Article ; Online: The tubulin mutation database: A resource for the cytoskeleton community.
2019 Volume 76, Issue 2, Page(s) 186–191
Abstract: ... to the parental amino acid sequence and citation(s) for the original research. The data is represented ...
| Abstract | Over the last 40 years, the phenotypic consequences of point mutations to tubulin genes have been described in a wide variety of eukaryotes. A publicly available web-based catalog of all published point mutations to tubulin was assembled. Each entry records a specific substitution to a discrete tubulin, the species where the mutation was described, the associated phenotype, and provides hyperlinks to the parental amino acid sequence and citation(s) for the original research. The data is represented in individual tables for the universal tubulin families (α-, β-, and γ-tubulins) with the smaller datasets for point mutations to δ-, ε-, and ζ-tubulins individually appended to the γ-tubulin mutation table. Because tubulins are highly conserved proteins, the benefit of organizing the database tables in order of amino acid position is that comparison between equivalent residues in different isotypes or species is straightforward. For example, it was shown that seven substitutions which are associated with human brain malformations known as tubulinopathies were previously identified in other contexts that suggest that they influence microtubule stability. It was anticipated that this resource will simplify evaluation of the role of specific amino acids or domains in microtubule function. |
|---|---|
| MeSH term(s) | Animals ; Cytoskeleton/genetics ; Databases, Genetic ; Humans ; Mutation/genetics ; Protein Multimerization ; Protein Structure, Secondary ; Tubulin/chemistry ; Tubulin/genetics ; User-Computer Interface |
| Chemical Substances | Tubulin |
| Language | English |
| Publishing date | 2019-02-04 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2534372-5 |
| ISSN | 1949-3592 ; 1949-3584 |
| ISSN (online) | 1949-3592 |
| ISSN | 1949-3584 |
| DOI | 10.1002/cm.21514 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 1840: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.