Result 1 - 10 of total 62847
an ethics of death in the time of COVID-19
2020
| Keywords | covid19 |
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| Language | English |
| Publishing date | 2020-04-25 |
| Publishing country | uk |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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Evidence-Based Complementary and Alternative Medicine, Vol
A Classic Chinese Medicine Prescription with Potential for the Treatment of Ulcerative Colitis
2021 Volume 2021
Abstract: The prescription of Tong Xie Yao Fang (TXYF) was derived from the Yuan dynasty “Dan Brook Heart Law ...
| Abstract | The prescription of Tong Xie Yao Fang (TXYF) was derived from the Yuan dynasty “Dan Brook Heart Law,” which was a representative formula for treating liver-spleen disharmony, diarrhea, and abdominal pain. The prescription is composed of four herbs for soothing the liver and strengthening the spleen. TXYF is reportedly capable of eliminating discomfort in ulcerative colitis (UC). This classic formula has been widely used for regulating gastrointestinal motor dysfunction and repairing colon mucosa. This review aims to provide current information on the pharmacology and clinical research of TXYF in the treatment of UC, and to critically appraise that information, in order to guide the future clinical use and experimental study of TXYF in the treatment of UC. We searched online databases including PubMed, CNKI, and Google Scholar for research published between 2010 and 2020 on TXYF and its efficacy in the treatment of UC. The findings indicated that TXYF has anti-inflammatory and immunomodulatory effects, regulates cell signal transduction, brain-gut axis, and intestinal flora in UC, and may promote targeting of bone mesenchymal stem cells (BMSCs) to the colonic mucosa and accelerate healing of the colonic mucosal barrier. In addition, the results of clinical studies showed that TXYF has good efficacy and few adverse reactions in the treatment of UC. Although it has achieved some success, the research is limited by deficiencies; there is a lack of unified standards for the construction of UC animal models and for administration regimen. In addition, the dosage of TXYF is not consistent and lacks pharmacological verification, and clinical trial data are not detailed or sufficiently rigorous. Therefore, a more rigorous, comprehensive, and in-depth study of TXYF in the treatment of UC is needed. |
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| Keywords | Other systems of medicine ; RZ201-999 |
| Language | English |
| Publishing date | 2021-01-01T00:00:00Z |
| Publisher | Hindawi Limited |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Evidence-based complementary and alternative medicine : eCAM
2020 Volume 2020, Page(s) 9058135
Abstract: Qingxin kaiqiao fang (QKF), a traditional Chinese medicine compound, has been applied to treat ...
| Abstract | Qingxin kaiqiao fang (QKF), a traditional Chinese medicine compound, has been applied to treat Alzheimer's disease (AD) for many years and has exhibited remarkable effects. However, the underlying mechanism is still not explicit. The current study aims to investigate whether QKF exerts an antiapoptotic role through the p38 MAPK pathway in the course of AD. Network pharmacology analysis was applied to study the effective components, possible therapeutic targets, and AD-related pathway of QKF. Further, the AD cell model was established using amyloid-beta (A |
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| Language | English |
| Publishing date | 2020-08-03 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2171158-6 |
| ISSN | 1741-4288 ; 1741-427X |
| ISSN (online) | 1741-4288 |
| ISSN | 1741-427X |
| DOI | 10.1155/2020/9058135 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5995: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2022 Volume 13, Page(s) 898360
Abstract: ... ...
| Abstract | Background |
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| Language | English |
| Publishing date | 2022-07-15 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2587355-6 |
| ISSN | 1663-9812 |
| ISSN | 1663-9812 |
| DOI | 10.3389/fphar.2022.898360 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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World journal of gastroenterology
2020 Volume 26, Issue 21, Page(s) 2810–2820
Abstract: ... of effective medicines. The Chinese herbal medicine, Gan Shen Fu Fang (GSFF) is composed of salvianolic acid B ...
