, H / Chee, S P

Clinical and experimental dermatology

2019 Volume 44, Issue 8, Page(s) 924–926

MeSH term(s)	Administration, Topical ; Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/therapeutic use ; Female ; Humans ; Hyperemia ; Medication Adherence/psychology ; Middle Aged ; Mydriatics/administration & dosage ; Mydriatics/therapeutic use ; Psoriasis/complications ; Psoriasis/pathology ; Treatment Outcome ; Uveal Diseases/pathology ; Uveitis, Anterior/diagnosis ; Uveitis, Anterior/etiology ; Uveitis, Anterior/pathology
Chemical Substances	Adrenal Cortex Hormones ; Mydriatics
Language	English
Publishing date	2019-02-11
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.13916
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Article ; Online: Stent Evaluation for Expiratory Central Airway Collapse: Does the Type of Stent Really Matter?

Majid, Adnan / Ospina-Delgado, Daniel / Ayala, Alvaro / Gangadharan, Sidhu P / Alape, Daniel / Buitrago, Daniel / Parikh, Mihir S / Wilson, Jennifer L / Chee, Alex C / Fernandez-Bussy, Sebastian / Herth, Felix J F / Kheir, Fayez

Journal of bronchology & interventional pulmonology

2023 Volume 30, Issue 1, Page(s) 37–46

Abstract: ... SYS and USEMAS pairs. The SYS group had an increased rate of mucus plugging (38.5% vs. 0%, P <0.047 ...

Abstract	Background: Careful selection of patients with expiratory central airway collapse (ECAC) that may benefit from tracheobronchoplasty (TBP) can be aided by a short-term airway stent evaluation. This can be performed with either silicone Y-stents (SYSs) or uncovered self-expanding metallic airway-stents (USEMAS). No direct comparison has been made between these 2 stent types. Methods: This was a small retrospective review of consecutive patients that underwent a stent evaluation. A propensity score was used to match patients in the USEMAS and SYS groups. Outcomes included complications, changes in the health-related quality-of-life (HR-QoL), and changes in exercise capacity. Baseline measurements were compared with those obtained during stent evaluation and after TBP. Results: Forty-two patients with severe ECAC underwent USEMAS placement, while 18 patients had an SYS placed. Propensity score matching resulted in 13 matched SYS and USEMAS pairs. The SYS group had an increased rate of mucus plugging (38.5% vs. 0%, P <0.047). Although not statically significant, a clinical improvement was observed in HR-QoL and exercise capacity in the USEMAS group during stent placement. In patients who underwent TBP, both USEMAS and SYS groups had a statistically significant change in the Modified Medical Research Council Dyspnea Scale during stent evaluation and after TBP. Conclusion: In patients with severe ECAC, short-term evaluation with airway stents appears to be safe and improves respiratory symptoms, HR-QoL, and exercise capacity. The use of USEMAS led to a lower complication rate, a greater improvement in HR-QoL and exercise capacity, and appeared to better predict how the patients would respond to TBP.
MeSH term(s)	Humans ; Quality of Life ; Treatment Outcome ; Stents ; Retrospective Studies ; Airway Obstruction/surgery
Language	English
Publishing date	2023-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2478320-1
ISSN	1948-8270 ; 1944-6586
ISSN (online)	1948-8270
ISSN	1944-6586
DOI	10.1097/LBR.0000000000000842
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Article ; Online: Relationships Between Socio-behavioral Factors and the Symptoms Among Asian American Breast Cancer Survivors: A Structural Equation Modeling.

Kim, Seo Yun / Kim, Heejung / Chee, Wonshik / Im, Eun-Ok

Cancer nursing

2024

Abstract: ... The overall fitness of the hypothetical model to the data is acceptable (χ2 = 51.36, P < .001; goodness-of-fit ... Both attitudes and social influences indirectly influenced symptom distress through self-efficacy (β = -0.054, P ... 019, and β = -0.053, P = .017, respectively). Perceived barriers had indirect effects ...

