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  1. Article ; Online: Synergistic Activity of Remdesivir-Nirmatrelvir Combination on a SARS-CoV-2 In Vitro Model and a Case Report.

    Gidari, Anna / Sabbatini, Samuele / Schiaroli, Elisabetta / Bastianelli, Sabrina / Pierucci, Sara / Busti, Chiara / Saraca, Lavinia Maria / Capogrossi, Luca / Pasticci, Maria Bruna / Francisci, Daniela

    Viruses

    2023  Volume 15, Issue 7

    Abstract: Background: This study aims to investigate the activity of the remdesivir-nirmatrelvir combination against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and to report a case of Coronavirus Disease 2019 (COVID-19) cured with this ... ...

    Abstract Background: This study aims to investigate the activity of the remdesivir-nirmatrelvir combination against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and to report a case of Coronavirus Disease 2019 (COVID-19) cured with this combination.
    Methods: A Vero E6 cell-based infection assay was used to investigate the in vitro activity of the remdesivir-nirmatrelvir combination. The SARS-CoV-2 strains tested were 20A.EU1, BA.1 and BA.5. After incubation, a viability assay was performed. The supernatants were collected and used for viral titration. The Highest Single Agent (HSA) reference model was calculated. An HSA score >10 is considered synergic.
    Results: Remdesivir and nirmatrelvir showed synergistic activity at 48 and 72 h, with an HSA score of 52.8 and 28.6, respectively (
    Conclusions: Remdesivir-nirmatrelvir combination has synergic activity in vitro. This combination may have a role in immunosuppressed patients with severe COVID-19 and prolonged viral shedding.
    MeSH term(s) Female ; Humans ; SARS-CoV-2 ; COVID-19 ; Ritonavir ; COVID-19 Drug Treatment ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use
    Chemical Substances Ritonavir (O3J8G9O825) ; remdesivir (3QKI37EEHE) ; Antiviral Agents
    Language English
    Publishing date 2023-07-19
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15071577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Listeria monocytogenes

    Tiri, Beatrice / Priante, Giulia / Saraca, Lavinia Maria / Martella, Lucia Assunta / Cappanera, Stefano / Francisci, Daniela

    Case reports in infectious diseases

    2018  Volume 2018, Page(s) 6549496

    Abstract: ... Listeria ... ...

    Abstract Listeria monocytogenes
    Language English
    Publishing date 2018-07-24
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2627642-2
    ISSN 2090-6633 ; 2090-6625
    ISSN (online) 2090-6633
    ISSN 2090-6625
    DOI 10.1155/2018/6549496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: When Does the Cytokine Storm Begin in COVID-19 Patients? A Quick Score to Recognize It.

    Cappanera, Stefano / Palumbo, Michele / Kwan, Sherman H / Priante, Giulia / Martella, Lucia Assunta / Saraca, Lavinia Maria / Sicari, Francesco / Vernelli, Carlo / Di Giuli, Cinzia / Andreani, Paolo / Mariottini, Alessandro / Francucci, Marsilio / Sensi, Emanuela / Costantini, Monya / Bruzzone, Paolo / D'Andrea, Vito / Gioia, Sara / Cirocchi, Roberto / Tiri, Beatrice

    Journal of clinical medicine

    2021  Volume 10, Issue 2

    Abstract: ... admitted to Infectious Disease Department in "St. Maria" Hospital in Terni with confirmed SARS-CoV-2 ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that is responsible for coronavirus disease 2019 (COVID-19), which has rapidly spread across the world, becoming a pandemic. The "cytokine storm" (CS) in COVID-19 leads to the worst stage of illness, and its timely control through immunomodulators, corticosteroids, and cytokine antagonists may be the key to reducing mortality. After reviewing published studies, we proposed a Cytokine Storm Score (CSs) to identify patients who were in this hyperinflammation state, and at risk of progression and poorer outcomes. We retrospectively analyzed 31 patients admitted to Infectious Disease Department in "St. Maria" Hospital in Terni with confirmed SARS-CoV-2 infections, and analyzed the "CS score" (CSs) and the severity of COVID-19. Then we conducted a prospective study of COVID-19 patients admitted after the definition of the CSscore. This is the first study that proposes and applies a new score to quickly identify COVID-19 patients who are in a hyperinflammation stage, to rapidly treat them in order to reduce the risk of intubation. CSs can accurately identify COVID-19 patients in the early stages of a CS, to conduct timely, safe, and effect administration of immunomodulators, corticosteroids, and cytokine antagonists, to prevent progression and reduce mortality.
    Language English
    Publishing date 2021-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10020297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Cytomegalovirus myocarditis in a patient with systemic lupus erythematosus (SLE) successfully treated with ganciclovir.

