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  1. Article ; Online: Transincisional quadratus lumborum block in robotic and laparoscopic renal and adrenal surgery: a novel approach.

    Gabriel, Joseph / Alanbuki, Ammar / Larner, Timothy R G

    BJU international

    2023  Volume 133, Issue 1, Page(s) 118–120

    MeSH term(s) Humans ; Robotic Surgical Procedures ; Nerve Block ; Kidney ; Laparoscopy ; Pain, Postoperative ; Anesthetics, Local ; Ultrasonography, Interventional
    Chemical Substances Anesthetics, Local
    Language English
    Publishing date 2023-10-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.16187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The utility of the ChatGPT artificial intelligence tool for patient education and enquiry in robotic radical prostatectomy.

    Gabriel, Joseph / Shafik, Lidia / Alanbuki, Ammar / Larner, Tim

    International urology and nephrology

    2023  Volume 55, Issue 11, Page(s) 2717–2732

    Abstract: Objectives: To assess the ChatGPT (Open AI) artificial intelligence platform's utility and accuracy as a patient education tool in robotic-assisted radical prostatectomy.: Materials and methods: The ChatGPT 3.5 interface ( https://chat.openai.com/ ... ...

    Abstract Objectives: To assess the ChatGPT (Open AI) artificial intelligence platform's utility and accuracy as a patient education tool in robotic-assisted radical prostatectomy.
    Materials and methods: The ChatGPT 3.5 interface ( https://chat.openai.com/chat ) was interrogated and asked the 14 questions related to the frequency of complications of robotic-assisted radical prostatectomy as listed on British Association of Urological Surgeons (BAUS) patient information leaflet "Robotic-Assisted Laparoscopic Radical Prostatectomy)" published July 2021. The AI's responses to each question were tabulated, and compared alongside the official figures quoted from the BAUS information leaflet. A global assessment of the AI's response was also made for accuracy and relevance to patients.
    Results: Of the 14 questions asked, 11/14 (78.6%) of ChatGPT's quoted figures were considered concordant and comparable to those quoted by the BAUS patient information leaflet. 13/14 (92.9%) of ChatGPT's responses were globally assessed to contain accurate information, appropriate, and pertinent to a patient's potential enquiry.
    Conclusion: ChatGPT is a powerful tool and is able to generate accurate and helpful information for patients seeking information regarding urological procedures and their potential complications. It is not, however, infallible, and urologists should remain vigilant in their patient interactions to any potential misinformation a patient may have gathered from it in their personal research prior to surgery.
    MeSH term(s) Male ; Humans ; Artificial Intelligence ; Robotic Surgical Procedures ; Patient Education as Topic ; Prostatectomy ; Urologists
    Language English
    Publishing date 2023-08-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-023-03729-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Artificial intelligence in the urology multidisciplinary team meeting: can ChatGPT suggest European Association of Urology guideline-recommended prostate cancer treatments?

    Gabriel, Joseph / Gabriel, Abraham / Shafik, Lidia / Alanbuki, Ammar / Larner, Tim

    BJU international

    2023  Volume 133, Issue 4, Page(s) 407–409

    MeSH term(s) Male ; Humans ; Urology ; Artificial Intelligence ; Prostatic Neoplasms/therapy ; Prostate ; Patient Care Team
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.16240
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  4. Article: The computer will see you now: ChatGPT and artificial intelligence large language models for health information in urology-an invited perspective.

    Gabriel, Joseph / Shafik, Lidia / Vincent, Elizabeth / Ajzajian, Jirayr / Alanbuki, Ammar / Larner, Timothy R G

    Translational andrology and urology

    2023  Volume 12, Issue 12, Page(s) 1772–1774

    Language English
    Publishing date 2023-12-07
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2851630-8
    ISSN 2223-4691 ; 2223-4691 ; 2223-4683
    ISSN (online) 2223-4691
    ISSN 2223-4691 ; 2223-4683
    DOI 10.21037/tau-23-491
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  5. Article ; Online: Inositol, glycogen, insulin, and six nobelists.

