LIVIVO - Search results -

Search results

Result 1 - 10 of total 188

Search options

Article: Functional characterization of human genomic variation linked to polygenic diseases.

Fabo, Tania / Khavari, Paul

2023 Volume 39, Issue 6, Page(s) 462–490

Abstract: The burden of human disease lies predominantly in polygenic diseases. Since the early 2000s, genome-wide association studies (GWAS) have identified genetic variants and loci associated with complex traits. These have ranged from variants in coding ... ...

Abstract	The burden of human disease lies predominantly in polygenic diseases. Since the early 2000s, genome-wide association studies (GWAS) have identified genetic variants and loci associated with complex traits. These have ranged from variants in coding sequences to mutations in regulatory regions, such as promoters and enhancers, as well as mutations affecting mediators of mRNA stability and other downstream regulators, such as 5' and 3'-untranslated regions (UTRs), long noncoding RNA (lncRNA), and miRNA. Recent research advances in genetics have utilized a combination of computational techniques, high-throughput in vitro and in vivo screening modalities, and precise genome editing to impute the function of diverse classes of genetic variants identified through GWAS. In this review, we highlight the vastness of genomic variants associated with polygenic disease risk and address recent advances in how genetic tools can be used to functionally characterize them.
MeSH term(s)	Humans ; Genome-Wide Association Study/methods ; Multifactorial Inheritance/genetics ; Genetic Predisposition to Disease ; Genetic Variation/genetics ; Genomics
Language	English
Publishing date	2023-03-28
Publishing country	England
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	619240-3
ISSN	1362-4555 ; 0168-9525 ; 0168-9479
ISSN (online)	1362-4555
ISSN	0168-9525 ; 0168-9479
DOI	10.1016/j.tig.2023.02.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2272: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Pain Related to Intradetrusor BotulinumtoxinA: A Randomized Clinical Trial.

Miceli, Lia M / Antosh, Danielle D / Nisar, Tariq / Stewart, Julie / Rutledge, Emily C / Khavari, Rose

Urogynecology (Philadelphia, Pa.)

2024 Volume 30, Issue 3, Page(s) 337–344

Abstract: ... injection group (P = 0.21). No difference was found when categorizing pain scores into ordinal outcomes ... of low (P = 0.55), medium (P = 0.70), and high (P = 1.0) or a binary outcome of low (P = 0.55) versus ... medium + high (P = 0.55). Multivariate analyses did not effect statistical significance between the 2 ...

Abstract	Importance: OnabotulinumtoxinA (BTX-A) is an effective treatment for overactive bladder (OAB), but few studies have been done to evaluate injection techniques. Objective: The primary objective was to evaluate procedural discomfort between 2 commonly used injection techniques for BTX-A. Study design: This was a single-blinded, randomized clinical trial of women undergoing injection of 100 U BTX-A for idiopathic OAB. Patients were randomized to 5 mL/5 injection or 10 mL/10 injection groups. Bladder pain was assessed by a validated Numeric Pain Rating Scale. Overactive bladder symptoms were assessed with a standardized questionnaire (Overactive Bladder Questionnaire Short Form). Patient satisfaction, treatment efficacy, and adverse events were assessed at 30 days after procedure. Results: One hundred eight patients were randomized to 52 in the 5 mL/5 injection arm and 56 in the 10 mL/10 injection arm. Mean procedural pain scores were 3.2 (±2.3) in the 5 mL/5 injection group versus 3.6 (±2.1) in the 10 mL/10 injection group (P = 0.21). No difference was found when categorizing pain scores into ordinal outcomes of low (P = 0.55), medium (P = 0.70), and high (P = 1.0) or a binary outcome of low (P = 0.55) versus medium + high (P = 0.55). Multivariate analyses did not effect statistical significance between the 2 groups for the ordinal outcome (odds ratio = 1.86; 95% confidence interval = 0.77 = 4.52; P = 0.17) or the binary outcome (odds ratio = 1.81; 95% confidence interval = 0.68-4.77; P = 0.28). No difference was observed between overall patient satisfaction, global impression of improvement, Overactive Bladder Questionnaire Short Form scores, or adverse outcomes. Conclusions: Procedural discomfort related to BTX-A injection for idiopathic OAB was not different between 2 injection protocols. Overall satisfaction was high for both groups, and there was no difference in symptom scores or adverse events.
MeSH term(s)	Humans ; Female ; Urinary Bladder, Overactive/drug therapy ; Botulinum Toxins, Type A/adverse effects ; Treatment Outcome ; Patient Satisfaction ; Pelvic Pain/chemically induced
Chemical Substances	Botulinum Toxins, Type A (EC 3.4.24.69)
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ISSN	2771-1897
ISSN (online)	2771-1897
DOI	10.1097/SPV.0000000000001487
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Contemporary management considerations of urinary tract infections for women with spina bifida.