| Abstract | Background: Liver fibrosis is a common health problem worldwide and there is still a lack of effective medicines. The Chinese herbal medicine, Gan Shen Fu Fang (GSFF) is composed of salvianolic acid B and diammonium glycyrrhizinate. In this study, we observed the effects of GSFF on liver fibrosis Aim: To observe the effects of GSFF on liver fibrosis Methods: Common bile duct-ligated rats were used for Results: GSFF improved liver function and inhibited liver fibrosis in common bile duct-ligated rats after 3 wk of treatment, as demonstrated by histological changes, hydroxyproline assays and collagen I concentrations. GSFF alleviated inflammatory cell infiltration and reduced the synthesis of pro-inflammatory cytokines [tumor necrosis factor-α (TNF-α) and interlukin-1β] and NF-κB. In addition, GSFF decreased ERK phosphorylation. Conclusion: GSFF inhibited liver fibrosis progression |
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| MeSH term(s) | Animals ; Benzofurans/pharmacology ; Benzofurans/therapeutic use ; Cell Line ; Disease Progression ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Glycyrrhetinic Acid/analogs & derivatives ; Glycyrrhetinic Acid/pharmacology ; Glycyrrhetinic Acid/therapeutic use ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/immunology ; Hepatic Stellate Cells/pathology ; Humans ; Liver/drug effects ; Liver/immunology ; Liver/pathology ; Liver Cirrhosis, Experimental/drug therapy ; Liver Cirrhosis, Experimental/immunology ; Liver Cirrhosis, Experimental/pathology ; Male ; Phosphorylation/drug effects ; Phosphorylation/immunology ; Rats ; Signal Transduction/drug effects ; Signal Transduction/immunology |
| Chemical Substances | Benzofurans ; Drugs, Chinese Herbal ; ganluotong ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Glycyrrhetinic Acid (P540XA09DR) |
| Language | English |
| Publishing date | 2020-06-16 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2185929-2 |
| ISSN | 2219-2840 ; 1007-9327 |
| ISSN (online) | 2219-2840 |
| ISSN | 1007-9327 |
| DOI | 10.3748/wjg.v26.i21.2810 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 6039: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Combinatorial chemistry & high throughput screening
2024 Volume 27, Issue 1, Page(s) 90–100
Abstract: Introduction: Fu-Fang-Jin-Qian-Cao is a Chinese herbal preparation used to treat urinary calculi ... Fu-Fang-Jin-Qian-Cao can protect renal tubular epithelial cells from calcium oxalateinduced renal ... pharmacology to study the mechanism of Fu-Fang-Jin-Qian-Cao inhibiting autophagy in calcium oxalate-induced ...
| Abstract | Introduction: Fu-Fang-Jin-Qian-Cao is a Chinese herbal preparation used to treat urinary calculi. Fu-Fang-Jin-Qian-Cao can protect renal tubular epithelial cells from calcium oxalateinduced renal injury by inhibiting ROS-mediated autopathy. The mechanism still needs further exploration. Metabonomics is a new subject; the combination of metabolomics and network pharmacology can find pathways for drugs to act on targets more efficiently. Methods: Comprehensive metabolomics and network pharmacology to study the mechanism of Fu-Fang-Jin-Qian-Cao inhibiting autophagy in calcium oxalate-induced renal injury. Based on UHPLC-Q-TOF-MS, combined with biochemical analysis, a mice model of Calcium oxalateinduced renal injury was established to study the therapeutic effect of Fu-Fang-Jin-Qian-Cao. Based on the network pharmacology, the target signaling pathway and the protective effect of Fu- Fang-Jin-Qian-Cao on Calcium oxalate-induced renal injury by inhibiting autophagy were explored. Autophagy-related proteins LC3-II, BECN1, ATG5, and ATG7 were studied by immunohistochemistry. Results: Combining network pharmacology and metabolomics, 50 differential metabolites and 2482 targets related to these metabolites were found. Subsequently, the targets enriched in PI3KAkt, MAPK and Ras signaling pathways. LC3-II, BECN1, ATG5 and ATG7 were up-regulated in Calcium oxalate-induced renal injury. All of them could be reversed after the Fu-Fang-Jin-Qian- Cao treatment. Conclusions: Fu-Fang-Jin-Qian-Cao can reverse ROS-induced activation of the MAPK signaling pathway and inhibition of the PI3K-Akt signaling pathway, thereby reducing autophagy damage of renal tubular epithelial cells in Calcium oxalate-induced renal injury. |
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| MeSH term(s) | Mice ; Animals ; Calcium Oxalate/metabolism ; Calcium Oxalate/pharmacology ; Calcium/metabolism ; Chromatography, High Pressure Liquid ; Network Pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Reactive Oxygen Species/metabolism ; Kidney/metabolism ; Autophagy ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/metabolism |
| Chemical Substances | Calcium Oxalate (2612HC57YE) ; Calcium (SY7Q814VUP) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Reactive Oxygen Species ; Drugs, Chinese Herbal |
| Language | English |
| Publishing date | 2024-01-12 |
| Publishing country | United Arab Emirates |
| Document type | Journal Article |
| ZDB-ID | 2064785-2 |
| ISSN | 1875-5402 ; 1386-2073 |
| ISSN (online) | 1875-5402 |
| ISSN | 1386-2073 |
| DOI | 10.2174/1386207326666230515151302 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5577: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2023 Volume 61, Issue 1, Page(s) 1222–1233
Abstract: ... Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating diabetic kidney disease ...