    Saraca, Lavinia Maria / Lazzari, Ludovico / di Giuli, Cinzia / Lavagna, Alessandro / Mezzetti, Paola / Bovelli, Daniela / Boschetti, Enrico / Francisci, Daniela

    IDCases

    2018  Volume 12, Page(s) 4–6

    Abstract: Myocarditis is an inflammatory disease of the myocardium. Viruses, such as enterovirus, adenovirus, parvovirus B19, HHV6 or cytomegalovirus (CMV) and autoimmune diseases are recognized causes of myocarditis. We describe the clinical case of a young ... ...

    Abstract Myocarditis is an inflammatory disease of the myocardium. Viruses, such as enterovirus, adenovirus, parvovirus B19, HHV6 or cytomegalovirus (CMV) and autoimmune diseases are recognized causes of myocarditis. We describe the clinical case of a young Indian woman with SLE and a concomitant acute CMV related myocarditis with favourable outcome after ganciclovir therapy. CMV myocarditis may range from being a subclinical infection with incidental findings on ECG to a life threating presentation. There are no trials demonstrating the efficacy of antiviral therapy in myocarditis. Case series of patients with CMV myocarditis have reported an excellent clinical outcome after antiviral agents. Lupus Myocarditis (LM) is more prevalent in young females. There are no specific ECG or echocardiographic signs. Treatment strategies of LM are based on corticosteroids, immunosuppressive agents and cardiovascular support, usually with a favorable prognosis, but LM often lead to a severe clinical picture, with mortality of 10.3%. Endomyocardial biopsy (EBM) is recommended as the gold standard but it is very underused in clinical practice, It should be performed in a specialized center but there are concerns on lack of specificity, low negative predictive value, risk of complication, and sampling errors due to the focal nature of myocarditis. Both SLE and CMV are potentially responsible of acute myocarditis. In our knowledge, CMV myocarditis with SLE was described in only one other patient. The initiation of antiviral therapy improved the clinical picture and, in our opinion, it is mandatory when CMV related life threating conditions develop.
    Language English
    Publishing date 2018-02-26
    Publishing country Netherlands
    Document type Journal Article ; Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2018.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Tuberculosis-Related Hospitalizations in a Low-Incidence Country: A Retrospective Analysis in Two Italian Infectious Diseases Wards.

    Campogiani, Laura / Compagno, Mirko / Coppola, Luigi / Malagnino, Vincenzo / Maffongelli, Gaetano / Saraca, Lavinia Maria / Francisci, Daniela / Baldelli, Franco / Fontana, Carla / Grelli, Sandro / Andreoni, Massimo / Sotgiu, Giovanni / Saderi, Laura / Sarmati, Loredana

    International journal of environmental research and public health

    2019  Volume 17, Issue 1

    Abstract: In recent years, a decrease in the incidence of tuberculosis (TB) has been recorded worldwide. However, an increase in TB cases has been reported in foreign people living in low-incidence countries, with an increase in extrapulmonary TB (EPTB) in the ... ...

    Abstract In recent years, a decrease in the incidence of tuberculosis (TB) has been recorded worldwide. However, an increase in TB cases has been reported in foreign people living in low-incidence countries, with an increase in extrapulmonary TB (EPTB) in the western region of the world. In the present work, a retrospective study was conducted in two Italian infectious diseases wards to evaluate the clinical characteristics of TB admission in the time period 2013-2017. A significant increase in TB was shown in the study period: 166 (71% males) patients with TB were enrolled, with ~70% coming from outside Italy (30% from Africa, 25% from Europe, and 13% from Asia and South America). Compared to foreign people, Italians were significantly older (71.5 (interquartile range, IQR: 44.5-80.0) vs. 30 (IQR: 24-40) years;
    MeSH term(s) Adolescent ; Adult ; Africa ; Aged ; Aged, 80 and over ; Asia ; Child ; Child, Preschool ; Emigrants and Immigrants/statistics & numerical data ; Female ; Hospitalization/statistics & numerical data ; Humans ; Incidence ; Infant ; Infant, Newborn ; Italy/epidemiology ; Male ; Middle Aged ; Retrospective Studies ; South America ; Tuberculosis/epidemiology ; Young Adult
    Language English
    Publishing date 2019-12-23
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph17010124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Tuberculosis-Related Hospitalizations in a Low-Incidence Country