Fremion, Ellen / Bustillos, Paola / Khavari, Rose

International urogynecology journal

2021 Volume 33, Issue 3, Page(s) 493–505

Abstract: Introduction and hypothesis: Urinary tract infections (UTIs) are one of the leading health concerns and causes of hospitalization for adults with spina bifida (SB). The risk factors, evaluation, management, and prevention of UTIs in women with SB must ... ...

Abstract	Introduction and hypothesis: Urinary tract infections (UTIs) are one of the leading health concerns and causes of hospitalization for adults with spina bifida (SB). The risk factors, evaluation, management, and prevention of UTIs in women with SB must take into consideration their unique pelvic anatomy and function as well as the desire for pregnancy or the occurrence UTI during pregnancy. This article reviews published literature regarding this topic and offers recommendations for UTI evaluation, management, and prevention in the context of the unique pelvic floor health needs of women with SB. Methods: A systematic review was conducted using the following keywords: spinal dysraphism, spina bifida, myelomeningocele, meningocele, urinary tract infections, females, and adults. Articles were included if they were in English, published during or after 2000, peer reviewed, included women with spina bifida aged 18 or greater, and included outcomes related to urinary tract infection. Results: No articles met inclusion criteria. Conclusion: As no articles were found based on the initial search criteria, articles pertaining to neurogenic bladder UTI risks, evaluation, and management were discussed to develop consensus recommendations for the unique care of UTIs in women with SB.
MeSH term(s)	Adolescent ; Adult ; Female ; Humans ; Pelvic Floor ; Pregnancy ; Risk Factors ; Spinal Dysraphism/complications ; Urinary Bladder, Neurogenic/etiology ; Urinary Tract Infections/complications ; Urinary Tract Infections/prevention & control
Language	English
Publishing date	2021-06-03
Publishing country	England
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	1050631-7
ISSN	1433-3023 ; 0937-3462
ISSN (online)	1433-3023
ISSN	0937-3462
DOI	10.1007/s00192-021-04860-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3070: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Comparing the Effects of Three Educational Methods (Lecture, Question & Answer, Pamphlet Presentation) on Nutrition Status and Sustainability of Nutritional Knowledge in the Elderly

Najmeh Khatoon Khavari / Laleh Hassani / Shokrullah Mohseni / Asiah Yaari

Sālmand, Vol 18, Iss 2, Pp 192-

2023 Volume 203

Abstract: ... that the effect of Q&A method was effective in improving nutrition status (F=4.397, P=0.031) and sustainability ... of nutritional knowledge (F=10.108, P=0.002). Education by presentation of pamphlets and lecture had no ...