| Abstract | Context: Diabetic nephropathy (DN) is the main cause of end-stage renal disease. Modified Shen-Yan-Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating diabetic kidney disease. However, the potential mechanism of M-SYFSF remains unknown. Objective: To investigate the mechanism of M-SYFSF against DN by network pharmacological analysis and biological experiments. Materials and methods: Utilizing a web-based pharmacology database, the potential mechanisms of M-SYFSF against DN were identified. Results: Network pharmacological analysis showed that MAPK pathway was the potential pathway. Results showed that compared with the Model group, M-SYFSF significantly reduced 24h urine albumin, UACR, and serum creatinine levels (54.90 ± 26.67 vs. 111.78 ± 4.28, 8.87 ± 1.69 vs. 53.94 ± 16.01, 11.56 ± 1.70 vs. 118.70 ± 49.57, respectively), and improved renal pathological changes. Furthermore, the intervention of M-SYFSF reduced the expression of pro-inflammatory cytokines and inhibited the activation of MAPK pathway in AGEs-treated HK-2 cells. Discussion and conclusion: M-SYFSF is likely to reduce inflammation in DN by inhibiting the MAPK pathway. It provides a theoretical basis for the clinical application of M-SYFSF in the treatment of DN. |
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| MeSH term(s) | Rats ; Male ; Humans ; Animals ; Diabetic Nephropathies/metabolism ; Network Pharmacology ; Rats, Sprague-Dawley ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Glycation End Products, Advanced/metabolism |
| Chemical Substances | Drugs, Chinese Herbal ; Glycation End Products, Advanced |
| Language | English |
| Publishing date | 2023-08-11 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1440131-9 |
| ISSN | 1744-5116 ; 1388-0209 |
| ISSN (online) | 1744-5116 |
| ISSN | 1388-0209 |
| DOI | 10.1080/13880209.2023.2241521 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.B 1300: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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International journal of general medicine
2023 Volume 16, Page(s) 2573–2583
Abstract: ... effect on cognitive function in AD patients. Bu Shen Kai Qiao Fang (BSKQF) is one such Chinese ...
| Abstract | Background: Alzheimer's disease (AD) is a common degenerative disease of the nervous system with serious impact on quality of life of patients and their families. With an aging population, AD has become a major public health problem in China and worldwide. However, the physiological and pathological mechanisms of AD have not been fully elucidated, and there is a lack of effective prevention and clinical treatment methods. Many studies have found that traditional Chinese medicine (TCM) has a good therapeutic effect on cognitive function in AD patients. Bu Shen Kai Qiao Fang (BSKQF) is one such Chinese herbal preparation used in the treatment of AD. We designed a protocol for a real-world clinical study of BSKQF combined with Donepezil hydrochloride (DH) to evaluate the efficacy and safety of this approach in the treatment of AD patients. Methods: This is a protocol for a real-world, multicenter, prospective, observational cohort study. The study will recruit 860 AD patients from four hospitals across China. Equal numbers of patients will be treated with BSKQF and DH or with DH only. The criteria for grouping are based primarily on patient preference. Outcome measures include scores on the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Scale (MOCA) and will be recorded at baseline, and at one, two and three months after enrollment. The plasma Aβ42 and plasma Tau levels of participating patients will also be measured by ELISA at baseline and after 3 months of treatment. Safety metrics and adverse events (AEs) of participating patients will be monitored and recorded. Discussion: This study will evaluate the clinical efficacy and safety of BSKQF in the treatment of AD. The results will provide reliable evidence for the clinical application of BSKQF in the treatment of AD. Study registration: Trial registration: Chinese Clinical Trial Registry, NO. ChiCTR2000039670, Registered 5 November 2020 https://www.chictr.org.cn/showprojEN.html?proj=63800. |
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| Language | English |
| Publishing date | 2023-06-17 |
| Publishing country | New Zealand |
| Document type | Journal Article |
| ZDB-ID | 2452220-X |
| ISSN | 1178-7074 |
| ISSN | 1178-7074 |
| DOI | 10.2147/IJGM.S418700 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Evidence-based complementary and alternative medicine : eCAM
2022 Volume 2022, Page(s) 1406820
Abstract: ... of ferroptosis. Huayu Jiedu Fang (HYJDF) is an empirical prescription for EM treatment. This study combined ...