Abstract	Background: Despite increased research on breast cancer survivors, little is known about how socio-behavioral factors influence the symptoms among racial/ethnic minority breast cancer survivors, particularly Asian American breast cancer survivors (AABCS). Objective: This study examined the relationship between multiple socio-behavioral factors in AABCS, including attitudes, perceived barriers, and social influences, and their symptom experiences, with an emphasis on the mediating effect of self-efficacy. Methods: This secondary analysis used data collected from 195 AABCS women recruited through online and offline communities from January 2017 to June 2020. Study variables were measured using validated instruments such as the Questions on Attitudes, Self-Efficacy, Perceived Barriers, and Social Influences; the Cancer Behavior Inventory; and the Memorial Symptom Assessment Scale-Short Form. For structural equation modeling based on Bandura's self-efficacy theory, mediation analysis was performed using SPSS version 26.0 and AMOS 28. Results: The overall fitness of the hypothetical model to the data is acceptable (χ2 = 51.36, P < .001; goodness-of-fit index = 0.95, adjusted goodness-of-fit index = 0.89, comparative fit index = 0.96, Tucker-Lewis index = 0.94, normed fit index = 0.94, and root-mean-square error of approximation index = 0.08). Both attitudes and social influences indirectly influenced symptom distress through self-efficacy (β = -0.054, P = .019, and β = -0.053, P = .017, respectively). Perceived barriers had indirect effects through self-efficacy (β = 0.121, P = .024) and significant direct effects (β = 0.605, P = .003) on symptom distress. Conclusions: Our findings supported that the self-efficacy for coping mediated their symptom experience among AABCS. In addition, there were significant relationships among attitudes, perceived barriers, social influences, and symptom experience. Implications for practice: Future theory-driven interventions need to consider self-efficacy and socio-behavioral factors in symptom management among AABCS.
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	391995-x
ISSN	1538-9804 ; 0162-220X
ISSN (online)	1538-9804
ISSN	0162-220X
DOI	10.1097/NCC.0000000000001354
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Article ; Online: Amplification-Based CRISPR/Cas12a Biosensor Targeting the

Janudin, Arifah A S / Kurup, Chitra P / Chee, Lim Ya / Mohd-Naim, Noor F / Ahmed, Minhaz U

ACS omega

2023 Volume 8, Issue 41, Page(s) 38212–38219

Abstract: We propose a CRISPR/Cas12a-mediated recombinase polymerase amplification (RPA) detection method that combines RPA with Cas12a cleavage for the detection of halal food adulteration, which is of global concern, particularly for Muslim consumers. We ... ...

Abstract	We propose a CRISPR/Cas12a-mediated recombinase polymerase amplification (RPA) detection method that combines RPA with Cas12a cleavage for the detection of halal food adulteration, which is of global concern, particularly for Muslim consumers. We optimized the reagent concentrations for the Cas12a cleavage steps and designed and screened gRNA targeting a conserved area of the mitochondrial cytochrome C oxidase subunit I (
Language	English
Publishing date	2023-10-08
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c04473
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Article ; Online: Comparison of microbial community assemblages in the rhizosphere of three Amaranthus spp.

Chee-Sanford, Joanne C / Connor, Lynn M

PloS one

2023 Volume 18, Issue 11, Page(s) e0294966

Abstract: ... redroot pigweed), A. palmeri S. Watson (Palmer amaranth), and A. tuberculatus (Moq.) J. D. Sauer ... distinct assemblages corresponded to plant species (PERMANOVA F = 14.776, p = 0.001), and further ... within each species, similar communities (F = 11.449, p = 0.001) were associated with three rhizosphere soil fractions ...

Abstract	Weed management remains a major challenge in cropping systems worldwide, with rising interest in ecological based approaches that can be integrated with herbicide use. Soil microbial communities may play important, yet undiscovered, roles in weed success. Little is known about the rhizosphere communities associated with weeds like Amaranthus, commonly known as pigweeds, and considered some of the most problematic weeds in agricultural systems. In a greenhouse experiment that allowed controlled plant growth conditions and a high number of individual plant specimens to analyze for statistical robustness (n = 8 per species), we show that specific bacterial assemblages form in the rhizospheres of A. retroflexus L. (redroot pigweed), A. palmeri S. Watson (Palmer amaranth), and A. tuberculatus (Moq.) J. D. Sauer (waterhemp). Using a relatively rapid and easy approach of T-RFLP community profiling of the 16S rRNA genes, distinct assemblages corresponded to plant species (PERMANOVA F = 14.776, p = 0.001), and further within each species, similar communities (F = 11.449, p = 0.001) were associated with three rhizosphere soil fractions taken in increasing distances away from the root tissue. These results provide the first solid basis for distinct plant-microbe relationships within three closely related Amaranthus species, warranting closer examination of the identities and function of the microorganisms that appear to be selectively recruited from the extant soil community. More intensive efforts to obtain the microbial taxonomic identities via sequencing are underway that can lead to further detailed studies to elucidate important functional plant-microbe interactions that may associate with weed success. Such data provides underlying key information that may ultimately exploit weed-microbe interactions in development of new integrated weed control tactics.
MeSH term(s)	Amaranthus ; Rhizosphere ; RNA, Ribosomal, 16S/genetics ; Plant Weeds ; Soil ; Microbiota
Chemical Substances	RNA, Ribosomal, 16S ; Soil
Language	English
Publishing date	2023-11-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0294966
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Article: Subconjunctival injection of triamcinolone in the treatment of lid retraction of patients with thyroid eye disease: a case series.