Abstract	Objectives It is necessary to implement educational programs to maintain the nutritional knowledge of the elderly. This study aims to compare the effects of three educational methods (lecture, question and answer, pamphlet presentation) on nutrition status and sustainability of nutritional knowledge in the elderly in Bandar Abbas, Iran. Methods & Materials In this quasi-experimental study, the study population consists of all older people aged ≥60 years in Bandar Abbas city. Of these, 120 people (30 people in the control group and 30 in each of three intervention groups) were selected by a two-stage sampling method. Educational intervention were done by presenting pamphlets, lecturing, and questions & answers (Q&A) sessions. Data collection tools were a 20-item questionnaire on sustainable nutrition knowledge of the Ministry of Health and a 35-item questionnaire on nutritional behavior of the elderly. Data were analyzed in SPSS software, version 23 using one-way analysis of variance and repeated measures analysis of variance. Results The age range of the elderly was 60-79 years. The majority were male (53.3%). The results showed that the effect of Q&A method was effective in improving nutrition status (F=4.397, P=0.031) and sustainability of nutritional knowledge (F=10.108, P=0.002). Education by presentation of pamphlets and lecture had no significant effect on nutrition status and sustainability of knowledge. Conclusion By the Q&A method, the nutritional knowledge can be maintained and the nutrition status can be improved in the elderly compared to lectures and pamphlet presentation methods. It helps formulate appropriate educational programs for the elderly.
Keywords	lecture ; pamphlet ; sustainability ; nutrition knowledge ; elderly ; Geriatrics ; RC952-954.6 ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	Persian
Publishing date	2023-06-01T00:00:00Z
Publisher	University of Social Welfare & Rehabilitation Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Brain activation patterns of female multiple sclerosis patients with voiding dysfunction.

Khavari, Rose / Chen, Jessie / Boone, Timothy / Karmonik, Christof

Neurourology and urodynamics

2020 Volume 39, Issue 3, Page(s) 969–977

Abstract: ... of significant activation were identified (P < .05). A priori regions of interest (ROIs), identified by prior ...

Abstract	Aims: We compared brain activation patterns between female multiple sclerosis (MS) patients with voiding dysfunction (VD) and those without. We aim to expand current knowledge of supraspinal correlates of voiding initiation within a cohort of female MS patients with and without VD. Materials and methods: Twenty-eight ambulatory female MS patients with stable disease and lower urinary tract dysfunction were recruited for this study. Subjects were divided into group 1, without VD (n = 14), and group 2, with VD (n = 14), defined as postvoid residual urine of ≥40% of maximum cystometric capacity or need for self-catheterization. We recorded brain activity via functional magnetic resonance imaging (fMRI) with simultaneous urodynamic testing. Average fMRI activation maps (the Student t test) were created for both groups, and areas of significant activation were identified (P < .05). A priori regions of interest (ROIs), identified by prior meta-analysis to be involved in voiding, were selected. Results: Group-averaged blood-oxygen level-dependent (BOLD) activation maps demonstrated significant differences between groups 1 and 2 during initiation of voiding with group 2 showing significantly lower levels of activation in all ROIs except for the left cerebellum and right cingulate gyrus. Interestingly, group 2 displayed negative BOLD signals, while group 1 displayed positive signals in the right and left pontine micturition center, right periaqueductal gray, left thalamus, and left cingulate gyrus. The activation map of group 1 was similar to healthy controls. Conclusions: Our results support the hypothesis that distinct supraspinal activation patterns exist between female MS patients with VD and those without.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Brain/diagnostic imaging ; Brain/physiopathology ; Case-Control Studies ; Cerebellum/diagnostic imaging ; Cerebellum/physiopathology ; Female ; Functional Neuroimaging ; Gyrus Cinguli/diagnostic imaging ; Gyrus Cinguli/physiopathology ; Humans ; Lower Urinary Tract Symptoms/etiology ; Lower Urinary Tract Symptoms/physiopathology ; Magnetic Resonance Imaging/methods ; Middle Aged ; Multiple Sclerosis/complications ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/physiopathology ; Periaqueductal Gray/diagnostic imaging ; Periaqueductal Gray/physiopathology ; Pons/diagnostic imaging ; Pons/physiopathology ; Thalamus/diagnostic imaging ; Thalamus/physiopathology ; Urinary Bladder/physiopathology ; Urinary Bladder, Neurogenic/etiology ; Urinary Bladder, Neurogenic/physiopathology ; Urination/physiology ; Urination Disorders/etiology ; Urination Disorders/physiopathology ; Urodynamics/physiology
Language	English
Publishing date	2020-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	604904-7
ISSN	1520-6777 ; 0733-2467
ISSN (online)	1520-6777
ISSN	0733-2467
DOI	10.1002/nau.24304
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1828: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Epigenomic Dysregulation in Schizophrenia