    Laura Campogiani / Mirko Compagno / Luigi Coppola / Vincenzo Malagnino / Gaetano Maffongelli / Lavinia Maria Saraca / Daniela Francisci / Franco Baldelli / Carla Fontana / Sandro Grelli / Massimo Andreoni / Giovanni Sotgiu / Laura Saderi / Loredana Sarmati

    International Journal of Environmental Research and Public Health, Vol 17, Iss 1, p

    A Retrospective Analysis in Two Italian Infectious Diseases Wards

    2019  Volume 124

    Abstract: In recent years, a decrease in the incidence of tuberculosis (TB) has been recorded worldwide. However, an increase in TB cases has been reported in foreign people living in low-incidence countries, with an increase in extrapulmonary TB (EPTB) in the ... ...

    Abstract In recent years, a decrease in the incidence of tuberculosis (TB) has been recorded worldwide. However, an increase in TB cases has been reported in foreign people living in low-incidence countries, with an increase in extrapulmonary TB (EPTB) in the western region of the world. In the present work, a retrospective study was conducted in two Italian infectious diseases wards to evaluate the clinical characteristics of TB admission in the time period 2013−2017. A significant increase in TB was shown in the study period: 166 (71% males) patients with TB were enrolled, with ~70% coming from outside Italy (30% from Africa, 25% from Europe, and 13% from Asia and South America). Compared to foreign people, Italians were significantly older (71.5 (interquartile range, IQR: 44.5−80.0) vs. 30 (IQR: 24−40) years; p < 0.0001) more immunocompromised (48% vs. 17%; p < 0.0001), and affected by comorbidities (44% vs. 14%; p < 0.0001). EPTB represented 37% of all forms of the disease, and it was more incident in subjects coming from Africa than in those coming from Europe (39.3% vs. 20%, respectively). In logistic regression analysis, being European was protective (odd ratio, OR (95% CI): 0.2 (0.1−0.6); p = 0.004) against the development of EPTB forms. In conclusion, an increase in the rate of TB diagnosis was documented in two Italian reference centers in the period 2013−2017, with 39% of EPTB diagnosed in patients from outside Europe.
    Keywords tuberculosis ; pulmonary tuberculosis ; extrapulmonary tuberculosis ; foreign people ; Medicine ; R
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: When Does the Cytokine Storm Begin in COVID-19 Patients? A Quick Score to Recognize It

    Stefano Cappanera / Michele Palumbo / Sherman H. Kwan / Giulia Priante / Lucia Assunta Martella / Lavinia Maria Saraca / Francesco Sicari / Carlo Vernelli / Cinzia Di Giuli / Paolo Andreani / Alessandro Mariottini / Marsilio Francucci / Emanuela Sensi / Monya Costantini / Paolo Bruzzone / Vito D’Andrea / Sara Gioia / Roberto Cirocchi / Beatrice Tiri

    Journal of Clinical Medicine, Vol 10, Iss 2, p

    2021  Volume 297

    Abstract: ... admitted to Infectious Disease Department in “St. Maria” Hospital in Terni with confirmed SARS-CoV-2 ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that is responsible for coronavirus disease 2019 (COVID-19), which has rapidly spread across the world, becoming a pandemic. The “cytokine storm” (CS) in COVID-19 leads to the worst stage of illness, and its timely control through immunomodulators, corticosteroids, and cytokine antagonists may be the key to reducing mortality. After reviewing published studies, we proposed a Cytokine Storm Score (CSs) to identify patients who were in this hyperinflammation state, and at risk of progression and poorer outcomes. We retrospectively analyzed 31 patients admitted to Infectious Disease Department in “St. Maria” Hospital in Terni with confirmed SARS-CoV-2 infections, and analyzed the “CS score” (CSs) and the severity of COVID-19. Then we conducted a prospective study of COVID-19 patients admitted after the definition of the CSscore. This is the first study that proposes and applies a new score to quickly identify COVID-19 patients who are in a hyperinflammation stage, to rapidly treat them in order to reduce the risk of intubation. CSs can accurately identify COVID-19 patients in the early stages of a CS, to conduct timely, safe, and effect administration of immunomodulators, corticosteroids, and cytokine antagonists, to prevent progression and reduce mortality.
    Keywords COVID-19 ; cytokine storm ; ARDS ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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