    Larner, Joseph

    The Journal of biological chemistry

    2013  Volume 288, Issue 17, Page(s) 12313–12324

    MeSH term(s) Glycogen ; History, 20th Century ; Inositol ; Insulin ; Nobel Prize
    Chemical Substances Insulin ; Inositol (4L6452S749) ; Glycogen (9005-79-2)
    Language English
    Publishing date 2013-03-20
    Publishing country United States
    Document type Autobiography ; Biography ; Historical Article ; Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.X113.471177
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  6. Book: Methods in diabetes research / 2

    Larner, Joseph

    1986  

    Author's details ed. by Joseph Larner
    Collection Methods in diabetes research
    Size XII, 718 S. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT002808479
    ISBN 0-471-88313-1 ; 978-0-471-88313-5
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1985 A 1980 -2- order for loan Magazin
    1985 A 1980 -2- order for loan Magazin

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  7. Book: Methods in diabetes research / 1. Laboratory methods, C

    Larner, Joseph

    1985  

    Author's details ed. by Joseph Larner
    Collection Methods in diabetes research
    Size XII, 475 S. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT002807830
    ISBN 0-471-80971-3 ; 978-0-471-80971-5
    Database Catalogue ZB MED Medicine, Health

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  8. Book: Methods in diabetes research / 1. Laboratory methods, B

    Larner, Joseph

    1984  

    Author's details ed. by Joseph Larner
    Collection Methods in diabetes research
    Keywords Diabetes mellitus ; Forschungsmethode
    Subject Forschung ; Diabetes verus ; Zuckerharnruhr ; Zuckerkrankheit
    Size XI, 387 S. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT002254767
    ISBN 0-471-80720-6 ; 978-0-471-80720-9
    Database Catalogue ZB MED Medicine, Health

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  9. Book: Methods in diabetes research / 1. Laboratory methods, A

    Larner, Joseph

    1984  

    Author's details ed. by Joseph Larner
    Collection Methods in diabetes research
    Keywords Diabetes mellitus ; Forschungsmethode
    Subject Forschung ; Diabetes verus ; Zuckerharnruhr ; Zuckerkrankheit
    Size XI, 425 S. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT002254766
    ISBN 0-471-88312-3 ; 978-0-471-88312-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Trophoblast uptake of DBP regulates intracellular actin and promotes matrix invasion.

    Ganguly, Ankana / Tamblyn, Jennifer A / Shattock, Alexandra / Joseph, Annsha / Larner, Dean P / Jenkinson, Carl / Gupta, Janesh / Gross, Stephane R / Hewison, Martin

    The Journal of endocrinology

    2021  Volume 249, Issue 1, Page(s) 43–55

    Abstract: Early pregnancy is characterised by elevated circulating levels of vitamin D binding protein (DBP). The impact of this on maternal and fetal health is unclear but DBP is present in the placenta, and DBP gene variants have been linked to malplacentation ... ...

    Abstract Early pregnancy is characterised by elevated circulating levels of vitamin D binding protein (DBP). The impact of this on maternal and fetal health is unclear but DBP is present in the placenta, and DBP gene variants have been linked to malplacentation disorders such as preeclampsia. The functional role of DBP in the placenta was investigated using trophoblastic JEG3, BeWo and HTR8 cells. All three cell lines showed intracellular DBP with increased expression and nuclear localisation of DBP in cells treated with the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D). When cultured in the serum of mice lacking DBP (DBP-/-), JEG3 cells showed no intracellular DBP indicating uptake of exogenous DBP. Inhibition of the membrane receptor for DBP, megalin, also suppressed intracellular DBP. Elimination of intracellular DBP with DBP-/- serum or megalin inhibitor suppressed matrix invasion by trophoblast cells and was associated with increased nuclear accumulation of G-actin. Conversely, treatment with 1,25D enhanced matrix invasion. This was independent of the nuclear vitamin D receptor but was associated with enhanced ERK phosphorylation, and inhibition of ERK kinase suppressed trophoblast matrix invasion. When cultured with serum from pregnant women, trophoblast matrix invasion correlated with DBP concentration, and DBP was lower in first-trimester serum from women who later developed preeclampsia. These data show that the trophoblast matrix invasion involves uptake of serum DBP and associated intracellular actin-binding and homeostasis. DBP is a potential marker of placentation disorders such as preeclampsia and may also provide a therapeutic option for improved placenta and pregnancy health.
    MeSH term(s) Actins/metabolism ; Cell Line ; Cell Line, Tumor ; Cell Nucleus/chemistry ; Cell Nucleus/metabolism ; Choriocarcinoma ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Female ; Gene Knockdown Techniques ; Humans ; Phosphorylation ; Placentation/physiology ; Pre-Eclampsia/blood ; Pregnancy ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/physiology ; Trophoblasts/physiology ; Uterine Neoplasms ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D/pharmacology ; Vitamin D-Binding Protein/blood ; Vitamin D-Binding Protein/genetics ; Vitamin D-Binding Protein/physiology
    Chemical Substances Actins ; Receptors, Calcitriol ; Vitamin D-Binding Protein ; Vitamin D (1406-16-2) ; 1,25-dihydroxyvitamin D (66772-14-3) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2021-02-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 3028-4
    ISSN 1479-6805 ; 0022-0795
    ISSN (online) 1479-6805
    ISSN 0022-0795
    DOI 10.1530/JOE-20-0626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.133: Show issues Location:
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