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  1. Article ; Online: Cytomegalovirus colitis mimicking rectal carcinoma in an immunocompetent elderly woman.

    Chidlovskii, Elena / Deroux, Alban / Bernard, Sylvain / Couturier, Pascal

    BMJ case reports

    2016  Volume 2016

    Abstract: Cytomegalovirus (CMV) colitis is uncommon in immunocompetent patients, despite a high seroprevalence rate of CMV in the general population. CMV infection has been described in individuals with compromised immune systems: in AIDS, under corticosteroid and ...

    Abstract Cytomegalovirus (CMV) colitis is uncommon in immunocompetent patients, despite a high seroprevalence rate of CMV in the general population. CMV infection has been described in individuals with compromised immune systems: in AIDS, under corticosteroid and immune modulating treatment, with cancer or haematological malignancies. Its most frequent clinical presentation is a necrotising ulcerative form; pseudotumoural CMV colitis has been described as highly exceptional. We report a case of CMV colitis mimicking rectal carcinoma in an immunocompetent elderly woman. The immunosenescence and protein-energy malnutrition increase incidence and severity of infectious diseases in elderly individuals. Immunosenescence may affect all aspects of immunity; severe protein malnutrition modifies mostly cellular immunity, growing susceptibility to infections.
    MeSH term(s) Aged, 80 and over ; Colitis/drug therapy ; Colitis/microbiology ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/etiology ; Diagnosis, Differential ; Fatal Outcome ; Female ; Humans ; Immunocompetence ; Immunosenescence ; Malnutrition/complications ; Rectal Neoplasms/diagnosis ; Rectal Neoplasms/pathology ; Rectovaginal Fistula/diagnostic imaging ; Rectovaginal Fistula/etiology
    Language English
    Publishing date 2016-05-10
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2016-214694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Primary hyperparathyroidism and multiple myeloma complicated by Fanconi syndrome: a fortuitous association?

    Deroux, Alban / Chidlovskii, Elena / Qin, Wen / Couturier, Pascal / Gavazzi, Gaetan

    Presse medicale (Paris, France : 1983)

    2015  Volume 44, Issue 3, Page(s) 360–362

    MeSH term(s) Aged, 80 and over ; Enterobacter aerogenes/isolation & purification ; Enterobacteriaceae Infections/complications ; Fanconi Syndrome/complications ; Fatal Outcome ; Humans ; Hypercalcemia/diagnosis ; Hypercalcemia/etiology ; Hyperparathyroidism, Primary/complications ; Male ; Multiple Myeloma/complications ; Shock, Septic/complications
    Language English
    Publishing date 2015-03
    Publishing country France
    Document type Case Reports ; Letter
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2014.08.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Article ; Online: Comparaison de l'efficacité des scores HAS-BLED et ATRIA dans la prédiction du risque hémorragique des patients de plus de 75 ans traités par anti-vitamine K (AVK) après démarche d'éducation thérapeutique.

    Soave, Claire / Chidlovskii, Elena / Lebelhomme, Audrey / Gaboreau, Yoann / Pernod, Gilles / Bosson, Jean Luc / Couturier, Pascal

    Geriatrie et psychologie neuropsychiatrie du vieillissement

    2015  Volume 13, Issue 3, Page(s) 279–288

    Abstract: Bleeding is the main complication on vitamin K antagonist treatment (VKA), particularly in elderly patients. However, the bleeding risk prediction in geriatric patients remains difficult. We evaluated the predictive value of the HAS-BLED and ATRIA ... ...

    Title translation Comparison of the HAS-BLED and ATRIA scores for the risk of bleeding in patients aged 75 and over receiving vitamin K antagonist (VKA) therapy and educated VKA-management.
    Abstract Bleeding is the main complication on vitamin K antagonist treatment (VKA), particularly in elderly patients. However, the bleeding risk prediction in geriatric patients remains difficult. We evaluated the predictive value of the HAS-BLED and ATRIA bleeding scores in VKA-treated patients aged 75 and over. Various clinical bleeding risk factors in elderly were also studied. 208 patients were included in a case-control study: 52 hemorrhages cases were compared to 156 hemorrhage-free cases (controls), mean age 83.1 years in cases and 82.6 in controls. This elderly subgroup was provided from the prospective SCORE cohort study (study designed to validate the use of bleeding scores in an ambulatory population). The patients were included during a VKA-therapeutic education between May 2009 and May 2010 in 4 French hospitals, and followed for 1 year. The primary endpoint, collected prospectively, was the occurrence of severe and clinically relevant bleeding events. According to the Receiver operating characteristics (ROC), the ATRIA score was as effective as HAS- BLED to predict all bleeding (c-statistic: 0.59 [95% CI 0.50-0.68] vs 0.56 [0.48-0.65]) including severe bleeding (c-statistic: 0.64 [95% CI 0.49-0.79] vs 0.62 [0.49-0.75]). Multivariate Cox regression analysis showed increasing bleeding risk with anemia (OR = 2.6 [95% CI 1.34-5.23], p = 0.005), serotonin reuptake inhibitors (2.8 [1.08-7.47], 0.034), and family-management of VKA-treatment (2.8 [1.28-6.15], 0.01). ATRIA hemorrhage predictive value can be improved by adding such parameters as family-management of VKA-treatment and serotonin reuptake inhibitors treatment. ATRIA appears as relevant as HAS-BLED in predicting all bleeding including major hemorrhages in elderly patients educated VKA-management. The ATRIA bleeding score is improved by including items of serotonin reuptake inhibitors treatment and family-management of VKA-treatment.
    MeSH term(s) Aged ; Aged, 80 and over ; Anticoagulants/adverse effects ; Cohort Studies ; Female ; Geriatric Assessment ; Hemorrhage/chemically induced ; Hemorrhage/diagnosis ; Hemorrhage/epidemiology ; Humans ; Male ; Prospective Studies ; Risk Assessment ; Risk Factors ; Vitamin K/antagonists & inhibitors
    Chemical Substances Anticoagulants ; Vitamin K (12001-79-5)
    Language French
    Publishing date 2015-09
    Publishing country France
    Document type Comparative Study ; Journal Article
    ISSN 2115-7863
    ISSN (online) 2115-7863
    DOI 10.1684/pnv.2015.0562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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