Chee, E / Chee, S-P

Eye (London, England)

2008 Volume 22, Issue 2, Page(s) 311–315

Abstract: ... and Muller's muscle under topical anaesthesia on upper lid eversion. Pre- and post-procedure ...

Abstract	Purpose: To report the results of subconjunctival injection of triamcinolone in the treatment of thyroid eye disease-related lid retraction. Intervention: Patients with either unilateral or bilateral upper lid retraction, secondary to thyroid eye disease, diagnosed during the period of February 2004 to June 2005 were recruited. An injection of 0.5 ml of triamcinolone acetonide (40 mg/ml kenalog) with 0.1 ml of 2% lignocaine was injected into the subconjunctival region of the lid between the conjunctiva and Muller's muscle under topical anaesthesia on upper lid eversion. Pre- and post-procedure measurements included lid aperture, marginal reflex distance, the amount of lagophthalmos, and intraocular pressure measurements. Photographs were also obtained before the procedure and at subsequent visits. Follow-up was done at 2 weeks, 1, 3, 6 months and at 1 year. Results: Three of the four patients had resolution of their upper lid retraction within 1 month of treatment, with one patient requiring a repeat triamcinolone injection. The patient who had fibrotic muscles did not respond to triamcinolone injections and required surgical correction. Conclusion: Upper lid subconjunctival triamcinolone appears to be an effective treatment option in reducing lid retraction in patients with recent onset of thyroid eye disease.
MeSH term(s)	Adult ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/therapeutic use ; Eyelid Diseases/drug therapy ; Female ; Follow-Up Studies ; Glucocorticoids/administration & dosage ; Glucocorticoids/therapeutic use ; Graves Ophthalmopathy/drug therapy ; Humans ; Injections/methods ; Triamcinolone Acetonide/administration & dosage ; Triamcinolone Acetonide/therapeutic use
Chemical Substances	Anti-Inflammatory Agents ; Glucocorticoids ; Triamcinolone Acetonide (F446C597KA)
Language	English
Publishing date	2008-02
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/sj.eye.6702933
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Article ; Online: Activating transcription factor 4 regulates hypoxia inducible factor 1α in chronic hypoxia in pancreatic cancer cells.

Chee, Nancy T / Carriere, Candace H / Miller, Zachary / Welford, Scott / Brothers, Shaun P

Oncology reports

2022 Volume 49, Issue 1

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and difficult to treat cancers with tumors typically exhibiting high levels of chronic hypoxia. Hypoxia activates hypoxia-inducible factors (HIFs) that mediate cellular responses to ... ...

Abstract	Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and difficult to treat cancers with tumors typically exhibiting high levels of chronic hypoxia. Hypoxia activates hypoxia-inducible factors (HIFs) that mediate cellular responses to adapt to low oxygen environments. Hypoxia also causes endoplasmic reticulum (ER) stress, increasing activating transcription factor 4 (ATF4), a master regulator of the unfolded protein response (UPR) pathway that mediates cellular response to ER stress. ATF4 is overexpressed in PDAC and is associated with poor prognoses. While ATF4 promotes cell proliferation and tumorigenesis, most studies have been conducted under normoxia or acute hypoxia. The functions of ATF4 in chronic hypoxia remain largely unexplored. Using siRNA knockdown experiments of healthy skin fibroblast cells WS1 and PDAC cell lines PANC-1 and Mia-PaCa2 to analyze mRNA and protein expression levels, a novel ATF4 function was identified, in which it decreases HIF2α mRNA and increases HIF1α mRNA in chronic hypoxia while having no effect in acute hypoxia. A scratch assay was used to show that ATF4 decreases cell migration in chronic hypoxia as opposed to the increase in cell migration ATF4 imparts in acute hypoxia. Colony formation assay and cell viability assay showed that ATF4 promotes colony formation and cell viability in both chronic and acute hypoxia. In addition to the differential response of ATF4 in chronic hypoxia compared with acute hypoxia, this is the first time ATF4 has been implicated in regulation of response to hypoxia via interaction with HIF proteins in PDAC.
MeSH term(s)	Humans ; Activating Transcription Factor 4/genetics ; Carcinoma, Pancreatic Ductal/genetics ; Graft vs Host Disease ; Hypoxia ; Pancreas ; Pancreatic Neoplasms/genetics ; RNA, Messenger ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Pancreatic Neoplasms
Chemical Substances	Activating Transcription Factor 4 (145891-90-3) ; RNA, Messenger ; HIF1A protein, human ; ATF4 protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit
Language	English
Publishing date	2022-11-23
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1222484-4
ISSN	1791-2431 ; 1021-335X
ISSN (online)	1791-2431
ISSN	1021-335X
DOI	10.3892/or.2022.8451
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