| Abstract | Endometriosis (EM) is a common chronic inflammatory disease in women. Sampson's retrograde menstruation theory is the most widely accepted theory of EM pathogenesis. The periodic bleeding of ectopic lesions is an important pathological feature of this disease, and the occurrence and progression of EM are closely associated with the iron overload caused by ectopic lesions. However, animal models that simulate menstrual-blood reflux and hemorrhage from EM lesions are lacking. In this study, we performed intraperitoneal injection of endometrial fragments and periodic intraperitoneal blood injection to simulate the real cause and disease state of EM and successfully constructed a mouse model of EM iron overload. Our research found that the number, size, and degree of adhesion of EM lesions in the iron-overload model mouse were significantly higher than those in the model mouse. Moreover, the iron concentration in the abdominal fluid and ovary significantly increased, and the level of malondialdehyde (MDA) in the ovary increased. Conversely, GPX4, GSH, and other anti-ferroptosis-related proteins were downregulated, proving the occurrence of ferroptosis. Huayu Jiedu Fang (HYJDF) is an empirical prescription for EM treatment. This study combined animal experiments, UHPLC-QE-MS analysis, and network pharmacology to analyze whether HYJDF can inhibit ferroptosis to slow down the progression of EM and protect ovarian function. Based on the constructed iron-overload model, HYJDF can reduce the volume of EM lesions and the degree of adhesion, downregulate the total iron concentration in the peritoneal fluid and ovary, upregulate GPX4 expression and GSSG in the ovary, downregulate the level of MDA in the ovary, and promote the development of follicles. We further confirmed that HYJDF can inhibit the progression of EM disease and improve the ovarian function of the model mouse by inhibiting ferroptosis. Finally, through UHPLC-QE-MS and network pharmacology analysis, the natural compounds in HYJDF were identified and verified and the regulatory effect of HYJDF on the EM ferroptosis pathway through the IL-6/hepcidin pathway was preliminarily elucidated. |
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| Language | English |
| Publishing date | 2022-08-30 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2171158-6 |
| ISSN | 1741-4288 ; 1741-427X |
| ISSN (online) | 1741-4288 |
| ISSN | 1741-427X |
| DOI | 10.1155/2022/1406820 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5995: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Journal of pharmaceutical and biomedical analysis
2023 Volume 236, Page(s) 115656
Abstract: ... NPCs) and extracellular matrix (ECM) (IDD). Bu-Shen-Huo-Xue-Fang (BSHXF ...
| Abstract | Degeneration of the intervertebral disc is primarily caused by the loss of nucleus pulposus cells (NPCs) and extracellular matrix (ECM) (IDD). Bu-Shen-Huo-Xue-Fang (BSHXF), a traditional Chinese medicine decoction, has been used to treat IDD in clinical; nevertheless, the active components and underlying molecular mechanisms remain unknown. BSHXF improved IL-1β and H |
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| Language | English |
| Publishing date | 2023-08-16 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 604917-5 |
| ISSN | 1873-264X ; 0731-7085 |
| ISSN (online) | 1873-264X |
| ISSN | 0731-7085 |
| DOI | 10.1016/j.jpba.2023.115656 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1850: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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