Behnaz Khavari / Murray J. Cairns

Cells, Vol 9, Iss 1837, p

In Search of Disease Etiology and Biomarkers

2020 Volume 1837

Abstract: Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms that causes very significant disability in young people. While schizophrenia has a strong genetic component, with heritability around 80%, there is also a very ... ...

Abstract	Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms that causes very significant disability in young people. While schizophrenia has a strong genetic component, with heritability around 80%, there is also a very significant range of environmental exposures and stressors that have been implicated in disease development and neuropathology, such as maternal immune infection, obstetric complications, childhood trauma and cannabis exposure. It is postulated that epigenetic factors, as well as regulatory non-coding RNAs, mediate the effects of these environmental stressors. In this review, we explore the most well-known epigenetic marks, including DNA methylation and histone modification, along with emerging RNA mediators of epigenomic state, including miRNAs and lncRNAs, and discuss their collective potential for involvement in the pathophysiology of schizophrenia implicated through the postmortem analysis of brain tissue. Given that peripheral tissues, such as blood, saliva, and olfactory epithelium have the same genetic composition and are exposed to many of the same environmental exposures, we also examine some studies supporting the application of peripheral tissues for epigenomic biomarker discovery in schizophrenia. Finally, we provide some perspective on how these biomarkers may be utilized to capture a signature of past events that informs future treatment.
Keywords	DNA methylation ; histone modification ; miRNA ; long non-coding RNA ; Schizophrenia ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Oxidative Stress Impact on the Transcriptome of Differentiating Neuroblastoma Cells: Implication for Psychiatric Disorders.

Khavari, Behnaz / Mahmoudi, Ebrahim / Geaghan, Michael P / Cairns, Murray J

International journal of molecular sciences

2020 Volume 21, Issue 23

Abstract: Prenatal environmental exposures that have been shown to induce oxidative stress (OS) during pregnancy, such as smoking and alcohol consumption, are risk factors for the onset of schizophrenia and other neurodevelopmental disorders (NDDs). While the OS ... ...

Abstract	Prenatal environmental exposures that have been shown to induce oxidative stress (OS) during pregnancy, such as smoking and alcohol consumption, are risk factors for the onset of schizophrenia and other neurodevelopmental disorders (NDDs). While the OS role in the etiology of neurodegenerative diseases is well known, its contribution to the genomic dysregulation associated with psychiatric disorders is less well defined. In this study we used the SH-SY5Y cell line and applied RNA-sequencing to explore transcriptomic changes in response to OS before or during neural differentiation. We observed differential expression of many genes, most of which localised to the synapse and were involved in neuronal differentiation. These genes were enriched in schizophrenia-associated signalling pathways, including PI3K/Akt, axon guidance, and signalling by retinoic acid. Interestingly, circulatory system development was affected by both treatments, which is concordant with observations of increased prevalence of cardiovascular disease in patients with NDDs. We also observed a very significant increase in the expression of immunity-related genes, supporting current hypotheses of immune system involvement in psychiatric disorders. While further investigation of this influence in other cell and animal models is warranted, our data suggest that early life exposure to OS has a disruptive influence on neuronal gene expression that may perturb normal differentiation and neurodevelopment, thereby contributing towards overall risk for developing psychiatric diseases.
MeSH term(s)	Cell Line, Tumor ; Computational Biology/methods ; Disease Susceptibility ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Regulatory Networks ; Humans ; Mental Disorders/etiology ; Mental Disorders/metabolism ; Models, Biological ; Neoplasm Grading ; Neuroblastoma/genetics ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Oxidative Stress ; Signal Transduction ; Transcriptome
Language	English
Publishing date	2020-12-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21239182
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Nonlocal Coherent Denoising of RF Data for Ultrasound Elastography.

Khavari, P / Asif, A / Boily, M / Rivaz, H

Journal of healthcare engineering

2018 Volume 2018, Page(s) 7979528

Abstract: Ultrasound elastography infers mechanical properties of living tissues from ultrasound radiofrequency (RF) data recorded while the tissues are undergoing deformation. A challenging yet critical step in ultrasound elastography is to estimate the tissue ... ...

Abstract	Ultrasound elastography infers mechanical properties of living tissues from ultrasound radiofrequency (RF) data recorded while the tissues are undergoing deformation. A challenging yet critical step in ultrasound elastography is to estimate the tissue displacement (or, equivalently the time delay estimate) fields from pairs of RF data. The RF data are often corrupted with noise, which causes the displacement estimator to fail in many
MeSH term(s)	Algorithms ; Bayes Theorem ; Computer Simulation ; Data Collection ; Elasticity Imaging Techniques ; Humans ; Image Enhancement/methods ; Image Processing, Computer-Assisted/methods ; Liver/diagnostic imaging ; Models, Statistical ; Normal Distribution ; Phantoms, Imaging ; Radio Waves ; Ultrasonography
Language	English
Publishing date	2018-06-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2018/7979528
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Treatment of refractory overactive bladder with OnabotulinumtoxinA vs PTNS: TROOP trial.

Kopcsay, Katelyn Smithling / Marczak, Tara Doyle / Jeppson, Peter C / Cameron, Anne P / Khavari, Rose / Tefera, Eshetu / Gutman, Robert E

International urogynecology journal

2022 Volume 33, Issue 4, Page(s) 851–860

Abstract: ... of therapy and were included. At baseline, BTX patients had more detrusor overactivity (70% vs 40%, p = 0.025 ... urgency incontinence (UUI; OABq-SSS#6 4 vs 3, p = 0.02, SSS 65 vs 56, p = 0.04), but similar ... health-related quality of life (HRQL 49 vs 54, p = 0.28), voids (7 vs 8, p = 0.13), and UUI episodes (2 vs 2, p ...

Abstract	Introduction and hypothesis: We hypothesized that patients with refractory overactive bladder (rOAB) have similar improvement with percutaneous tibial nerve stimulation (PTNS) and OnabotulinumtoxinA (BTX). Methods: This multicenter cohort study compared BTX and PTNS in women with rOAB. Baseline information included Overactive Bladder Questionnaire (OABq) short form, Urinary Distress Inventory-6 (UDI-6), and voiding diary. Primary outcome was cure, defined as "very much better" or "much better" on the Patient Global Impression of Improvement (PGII) AND a reduction in OABq symptom severity scale (SSS) ≥10 at 3 months after treatment. Assuming 80% power to detect a ten-point difference in OABq-SSS, 80 participants were required per group. Results: A total of 150 patients were enrolled; 97 completed 3 months of therapy and were included. At baseline, BTX patients had more detrusor overactivity (70% vs 40%, p = 0.025), urgency incontinence (UUI; OABq-SSS#6 4 vs 3, p = 0.02, SSS 65 vs 56, p = 0.04), but similar health-related quality of life (HRQL 49 vs 54, p = 0.28), voids (7 vs 8, p = 0.13), and UUI episodes (2 vs 2, p = 1.0). At 3 months, cure rates were similar: BTX 50% vs PTNS 44.2% (p = 0.56). Both groups had improved SSS (-37 vs -29, p = 0.08) and HRQL (31 vs 24, p = 0.14). Patients receiving BTX had a greater improvement in urgency (ΔOABq-SSS#2-3 vs -2; p = 0.02) and UUI (ΔOABq-SSS#6-2 vs -1; p = 0.02). No characteristics were predictive of cure. Conclusions: BTX resulted in significantly greater improvement in urgency and UUI than PTNS, but no difference in success based on PGII and OABq-SSS, which may be due to a lack of power.
MeSH term(s)	Botulinum Toxins, Type A/therapeutic use ; Cohort Studies ; Female ; Humans ; Male ; Quality of Life ; Tibial Nerve ; Transcutaneous Electric Nerve Stimulation ; Treatment Outcome ; Urinary Bladder, Overactive/drug therapy
Chemical Substances	Botulinum Toxins, Type A (EC 3.4.24.69)
Language	English
Publishing date	2022-01-07
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1050631-7
ISSN	1433-3023 ; 0937-3462
ISSN (online)	1433-3023
ISSN	0937-3462
DOI	10.1007/s00192-021-05030-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3070: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Sequential treatment of landfill leachate by electrocoagulation/aeration, PMS/ZVI/UV and electro-Fenton: Performance, biodegradability and toxicity studies

Khavari Kashani, Mohammad Reza / Wang, Qilin / Khatebasreh, Masoumeh / Li, Xuan / Sheikh Asadi, Amir Mohammad / Boczkaj, Grzegorz / Ghanbari, Farshid

Journal of Environmental Management. 2023 July, v. 338 p.117781-

2023

Abstract: This study presents a systematic study on sequential treatment of highly resistant landfill leachate by electrocoagulation (EC)/aeration, sulfate radical advanced oxidation process (SR-AOP) and electro-Fenton (EF). In case of SR-AOP, peroxymonosulfate ( ... ...

Abstract	This study presents a systematic study on sequential treatment of highly resistant landfill leachate by electrocoagulation (EC)/aeration, sulfate radical advanced oxidation process (SR-AOP) and electro-Fenton (EF). In case of SR-AOP, peroxymonosulfate (PMS) catalyzed by zero valent iron (ZVI) and ultraviolet irradiation (UV) system was developed. Treatment process was optimized in respect to COD removal. Analysis of results revealed that sequential application of EC/aeration, PMS/ZVI/UV, and EF processes provide an extraordinary performance and meet the environmental regulations. The source of iron for EF process was provided from previous process reducing the cost of sequential process. Separately, EC/aeration (inlet COD = 4040 mg/L), PMS/ZVI/UV (inlet COD = 1560 mg/L), and EF (inlet COD = 471 mg/L) removed 61, 69 and 82% of COD respectively. Overall, sequential processes of EC/aeration, PMS/ZVI/UV and EF could remove the COD, TOC and ammonia of the landfill leachate around 98%, 93% and 94%, respectively. The comparison of different sequences of following processes indicated that current configuration (EC/aeration-PMS/ZVI/UV-EF) could meet the discharge standards. Furthermore, humification degree was significantly improved after oxidative processes. Biodegradability study was also performed by means of BOD/COD, average oxidation state (AOS), and Zahn-Wellens test, and the best results associated with these indices were obtained 0.56, 2.37, and over 98%, respectively. Phytotoxicity of leachate was remarkably reduced and the final effluent can be considered as a non-phytotoxic wastewater.
Keywords	aeration ; ammonia ; biodegradability ; chemical oxygen demand ; electrocoagulation ; environmental management ; humification ; iron ; landfill leachates ; oxidation ; phytotoxicity ; sulfates ; ultraviolet radiation ; wastewater ; Waste management ; Electro-Fenton ; Chemical treatment ; Landfill leachate
Language	English
Dates of publication	2023-07
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.117781
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 7556: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED